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The map label for this gene is hemE

Identifier: 92112251

GI number: 92112251

Start: 139207

End: 140268

Strand: Direct

Name: hemE

Synonym: Csal_0116

Alternate gene names: 92112251

Gene position: 139207-140268 (Clockwise)

Preceding gene: 92112247

Following gene: 92112252

Centisome position: 3.77

GC content: 64.88

Gene sequence:

>1062_bases
ATGCCATTGCAAAACGACCGCCTACTGCGTGCCTTGGCGCGCCAACCGGTAGACCGCACACCGGTGTGGATGATGCGCCA
AGCGGGCCGTTATCTGCCCGAATATCGGGAGACGCGCGGCCAGGCCGGCAGTTTCATGGACCTGTGCCGCAACGCCGAAC
TGGCGTGCGAGGTCACCATGCAGCCGCTTCGCCGCTATGCGCTCGATGCGGCGATCCTGTTTTCCGACATCCTCACGATT
CCCGACGCCATGGATCTGGGGCTGTACTTCGAAACGGGCGAAGGCCCCAAGTTTCGCAAGACGGTGCGCAGCGCCGAGGC
TGTGGACGCCTTGCCGGTGCCGGATGCCGAGCGGGATCTCGATTATGTGATGAACGCGGTGCGCACCATTCGCCACGAAC
TGGCGGACAGCGTGCCGTTGATCGGCTTTTCGGGCAGCCCCTGGACGCTGGCGACCTACATGATCGAAGGCGGCTCGAGC
AAGGACTTCCGGCACGCCAAGGCATTGATGTACGGCGATCCCGCGGCGATGCACGCGCTGCTCGACAAGCTGGCGCGGTC
GGTCACCGACTACCTCAATGCGCAGATTCGTGCCGGAGCCCAGATCGTGCAGATCTTCGACACCTGGGGCGGCGTGTTGT
CGACGCCGGCCTACCGCGAGTTCTCGCTGGCCTACATGGCGCGCATCGTCGAAGGACTGATCCGGGAGCACGAGGGGCGC
CACGTGCCGGTGATCCTGTTCACCAAGCAGGGCGGCCAGTGGCTGGAGACCATCGCCGACAGCGGCGCCGATGCCGTGGG
CCTGGACTGGACCACCGAGCTGAGCGACGCCCGGGCCCGTGTCGGGGATCGCGTGGCGCTGCAGGGCAATCTCGATCCCA
ATGTGCTCTTCGCCTCGCCCCAGGCGATTCGCGATGAGGTGGCGCGCATTCTGGCCAGCTATGGCAGCGGTCCCGGCCAT
GTCTTCAACCTGGGGCATGGTGTCAGCCAATTCACTGATCCCGATCATGTCGCCGCCTTCATCGAGGCACTGCATGAACT
CAGCCCGCGTTATCATGGCTGA

Upstream 100 bases:

>100_bases
GGCGAGATATCGATGCTAGATGGGGATGCGTCACCGTGAATCAAGTCGCCGCGCGCGGCATTCGTTACAATGGTGGGCAA
AACCGACGTCTGGAGCTTCC

Downstream 100 bases:

>100_bases
ACGTGCCATGCTGCTCGTGCTCGACGCCGAGTGCCCGTTGTGTCGCCGTGCGGCACACTTCGTGCTGCGCCACGCGCGGG
CGCCGGTGTACCTGGCGAGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MPLQNDRLLRALARQPVDRTPVWMMRQAGRYLPEYRETRGQAGSFMDLCRNAELACEVTMQPLRRYALDAAILFSDILTI
PDAMDLGLYFETGEGPKFRKTVRSAEAVDALPVPDAERDLDYVMNAVRTIRHELADSVPLIGFSGSPWTLATYMIEGGSS
KDFRHAKALMYGDPAAMHALLDKLARSVTDYLNAQIRAGAQIVQIFDTWGGVLSTPAYREFSLAYMARIVEGLIREHEGR
HVPVILFTKQGGQWLETIADSGADAVGLDWTTELSDARARVGDRVALQGNLDPNVLFASPQAIRDEVARILASYGSGPGH
VFNLGHGVSQFTDPDHVAAFIEALHELSPRYHG

Sequences:

