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The map label for this gene is gyrA [H]

Identifier: 91787677

GI number: 91787677

Start: 1856503

End: 1859145

Strand: Reverse

Name: gyrA [H]

Synonym: Bpro_1795

Alternate gene names: 91787677

Gene position: 1859145-1856503 (Counterclockwise)

Preceding gene: 91787682

Following gene: 91787676

Centisome position: 35.75

GC content: 60.73

Gene sequence:

>2643_bases
ATGACCCAGTTCGCCAAAGAAACCCTGCCCATCAGTCTTGAAGAGGAAATGCGACGAAGCTATCTCGATTACGCGATGAG
CGTGATCGTGGGCCGAGCCCTGCCCGATGCGCGGGACGGCCTCAAGCCTGTGCACCGGCGCGTGCTGTTCGCCATGCACG
AGCTGAACAACGACTGGAACAGGCCTTACAAGAAATCCGCCCGTATCGTGGGCGATGTGATTGGTAAATACCATCCGCAC
GGCGACCAGTCGGTCTACGACACCATCGTGCGCATGGCGCAGGATTTTTCCTTGCGTCATTTGCTGGTTGATGGCCAGGG
CAACTTCGGTTCGGTCGACGGCGACAACGCCGCGGCCATGCGTTACACCGAAATCCGCCTGTCCAAAATTGCCCACGAAT
TGCTGGCCGACCTCGACAAGGAAACCGTCGACTTCGGCCCCAACTACGACGGCAGTGAGCAGGAGCCGCTGGTCATGCCA
ACCCGGCTGCCCAACCTGCTGGTGAATGGTTCCGGCGGCATCGCGGTGGGCATGGCCACCAACATTCCGCCCCACAACCT
CAACGAGGTGGTCGACGCGTGCCTGCACATGCTGAAGAATCCGGAAGCCTCGATTGACGAGTTGATGGAGATCGTGCCGG
CACCCGACTTCCCCACCGGCGGCATTATTTATGGCATCAATGGTGTCAAGGATGGCTACCGTACCGGGCGCGGCAAGGTG
GTCATGCGCGCCAAATGCCACTTTGAAGACATCGACAAGGGCCAGCGGCAGTCCATCATCGTGGACGAACTGCCCTACCA
GGTCAACAAGAAGACGCTGCAGGAGCGCATGGCCGAACTGGTTCACGAGAAAAAGATCGAAGGCATCAGCCATATCCAGG
ACGAGAGCGACAAGTCGGGCATGCGCCTGGTGATTGAACTCAAGCGCGGCGAAGTGCCCGAAGTGGTGCTGAACAATCTG
TACAAACAGACGCAGCTGCAGGACACCTTCGGCATCAACATGGTGGCGCTGGTCAATGGCCAGCCCAAGCTCTGCAACCT
GAAAGACCTGATCCAGGTCTTCCTGTCGCATCGCCGCGAAGTGGTGACGCGCCGTACCGTGTTCACCTTGCGCAAGGCGC
GCGAACGGGGCCATGTGCTGGAAGGCCTGGCCGTTGCATTGGCCAACATCGACGACTTCATTGCCATCATCCGCAATGCG
CCCACACCGCCGGTGGCCAAGGCCGAACTGATGCTGCGCCCGTGGGACAGCAGCCTGGTGCGCGAAATGCTCACGCGCAC
GCGCGCCGATGGCGGCGTGGTCAACGCAGACGACTACCGTCCCGATGGACTGGAGAAGGCCTTTGGCATGGGCAGCGACG
GACTGTACCGCCTGTCCGAGACGCAAGCGCAGGAAATCCTGCAGATGCGCCTGCAACGCCTGACCGGCCTTGAGCAGGAC
AAGATCGTGGCCGAGTACAAGGAAGTCATGGCCGAAATCGACGACCTGCTTGACATCCTGGCAAAGCCAGAGCGGGTGTC
CATTATCATTGGCGAAGAGCTGTCCGCGATCAAGCTGGAGTTCGGCCAGACCAAGCTCGGCGCGCGGCGCAGCCAGATCG
AGCACAGCTCGTTCGACCTCAGCACCGAAGACCTGATCACGCCGACCGACATGGTGGTGACCCTGTCGCACTCCGGCTAC
ATCAAGAGCCAGCCTCTGTCCGAATACCGGGCGCAAAAACGCGGCGGCCGTGGCAAGCAGGCCACCGCGACCAAGGAAGA
CGACTGGGTCGACCAGCTGTTCATCGCCAACACGCACGACTACATCCTGTGCTTTTCCAACCGCGGCCGGCTCTACTGGC
TCAAAGTCTGGGAAGTGCCGGCTGGCTCGCGCGGCTCGCGCGGTCGGCCCATCGTCAACATGTTCCCGCTGCAGGAAGGT
GAAAAAATCACGGTGGTGCTGCCGCTGACCGGTGAAAAGCGCAGCTTCCCGGCCGACCAGTATGTGTTCATGGCCACCTC
CATGGGTACCGTCAAGAAAACGACGCTGGACGAATTCAGCAACCCGCGCAAGGCCGGCATCATCGCCGTGGACCTGGACG
ACGGCGACTATTTGATTGGTGCCTCCCTGACCGACGGCAAGCACGACGTGATGCTGTTCAGCGATGGCGGCAAGGCCGTG
CGCTTTGACGAGAACGATGTTCGCCCCATGGGCCGCAACGCACGCGGCGTGCGTGGCATGACGCTCGAAGACGGCCAGGG
CGTCATTGCGATGCTGGTCGCCGAGGACGAGCAGCAAAGCGTGCTTACCGCCACCCAGAACGGCTATGGCAAGCGCACCT
CCATCACCGAATACACCCGTCATGGTCGCGGCACCAAGGGCATGATTGCGATCCAGCAGAGCGAGCGTAACGGCAAAGTG
GTTGCCGCGACACTGGTGCATGTCGACGATGAAATCATGCTGATTACCGACAAGGGTGTCCTGGTGCGCACGCGGGTCAG
TGAAATCCGGGAGATGGGAAGGGCTACACAGGGTGTTACGCTTATTGGCCTTGATGAGGGCTCACAATTGAGCGGTCTCC
AGCGAATCGTCGAGAACGATGCCACCCTGGACGACAACGACGTTGAAAACGACGCAGGCAAGGACGCCTCGACTCCGCTC
TAA

Upstream 100 bases:

>100_bases
TCATTTGTTGCTGACTCGCCACAAACAAGCCGCTATAAACTCAAGCCTTAAAATTATGGGTTCCCCTCAAGAATCTTGAA
AAATCCCAACCAGGCCTCTC

Downstream 100 bases:

>100_bases
CGCTCTAACCACCTTAATCTGTCCCAATCCGGAAGCTATTCATGAAAAAACTGATCACCACACTGGCGATGGCCGGCCTT
GCCTGCTCCACCGCCATTCA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 880; Mature: 879

Protein sequence:

>880_residues
MTQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDQSVYDTIVRMAQDFSLRHLLVDGQGNFGSVDGDNAAAMRYTEIRLSKIAHELLADLDKETVDFGPNYDGSEQEPLVMP
TRLPNLLVNGSGGIAVGMATNIPPHNLNEVVDACLHMLKNPEASIDELMEIVPAPDFPTGGIIYGINGVKDGYRTGRGKV
VMRAKCHFEDIDKGQRQSIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSGMRLVIELKRGEVPEVVLNNL
YKQTQLQDTFGINMVALVNGQPKLCNLKDLIQVFLSHRREVVTRRTVFTLRKARERGHVLEGLAVALANIDDFIAIIRNA
PTPPVAKAELMLRPWDSSLVREMLTRTRADGGVVNADDYRPDGLEKAFGMGSDGLYRLSETQAQEILQMRLQRLTGLEQD
KIVAEYKEVMAEIDDLLDILAKPERVSIIIGEELSAIKLEFGQTKLGARRSQIEHSSFDLSTEDLITPTDMVVTLSHSGY
IKSQPLSEYRAQKRGGRGKQATATKEDDWVDQLFIANTHDYILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEG
EKITVVLPLTGEKRSFPADQYVFMATSMGTVKKTTLDEFSNPRKAGIIAVDLDDGDYLIGASLTDGKHDVMLFSDGGKAV
RFDENDVRPMGRNARGVRGMTLEDGQGVIAMLVAEDEQQSVLTATQNGYGKRTSITEYTRHGRGTKGMIAIQQSERNGKV
VAATLVHVDDEIMLITDKGVLVRTRVSEIREMGRATQGVTLIGLDEGSQLSGLQRIVENDATLDDNDVENDAGKDASTPL

