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The map label for this gene is gyaR [H]

Identifier: 91788938

GI number: 91788938

Start: 3246111

End: 3247097

Strand: Reverse

Name: gyaR [H]

Synonym: Bpro_3078

Alternate gene names: 91788938

Gene position: 3247097-3246111 (Counterclockwise)

Preceding gene: 91788939

Following gene: 91788937

Centisome position: 62.44

GC content: 62.11

Gene sequence:

>987_bases
ATGAGCAAACCCAAAATTCTGGTCGCACGAGCCGTCTTTCCTGAAGTGATTGCCCGCCTGGAGCAGCATTTCGAGGTGCA
GGCCAACCAGGACGACCAAACCTGGTCCAAGGCCGAACTCACGGAACGCCTGCGTGACAAGGATGGTGCTTTCACCACCG
GCGGTGACCGCATTGACGCAGAGGTTCTTGCGGCTTGTCCCCGGCTCAAGATCTGCGCCAACATGGCCGTGGGCTATAAC
AACTTTGATGTCGATGCCATGACGGCGGCCAGGGTGCTGGCCACCAATGCCCCCGATGTGCTGACCGAAACCACGGCGGA
CTTCGGCTTTGCGTTGCTGATGGCCACCGCCCGCCGCATCACCGAGAGCGAGCACTACCTGCGTGCCGGAAAATGGACCA
AGTGGAGCTACGACATGTTTGCCGGCTCCGACATCCATGGCGCCACGCTGGGCATTCTGGGCATGGGCCGCATCGGGCAG
GGCATCGCCAAACGAGGTGCGCTGGGTTTCGGCATGAAGGTGATTTACCACAACCGGTCCCGCCTGGAGGCCGCACTGGA
AGCGGAATGCCTGGCCAGTTATGTGAGCAAGGATGAGCTGCTCAAGACCGCCGACCACCTGGTGCTGGTGCTGCCGTACT
CGCTGGCCTCACATCACACCATAGGCGCGGCCGAGCTGGCCCTGATGAAGCCGACGGCCACGCTGATCAACATTGCGCGC
GGCGGCATCGTGGATGACGCCGCCTTGGCCGCTGCCTTGCGTGACAGGCGCATCGCCGCTGCCGGCCTGGATGTGTTTGA
AGGCGAGCCCAAGGTGCATCCTGACCTGCTGACCGTGCCCAATGTGGTGCTGACGCCCCACATCGCCAGCGCCACCGTGC
CCACACGACTGGCGATGGCCAACCTGGCGGCCGACAACCTGATTGCTTTCTTCGATGGAAAAAAGCCCCTGACTCCGCTG
AATCCTGCGGTGTTGACTGTCCAATAA

Upstream 100 bases:

>100_bases
TTTGTCCTCATCACCTTCATCTGGTTCTAGTCGACCATTCCAGATTGACCATTCAAGCCAACCATTCAACCGTTCAAGCA
AAGAAAGTCGAGATCTTCTC

Downstream 100 bases:

>100_bases
ATAGCAACATAAATAGCGAACCGCAGACCCTATGGATTACTGGTTGATGATGGCCCTGCTGCTGGCCAACCTGCTGTTGC
TGGTCTGGCTGCTGGTGCGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSKPKILVARAVFPEVIARLEQHFEVQANQDDQTWSKAELTERLRDKDGAFTTGGDRIDAEVLAACPRLKICANMAVGYN
NFDVDAMTAARVLATNAPDVLTETTADFGFALLMATARRITESEHYLRAGKWTKWSYDMFAGSDIHGATLGILGMGRIGQ
GIAKRGALGFGMKVIYHNRSRLEAALEAECLASYVSKDELLKTADHLVLVLPYSLASHHTIGAAELALMKPTATLINIAR
GGIVDDAALAAALRDRRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRLAMANLAADNLIAFFDGKKPLTPL
NPAVLTVQ

Sequences:

