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The map label for this gene is dxs

Identifier: 92112234

GI number: 92112234

Start: 123344

End: 125305

Strand: Direct

Name: dxs

Synonym: Csal_0099

Alternate gene names: 92112234

Gene position: 123344-125305 (Clockwise)

Preceding gene: 92112233

Following gene: 92112235

Centisome position: 3.34

GC content: 66.72

Gene sequence:

>1962_bases
ATGAAGCTGTTCGACGAGATTCCTGCCGAACGTCCGGCCACGCCCTTGCTCGATACCTGCGAGCATCCCGCGGCGTTACA
CGATTTCAACGCGACCCAGTTGCGCCAGCTGGCCGACGAGTTGCGTGCCTATTTGCTGTACAGCGTCGGCTGTACCGGCG
GACACTTCGGCGCCGGCCTGGGTGTGGTCGAGTTGACCGTGGCCCTGCATCACATCCTGGATACGCCGTATGACCGCCTG
GTGTGGGACGTCGGTCACCAGGCCTACCCCCACAAGATCCTGACCGGGCGTCGCGAGCAGATGTCGACCATTCGGCAGTT
CGGGGGTCTGGCGGCGTTTCCCAAGCGCGACGAGTCGCCCTATGACACCTTCGGTGTCGGTCATTCGAGCACCTCGATCT
CGGCGGCGCTGGGCATGGCGCTGGCGGCGCGGACCAAGGGCGAACGGCGTCGTGTGTGTGCGGTCATCGGCGATGGCGCC
TTGAGCGCGGGCATGGCATTCGAGGCGCTGGCGCATGCCGGCCATGTCGATGCCAACATGCTGGTGATTCTCAACGACAA
CGAGATGTCGATCTCCGAGAACGTCGGCGGCATGGCGAGCTATCTGGCACGCATTCTGGTCAGCAAGCCGTACACGGTGA
TGCGCGAGAACAGCAAGCGCGTGCTCTCGCACCTGCCGGGCGCGCTGGAGCTGGCCCGGCGCACCGAGGAGCACGTCAAG
GGCATGGTCAGCCCGGCGACCCTGTTCGAGGAGATGGGATTCAACTACATCGGTCCCATCGACGGTCATGACCTGCCGAC
GCTGGTGCAGACGCTGGGCAACATGGCGAATCTGGAGGGGCCGCAGTTCCTGCATATCAAGACCTGCAAGGGGCGCGGCT
TTCGTCCCGCCGAGGCCGATCCCATCGGTTACCACGCCATCACCAAGCTCGAGAAGACCACCAGCGAGCCGCCGCCCAAA
AAAGAGCCGCGCTCGCCCAACGCGGCCACGGCGGAGCCGGAAGCCCAGCCCAAGCCCCAGCCCAAGCCGCGCAAGTATTG
CAATGTCTTCGGCGAGTGGATCTGCGACATGGCGGCGGTGGACGCGCGTCTGATTGGCATCACGCCGGCGATGCGCGAGG
GCTCCGACCTGATCCGCTTCTCGCGCGAGTATCCCGAGCGCTACTACGACGTGGCGATCGCCGAACAGCATGCGGTGACG
CTGGCGGCGGGCATGGCGTGCGAGGCGATGAAGCCCGTGGTGGCGATCTACTCGACCTTCCTGCAGCGCGGCTATGACCA
GTTGATCCACGACGTGGCGGTGCAGGCGCTCGATGTGACCTTCGCCATCGACCGTGCCGGCGTGGTGGGCGAGGACGGCC
CGACTCACCATGGTGCGCTGGACCTTTCCTTCCTGCGCTGCATTCCCGGCATGATCGTGCTGGCGCCCGCCGATGAGGCC
GAGTGTCGAGCCATGCTGAGCGCCGCGTACCATCACCCCGGACCGGCGGCGGTACGTTATCCGCGTGGCACCGGTCCCGG
CACGCAGGTGGCATCGAACCTGGAGGCGCTGCCCATCGGCGAGGCCGAGACACGGCGCAGCGGTCGCGAAGGCGGCGTGG
CGTTGCTGGCGTTCGGCAGCATGAACGGCCCTGCCGGCGAGGTGGCCGAGCGTCTCGATGCCACGCACCTCAACATGCGC
AGCGTGAAGCCGCTGGATCGTGAGGCGATCCTCGCGGCAGCGCGCGACCACCGGCTGCTGGTGACCCTCGAGGAGAGCGT
CGTCGCCGGTGGCGCGGGAAGCGGCGTCAATGAACTCCTGGCCGCCGAGGGTGTCCAGGTCGAAGTATTGAACCTGGGGC
TGCCGGACGATTTCGTCGAGCACGGCAAACCCGCCGAGTTGCTGGCGGCGTGCGGGCTCGATGCCGAGGGCATCGAAACC
GCCGTGCGTCGGCGCCTGGAAACGTCGCGTGCCGATGACTGA

Upstream 100 bases:

>100_bases
CTGAGCGCTCTGGCTCCGTTGGGCGAACGTGCCTATCCTCTGGCCGAGCTGGCCCGCCACATGATCGACCGCGATCACTG
ATCGGTTGTAGATAACGCTT

Downstream 100 bases:

>100_bases
CACTTAACGACAAGACGAGATTTTCATGCTGATCGCCATATTGATTGGAGCCGGCCTCGGCTTCATGTTCGGGAAATTGC
CGGGACTGATCATCGGTGCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MKLFDEIPAERPATPLLDTCEHPAALHDFNATQLRQLADELRAYLLYSVGCTGGHFGAGLGVVELTVALHHILDTPYDRL
VWDVGHQAYPHKILTGRREQMSTIRQFGGLAAFPKRDESPYDTFGVGHSSTSISAALGMALAARTKGERRRVCAVIGDGA
LSAGMAFEALAHAGHVDANMLVILNDNEMSISENVGGMASYLARILVSKPYTVMRENSKRVLSHLPGALELARRTEEHVK
GMVSPATLFEEMGFNYIGPIDGHDLPTLVQTLGNMANLEGPQFLHIKTCKGRGFRPAEADPIGYHAITKLEKTTSEPPPK
KEPRSPNAATAEPEAQPKPQPKPRKYCNVFGEWICDMAAVDARLIGITPAMREGSDLIRFSREYPERYYDVAIAEQHAVT
LAAGMACEAMKPVVAIYSTFLQRGYDQLIHDVAVQALDVTFAIDRAGVVGEDGPTHHGALDLSFLRCIPGMIVLAPADEA
ECRAMLSAAYHHPGPAAVRYPRGTGPGTQVASNLEALPIGEAETRRSGREGGVALLAFGSMNGPAGEVAERLDATHLNMR
SVKPLDREAILAAARDHRLLVTLEESVVAGGAGSGVNELLAAEGVQVEVLNLGLPDDFVEHGKPAELLAACGLDAEGIET
AVRRRLETSRADD

Sequences:

>Translated_653_residues
MKLFDEIPAERPATPLLDTCEHPAALHDFNATQLRQLADELRAYLLYSVGCTGGHFGAGLGVVELTVALHHILDTPYDRL
VWDVGHQAYPHKILTGRREQMSTIRQFGGLAAFPKRDESPYDTFGVGHSSTSISAALGMALAARTKGERRRVCAVIGDGA
LSAGMAFEALAHAGHVDANMLVILNDNEMSISENVGGMASYLARILVSKPYTVMRENSKRVLSHLPGALELARRTEEHVK
GMVSPATLFEEMGFNYIGPIDGHDLPTLVQTLGNMANLEGPQFLHIKTCKGRGFRPAEADPIGYHAITKLEKTTSEPPPK
KEPRSPNAATAEPEAQPKPQPKPRKYCNVFGEWICDMAAVDARLIGITPAMREGSDLIRFSREYPERYYDVAIAEQHAVT
LAAGMACEAMKPVVAIYSTFLQRGYDQLIHDVAVQALDVTFAIDRAGVVGEDGPTHHGALDLSFLRCIPGMIVLAPADEA
ECRAMLSAAYHHPGPAAVRYPRGTGPGTQVASNLEALPIGEAETRRSGREGGVALLAFGSMNGPAGEVAERLDATHLNMR
SVKPLDREAILAAARDHRLLVTLEESVVAGGAGSGVNELLAAEGVQVEVLNLGLPDDFVEHGKPAELLAACGLDAEGIET
AVRRRLETSRADD
>Mature_653_residues
MKLFDEIPAERPATPLLDTCEHPAALHDFNATQLRQLADELRAYLLYSVGCTGGHFGAGLGVVELTVALHHILDTPYDRL
VWDVGHQAYPHKILTGRREQMSTIRQFGGLAAFPKRDESPYDTFGVGHSSTSISAALGMALAARTKGERRRVCAVIGDGA
LSAGMAFEALAHAGHVDANMLVILNDNEMSISENVGGMASYLARILVSKPYTVMRENSKRVLSHLPGALELARRTEEHVK
GMVSPATLFEEMGFNYIGPIDGHDLPTLVQTLGNMANLEGPQFLHIKTCKGRGFRPAEADPIGYHAITKLEKTTSEPPPK
KEPRSPNAATAEPEAQPKPQPKPRKYCNVFGEWICDMAAVDARLIGITPAMREGSDLIRFSREYPERYYDVAIAEQHAVT
LAAGMACEAMKPVVAIYSTFLQRGYDQLIHDVAVQALDVTFAIDRAGVVGEDGPTHHGALDLSFLRCIPGMIVLAPADEA
ECRAMLSAAYHHPGPAAVRYPRGTGPGTQVASNLEALPIGEAETRRSGREGGVALLAFGSMNGPAGEVAERLDATHLNMR
SVKPLDREAILAAARDHRLLVTLEESVVAGGAGSGVNELLAAEGVQVEVLNLGLPDDFVEHGKPAELLAACGLDAEGIET
AVRRRLETSRADD