Sequences:

>Translated_880_residues
MTQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDQSVYDTIVRMAQDFSLRHLLVDGQGNFGSVDGDNAAAMRYTEIRLSKIAHELLADLDKETVDFGPNYDGSEQEPLVMP
TRLPNLLVNGSGGIAVGMATNIPPHNLNEVVDACLHMLKNPEASIDELMEIVPAPDFPTGGIIYGINGVKDGYRTGRGKV
VMRAKCHFEDIDKGQRQSIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSGMRLVIELKRGEVPEVVLNNL
YKQTQLQDTFGINMVALVNGQPKLCNLKDLIQVFLSHRREVVTRRTVFTLRKARERGHVLEGLAVALANIDDFIAIIRNA
PTPPVAKAELMLRPWDSSLVREMLTRTRADGGVVNADDYRPDGLEKAFGMGSDGLYRLSETQAQEILQMRLQRLTGLEQD
KIVAEYKEVMAEIDDLLDILAKPERVSIIIGEELSAIKLEFGQTKLGARRSQIEHSSFDLSTEDLITPTDMVVTLSHSGY
IKSQPLSEYRAQKRGGRGKQATATKEDDWVDQLFIANTHDYILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEG
EKITVVLPLTGEKRSFPADQYVFMATSMGTVKKTTLDEFSNPRKAGIIAVDLDDGDYLIGASLTDGKHDVMLFSDGGKAV
RFDENDVRPMGRNARGVRGMTLEDGQGVIAMLVAEDEQQSVLTATQNGYGKRTSITEYTRHGRGTKGMIAIQQSERNGKV
VAATLVHVDDEIMLITDKGVLVRTRVSEIREMGRATQGVTLIGLDEGSQLSGLQRIVENDATLDDNDVENDAGKDASTPL
>Mature_879_residues
TQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPHG
DQSVYDTIVRMAQDFSLRHLLVDGQGNFGSVDGDNAAAMRYTEIRLSKIAHELLADLDKETVDFGPNYDGSEQEPLVMPT
RLPNLLVNGSGGIAVGMATNIPPHNLNEVVDACLHMLKNPEASIDELMEIVPAPDFPTGGIIYGINGVKDGYRTGRGKVV
MRAKCHFEDIDKGQRQSIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSGMRLVIELKRGEVPEVVLNNLY
KQTQLQDTFGINMVALVNGQPKLCNLKDLIQVFLSHRREVVTRRTVFTLRKARERGHVLEGLAVALANIDDFIAIIRNAP
TPPVAKAELMLRPWDSSLVREMLTRTRADGGVVNADDYRPDGLEKAFGMGSDGLYRLSETQAQEILQMRLQRLTGLEQDK
IVAEYKEVMAEIDDLLDILAKPERVSIIIGEELSAIKLEFGQTKLGARRSQIEHSSFDLSTEDLITPTDMVVTLSHSGYI
KSQPLSEYRAQKRGGRGKQATATKEDDWVDQLFIANTHDYILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGE
KITVVLPLTGEKRSFPADQYVFMATSMGTVKKTTLDEFSNPRKAGIIAVDLDDGDYLIGASLTDGKHDVMLFSDGGKAVR
FDENDVRPMGRNARGVRGMTLEDGQGVIAMLVAEDEQQSVLTATQNGYGKRTSITEYTRHGRGTKGMIAIQQSERNGKVV
AATLVHVDDEIMLITDKGVLVRTRVSEIREMGRATQGVTLIGLDEGSQLSGLQRIVENDATLDDNDVENDAGKDASTPL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=407, Percent_Identity=25.7985257985258, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI19913408, Length=343, Percent_Identity=25.0728862973761, Blast_Score=84, Evalue=8e-16,
Organism=Escherichia coli, GI1788562, Length=881, Percent_Identity=59.5913734392736, Blast_Score=1041, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=732, Percent_Identity=34.8360655737705, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535065, Length=491, Percent_Identity=24.847250509165, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=520, Percent_Identity=24.2307692307692, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI212645845, Length=411, Percent_Identity=24.8175182481752, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=175, Percent_Identity=30.2857142857143, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136538, Length=351, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97879; Mature: 97748

