Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 91788800

GI number: 91788800

Start: 3101796

End: 3104132

Strand: Reverse

Name: clpA [H]

Synonym: Bpro_2940

Alternate gene names: 91788800

Gene position: 3104132-3101796 (Counterclockwise)

Preceding gene: 91788801

Following gene: 91788799

Centisome position: 59.69

GC content: 61.75

Gene sequence:

>2337_bases
ATGATTGCCCAGGAACTAGAAGTCAGCTTGCACATGGCCTTTGTCGAAGCGCGGCAGCAACGTCACGAGTTCATCACGGT
GGAACACCTGCTGCTCGCCTTGCTGGACAACCCCAGTGCGGCTGAAGTGCTGCGCGCCTGTTCAGCCAATGTGGATGATC
TGCGCAAGTCGCTTGCCAATTTCATCAAGGACAACACGCCGCAGGTGGCAGGCACCGACGACGTCGACACGCAACCCACG
CTGGGTTTCCAGCGTGTGATCCAGCGCGCCATCATGCATGTGCAGTCCACCGGCAACGGTAAAAAAGAAGTCACCGGTGC
CAATGTGCTGGTCGCCATTTTTGGCGAGAAGGATTCCCACGCGGTGTATTACCTGCACCAGCAGGGCGTGACGCGCCTGG
ACGTGGTGAATTTCATCGCCCATGGCATCAAGAAAAGCGATCCGCCCGAGCCCGCCAAGAGCGGCGAAAGCGCCGCCGAG
AACGAGGAAGGCAGCGAAAAGAACGAAAAGGCTTCTCCGCTGGAGCAGTTCACGCAGAACCTCAACCAGCTCGCCAAGGA
TGGCAAGATCGATCCCCTGATCGGCCGCCAGTACGAAGTCGAGCGGGTGATCCAGATTCTCTGCCGTCGCCGCAAGAACA
ACCCGCTGCTGGTGGGTGAGGCTGGCGTGGGTAAAACCGCCATTGCCGAGGGCCTGGCCTGGCGCATCACGCAAAAAGAT
GTGCCGGAAATCCTGGCCGAGGCGAACGTGTATTCGCTCGACATGGGTGCCTTGCTGGCCGGTACCAAATACCGCGGCGA
CTTTGAGCAGCGCCTCAAGGGCGTGCTGAAGGCGCTGAAAGACAAGCCCAACGGCATCCTGTTCATTGACGAAATCCACA
CCCTGATCGGTGCCGGTGCGGCCTCGGGCGGTACGCTGGACGCGTCCAACCTGCTCAAGCCTGCGCTGAGTTCCGGCCAG
CTCAAGTGCATTGGCGCGACCACCTTCACGGAATACCGCGGTATTTTCGAGAAGGATGCGGCCCTGTCGCGGCGCTTCCA
GAAGGTCGATGTGGTCGAGCCGACGGTGCAGGAAACAGTCGAGATTCTGAAGGGTCTCAAGTCGCGCTTTGAAGAGCACC
ACAGCGTCAAGTACGCCGTGGCGGCCCTGCAGGCCGCGGCCGAGCTGAGCGCCAAGTACATCAATGACCGCCATCTGCCC
GACAAGGCGATCGACGTCATTGATGAGGCGGGCGCCGCCCAGCGCATCCTGCCCGCCAACAAGCGCAAGAAAACCATCAC
CAAGACCGAGGTCGAGGAAATCGTGGCGAAGATTGCCCGCATTCCGCCCGCCAACGTCTCCAATGATGACCGCGGCAAGC
TCAAGACCCTGGAACGCGACCTCAAAAGCGTGGTGTTCGGCCAGGACAAGGCGCTGGACGTGCTTGCGTCGTCTGTCAAG
ATGGCGCGTTCCGGCCTGGGCAAGGACGACAAGCCGATTGGCTGCTTCCTGTTCTCCGGCCCCACGGGTGTCGGCAAGAC
CGAGGCCGCCAAGCAGCTGGCCTACATCATGGGCATCGAGCTGATCCGCTTCGACATGTCGGAGTACATGGAGCGCCATG
CCGTGAGCCGCCTGATCGGCGCGCCTCCGGGCTACGTCGGTTTTGACCAGGGCGGTTTGCTGACCGAGGCGATCACCAAG
AAGCCGCACGCGGTGCTGCTGCTCGACGAGATCGAGAAGGCGCACCCCGACATCTTCAACGTGCTGCTGCAGGTGATGGA
CCATGGCACGCTCACGGACAACAACGGGCGCAAGGCCGATTTCCGTAACGTGATCATTGTCATGACCACCAATGCCGGTG
CCGAGACCATGAACAAGGCGACCATCGGCTTTACCAACCCGCGTGAGGCGGGCGACGAGATGGCGGACATCAAACGCCTG
TTCACGCCAGAGTTCCGCAACCGCCTCGATGCGGTGGTGAGCTTCAAGGCGCTGGACGAAGTCGTCATCCTGCGCGTGGT
CGACAAGTTCCTGCTGCAGCTGGAGACGCAGCTGGCCGAGAAGAAAGTCGAAGTCACCTTCACCGACGGGCTGCGCAAGT
ACCTGGCCAAGAAGGGCTTCGATCCGCTCATGGGCGCTCGCCCGATGCAGCGCCTGATCCAGGACACGATTCGTCGCGCG
CTGGCTGACGAGCTGCTGTTTGGGCGCCTGATCGATGGCGGCCGCCTCACGGTCGACATGAAGGTCACGACGGACGAGAA
GGGCGTCGAGACCGGCGAGGTCCAGCTCGACATCCAGCCGCTGCCGAAGAAAGAGGGCAAAGCCAGGCCCGAGGCGGAGG
CCGCAGAGACCAACTGA