>Translated_328_residues
MSKPKILVARAVFPEVIARLEQHFEVQANQDDQTWSKAELTERLRDKDGAFTTGGDRIDAEVLAACPRLKICANMAVGYN
NFDVDAMTAARVLATNAPDVLTETTADFGFALLMATARRITESEHYLRAGKWTKWSYDMFAGSDIHGATLGILGMGRIGQ
GIAKRGALGFGMKVIYHNRSRLEAALEAECLASYVSKDELLKTADHLVLVLPYSLASHHTIGAAELALMKPTATLINIAR
GGIVDDAALAAALRDRRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRLAMANLAADNLIAFFDGKKPLTPL
NPAVLTVQ
>Mature_327_residues
SKPKILVARAVFPEVIARLEQHFEVQANQDDQTWSKAELTERLRDKDGAFTTGGDRIDAEVLAACPRLKICANMAVGYNN
FDVDAMTAARVLATNAPDVLTETTADFGFALLMATARRITESEHYLRAGKWTKWSYDMFAGSDIHGATLGILGMGRIGQG
IAKRGALGFGMKVIYHNRSRLEAALEAECLASYVSKDELLKTADHLVLVLPYSLASHHTIGAAELALMKPTATLINIARG
GIVDDAALAAALRDRRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRLAMANLAADNLIAFFDGKKPLTPLN
PAVLTVQ

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=293, Percent_Identity=36.1774744027304, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI23308577, Length=300, Percent_Identity=29.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=288, Percent_Identity=30.2083333333333, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=288, Percent_Identity=30.2083333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=31.1023622047244, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=31.1023622047244, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=41.5384615384615, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789279, Length=291, Percent_Identity=29.8969072164948, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=26.8774703557312, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=31.2302839116719, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=26.1224489795918, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=255, Percent_Identity=35.2941176470588, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=285, Percent_Identity=27.3684210526316, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=285, Percent_Identity=25.6140350877193, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=30.2857142857143, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=181, Percent_Identity=29.8342541436464, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28574286, Length=323, Percent_Identity=36.5325077399381, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45551003, Length=319, Percent_Identity=37.6175548589342, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552429, Length=319, Percent_Identity=37.6175548589342, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574284, Length=319, Percent_Identity=37.6175548589342, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24585514, Length=319, Percent_Identity=37.6175548589342, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574282, Length=319, Percent_Identity=37.6175548589342, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571528, Length=320, Percent_Identity=36.25, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585516, Length=286, Percent_Identity=29.7202797202797, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=29.9065420560748, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646446, Length=261, Percent_Identity=32.183908045977, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646448, Length=261, Percent_Identity=32.183908045977, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646452, Length=261, Percent_Identity=32.183908045977, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646450, Length=261, Percent_Identity=32.183908045977, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI62472511, Length=261, Percent_Identity=32.183908045977, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35295; Mature: 35164

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPKILVARAVFPEVIARLEQHFEVQANQDDQTWSKAELTERLRDKDGAFTTGGDRIDA
CCCCCEEEHHHHHHHHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCH
EVLAACPRLKICANMAVGYNNFDVDAMTAARVLATNAPDVLTETTADFGFALLMATARRI
HHHHHCCCHHHHHHHEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TESEHYLRAGKWTKWSYDMFAGSDIHGATLGILGMGRIGQGIAKRGALGFGMKVIYHNRS
HCCHHHHHCCCCCEEEECCCCCCCCCCCHHHEEECCHHHHHHHHHCCCCCCEEEEEECHH
RLEAALEAECLASYVSKDELLKTADHLVLVLPYSLASHHTIGAAELALMKPTATLINIAR
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHCCCCCCCHHHHEEECCHHHHHHHHC
GGIVDDAALAAALRDRRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRLAMA
CCCCHHHHHHHHHHHCHHHHHCCHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHH
NLAADNLIAFFDGKKPLTPLNPAVLTVQ
HHHHCCEEEEECCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SKPKILVARAVFPEVIARLEQHFEVQANQDDQTWSKAELTERLRDKDGAFTTGGDRIDA
CCCCEEEHHHHHHHHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCH
EVLAACPRLKICANMAVGYNNFDVDAMTAARVLATNAPDVLTETTADFGFALLMATARRI
HHHHHCCCHHHHHHHEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TESEHYLRAGKWTKWSYDMFAGSDIHGATLGILGMGRIGQGIAKRGALGFGMKVIYHNRS
HCCHHHHHCCCCCEEEECCCCCCCCCCCHHHEEECCHHHHHHHHHCCCCCCEEEEEECHH
RLEAALEAECLASYVSKDELLKTADHLVLVLPYSLASHHTIGAAELALMKPTATLINIAR
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHCCCCCCCHHHHEEECCHHHHHHHHC
GGIVDDAALAAALRDRRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRLAMA
CCCCHHHHHHHHHHHCHHHHHCCHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHH
NLAADNLIAFFDGKKPLTPLNPAVLTVQ
HHHHCCEEEEECCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA