| Definition | Polaromonas sp. JS666 chromosome, complete genome. |
|---|---|
| Accession | NC_007948 |
| Length | 5,200,264 |
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The map label for this gene is coaBC [H]
Identifier: 91789040
GI number: 91789040
Start: 3363403
End: 3364638
Strand: Reverse
Name: coaBC [H]
Synonym: Bpro_3180
Alternate gene names: 91789040
Gene position: 3364638-3363403 (Counterclockwise)
Preceding gene: 91789047
Following gene: 91789039
Centisome position: 64.7
GC content: 64.24
Gene sequence:
>1236_bases TTGGACCTGGCCGGCAGGCATCTGGTGCTGGGCCTGTCGGGCGGCATTGCCTGCTACAAGTCGGCCGAGCTGTGCCGCGC GCTGATCAAGGCTGGCGCCACCGTGCAGGTGGTCATGACGGAAGCGGCCGAGCAGTTCATCACACCTGTCACCATGCAGG CGCTGAGCGGCCGGCCGGTTTACACCAGCCAGTGGGACAGTCGCGAAGCCAACAACATGGCGCATATCAACCTGTCGCGC GAGGCCGATGCGATTTTGATCGCACCCATGAGCGCTGACTTCATGGCGAAGCTCCTCCATGGCCGCGCCGATGATTTGCT GAGCCTGATGTGCCTGGCCCGGCCCATCGACAAGGTGTCGCTGCTGGTGGCGCCGGCGATGAACCGCGAGATGTATGCGC ACCCGGCGACGCAGCGCAACTTTGTTCAGCTTGAAGCAGACGGCGCCAGGGTGCTGGGCGTGGGCAACGGCTTTCAGGCG TGCGGGGAAACGGGTGATGGGCGCATGCTGGAACCCGAGCAACTGCTGGAAGACATCATTGCCTTCTTTGCGCCCAAGGT GCTGGCCGGTCAGCGCGTGCTGGTCACGGCTGGCCCCACATATGAGGCCATTGACCCGGTGCGCGGCATTACCAACCTGT CCAGCGGGAAGATGGGTTTTGCCATTGCACGCGCTGCGCGTGAAGCGGGTGCCGAGGTCACGCTGGTCGCCGGCCCGGTG GGCCTGCCCACACCACGGGGTGTCACGCGCATTGACGTGAGATCTGCACAGAATATGCTCGATACCGTGATGGACCGGGT GCAGGGCGCTGCTGTTTTCATCGCTACCGCGGCTGTGGCCGACTGGCGTCCTGCGACACCATCAACCCAAAAGATCAAGA AAGACGGCTCGGGCCACGCGCCGCAACTGGGATTCACGGAAAACGCGGATATCCTCGCCACCGTTGCCAAGTCTGCCGCC GCCCGGGCGGGCAAGCTGTTTTGCGTGGGCTTTGCCGCAGAAAGCCATGACCTGGCCGAGAACGCCCAAGCCAAGCGCCT GCGCAAAAACGTCCCACTGCTGGTAGGTAACATCGGGCCCGATACTTTTGGACAGGACCATAACGCGTTGCTGCTGGTTG ACGAGCAAGGCAGCACCGAGGTGGCCCGGGCGTCCAAGCTGTCGCTGGCACGCCGGCTGGTTCAGGAAATCGCTGCCAGG CTGGCGGCGCCGGCCGCTTCGACCCGGAAAGGGTGA
Upstream 100 bases:
>100_bases ACACGCAGTGAAAAGCGTGGGGGCCCATCTAGCTGCTACATTGCGAAACATGACAAATCAAGCCAATCCCCTGGAAAACA GCGCGGCCGGCGGCGAAGCC
Downstream 100 bases:
>100_bases GCTGCTTGATACACCCCTCCGACACCCCTCCTGATGGCGATTTCGCGCGGTACGTCGAACGCTTGACCAGCGGAAATATT TCAGCCGGCGCGCGCCCGGA
Product: phosphopantothenate-cysteine ligase/phosphopantothenoylcysteine decarboxylase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 411; Mature: 411
Protein sequence:
>411_residues MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPVYTSQWDSREANNMAHINLSR EADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVSLLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQA CGETGDGRMLEPEQLLEDIIAFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHAPQLGFTENADILATVAKSAA ARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGPDTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAAR LAAPAASTRKG
Sequences:
>Translated_411_residues MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPVYTSQWDSREANNMAHINLSR EADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVSLLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQA CGETGDGRMLEPEQLLEDIIAFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHAPQLGFTENADILATVAKSAA ARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGPDTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAAR LAAPAASTRKG >Mature_411_residues MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPVYTSQWDSREANNMAHINLSR EADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVSLLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQA CGETGDGRMLEPEQLLEDIIAFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHAPQLGFTENADILATVAKSAA ARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGPDTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAAR LAAPAASTRKG
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=171, Percent_Identity=34.5029239766082, Blast_Score=83, Evalue=5e-16, Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=45.679012345679, Blast_Score=297, Evalue=8e-82, Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=29.5336787564767, Blast_Score=71, Evalue=3e-13, Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=1e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43394; Mature: 43394
Theoretical pI: Translated: 8.23; Mature: 8.23
Prosite motif: PS00013 PROKAR_LIPOPROTEIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPV CCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCHHHHHHHCCCCC YTSQWDSREANNMAHINLSREADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVS CCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHH LLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQACGETGDGRMLEPEQLLEDII EEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHCCCCCCCEECHHHHHHHHH AFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV HHHCHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCC GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHA CCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCHHHHHCCCCCCC PQLGFTENADILATVAKSAAARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGP CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCC DTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAARLAAPAASTRKG CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC >Mature Secondary Structure MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPV CCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCHHHHHHHCCCCC YTSQWDSREANNMAHINLSREADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVS CCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHH LLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQACGETGDGRMLEPEQLLEDII EEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHCCCCCCCEECHHHHHHHHH AFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV HHHCHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCC GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHA CCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCHHHHHCCCCCCC PQLGFTENADILATVAKSAAARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGP CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCC DTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAARLAAPAASTRKG CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10952301 [H]