Upstream 100 bases:

>100_bases
CTGCAATGTGTCAGTGAGCCCATTGAATAATGACAAATCCGGCCAATATTCCATTCAGAAGTCAGTGAAGTAAAACGTCA
GCAAGCCGAAAGGAAAATCA

Downstream 100 bases:

>100_bases
CCACGCGGATTTTTCAGCGTATCCCCAAAAGGCCGGTAGCATCATGCTATCGGCCTTTTTCATGCAGCTATCAAAGTAAT
AGCTGCCTGCGACCGGACTA

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANVDDLRKSLANFIKDNTPQVAGTDDVDTQPT
LGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSHAVYYLHQQGVTRLDVVNFIAHGIKKSDPPEPAKSGESAAE
NEEGSEKNEKASPLEQFTQNLNQLAKDGKIDPLIGRQYEVERVIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQKD
VPEILAEANVYSLDMGALLAGTKYRGDFEQRLKGVLKALKDKPNGILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQ
LKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVQETVEILKGLKSRFEEHHSVKYAVAALQAAAELSAKYINDRHLP
DKAIDVIDEAGAAQRILPANKRKKTITKTEVEEIVAKIARIPPANVSNDDRGKLKTLERDLKSVVFGQDKALDVLASSVK
MARSGLGKDDKPIGCFLFSGPTGVGKTEAAKQLAYIMGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAITK
KPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIVMTTNAGAETMNKATIGFTNPREAGDEMADIKRL
FTPEFRNRLDAVVSFKALDEVVILRVVDKFLLQLETQLAEKKVEVTFTDGLRKYLAKKGFDPLMGARPMQRLIQDTIRRA
LADELLFGRLIDGGRLTVDMKVTTDEKGVETGEVQLDIQPLPKKEGKARPEAEAAETN

Sequences:

>Translated_778_residues
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANVDDLRKSLANFIKDNTPQVAGTDDVDTQPT
LGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSHAVYYLHQQGVTRLDVVNFIAHGIKKSDPPEPAKSGESAAE
NEEGSEKNEKASPLEQFTQNLNQLAKDGKIDPLIGRQYEVERVIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQKD
VPEILAEANVYSLDMGALLAGTKYRGDFEQRLKGVLKALKDKPNGILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQ
LKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVQETVEILKGLKSRFEEHHSVKYAVAALQAAAELSAKYINDRHLP
DKAIDVIDEAGAAQRILPANKRKKTITKTEVEEIVAKIARIPPANVSNDDRGKLKTLERDLKSVVFGQDKALDVLASSVK
MARSGLGKDDKPIGCFLFSGPTGVGKTEAAKQLAYIMGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAITK
KPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIVMTTNAGAETMNKATIGFTNPREAGDEMADIKRL
FTPEFRNRLDAVVSFKALDEVVILRVVDKFLLQLETQLAEKKVEVTFTDGLRKYLAKKGFDPLMGARPMQRLIQDTIRRA
LADELLFGRLIDGGRLTVDMKVTTDEKGVETGEVQLDIQPLPKKEGKARPEAEAAETN
>Mature_778_residues
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANVDDLRKSLANFIKDNTPQVAGTDDVDTQPT
LGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSHAVYYLHQQGVTRLDVVNFIAHGIKKSDPPEPAKSGESAAE
NEEGSEKNEKASPLEQFTQNLNQLAKDGKIDPLIGRQYEVERVIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQKD
VPEILAEANVYSLDMGALLAGTKYRGDFEQRLKGVLKALKDKPNGILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQ
LKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVQETVEILKGLKSRFEEHHSVKYAVAALQAAAELSAKYINDRHLP
DKAIDVIDEAGAAQRILPANKRKKTITKTEVEEIVAKIARIPPANVSNDDRGKLKTLERDLKSVVFGQDKALDVLASSVK
MARSGLGKDDKPIGCFLFSGPTGVGKTEAAKQLAYIMGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAITK
KPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIVMTTNAGAETMNKATIGFTNPREAGDEMADIKRL
FTPEFRNRLDAVVSFKALDEVVILRVVDKFLLQLETQLAEKKVEVTFTDGLRKYLAKKGFDPLMGARPMQRLIQDTIRRA
LADELLFGRLIDGGRLTVDMKVTTDEKGVETGEVQLDIQPLPKKEGKARPEAEAAETN