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=553, Percent_Identity=24.5931283905967, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI4507521, Length=553, Percent_Identity=24.5931283905967, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI225637463, Length=434, Percent_Identity=26.036866359447, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637461, Length=431, Percent_Identity=25.9860788863109, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637459, Length=434, Percent_Identity=26.036866359447, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI133778974, Length=559, Percent_Identity=23.9713774597496, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1786622, Length=639, Percent_Identity=55.7120500782473, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=429, Percent_Identity=25.1748251748252, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24666278, Length=619, Percent_Identity=25.686591276252, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24645119, Length=622, Percent_Identity=24.7588424437299, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45551847, Length=662, Percent_Identity=24.4712990936556, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550715, Length=662, Percent_Identity=24.4712990936556, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CHRSD (Q1R1E5)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572162.1
- ProteinModelPortal:   Q1R1E5
- SMR:   Q1R1E5
- STRING:   Q1R1E5
- GeneID:   4026021
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0099
- NMPDR:   fig|290398.4.peg.399
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- BioCyc:   CSAL290398:CSAL_0099-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70248; Mature: 70248

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFDEIPAERPATPLLDTCEHPAALHDFNATQLRQLADELRAYLLYSVGCTGGHFGAGL
CCCHHHCCCCCCCCCHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
GVVELTVALHHILDTPYDRLVWDVGHQAYPHKILTGRREQMSTIRQFGGLAAFPKRDESP
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
YDTFGVGHSSTSISAALGMALAARTKGERRRVCAVIGDGALSAGMAFEALAHAGHVDANM
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEE
LVILNDNEMSISENVGGMASYLARILVSKPYTVMRENSKRVLSHLPGALELARRTEEHVK
EEEECCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCHHHHHHHHHHHHHH
GMVSPATLFEEMGFNYIGPIDGHDLPTLVQTLGNMANLEGPQFLHIKTCKGRGFRPAEAD
HCCCHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCC
PIGYHAITKLEKTTSEPPPKKEPRSPNAATAEPEAQPKPQPKPRKYCNVFGEWICDMAAV
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DARLIGITPAMREGSDLIRFSREYPERYYDVAIAEQHAVTLAAGMACEAMKPVVAIYSTF
HHEEEECCCCHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQRGYDQLIHDVAVQALDVTFAIDRAGVVGEDGPTHHGALDLSFLRCIPGMIVLAPADEA
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCHH
ECRAMLSAAYHHPGPAAVRYPRGTGPGTQVASNLEALPIGEAETRRSGREGGVALLAFGS
HHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEECC
MNGPAGEVAERLDATHLNMRSVKPLDREAILAAARDHRLLVTLEESVVAGGAGSGVNELL
CCCCHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCEEEEEEECHHHCCCCCCCHHHHH
AAEGVQVEVLNLGLPDDFVEHGKPAELLAACGLDAEGIETAVRRRLETSRADD
HCCCCEEEEEECCCCHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLFDEIPAERPATPLLDTCEHPAALHDFNATQLRQLADELRAYLLYSVGCTGGHFGAGL
CCCHHHCCCCCCCCCHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
GVVELTVALHHILDTPYDRLVWDVGHQAYPHKILTGRREQMSTIRQFGGLAAFPKRDESP
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
YDTFGVGHSSTSISAALGMALAARTKGERRRVCAVIGDGALSAGMAFEALAHAGHVDANM
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEE
LVILNDNEMSISENVGGMASYLARILVSKPYTVMRENSKRVLSHLPGALELARRTEEHVK
EEEECCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCHHHHHHHHHHHHHH
GMVSPATLFEEMGFNYIGPIDGHDLPTLVQTLGNMANLEGPQFLHIKTCKGRGFRPAEAD
HCCCHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCC
PIGYHAITKLEKTTSEPPPKKEPRSPNAATAEPEAQPKPQPKPRKYCNVFGEWICDMAAV
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DARLIGITPAMREGSDLIRFSREYPERYYDVAIAEQHAVTLAAGMACEAMKPVVAIYSTF
HHEEEECCCCHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQRGYDQLIHDVAVQALDVTFAIDRAGVVGEDGPTHHGALDLSFLRCIPGMIVLAPADEA
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCHH
ECRAMLSAAYHHPGPAAVRYPRGTGPGTQVASNLEALPIGEAETRRSGREGGVALLAFGS
HHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEECC
MNGPAGEVAERLDATHLNMRSVKPLDREAILAAARDHRLLVTLEESVVAGGAGSGVNELL
CCCCHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHCCCEEEEEEECHHHCCCCCCCHHHHH
AAEGVQVEVLNLGLPDDFVEHGKPAELLAACGLDAEGIETAVRRRLETSRADD
HCCCCEEEEEECCCCHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA