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The map label for this gene is czcS [H]

Identifier: 92112238

GI number: 92112238

Start: 127408

End: 128805

Strand: Direct

Name: czcS [H]

Synonym: Csal_0103

Alternate gene names: 92112238

Gene position: 127408-128805 (Clockwise)

Preceding gene: 92112237

Following gene: 92112239

Centisome position: 3.45

GC content: 69.38

Gene sequence:

>1398_bases
ATGCGCGCGCCGGCCTCTCTGTCGATGCGTCTGTCGCTGTTGTTCGCCCTGGTGAGTCTGGGGCTGCTCGGCGGCCTGGG
CGCCTATCTCTACCATGCCCTGGGCCAACAGATCGCCTGGCGCGACGACCAGATGCTGCAGGGTCGCCTCGAACGCATGG
AAGCGCTTCTGGACGACGGCGAGAGCATCGCGGCGCTGCGCCGCCGCCCGTTGCTCTATGCCAACATGCTGGGCAATCGC
GAGAGCCTGCTGTGGATGCTCGATGCGCGCGGCGTGCCGCTGATCGAGGTCAATCCCCCGGGCCTGCCGGTGCCGGAACT
GCCGCCGGCTCCGGAGGGACGACTCGGGGAGCATCCTGCTGCCGGGTCGACGCGCCTGGCCTGGCGCAGTCTTGAGCATG
ACGGGCGCCGCCTGACCCTGGTGGCCGGCAAGACGCTCGATGAGCGCGAGCGGATGCTGGCCGCCTATCGGTTGCGGTTG
TGGCTCGCCATGGGGGCGGGCGCGGTGCTGGCCTGCGGCCTGGGCTGGGTCGTCGTGCGCCGCGGTCTGCGTCCGGTGAG
ACGGCTGGCCGCGCGGGCGCGCACGATCGACGTGGCGCATCTGCATCGGCGCCTGGAGGCGAACGACGAGACGGCGGAGT
TGCGCGAGCTGAGTCGCGCGCTCAACCAGATGCTGGCGCGCCTGGAGGAAGGGTTCGCCCAGCTGTCGCGCTTTTCCGAG
GACCTCGCCCACGAGATGCGTACGCCCCTGGGCAATCTGCTGGGGGCGACCCAGCAGGCCTTGCAGCGGGAGCGCACGGC
AGAGGAATACCGTCAACTGCTGGGCTCTCACGTCGAAGAGTACGAGCGACTGTCGCGCATGATAGAGACCATGCTGTTCC
TGGCACGCACCGAGCAGCCTGCGAGGGTGCTGCCCCGTGAAACGGTCGATCTGCGAGGCCTCGCCGACCAGCTCTGCGAC
TATTTCGAGGGCATGGCCGACGAGGACGGTCGCGAGCTGGCGAGCGACATGCAGGGGCGGGTGACGGCCAATCTCGACCT
GCTGCGCCGAGCGCTCGCCAACCTCATCGATAACGCGCTGCGCCATGGACGCAGCGGTACCGAGATCCGTCTGGTGTCGC
GGCGAGAGGCCGGGGACTGGCACCTCGGGGTGGTCAATCACGGGGAACCGATTCCCGATGCGGAGCGGGCGCGGCTCTTC
GAGCGCTTCTATCGCGGCGATCCGGCGCGATCCCGGCCGGTGGGCACCGGTGGCCTGGGGCTGGCCATCGTGCGTTCCGT
GGCGCAGCTGCATGGGGGCGAGGCCTGGTGCGAAAGCGACGCGGCCGTCAACGTCTTCTGGTTGAGCTTGCCAGCGGATG
ACGATGACCGCGTTGACAGCTGCCCGGTGCGCCGGTAA

Upstream 100 bases:

>100_bases
TGGCCGTGCGGCGGTTGCGGGCCAAGGTGGACGACCCCTTCACGCGTCGGCTGATTCACACCGAGCGGGGCATGGGCTAC
GTGCTGGAGGACCGCGGTTG

Downstream 100 bases:

>100_bases
CTCTGAACGGTGTCATCGCCTGCACGGCGCAACCCGGGAGACGCGGATGCCAGCGAGACTGAAGACCTATCGCGCCGTGG
CGCACCTGCTGGGCGTGCTG

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRAPASLSMRLSLLFALVSLGLLGGLGAYLYHALGQQIAWRDDQMLQGRLERMEALLDDGESIAALRRRPLLYANMLGNR
ESLLWMLDARGVPLIEVNPPGLPVPELPPAPEGRLGEHPAAGSTRLAWRSLEHDGRRLTLVAGKTLDERERMLAAYRLRL
WLAMGAGAVLACGLGWVVVRRGLRPVRRLAARARTIDVAHLHRRLEANDETAELRELSRALNQMLARLEEGFAQLSRFSE
DLAHEMRTPLGNLLGATQQALQRERTAEEYRQLLGSHVEEYERLSRMIETMLFLARTEQPARVLPRETVDLRGLADQLCD
YFEGMADEDGRELASDMQGRVTANLDLLRRALANLIDNALRHGRSGTEIRLVSRREAGDWHLGVVNHGEPIPDAERARLF
ERFYRGDPARSRPVGTGGLGLAIVRSVAQLHGGEAWCESDAAVNVFWLSLPADDDDRVDSCPVRR

