Click here to switch to the map view.

The map label for this gene is mro [H]

Identifier: 91788960

GI number: 91788960

Start: 3272315

End: 3273448

Strand: Reverse

Name: mro [H]

Synonym: Bpro_3100

Alternate gene names: 91788960

Gene position: 3273448-3272315 (Counterclockwise)

Preceding gene: 91788961

Following gene: 91788958

Centisome position: 62.95

GC content: 65.78

Gene sequence:

>1134_bases
ATGCCGCCGATCCAACCCGTATCGCCACCACCGCACGCGGGCGCTGTCCTGCTCGATCCTGCCCGTTTTCGCGGCGATAT
CGATGGCAAACCGGTCGGGCTGTTCACGCTGCGCAATCAGCGGGGCATGGTGGCGGGCATCACCAGTTACGGCGCCAAGA
TCGAGCAGCTGCTGGTGCCCGACCGTGACGGCCTGCTGGACGACGTGGTGCTTGGCTATGACAGCCTGGAGGCTGTGGTG
AATGGCTCGGCGTCCATGGGCGCCTTTGTGGGGCGTTATGCGGGGCGCATCGAGAATGCCCGCTTCACACTGGGCGGGAC
CGGGCATGTGCTGACGGCCAACAACGGCTGCCATTGCCTGCACGGCGGGCAGAAGGGGTCGCGCTTTCGCGTCTTCGATG
CCGCTCAGCGTGACGATGCCAGCGTGGAAATGCGCTATGTATTTGCCGACGGGGAAGAGGGCTTCCCCGGCACGCTGGCG
CTGCGCCTGGTCTATAGCGTCACCGAAGCCAATGAGCTCCAGCTGGACTATGAAGCCCTGGCCCTGGACAAACCCACGGT
GGCCAGTTTCACCACGCATGCTTTTTTCAACTTGAATGGCGAGGCCAGCGGTAGCGCGATGGGTCATGAGGTCATGATTT
GTGCGGACCGCTACTTCGGGATGACAACAGACCTCATCGCCACCGGCGAGATCCTGCCGGTGGCGGGCACCCCCTTTGAC
CTCCGCCAGGCCACCGCGCTCAATACGCGGGTGCCGGGTACGCCGCAGGCCGATGCCGGGACGCCTCCGAGGGATGGGGT
GGACGGCTACGACAGCTGTTTTCTGCTGGACCATCCCGCCGATGGCACGCTGGCCCTGTGCGCCCGCGTTCGCGCGCCGG
AAAGCGGCCGGGTGATGGAAGTCTGGTCGACAGAGCCGGCCCTGCAGTTCTACAGCGGCTTGCAGCCGCAAGAGCCGTTG
GCGGGTGGCCCGGGCAAGGGTGGCCGGACCTACTTCCAGCAGCAAGGGCTGTGCTTTGAGCCACAGGGCTATCCCAACGC
ACCCAACCGGCCGGCATTTCCGTCATCGGTGCATGTACCCGGCCAGCGCCGGGTGGGCCGCACGGTGTACCGGTTCAGCA
CGGACCCGGTGTGA

Upstream 100 bases:

>100_bases
TCAAGCTGGAGTGATAGGTAACAGGTTACAGGTGACAGGCTTCGGCCTGTGGGCAGGTTCGCACCAGGCCTTTTAATACT
CGCCTCCAGGGGGAATTGTC

Downstream 100 bases:

>100_bases
CGTTTCAATCGATTGGGCCGGCTGCCTTGGGGTGAGTCGTCGATCCAGTGCCGCGCTTGTTCACTGACAAGCGCTGCCGT
CACGGGTGTCGCCGCCGCGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPPIQPVSPPPHAGAVLLDPARFRGDIDGKPVGLFTLRNQRGMVAGITSYGAKIEQLLVPDRDGLLDDVVLGYDSLEAVV
NGSASMGAFVGRYAGRIENARFTLGGTGHVLTANNGCHCLHGGQKGSRFRVFDAAQRDDASVEMRYVFADGEEGFPGTLA
LRLVYSVTEANELQLDYEALALDKPTVASFTTHAFFNLNGEASGSAMGHEVMICADRYFGMTTDLIATGEILPVAGTPFD
LRQATALNTRVPGTPQADAGTPPRDGVDGYDSCFLLDHPADGTLALCARVRAPESGRVMEVWSTEPALQFYSGLQPQEPL
AGGPGKGGRTYFQQQGLCFEPQGYPNAPNRPAFPSSVHVPGQRRVGRTVYRFSTDPV

Sequences:

>Translated_377_residues
MPPIQPVSPPPHAGAVLLDPARFRGDIDGKPVGLFTLRNQRGMVAGITSYGAKIEQLLVPDRDGLLDDVVLGYDSLEAVV
NGSASMGAFVGRYAGRIENARFTLGGTGHVLTANNGCHCLHGGQKGSRFRVFDAAQRDDASVEMRYVFADGEEGFPGTLA
LRLVYSVTEANELQLDYEALALDKPTVASFTTHAFFNLNGEASGSAMGHEVMICADRYFGMTTDLIATGEILPVAGTPFD
LRQATALNTRVPGTPQADAGTPPRDGVDGYDSCFLLDHPADGTLALCARVRAPESGRVMEVWSTEPALQFYSGLQPQEPL
AGGPGKGGRTYFQQQGLCFEPQGYPNAPNRPAFPSSVHVPGQRRVGRTVYRFSTDPV
>Mature_376_residues
PPIQPVSPPPHAGAVLLDPARFRGDIDGKPVGLFTLRNQRGMVAGITSYGAKIEQLLVPDRDGLLDDVVLGYDSLEAVVN
GSASMGAFVGRYAGRIENARFTLGGTGHVLTANNGCHCLHGGQKGSRFRVFDAAQRDDASVEMRYVFADGEEGFPGTLAL
RLVYSVTEANELQLDYEALALDKPTVASFTTHAFFNLNGEASGSAMGHEVMICADRYFGMTTDLIATGEILPVAGTPFDL
RQATALNTRVPGTPQADAGTPPRDGVDGYDSCFLLDHPADGTLALCARVRAPESGRVMEVWSTEPALQFYSGLQPQEPLA
GGPGKGGRTYFQQQGLCFEPQGYPNAPNRPAFPSSVHVPGQRRVGRTVYRFSTDPV

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=328, Percent_Identity=35.9756097560976, Blast_Score=184, Evalue=9e-47,
Organism=Escherichia coli, GI1786971, Length=347, Percent_Identity=34.5821325648415, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17557428, Length=341, Percent_Identity=27.8592375366569, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI115533334, Length=341, Percent_Identity=27.8592375366569, Blast_Score=151, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319493, Length=322, Percent_Identity=29.8136645962733, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6322004, Length=362, Percent_Identity=26.7955801104972, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324399, Length=363, Percent_Identity=25.8953168044077, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24668278, Length=346, Percent_Identity=30.9248554913295, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24668282, Length=349, Percent_Identity=34.0974212034384, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24659048, Length=351, Percent_Identity=34.1880341880342, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24583720, Length=348, Percent_Identity=30.1724137931034, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24641876, Length=347, Percent_Identity=29.971181556196, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 40278; Mature: 40147

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPIQPVSPPPHAGAVLLDPARFRGDIDGKPVGLFTLRNQRGMVAGITSYGAKIEQLLVP
CCCCCCCCCCCCCCEEEECHHHHCCCCCCCCEEEEEEECCCCEEEEHHHHCCEEHHHCCC
DRDGLLDDVVLGYDSLEAVVNGSASMGAFVGRYAGRIENARFTLGGTGHVLTANNGCHCL
CCCCCHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCEEEE
HGGQKGSRFRVFDAAQRDDASVEMRYVFADGEEGFPGTLALRLVYSVTEANELQLDYEAL
ECCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCHHEEEEEEHHHCCCCCEEEEEHHE
ALDKPTVASFTTHAFFNLNGEASGSAMGHEVMICADRYFGMTTDLIATGEILPVAGTPFD
ECCCCCHHEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCEEHEEECCCEEECCCCCHH
LRQATALNTRVPGTPQADAGTPPRDGVDGYDSCFLLDHPADGTLALCARVRAPESGRVME
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEEE
VWSTEPALQFYSGLQPQEPLAGGPGKGGRTYFQQQGLCFEPQGYPNAPNRPAFPSSVHVP
EECCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCCCCCCCCCCCCCEECC
GQRRVGRTVYRFSTDPV
CCHHHCCEEEEEECCCC
>Mature Secondary Structure 
PPIQPVSPPPHAGAVLLDPARFRGDIDGKPVGLFTLRNQRGMVAGITSYGAKIEQLLVP
CCCCCCCCCCCCCEEEECHHHHCCCCCCCCEEEEEEECCCCEEEEHHHHCCEEHHHCCC
DRDGLLDDVVLGYDSLEAVVNGSASMGAFVGRYAGRIENARFTLGGTGHVLTANNGCHCL
CCCCCHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCEEEE
HGGQKGSRFRVFDAAQRDDASVEMRYVFADGEEGFPGTLALRLVYSVTEANELQLDYEAL
ECCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCHHEEEEEEHHHCCCCCEEEEEHHE
ALDKPTVASFTTHAFFNLNGEASGSAMGHEVMICADRYFGMTTDLIATGEILPVAGTPFD
ECCCCCHHEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCEEHEEECCCEEECCCCCHH
LRQATALNTRVPGTPQADAGTPPRDGVDGYDSCFLLDHPADGTLALCARVRAPESGRVME
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEEE
VWSTEPALQFYSGLQPQEPLAGGPGKGGRTYFQQQGLCFEPQGYPNAPNRPAFPSSVHVP
EECCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCCCCCCCCCCCCCEECC
GQRRVGRTVYRFSTDPV
CCHHHCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]