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The map label for this gene is ctaB

Identifier: 91787151

GI number: 91787151

Start: 1298452

End: 1299366

Strand: Direct

Name: ctaB

Synonym: Bpro_1254

Alternate gene names: 91787151

Gene position: 1298452-1299366 (Clockwise)

Preceding gene: 91787150

Following gene: 91787152

Centisome position: 24.97

GC content: 64.92

Gene sequence:

>915_bases
ATGAACCCCAGCAACCCTGCCGCTTCGGCCCCCCATTCCCGCGCACCGTCCAGGTTCGCCCAGTTCTACGCGCTGACCAA
GCCGCGCGTGGTGCAGCTCATTGTGTTCTGCGCGTTGATCGGCATGGTGCTGGCCGTCCCCCACGTCCCGACCTGGCCCG
AGGTCAAGCTGGCCCTGATTGCCTGTGCCGGCATCTGGCTGGTGGCGGGAGCCGCGGCGGCCTTCAACTGCATCGTCGAG
CAGCGGATCGACGCCAGGATGCGGCGTACGGCCTGGCGCCCCACGGCCAAAGGCGAGCTCAGCAACCCCCTGACCCTGGC
CTTCTCAGCCGCCCTGTGCGCCGCCGGCTCGGTGATTCTGTATGTGTGGGTCAACCCGCTCACCATGTGGCTGACCTTTG
CCACCTTTGTCGGCTATGCGGTGGTCTACACCGTGATCCTCAAGCCGCTCACGCCGCAAAACATCGTGATCGGGGGCGCC
TCGGGTGCCATGCCGCCGGTGCTGGGCTGGGCGGCCATGACGGGCACCGTGGGACCGGAGGCGCTCATCCTCTTCCTGAT
CATTTTCCTCTGGACCCCCCCGCATTTCTGGGCGCTGGCGTTGTACCGCGTCGAGGACTACCGCAAGTCGGGCTTGCCCA
TGCTGCCCGTCACGCATGGCAACGAGTTCACGCGGCTGCAGGTGTTTTTGTACACGCTGGTACTGTTTGCCGCCTGCCTG
ATGCCCTTTGTTTTCAAGATGAGCGGCTGGCTCTATCTCGTGGTGGCCGTGGTGCTCAGCGTGGGCTTCAGCTGGCATGC
GTGGCGCCTGTGGCGCAGCTACTCGGACGCCCTGGCGCGCAAGACCTTCCGCTTTTCGCTGATCCATCTCTCGGTGTTAT
TCGCAGCCCTGCTGCTGGACCATTACCTCGTATGA

Upstream 100 bases:

>100_bases
CCGCAGCGCTGGTGGTGGTGCTCACCGGCATCGTTTTTTCCAGCCGCAGCATCCCCAGCGCAGTCCATGCGTCAAAATGG
AAAGCTTCGAGATTGTCCGC

Downstream 100 bases:

>100_bases
AATCTCTCACCCTGCCACCCAGCCGCCGGCTCGCCCTTCAAACCATCGCTGGTACCGGCTTGCTGGCAATCACGGCGGGT
CTCCTGACGGCCTGCGCGCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNPSNPAASAPHSRAPSRFAQFYALTKPRVVQLIVFCALIGMVLAVPHVPTWPEVKLALIACAGIWLVAGAAAAFNCIVE
QRIDARMRRTAWRPTAKGELSNPLTLAFSAALCAAGSVILYVWVNPLTMWLTFATFVGYAVVYTVILKPLTPQNIVIGGA
SGAMPPVLGWAAMTGTVGPEALILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVFLYTLVLFAACL
MPFVFKMSGWLYLVVAVVLSVGFSWHAWRLWRSYSDALARKTFRFSLIHLSVLFAALLLDHYLV

Sequences:

>Translated_304_residues
MNPSNPAASAPHSRAPSRFAQFYALTKPRVVQLIVFCALIGMVLAVPHVPTWPEVKLALIACAGIWLVAGAAAAFNCIVE
QRIDARMRRTAWRPTAKGELSNPLTLAFSAALCAAGSVILYVWVNPLTMWLTFATFVGYAVVYTVILKPLTPQNIVIGGA
SGAMPPVLGWAAMTGTVGPEALILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVFLYTLVLFAACL
MPFVFKMSGWLYLVVAVVLSVGFSWHAWRLWRSYSDALARKTFRFSLIHLSVLFAALLLDHYLV
>Mature_304_residues
MNPSNPAASAPHSRAPSRFAQFYALTKPRVVQLIVFCALIGMVLAVPHVPTWPEVKLALIACAGIWLVAGAAAAFNCIVE
QRIDARMRRTAWRPTAKGELSNPLTLAFSAALCAAGSVILYVWVNPLTMWLTFATFVGYAVVYTVILKPLTPQNIVIGGA
SGAMPPVLGWAAMTGTVGPEALILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVFLYTLVLFAACL
MPFVFKMSGWLYLVVAVVLSVGFSWHAWRLWRSYSDALARKTFRFSLIHLSVLFAALLLDHYLV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=261, Percent_Identity=31.8007662835249, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786631, Length=283, Percent_Identity=33.5689045936396, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71998235, Length=223, Percent_Identity=30.9417040358744, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=291, Percent_Identity=27.1477663230241, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921064, Length=292, Percent_Identity=28.4246575342466, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_POLSJ (Q12E37)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548103.1
- STRING:   Q12E37
- GeneID:   4011838
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1254
- NMPDR:   fig|296591.1.peg.2004
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q12E37
- ProtClustDB:   PRK04375
- BioCyc:   PSP296591:BPRO_1254-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33640; Mature: 33640

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13d4abd4)-; HASH(0x15074360)-; HASH(0x1507ea94)-; HASH(0x1507b860)-; HASH(0x14e1f00c)-; HASH(0x145975ac)-; HASH(0x152e7a68)-; HASH(0x14ed1b00)-; HASH(0x14bedcac)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSNPAASAPHSRAPSRFAQFYALTKPRVVQLIVFCALIGMVLAVPHVPTWPEVKLALI
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ACAGIWLVAGAAAAFNCIVEQRIDARMRRTAWRPTAKGELSNPLTLAFSAALCAAGSVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEE
YVWVNPLTMWLTFATFVGYAVVYTVILKPLTPQNIVIGGASGAMPPVLGWAAMTGTVGPE
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCHH
ALILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVFLYTLVLFAACL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
MPFVFKMSGWLYLVVAVVLSVGFSWHAWRLWRSYSDALARKTFRFSLIHLSVLFAALLLD
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYLV
HHCH
>Mature Secondary Structure
MNPSNPAASAPHSRAPSRFAQFYALTKPRVVQLIVFCALIGMVLAVPHVPTWPEVKLALI
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ACAGIWLVAGAAAAFNCIVEQRIDARMRRTAWRPTAKGELSNPLTLAFSAALCAAGSVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEE
YVWVNPLTMWLTFATFVGYAVVYTVILKPLTPQNIVIGGASGAMPPVLGWAAMTGTVGPE
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCHH
ALILFLIIFLWTPPHFWALALYRVEDYRKSGLPMLPVTHGNEFTRLQVFLYTLVLFAACL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
MPFVFKMSGWLYLVVAVVLSVGFSWHAWRLWRSYSDALARKTFRFSLIHLSVLFAALLLD
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYLV
HHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA