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The map label for this gene is fkpA [H]

Identifier: 91787743

GI number: 91787743

Start: 1924432

End: 1924854

Strand: Reverse

Name: fkpA [H]

Synonym: Bpro_1864

Alternate gene names: 91787743

Gene position: 1924854-1924432 (Counterclockwise)

Preceding gene: 91787744

Following gene: 91787738

Centisome position: 37.01

GC content: 65.01

Gene sequence:

>423_bases
ATGACCAACCCCATGAACATCATGAAATCCGTTCCAGCCCTGCTGGCCTCCTGCGCTCTGGCCACCAGCGTGCTGGCCGC
AGCACCCGCCGAAACGCTGCCCACCGGCGTGAAAATTGTGCACAGCGTGGACGGCACCGGCGCGCAGCCCAAGGCCTCGG
ACACGGTCAAAGTGCACTACCGCGGAACGCTCGCCGACGGCAAGGAATTTGACAGCTCCTACAAACGCGGCACACCCGCC
ACCTTCCCGCTCAGCCGGGTGGTGCCGTGCTGGACGGAAGGCCTGCAGAAAATCAAGGTCGGCGGCAAGGCCACGCTGAC
CTGCCCACCCGCCACGGCGTATGGCGAGCGCGGCGCCGGCGGTGTGGTGCCGCCCAATGCCACGCTGACGTTTGAAGTTG
AGTTGCTGGCCATCGAGAAATAA

Upstream 100 bases:

>100_bases
CATTGCGCCGACCCGGAGATAATGCGGCGGACTGTTTCCCGCGCGTTTTCCGTTTTGCCTGCTTCCGTCAGCGGTACCCC
GCCACCATCCGCCACCATTT

Downstream 100 bases:

>100_bases
GCAGCCCGCACGGACGCGGCCTCACGCCACCGCTTACGGTGCCTCGCTGAGTGCCGCCAGCAGTGCCTGGTTAAAGGCAT
CTGCCCGTTCAAACTGAACC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTNPMNIMKSVPALLASCALATSVLAAAPAETLPTGVKIVHSVDGTGAQPKASDTVKVHYRGTLADGKEFDSSYKRGTPA
TFPLSRVVPCWTEGLQKIKVGGKATLTCPPATAYGERGAGGVVPPNATLTFEVELLAIEK

Sequences:

>Translated_140_residues
MTNPMNIMKSVPALLASCALATSVLAAAPAETLPTGVKIVHSVDGTGAQPKASDTVKVHYRGTLADGKEFDSSYKRGTPA
TFPLSRVVPCWTEGLQKIKVGGKATLTCPPATAYGERGAGGVVPPNATLTFEVELLAIEK
>Mature_139_residues
TNPMNIMKSVPALLASCALATSVLAAAPAETLPTGVKIVHSVDGTGAQPKASDTVKVHYRGTLADGKEFDSSYKRGTPAT
FPLSRVVPCWTEGLQKIKVGGKATLTCPPATAYGERGAGGVVPPNATLTFEVELLAIEK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=9e-19,
Organism=Homo sapiens, GI4503725, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=9e-19,
Organism=Homo sapiens, GI4758380, Length=92, Percent_Identity=47.8260869565217, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI224809329, Length=102, Percent_Identity=43.1372549019608, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI224809327, Length=102, Percent_Identity=43.1372549019608, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI4758384, Length=102, Percent_Identity=43.1372549019608, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI224809331, Length=105, Percent_Identity=41.9047619047619, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI206725530, Length=133, Percent_Identity=39.0977443609023, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI17149844, Length=133, Percent_Identity=39.0977443609023, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI17149842, Length=133, Percent_Identity=39.0977443609023, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI4503729, Length=132, Percent_Identity=38.6363636363636, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI192448443, Length=90, Percent_Identity=40, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI4503727, Length=100, Percent_Identity=40, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI33469985, Length=88, Percent_Identity=43.1818181818182, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=95, Percent_Identity=55.7894736842105, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1789745, Length=95, Percent_Identity=58.9473684210526, Blast_Score=105, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540882, Length=136, Percent_Identity=37.5, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71993519, Length=93, Percent_Identity=44.0860215053763, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=96, Percent_Identity=41.6666666666667, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=113, Percent_Identity=45.1327433628319, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=49.438202247191, Blast_Score=87, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=48.5981308411215, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281363946, Length=132, Percent_Identity=40.1515151515151, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17352457, Length=132, Percent_Identity=40.1515151515151, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24647110, Length=116, Percent_Identity=45.6896551724138, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583150, Length=97, Percent_Identity=43.298969072165, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356629, Length=128, Percent_Identity=42.1875, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 14481; Mature: 14350

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPMNIMKSVPALLASCALATSVLAAAPAETLPTGVKIVHSVDGTGAQPKASDTVKVHY
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEE
RGTLADGKEFDSSYKRGTPATFPLSRVVPCWTEGLQKIKVGGKATLTCPPATAYGERGAG
EEECCCCHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
GVVPPNATLTFEVELLAIEK
CCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure 
TNPMNIMKSVPALLASCALATSVLAAAPAETLPTGVKIVHSVDGTGAQPKASDTVKVHY
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEE
RGTLADGKEFDSSYKRGTPATFPLSRVVPCWTEGLQKIKVGGKATLTCPPATAYGERGAG
EEECCCCHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
GVVPPNATLTFEVELLAIEK
CCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]