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The map label for this gene is ispA [H]

Identifier: 92112233

GI number: 92112233

Start: 122467

End: 123324

Strand: Direct

Name: ispA [H]

Synonym: Csal_0098

Alternate gene names: 92112233

Gene position: 122467-123324 (Clockwise)

Preceding gene: 92112232

Following gene: 92112234

Centisome position: 3.31

GC content: 70.98

Gene sequence:

>858_bases
ATGACCACGGCCCGTGCGCGCACCGAGCAGGTGCTCGCCGGTATCGTCGAGCGTGCGGCGCCCGTCTCCGGCGAGCTCGA
CGCCGCCATGCGGTACAGCGTGCTGGGGGGCGGCAAGCGCCTGCGCCCGATCCTGGTCTACGCGGCCGGCCATGCGCTGG
GCGCCGAGGACAAGGCCCTGGATGCGCCGGCCGCTGCCGTCGAGCTGATCCACGCCTACTCGCTGGTGCACGACGACCTG
CCGGCCATGGACGACGACGACATGCGTCGTGGCCGTCCCACCGTACATCGTGCCTACAGCGAGGCGATGGCGATTCTGGC
CGGTGACGCCCTGCAGACGCTGGCCTTCGAGGTATTGGCCGAGACGCGTCACCCGCGCCTGGGGGCGATGGTGCGTGCGC
TGGCCAACGCCTCGGGACGCGAAGGCATGGCCGCCGGACAGGCGCTGGACCTTTCCGCCGTGGGCGGGCGCCTGGATGTC
GACGCGCTGGCCACCATGCACGGCTACAAGACCGGTGCGCTGATTCGTGCCGCCGTGCGTCTGGGCGCCCTGGCCGCTGC
CGACGAGGACGACCCTCGTGTGGCGGCCCTGGACACCTACGCGGCGGCCATCGGCTTGGCGTTCCAGATCCAGGATGACA
TTCTCGATGTCGCCGGCGACGCCGCGACCCTGGGCAAGGCCACCGGCGCCGATGCGGCGCGTGCCAAGCCTACTTATCCG
GCCTTGCTCGGCCTTGATGGCGCCCGTGCCAAGGCACGAGGCTTGCTCGACGAGGCCCTGAGCGCTCTGGCTCCGTTGGG
CGAACGTGCCTATCCTCTGGCCGAGCTGGCCCGCCACATGATCGACCGCGATCACTGA

Upstream 100 bases:

>100_bases
AAGGCCTTGCTGGAGCAGCCCGATGGCAGCTTCCAGACGGTACCGTTCGAGACCGGGGAGGCCGATGGTGAGCGTTGAGC
CCTTGAGCGACCGCGACATC

Downstream 100 bases:

>100_bases
TCGGTTGTAGATAACGCTTATGAAGCTGTTCGACGAGATTCCTGCCGAACGTCCGGCCACGCCCTTGCTCGATACCTGCG
AGCATCCCGCGGCGTTACAC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTTARARTEQVLAGIVERAAPVSGELDAAMRYSVLGGGKRLRPILVYAAGHALGAEDKALDAPAAAVELIHAYSLVHDDL
PAMDDDDMRRGRPTVHRAYSEAMAILAGDALQTLAFEVLAETRHPRLGAMVRALANASGREGMAAGQALDLSAVGGRLDV
DALATMHGYKTGALIRAAVRLGALAAADEDDPRVAALDTYAAAIGLAFQIQDDILDVAGDAATLGKATGADAARAKPTYP
ALLGLDGARAKARGLLDEALSALAPLGERAYPLAELARHMIDRDH

Sequences:

>Translated_285_residues
MTTARARTEQVLAGIVERAAPVSGELDAAMRYSVLGGGKRLRPILVYAAGHALGAEDKALDAPAAAVELIHAYSLVHDDL
PAMDDDDMRRGRPTVHRAYSEAMAILAGDALQTLAFEVLAETRHPRLGAMVRALANASGREGMAAGQALDLSAVGGRLDV
DALATMHGYKTGALIRAAVRLGALAAADEDDPRVAALDTYAAAIGLAFQIQDDILDVAGDAATLGKATGADAARAKPTYP
ALLGLDGARAKARGLLDEALSALAPLGERAYPLAELARHMIDRDH
>Mature_284_residues
TTARARTEQVLAGIVERAAPVSGELDAAMRYSVLGGGKRLRPILVYAAGHALGAEDKALDAPAAAVELIHAYSLVHDDLP
AMDDDDMRRGRPTVHRAYSEAMAILAGDALQTLAFEVLAETRHPRLGAMVRALANASGREGMAAGQALDLSAVGGRLDVD
ALATMHGYKTGALIRAAVRLGALAAADEDDPRVAALDTYAAAIGLAFQIQDDILDVAGDAATLGKATGADAARAKPTYPA
LLGLDGARAKARGLLDEALSALAPLGERAYPLAELARHMIDRDH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=230, Percent_Identity=30.4347826086957, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786623, Length=263, Percent_Identity=58.93536121673, Blast_Score=257, Evalue=6e-70,
Organism=Escherichia coli, GI1789578, Length=218, Percent_Identity=35.3211009174312, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=268, Percent_Identity=26.1194029850746, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24651612, Length=231, Percent_Identity=29.004329004329, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 29597; Mature: 29466

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTARARTEQVLAGIVERAAPVSGELDAAMRYSVLGGGKRLRPILVYAAGHALGAEDKAL
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
DAPAAAVELIHAYSLVHDDLPAMDDDDMRRGRPTVHRAYSEAMAILAGDALQTLAFEVLA
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETRHPRLGAMVRALANASGREGMAAGQALDLSAVGGRLDVDALATMHGYKTGALIRAAVR
HHCCCHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCCCCHHHHHHHHCCHHHHHHHHHHH
LGALAAADEDDPRVAALDTYAAAIGLAFQIQDDILDVAGDAATLGKATGADAARAKPTYP
HHHHHCCCCCCCCEEHHHHHHHHHHHHEEEHHHHHHHCCCHHHHCCCCCCCCCCCCCCCC
ALLGLDGARAKARGLLDEALSALAPLGERAYPLAELARHMIDRDH
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TTARARTEQVLAGIVERAAPVSGELDAAMRYSVLGGGKRLRPILVYAAGHALGAEDKAL
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
DAPAAAVELIHAYSLVHDDLPAMDDDDMRRGRPTVHRAYSEAMAILAGDALQTLAFEVLA
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETRHPRLGAMVRALANASGREGMAAGQALDLSAVGGRLDVDALATMHGYKTGALIRAAVR
HHCCCHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCCCCHHHHHHHHCCHHHHHHHHHHH
LGALAAADEDDPRVAALDTYAAAIGLAFQIQDDILDVAGDAATLGKATGADAARAKPTYP
HHHHHCCCCCCCCEEHHHHHHHHHHHHEEEHHHHHHHCCCHHHHCCCCCCCCCCCCCCCC
ALLGLDGARAKARGLLDEALSALAPLGERAYPLAELARHMIDRDH
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]