Click here to switch to the map view.

The map label for this gene is 91787717

Identifier: 91787717

GI number: 91787717

Start: 1898878

End: 1900437

Strand: Reverse

Name: 91787717

Synonym: Bpro_1838

Alternate gene names: NA

Gene position: 1900437-1898878 (Counterclockwise)

Preceding gene: 91787718

Following gene: 91787715

Centisome position: 36.55

GC content: 62.56

Gene sequence:

>1560_bases
ATGAAAAAAACCCTCCTCACTCGCCTCCTGGCGCTCAGCGTGTACGCAACAGCGCTCGCCATTGGCGCACCAGCGGCCCT
CGCCCAGGCGGTCGATCCCCCGGCTACCCATCCCTACGCGCAGTCGCAGCCGATTCCCGGGCGTTACATCGTGGTGTTCA
AGGACAGTGTGGCCAACCCGGCCGCGGAAGCCGCCAACCTGACACGCGGGCTGGGCGGGCAACTGCACCATACCTATACC
AGCGCCCTCAAGGGCTTTGCCGCCAGCCTGCCGGACGCGGCGCTGCAGGGCATACGCAATAACCCGAACGTGGACTACAT
CGAGCAGGACCAGACGGTTTCGCTCAATGAAGCCAAGTTATCGTCGACGCAAGTGCAGAGCACCGCAACTTGGGGGTTGG
ATCGAATCGACCAGACCGATCGCCCCCTCGACACCTGGTACCACTACAACTACACCGGCGCGGGCGTGAATGCCTTCATC
ATCGACACCGGCATTCTCGCGACGCACACCGACTTCCAAGGCCGTGTGCAATCCGGCTACACCGCAATTACCGATAACAA
TAGCACCAACGACTGCAATGGTCACGGCACGCATGTCGCCGGCACTGTGGGTGGCTTAACCTGGGGCGTGGCCAAGGGGG
TTGCACTGATTCCAGTGCGCGTACTCGATTGCAGTGGTTCCGGCACCTGGAGCGGCGTGATTGCCGGCATTAATTGGGTG
ATCGGGCAAGCCACCAAGTCTCCAAATCCGCTGCTCCCCGCCGTGGCCAACATGTCGCTGGGTGGTGGCGCATCCCCAGC
GGTGGACACCGCCGTGGCAAATGCCGTGAACAACGGCGTGACCATGGTGGTGGCGGCCGGCAACAGCAGCGCCGATGCCT
GCAGATATTCTCCGGCCCGGGAACCAAGCGCCATCACGGTGGGCGCAACCACCAGCAGCGACAAGCGCGCCTTCTACTCG
AACTATGGCAAGTGTCTGGACCTTTTCGCGCCAGGCAGCAGCATCACCTCGGCCTCGATTTCCAGCAACGATGCGTCGAC
TATCAAAAGCGGCACTTCAATGGCATCGCCCCACGTAGCCGGGGTCGCCGCGCTGGCGCTGGCAGAAAAACCCGCGACAT
TGCCTGCGGGCATTGCCTCCTTCCTGACCGACAATGCCACGCGCAACAAGCTCGGTTCGATCGGACGAGGCTCGCCCAAC
CTGCTCGTTTATTCCCTGGGAACGACGTGGGCATCAACGTCCGTGGCGATCTCGTCCATAACCGATAGCACGCTCAGCGG
TCGCAATGGCTGGAACGCCTCGGCCACGGTGACGGTTCGCAAGCGGAACAGCGACTGGAGTATCGGTGATCCCGCAGCCG
GCGCCACCGTCACGGGCAGCTTCTCACCAGGCGGCTCGGTCAGTTGCGTGACGGACCCCAGCGGCAGTTGCACACTGACC
AGTTCCATCATCCGGAGCACAGATTCGGCCAAGGTCACCGTGACCGGCATCTCCGGTCCGCTGATGACCTACGACGCGAG
CCAGAACGCCGTCACTGAAATTGTCATCGCAAAACCCTGA

Upstream 100 bases:

>100_bases
GGACGATGTGGGAGTCTGTAAAACGGCTTGACCCCCCAGCATGACAAGCACAGAATCGAGAGTGCTCTTTCATTGTCCCA
GCATCCATGTCGGGGTCATC

Downstream 100 bases:

>100_bases
CTCCGGTTGACGCCAAGGCGCGCCAAGCGGGTTGTGCCAAGCTCACGGCAGCTTGGACTCGCCCTCTTCTTCCTGCCCGG
CCGGCCAGTCGCGGATGTAA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MKKTLLTRLLALSVYATALAIGAPAALAQAVDPPATHPYAQSQPIPGRYIVVFKDSVANPAAEAANLTRGLGGQLHHTYT
SALKGFAASLPDAALQGIRNNPNVDYIEQDQTVSLNEAKLSSTQVQSTATWGLDRIDQTDRPLDTWYHYNYTGAGVNAFI
IDTGILATHTDFQGRVQSGYTAITDNNSTNDCNGHGTHVAGTVGGLTWGVAKGVALIPVRVLDCSGSGTWSGVIAGINWV
IGQATKSPNPLLPAVANMSLGGGASPAVDTAVANAVNNGVTMVVAAGNSSADACRYSPAREPSAITVGATTSSDKRAFYS
NYGKCLDLFAPGSSITSASISSNDASTIKSGTSMASPHVAGVAALALAEKPATLPAGIASFLTDNATRNKLGSIGRGSPN
LLVYSLGTTWASTSVAISSITDSTLSGRNGWNASATVTVRKRNSDWSIGDPAAGATVTGSFSPGGSVSCVTDPSGSCTLT
SSIIRSTDSAKVTVTGISGPLMTYDASQNAVTEIVIAKP

Sequences:

>Translated_519_residues
MKKTLLTRLLALSVYATALAIGAPAALAQAVDPPATHPYAQSQPIPGRYIVVFKDSVANPAAEAANLTRGLGGQLHHTYT
SALKGFAASLPDAALQGIRNNPNVDYIEQDQTVSLNEAKLSSTQVQSTATWGLDRIDQTDRPLDTWYHYNYTGAGVNAFI
IDTGILATHTDFQGRVQSGYTAITDNNSTNDCNGHGTHVAGTVGGLTWGVAKGVALIPVRVLDCSGSGTWSGVIAGINWV
IGQATKSPNPLLPAVANMSLGGGASPAVDTAVANAVNNGVTMVVAAGNSSADACRYSPAREPSAITVGATTSSDKRAFYS
NYGKCLDLFAPGSSITSASISSNDASTIKSGTSMASPHVAGVAALALAEKPATLPAGIASFLTDNATRNKLGSIGRGSPN
LLVYSLGTTWASTSVAISSITDSTLSGRNGWNASATVTVRKRNSDWSIGDPAAGATVTGSFSPGGSVSCVTDPSGSCTLT
SSIIRSTDSAKVTVTGISGPLMTYDASQNAVTEIVIAKP
>Mature_519_residues
MKKTLLTRLLALSVYATALAIGAPAALAQAVDPPATHPYAQSQPIPGRYIVVFKDSVANPAAEAANLTRGLGGQLHHTYT
SALKGFAASLPDAALQGIRNNPNVDYIEQDQTVSLNEAKLSSTQVQSTATWGLDRIDQTDRPLDTWYHYNYTGAGVNAFI
IDTGILATHTDFQGRVQSGYTAITDNNSTNDCNGHGTHVAGTVGGLTWGVAKGVALIPVRVLDCSGSGTWSGVIAGINWV
IGQATKSPNPLLPAVANMSLGGGASPAVDTAVANAVNNGVTMVVAAGNSSADACRYSPAREPSAITVGATTSSDKRAFYS
NYGKCLDLFAPGSSITSASISSNDASTIKSGTSMASPHVAGVAALALAEKPATLPAGIASFLTDNATRNKLGSIGRGSPN
LLVYSLGTTWASTSVAISSITDSTLSGRNGWNASATVTVRKRNSDWSIGDPAAGATVTGSFSPGGSVSCVTDPSGSCTLT
SSIIRSTDSAKVTVTGISGPLMTYDASQNAVTEIVIAKP