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDQSVYDTIVRMAQDFSLRHLLVDGQGNFGSVDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRLSKIAHELLADLDKETVDFGPNYDGSEQEPLVMPTRLPNLLVNGSGGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACLHMLKNPEASIDELMEIVPAPDFPTGGIIYGINGVKDGYRTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCE
VMRAKCHFEDIDKGQRQSIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSG
EEEEECCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRLVIELKRGEVPEVVLNNLYKQTQLQDTFGINMVALVNGQPKLCNLKDLIQVFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
VVTRRTVFTLRKARERGHVLEGLAVALANIDDFIAIIRNAPTPPVAKAELMLRPWDSSLV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHH
REMLTRTRADGGVVNADDYRPDGLEKAFGMGSDGLYRLSETQAQEILQMRLQRLTGLEQD
HHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCCCHH
KIVAEYKEVMAEIDDLLDILAKPERVSIIIGEELSAIKLEFGQTKLGARRSQIEHSSFDL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCHHCHHHHHCCCCCCCC
STEDLITPTDMVVTLSHSGYIKSQPLSEYRAQKRGGRGKQATATKEDDWVDQLFIANTHD
CHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEECCCC
YILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGEKITVVLPLTGEKRSFPADQ
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCC
YVFMATSMGTVKKTTLDEFSNPRKAGIIAVDLDDGDYLIGASLTDGKHDVMLFSDGGKAV
EEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCEE
RFDENDVRPMGRNARGVRGMTLEDGQGVIAMLVAEDEQQSVLTATQNGYGKRTSITEYTR
EECCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCHHHEEECCCCCCCCCCHHHHHH
HGRGTKGMIAIQQSERNGKVVAATLVHVDDEIMLITDKGVLVRTRVSEIREMGRATQGVT
CCCCCCCEEEEEECCCCCCEEEEEEEEECCCEEEEECCCEEEEHHHHHHHHHCCHHCCEE
LIGLDEGSQLSGLQRIVENDATLDDNDVENDAGKDASTPL
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDQSVYDTIVRMAQDFSLRHLLVDGQGNFGSVDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRLSKIAHELLADLDKETVDFGPNYDGSEQEPLVMPTRLPNLLVNGSGGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACLHMLKNPEASIDELMEIVPAPDFPTGGIIYGINGVKDGYRTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCE
VMRAKCHFEDIDKGQRQSIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSG
EEEEECCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRLVIELKRGEVPEVVLNNLYKQTQLQDTFGINMVALVNGQPKLCNLKDLIQVFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
VVTRRTVFTLRKARERGHVLEGLAVALANIDDFIAIIRNAPTPPVAKAELMLRPWDSSLV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHH
REMLTRTRADGGVVNADDYRPDGLEKAFGMGSDGLYRLSETQAQEILQMRLQRLTGLEQD
HHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCCCHH
KIVAEYKEVMAEIDDLLDILAKPERVSIIIGEELSAIKLEFGQTKLGARRSQIEHSSFDL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCHHCHHHHHCCCCCCCC
STEDLITPTDMVVTLSHSGYIKSQPLSEYRAQKRGGRGKQATATKEDDWVDQLFIANTHD
CHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEECCCC
YILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGEKITVVLPLTGEKRSFPADQ
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCC
YVFMATSMGTVKKTTLDEFSNPRKAGIIAVDLDDGDYLIGASLTDGKHDVMLFSDGGKAV
EEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCEE
RFDENDVRPMGRNARGVRGMTLEDGQGVIAMLVAEDEQQSVLTATQNGYGKRTSITEYTR
EECCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCHHHEEECCCCCCCCCCHHHHHH
HGRGTKGMIAIQQSERNGKVVAATLVHVDDEIMLITDKGVLVRTRVSEIREMGRATQGVT
CCCCCCCEEEEEECCCCCCEEEEEEEEECCCEEEEECCCEEEEHHHHHHHHHCCHHCCEE
LIGLDEGSQLSGLQRIVENDATLDDNDVENDAGKDASTPL
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]