Sequences:

>Translated_465_residues
MRAPASLSMRLSLLFALVSLGLLGGLGAYLYHALGQQIAWRDDQMLQGRLERMEALLDDGESIAALRRRPLLYANMLGNR
ESLLWMLDARGVPLIEVNPPGLPVPELPPAPEGRLGEHPAAGSTRLAWRSLEHDGRRLTLVAGKTLDERERMLAAYRLRL
WLAMGAGAVLACGLGWVVVRRGLRPVRRLAARARTIDVAHLHRRLEANDETAELRELSRALNQMLARLEEGFAQLSRFSE
DLAHEMRTPLGNLLGATQQALQRERTAEEYRQLLGSHVEEYERLSRMIETMLFLARTEQPARVLPRETVDLRGLADQLCD
YFEGMADEDGRELASDMQGRVTANLDLLRRALANLIDNALRHGRSGTEIRLVSRREAGDWHLGVVNHGEPIPDAERARLF
ERFYRGDPARSRPVGTGGLGLAIVRSVAQLHGGEAWCESDAAVNVFWLSLPADDDDRVDSCPVRR
>Mature_465_residues
MRAPASLSMRLSLLFALVSLGLLGGLGAYLYHALGQQIAWRDDQMLQGRLERMEALLDDGESIAALRRRPLLYANMLGNR
ESLLWMLDARGVPLIEVNPPGLPVPELPPAPEGRLGEHPAAGSTRLAWRSLEHDGRRLTLVAGKTLDERERMLAAYRLRL
WLAMGAGAVLACGLGWVVVRRGLRPVRRLAARARTIDVAHLHRRLEANDETAELRELSRALNQMLARLEEGFAQLSRFSE
DLAHEMRTPLGNLLGATQQALQRERTAEEYRQLLGSHVEEYERLSRMIETMLFLARTEQPARVLPRETVDLRGLADQLCD
YFEGMADEDGRELASDMQGRVTANLDLLRRALANLIDNALRHGRSGTEIRLVSRREAGDWHLGVVNHGEPIPDAERARLF
ERFYRGDPARSRPVGTGGLGLAIVRSVAQLHGGEAWCESDAAVNVFWLSLPADDDDRVDSCPVRR

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=444, Percent_Identity=29.954954954955, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786783, Length=478, Percent_Identity=28.8702928870293, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=29.8181818181818, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787894, Length=299, Percent_Identity=30.1003344481605, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=302, Percent_Identity=26.8211920529801, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786600, Length=206, Percent_Identity=29.6116504854369, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=280, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=26.7716535433071, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082128, Length=252, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789808, Length=270, Percent_Identity=28.5185185185185, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=304, Percent_Identity=25.9868421052632, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=325, Percent_Identity=26.4615384615385, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=26.3392857142857, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786912, Length=201, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=26.3374485596708, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=264, Percent_Identity=29.9242424242424, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51968; Mature: 51968

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPASLSMRLSLLFALVSLGLLGGLGAYLYHALGQQIAWRDDQMLQGRLERMEALLDDG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
ESIAALRRRPLLYANMLGNRESLLWMLDARGVPLIEVNPPGLPVPELPPAPEGRLGEHPA
HHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
AGSTRLAWRSLEHDGRRLTLVAGKTLDERERMLAAYRLRLWLAMGAGAVLACGLGWVVVR
CCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RGLRPVRRLAARARTIDVAHLHRRLEANDETAELRELSRALNQMLARLEEGFAQLSRFSE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLAHEMRTPLGNLLGATQQALQRERTAEEYRQLLGSHVEEYERLSRMIETMLFLARTEQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ARVLPRETVDLRGLADQLCDYFEGMADEDGRELASDMQGRVTANLDLLRRALANLIDNAL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RHGRSGTEIRLVSRREAGDWHLGVVNHGEPIPDAERARLFERFYRGDPARSRPVGTGGLG
HCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHH
LAIVRSVAQLHGGEAWCESDAAVNVFWLSLPADDDDRVDSCPVRR
HHHHHHHHHHHCCHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAPASLSMRLSLLFALVSLGLLGGLGAYLYHALGQQIAWRDDQMLQGRLERMEALLDDG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
ESIAALRRRPLLYANMLGNRESLLWMLDARGVPLIEVNPPGLPVPELPPAPEGRLGEHPA
HHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
AGSTRLAWRSLEHDGRRLTLVAGKTLDERERMLAAYRLRLWLAMGAGAVLACGLGWVVVR
CCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RGLRPVRRLAARARTIDVAHLHRRLEANDETAELRELSRALNQMLARLEEGFAQLSRFSE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLAHEMRTPLGNLLGATQQALQRERTAEEYRQLLGSHVEEYERLSRMIETMLFLARTEQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ARVLPRETVDLRGLADQLCDYFEGMADEDGRELASDMQGRVTANLDLLRRALANLIDNAL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RHGRSGTEIRLVSRREAGDWHLGVVNHGEPIPDAERARLFERFYRGDPARSRPVGTGGLG
HCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHH
LAIVRSVAQLHGGEAWCESDAAVNVFWLSLPADDDDRVDSCPVRR
HHHHHHHHHHHCCHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]