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=165, Percent_Identity=41.8181818181818, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1787109, Length=742, Percent_Identity=62.1293800539084, Blast_Score=970, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=398, Percent_Identity=46.4824120603015, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=245, Percent_Identity=56.734693877551, Blast_Score=273, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6323002, Length=250, Percent_Identity=51.2, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 85442; Mature: 85442

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANVDDLRKSLAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FIKDNTPQVAGTDDVDTQPTLGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEEECCCCCC
AVYYLHQQGVTRLDVVNFIAHGIKKSDPPEPAKSGESAAENEEGSEKNEKASPLEQFTQN
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LNQLAKDGKIDPLIGRQYEVERVIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQKD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCHHEECCHHH
VPEILAEANVYSLDMGALLAGTKYRGDFEQRLKGVLKALKDKPNGILFIDEIHTLIGAGA
HHHHHHCCCCEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCC
ASGGTLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVQETV
CCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHH
EILKGLKSRFEEHHSVKYAVAALQAAAELSAKYINDRHLPDKAIDVIDEAGAAQRILPAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCCC
KRKKTITKTEVEEIVAKIARIPPANVSNDDRGKLKTLERDLKSVVFGQDKALDVLASSVK
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MARSGLGKDDKPIGCFLFSGPTGVGKTEAAKQLAYIMGIELIRFDMSEYMERHAVSRLIG
HHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGFDQGGLLTEAITKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKAD
CCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCC
FRNVIIVMTTNAGAETMNKATIGFTNPREAGDEMADIKRLFTPEFRNRLDAVVSFKALDE
CCCEEEEEECCCCCHHHCCCEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
VVILRVVDKFLLQLETQLAEKKVEVTFTDGLRKYLAKKGFDPLMGARPMQRLIQDTIRRA
HHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LADELLFGRLIDGGRLTVDMKVTTDEKGVETGEVQLDIQPLPKKEGKARPEAEAAETN
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANVDDLRKSLAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FIKDNTPQVAGTDDVDTQPTLGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEEECCCCCC
AVYYLHQQGVTRLDVVNFIAHGIKKSDPPEPAKSGESAAENEEGSEKNEKASPLEQFTQN
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LNQLAKDGKIDPLIGRQYEVERVIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQKD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCHHEECCHHH
VPEILAEANVYSLDMGALLAGTKYRGDFEQRLKGVLKALKDKPNGILFIDEIHTLIGAGA
HHHHHHCCCCEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCC
ASGGTLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVQETV
CCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHH
EILKGLKSRFEEHHSVKYAVAALQAAAELSAKYINDRHLPDKAIDVIDEAGAAQRILPAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCCC
KRKKTITKTEVEEIVAKIARIPPANVSNDDRGKLKTLERDLKSVVFGQDKALDVLASSVK
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MARSGLGKDDKPIGCFLFSGPTGVGKTEAAKQLAYIMGIELIRFDMSEYMERHAVSRLIG
HHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGFDQGGLLTEAITKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKAD
CCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCC
FRNVIIVMTTNAGAETMNKATIGFTNPREAGDEMADIKRLFTPEFRNRLDAVVSFKALDE
CCCEEEEEECCCCCHHHCCCEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
VVILRVVDKFLLQLETQLAEKKVEVTFTDGLRKYLAKKGFDPLMGARPMQRLIQDTIRRA
HHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LADELLFGRLIDGGRLTVDMKVTTDEKGVETGEVQLDIQPLPKKEGKARPEAEAAETN
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]