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The map label for this gene is tdcB [H]

Identifier: 91789075

GI number: 91789075

Start: 3401955

End: 3402929

Strand: Reverse

Name: tdcB [H]

Synonym: Bpro_3215

Alternate gene names: 91789075

Gene position: 3402929-3401955 (Counterclockwise)

Preceding gene: 91789076

Following gene: 91789068

Centisome position: 65.44

GC content: 67.08

Gene sequence:

>975_bases
ATGCTGCAACTTCCCGTTTACGACGACGTCCTCGCCGCAGCCGCGCGGCTTGAGGGCCACGCGCACCGCACGCCGGTACT
GACCTCCGCCACGGCCGATGCCCGCTGGGGTTCCCAGTTTTTCTTCAAGTGCGAAAACTTCCAGCGCATGGGGGCGTTTA
AGTTCCGTGGAGCGTTCAATGCGCTGTCAAAGTTCGACGCGGGCCAGCGCCGGGCCGGGGCGATCGCGTTTTCGTCGGGC
AACCATGCACAGGCGGTGGCGCTGTCGGCGCGGCTGCTCGGCATGCCCGCGTTGATCGTGATGCCGCAGGACGCACCGGC
TGCCAAGCTGGCCGCGACGCGTGGCTACGGCGCCGAGGTGGTGCTGTACGACCGCTTCAGCGAAGACCGCGAGGCGCTCA
CGCAGCGGCTGGCGGCCGAGCGGGGTATGACCCTGATTCCGCCCTATGACCATCCCGACGTGATTGCCGGCCAGGGCACG
GCCGCCAAGGAACTGCTTGAAGAGACCGGTCCGCTCGACCGCCTGTATGTCTGCCTGGGCGGTGGCGGGCTGACCAGCGG
CTCGGCGCTGGCCGCGCGGGCCCTGGCGCCGCAATGCAAGGTGTATGGCGTGGAGCCCGAAGCCGGCAACGATGGCCAGC
AGTCGCTGCGCGCGGGCCGGATTGTTCATATCGAAACGCCCAAGACCATTGCCGACGGTGCGCAAACCCAGCATCTGGGT
CAGTACACCTTCGGCATCATTCGACGCGATGTTGATGACATCCTCACGGTGAGCGACGCGCAGCTGGTCGAGGCCATGCG
CTTTTTTGCCGAGCGCATGAAGATGGTGGTTGAGCCTACCGGTTGCCTGGCGTTTGCCGGGGCCTGCGCGGCGCTTGAAG
CGGACGCGGCCCTCAAGGGCAGGCGTGTTGGCGTCATCGTGAGCGGCGGCAATGTCGACCTGGCGCGCTACGCGGAGCTG
CTGGCTGCACGCTGA

Upstream 100 bases:

>100_bases
AAACGTCACCGCTTTTTGCCTTAAGGTACGCTGTTGTTTTTTCCTTTTGGCTTTTCCTGGTGGCTCTTCCCGCCTTATCC
GAACGAAAGCGCTTTCTGCC

Downstream 100 bases:

>100_bases
GCGCTGACGGACCCCTGAGCCACCGCGCACGGGAAGTGCGTGTTGATCCGCGCAAGGTCAACGCAAACTTGCGCAACTTT
CTCCCCCGGCGGCCATCAGG

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MLQLPVYDDVLAAAARLEGHAHRTPVLTSATADARWGSQFFFKCENFQRMGAFKFRGAFNALSKFDAGQRRAGAIAFSSG
NHAQAVALSARLLGMPALIVMPQDAPAAKLAATRGYGAEVVLYDRFSEDREALTQRLAAERGMTLIPPYDHPDVIAGQGT
AAKELLEETGPLDRLYVCLGGGGLTSGSALAARALAPQCKVYGVEPEAGNDGQQSLRAGRIVHIETPKTIADGAQTQHLG
QYTFGIIRRDVDDILTVSDAQLVEAMRFFAERMKMVVEPTGCLAFAGACAALEADAALKGRRVGVIVSGGNVDLARYAEL
LAAR

Sequences:

>Translated_324_residues
MLQLPVYDDVLAAAARLEGHAHRTPVLTSATADARWGSQFFFKCENFQRMGAFKFRGAFNALSKFDAGQRRAGAIAFSSG
NHAQAVALSARLLGMPALIVMPQDAPAAKLAATRGYGAEVVLYDRFSEDREALTQRLAAERGMTLIPPYDHPDVIAGQGT
AAKELLEETGPLDRLYVCLGGGGLTSGSALAARALAPQCKVYGVEPEAGNDGQQSLRAGRIVHIETPKTIADGAQTQHLG
QYTFGIIRRDVDDILTVSDAQLVEAMRFFAERMKMVVEPTGCLAFAGACAALEADAALKGRRVGVIVSGGNVDLARYAEL
LAAR
>Mature_324_residues
MLQLPVYDDVLAAAARLEGHAHRTPVLTSATADARWGSQFFFKCENFQRMGAFKFRGAFNALSKFDAGQRRAGAIAFSSG
NHAQAVALSARLLGMPALIVMPQDAPAAKLAATRGYGAEVVLYDRFSEDREALTQRLAAERGMTLIPPYDHPDVIAGQGT
AAKELLEETGPLDRLYVCLGGGGLTSGSALAARALAPQCKVYGVEPEAGNDGQQSLRAGRIVHIETPKTIADGAQTQHLG
QYTFGIIRRDVDDILTVSDAQLVEAMRFFAERMKMVVEPTGCLAFAGACAALEADAALKGRRVGVIVSGGNVDLARYAEL
LAAR

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=312, Percent_Identity=40.0641025641026, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI19923959, Length=316, Percent_Identity=27.5316455696203, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI33469958, Length=306, Percent_Identity=25.4901960784314, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=39.3081761006289, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1790207, Length=294, Percent_Identity=38.0952380952381, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=34.7266881028939, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=33.7662337662338, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=308, Percent_Identity=33.4415584415584, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322631, Length=321, Percent_Identity=66.6666666666667, Blast_Score=421, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320930, Length=301, Percent_Identity=33.8870431893688, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=278, Percent_Identity=24.4604316546763, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355833, Length=315, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645328, Length=221, Percent_Identity=32.579185520362, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34467; Mature: 34467

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLPVYDDVLAAAARLEGHAHRTPVLTSATADARWGSQFFFKCENFQRMGAFKFRGAFN
CCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHEEEECCHHHCCCCHHHHHHH
ALSKFDAGQRRAGAIAFSSGNHAQAVALSARLLGMPALIVMPQDAPAAKLAATRGYGAEV
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEE
VLYDRFSEDREALTQRLAAERGMTLIPPYDHPDVIAGQGTAAKELLEETGPLDRLYVCLG
EEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCHHHHHHHHHHCCCEEEEEEEC
GGGLTSGSALAARALAPQCKVYGVEPEAGNDGQQSLRAGRIVHIETPKTIADGAQTQHLG
CCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCEEEEECCCHHHCCCHHHHHH
QYTFGIIRRDVDDILTVSDAQLVEAMRFFAERMKMVVEPTGCLAFAGACAALEADAALKG
HHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
RRVGVIVSGGNVDLARYAELLAAR
CEEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLQLPVYDDVLAAAARLEGHAHRTPVLTSATADARWGSQFFFKCENFQRMGAFKFRGAFN
CCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHEEEECCHHHCCCCHHHHHHH
ALSKFDAGQRRAGAIAFSSGNHAQAVALSARLLGMPALIVMPQDAPAAKLAATRGYGAEV
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEE
VLYDRFSEDREALTQRLAAERGMTLIPPYDHPDVIAGQGTAAKELLEETGPLDRLYVCLG
EEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCHHHHHHHHHHCCCEEEEEEEC
GGGLTSGSALAARALAPQCKVYGVEPEAGNDGQQSLRAGRIVHIETPKTIADGAQTQHLG
CCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCEEEEECCCHHHCCCHHHHHH
QYTFGIIRRDVDDILTVSDAQLVEAMRFFAERMKMVVEPTGCLAFAGACAALEADAALKG
HHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
RRVGVIVSGGNVDLARYAELLAAR
CEEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]