Specific function: Serine proteinase with preferred activity for amino acids with aromatic side groups at the P1' side of the scissible bond [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI31317307, Length=363, Percent_Identity=33.0578512396694, Blast_Score=172, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320775, Length=448, Percent_Identity=37.2767857142857, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324576, Length=342, Percent_Identity=40.0584795321637, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6319893, Length=267, Percent_Identity=40.0749063670412, Blast_Score=182, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 52914; Mature: 52914

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTLLTRLLALSVYATALAIGAPAALAQAVDPPATHPYAQSQPIPGRYIVVFKDSVANP
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
AAEAANLTRGLGGQLHHTYTSALKGFAASLPDAALQGIRNNPNVDYIEQDQTVSLNEAKL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCEEECCHHHC
SSTQVQSTATWGLDRIDQTDRPLDTWYHYNYTGAGVNAFIIDTGILATHTDFQGRVQSGY
CHHHHHHHHHCCCHHCCCCCCCCHHEEEEEEECCCCEEEEEECCEEEECCCCCCHHCCCE
TAITDNNSTNDCNGHGTHVAGTVGGLTWGVAKGVALIPVRVLDCSGSGTWSGVIAGINWV
EEEECCCCCCCCCCCCCEEEECCCCHHHHHHCCEEEEEEEEEECCCCCCCHHHHCCCEEE
IGQATKSPNPLLPAVANMSLGGGASPAVDTAVANAVNNGVTMVVAAGNSSADACRYSPAR
EECCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHCCCCCC
EPSAITVGATTSSDKRAFYSNYGKCLDLFAPGSSITSASISSNDASTIKSGTSMASPHVA
CCCEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCHHH
GVAALALAEKPATLPAGIASFLTDNATRNKLGSIGRGSPNLLVYSLGTTWASTSVAISSI
HHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECC
TDSTLSGRNGWNASATVTVRKRNSDWSIGDPAAGATVTGSFSPGGSVSCVTDPSGSCTLT
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEEE
SSIIRSTDSAKVTVTGISGPLMTYDASQNAVTEIVIAKP
HHHHCCCCCCEEEEEECCCCEEEECCCCCCEEEEEEECC
>Mature Secondary Structure
MKKTLLTRLLALSVYATALAIGAPAALAQAVDPPATHPYAQSQPIPGRYIVVFKDSVANP
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
AAEAANLTRGLGGQLHHTYTSALKGFAASLPDAALQGIRNNPNVDYIEQDQTVSLNEAKL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCEEECCHHHC
SSTQVQSTATWGLDRIDQTDRPLDTWYHYNYTGAGVNAFIIDTGILATHTDFQGRVQSGY
CHHHHHHHHHCCCHHCCCCCCCCHHEEEEEEECCCCEEEEEECCEEEECCCCCCHHCCCE
TAITDNNSTNDCNGHGTHVAGTVGGLTWGVAKGVALIPVRVLDCSGSGTWSGVIAGINWV
EEEECCCCCCCCCCCCCEEEECCCCHHHHHHCCEEEEEEEEEECCCCCCCHHHHCCCEEE
IGQATKSPNPLLPAVANMSLGGGASPAVDTAVANAVNNGVTMVVAAGNSSADACRYSPAR
EECCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHCCCCCC
EPSAITVGATTSSDKRAFYSNYGKCLDLFAPGSSITSASISSNDASTIKSGTSMASPHVA
CCCEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCHHH
GVAALALAEKPATLPAGIASFLTDNATRNKLGSIGRGSPNLLVYSLGTTWASTSVAISSI
HHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECC
TDSTLSGRNGWNASATVTVRKRNSDWSIGDPAAGATVTGSFSPGGSVSCVTDPSGSCTLT
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEEE
SSIIRSTDSAKVTVTGISGPLMTYDASQNAVTEIVIAKP
HHHHCCCCCCEEEEEECCCCEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7551039; 1499549 [H]