>Translated_353_residues
MPLQNDRLLRALARQPVDRTPVWMMRQAGRYLPEYRETRGQAGSFMDLCRNAELACEVTMQPLRRYALDAAILFSDILTI
PDAMDLGLYFETGEGPKFRKTVRSAEAVDALPVPDAERDLDYVMNAVRTIRHELADSVPLIGFSGSPWTLATYMIEGGSS
KDFRHAKALMYGDPAAMHALLDKLARSVTDYLNAQIRAGAQIVQIFDTWGGVLSTPAYREFSLAYMARIVEGLIREHEGR
HVPVILFTKQGGQWLETIADSGADAVGLDWTTELSDARARVGDRVALQGNLDPNVLFASPQAIRDEVARILASYGSGPGH
VFNLGHGVSQFTDPDHVAAFIEALHELSPRYHG
>Mature_352_residues
PLQNDRLLRALARQPVDRTPVWMMRQAGRYLPEYRETRGQAGSFMDLCRNAELACEVTMQPLRRYALDAAILFSDILTIP
DAMDLGLYFETGEGPKFRKTVRSAEAVDALPVPDAERDLDYVMNAVRTIRHELADSVPLIGFSGSPWTLATYMIEGGSSK
DFRHAKALMYGDPAAMHALLDKLARSVTDYLNAQIRAGAQIVQIFDTWGGVLSTPAYREFSLAYMARIVEGLIREHEGRH
VPVILFTKQGGQWLETIADSGADAVGLDWTTELSDARARVGDRVALQGNLDPNVLFASPQAIRDEVARILASYGSGPGHV
FNLGHGVSQFTDPDHVAAFIEALHELSPRYHG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=45.1428571428571, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=70, Blast_Score=518, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320252, Length=358, Percent_Identity=40.7821229050279, Blast_Score=279, Evalue=5e-76,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=41.7867435158501, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=41.7867435158501, Blast_Score=278, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CHRSD (Q1R1C8)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572179.1
- ProteinModelPortal:   Q1R1C8
- SMR:   Q1R1C8
- STRING:   Q1R1C8
- GeneID:   4027042
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0116
- NMPDR:   fig|290398.4.peg.447
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- BioCyc:   CSAL290398:CSAL_0116-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39042; Mature: 38911

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 153-153 BINDING 208-208 BINDING 326-326

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLQNDRLLRALARQPVDRTPVWMMRQAGRYLPEYRETRGQAGSFMDLCRNAELACEVTM
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCCHHHHHHH
QPLRRYALDAAILFSDILTIPDAMDLGLYFETGEGPKFRKTVRSAEAVDALPVPDAERDL
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHH
DYVMNAVRTIRHELADSVPLIGFSGSPWTLATYMIEGGSSKDFRHAKALMYGDPAAMHAL
HHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
LDKLARSVTDYLNAQIRAGAQIVQIFDTWGGVLSTPAYREFSLAYMARIVEGLIREHEGR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
HVPVILFTKQGGQWLETIADSGADAVGLDWTTELSDARARVGDRVALQGNLDPNVLFASP
EEEEEEEECCCCHHHHHHHCCCCCEECCCCCHHHHHHHHHCCCEEEEECCCCCCEEECCC
QAIRDEVARILASYGSGPGHVFNLGHGVSQFTDPDHVAAFIEALHELSPRYHG
HHHHHHHHHHHHHHCCCCCCEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PLQNDRLLRALARQPVDRTPVWMMRQAGRYLPEYRETRGQAGSFMDLCRNAELACEVTM
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCCHHHHHHH
QPLRRYALDAAILFSDILTIPDAMDLGLYFETGEGPKFRKTVRSAEAVDALPVPDAERDL
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHH
DYVMNAVRTIRHELADSVPLIGFSGSPWTLATYMIEGGSSKDFRHAKALMYGDPAAMHAL
HHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
LDKLARSVTDYLNAQIRAGAQIVQIFDTWGGVLSTPAYREFSLAYMARIVEGLIREHEGR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
HVPVILFTKQGGQWLETIADSGADAVGLDWTTELSDARARVGDRVALQGNLDPNVLFASP
EEEEEEEECCCCHHHHHHHCCCCCEECCCCCHHHHHHHHHCCCEEEEECCCCCCEEECCC
QAIRDEVARILASYGSGPGHVFNLGHGVSQFTDPDHVAAFIEALHELSPRYHG
HHHHHHHHHHHHHHCCCCCCEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA