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The map label for this gene is czcR [H]

Identifier: 92112237

GI number: 92112237

Start: 126737

End: 127408

Strand: Direct

Name: czcR [H]

Synonym: Csal_0102

Alternate gene names: 92112237

Gene position: 126737-127408 (Clockwise)

Preceding gene: 92112235

Following gene: 92112238

Centisome position: 3.43

GC content: 66.37

Gene sequence:

>672_bases
ATGCGCATCCTGCTGGTGGAAGACGAAAGCAAGACCGCCGACTACCTTGCCAGGGGGCTGGGCGAGGCCGGATACCGGGT
CGAGGTGGCCCGGGACGGGCTGGACGGCCGGCACCTGATCGAGGAGGCCGACTTCGAGCTGATCATCCTCGACGTCATGT
TGCCGGGGCTCGACGGCTGGGAACTGCTGCGGCTGATCCGTCGCCATGGCCAGGTGCCGGTGTTGTTCCTGACCGCCCGG
GATGCCGTGGAATACCGGGTCAAGGGATTGGAGCTGGGCGCTGACGACTATCTGGTCAAACCCTTTTCTTTCGTCGAGCT
GCTGGCCCGGGTGAGGACGCTGCTGCGCCGTGGTCCGCTGCGGGAGCGGGAGCGCTTCCAGGTGGCCGATCTGCACATGG
ACGTGCTGAAACGCCGGGTCACGCGGGGCGAGACGCGGCTTGCGCTGACCAACAAGGAGTTCGCGCTGCTGCAGCTGCTG
CTCGAGCGCGAGGGCGAGGTATTGTCACGGACCTTGATCGCCTCCGAGGTGTGGGGCATGAACTTCGACAGCGACACCAA
TGTGGTGGAGGTGGCCGTGCGGCGGTTGCGGGCCAAGGTGGACGACCCCTTCACGCGTCGGCTGATTCACACCGAGCGGG
GCATGGGCTACGTGCTGGAGGACCGCGGTTGA

Upstream 100 bases:

>100_bases
CCTTGCCGTCACCGGCCTGACGGCAGGATTACGACTTTGTAATGGGCAGCCCGCGCGCGACGGGCTAGCCTGTGGCGTCA
TTTAGCGAGAGGCATGCTGC

Downstream 100 bases:

>100_bases
TGCGCGCGCCGGCCTCTCTGTCGATGCGTCTGTCGCTGTTGTTCGCCCTGGTGAGTCTGGGGCTGCTCGGCGGCCTGGGC
GCCTATCTCTACCATGCCCT

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILLVEDESKTADYLARGLGEAGYRVEVARDGLDGRHLIEEADFELIILDVMLPGLDGWELLRLIRRHGQVPVLFLTAR
DAVEYRVKGLELGADDYLVKPFSFVELLARVRTLLRRGPLRERERFQVADLHMDVLKRRVTRGETRLALTNKEFALLQLL
LEREGEVLSRTLIASEVWGMNFDSDTNVVEVAVRRLRAKVDDPFTRRLIHTERGMGYVLEDRG

Sequences:

>Translated_223_residues
MRILLVEDESKTADYLARGLGEAGYRVEVARDGLDGRHLIEEADFELIILDVMLPGLDGWELLRLIRRHGQVPVLFLTAR
DAVEYRVKGLELGADDYLVKPFSFVELLARVRTLLRRGPLRERERFQVADLHMDVLKRRVTRGETRLALTNKEFALLQLL
LEREGEVLSRTLIASEVWGMNFDSDTNVVEVAVRRLRAKVDDPFTRRLIHTERGMGYVLEDRG
>Mature_223_residues
MRILLVEDESKTADYLARGLGEAGYRVEVARDGLDGRHLIEEADFELIILDVMLPGLDGWELLRLIRRHGQVPVLFLTAR
DAVEYRVKGLELGADDYLVKPFSFVELLARVRTLLRRGPLRERERFQVADLHMDVLKRRVTRGETRLALTNKEFALLQLL
LEREGEVLSRTLIASEVWGMNFDSDTNVVEVAVRRLRAKVDDPFTRRLIHTERGMGYVLEDRG

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=59.009009009009, Blast_Score=266, Evalue=8e-73,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=55.2995391705069, Blast_Score=247, Evalue=4e-67,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=41.7040358744395, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.4444444444444, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=36.3636363636364, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=40.0881057268723, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=33.7662337662338, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=37.7272727272727, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=29.4117647058824, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=33.920704845815, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.3636363636364, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=34.2465753424658, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=31.5555555555556, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.0877192982456, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=31.404958677686, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=31.8181818181818, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25695; Mature: 25695

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDESKTADYLARGLGEAGYRVEVARDGLDGRHLIEEADFELIILDVMLPGLDGW
CEEEEEECCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHH
ELLRLIRRHGQVPVLFLTARDAVEYRVKGLELGADDYLVKPFSFVELLARVRTLLRRGPL
HHHHHHHHCCCCCEEEEECCHHHHHHHHCEEECCCCCEECHHHHHHHHHHHHHHHHHCCC
RERERFQVADLHMDVLKRRVTRGETRLALTNKEFALLQLLLEREGEVLSRTLIASEVWGM
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
NFDSDTNVVEVAVRRLRAKVDDPFTRRLIHTERGMGYVLEDRG
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure
MRILLVEDESKTADYLARGLGEAGYRVEVARDGLDGRHLIEEADFELIILDVMLPGLDGW
CEEEEEECCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCHH
ELLRLIRRHGQVPVLFLTARDAVEYRVKGLELGADDYLVKPFSFVELLARVRTLLRRGPL
HHHHHHHHCCCCCEEEEECCHHHHHHHHCEEECCCCCEECHHHHHHHHHHHHHHHHHCCC
RERERFQVADLHMDVLKRRVTRGETRLALTNKEFALLQLLLEREGEVLSRTLIASEVWGM
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
NFDSDTNVVEVAVRRLRAKVDDPFTRRLIHTERGMGYVLEDRG
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]