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The map label for this gene is hemN [H]

Identifier: 91787105

GI number: 91787105

Start: 1250767

End: 1252155

Strand: Direct

Name: hemN [H]

Synonym: Bpro_1208

Alternate gene names: 91787105

Gene position: 1250767-1252155 (Clockwise)

Preceding gene: 91787103

Following gene: 91787106

Centisome position: 24.05

GC content: 66.45

Gene sequence:

>1389_bases
ATGACCACTGTTTCGCCCGATCTTTTGCGCCGATTCGACGTCCCCGGGCCCCGGTACACCTCCTATCCGACGGCCGACCG
CTTCGTCGAGGCATTTACCGCCGCCGACTATGGTCAGGCGCTGGCCCAGCGCCGCAGCGGACCGGCCGCGCTCGGGCAGC
CACAGCCGCTGTCGCTGTACCTGCACATCCCGTTTTGCGAATCGCTGTGTTACTACTGTGCCTGCAACAAGATCATCACC
AAACACCACGAGCGGGCGGCCACCTACCTGCGATACCTCAGCCGCGAAGTGGACCTGCACACGGCCCGGCTGGGCCTGGA
GCAGCCCGTCACGCAGCTACACCTGGGCGGCGGCACGCCGACCTTCCTGTCTGACGCCGAGCTCGGGGAACTGATGGCCA
TGCTGCGGCGCAGTTTTGCGCTGGTGCCCGGCGGCGAATATTCGATCGAGATCGACCCGCGTACCGTGGACGGCGCCCGC
CTGGCCACGCTGGCCGAACTGGGCTTTAACCGGATCAGCTTCGGCGTGCAGGACTTCGACCCCGACGTGCAGAAAGCGGT
GCACCGCATCCAGCCTGCCGAGCAAGTGTTCGCGCTGATGGAGCAGGCCCGTGCGATCGGTTTCGACTCGGTCAACATCG
ACCTGATTTATGGCCTGCCGCGGCAGACGCCGGAATCATTCGCGCGCACACTGGCCCAGGTGCAGCAGCTGCGGCCCGAC
CGCATCGCGCTGTATGCCTACGCCCACCTGCCCGAGCGCTTCAAGCCGCAGCGGCGCATCGTGTCCGCCGAACTGCCCGG
CGCTGCGGCCAAGCTGGCGATGCTGTCGCAGTCGCTCTCGGCCTTCGAGGCGGCGGGCTATGTCTACATCGGCATGGACC
ATTTCGCGCTGCCCGGCGACGCGCTGGCCGTGGCCAAGCGCCAGGGGCGCCTGCACCGCAACTTTCAGGGCTACAGCACC
CAGCCCGACTGCGACCTGATCGGCCTGGGTGTCTCGGCGATTGGCCGCATAGGCGCCACCTACAGCCAGAACGCCAAGAC
CATGGAAGAGTATTGCGACCACCTCGACCAGGGACGGCTGCCCGTGGCACGCGGTCTGGCCTTGAGCCGGGACGACCTGG
CCCGCCGGGCCGTGATCGTGGCGCTGATGTGCCAGGGCCAGGTGCTGTTTGAATCGATAGAGCAGGCGTGGCTGCTGGAC
TTCCAGACCTACTTCGCGGCCGAGCTCGAGCAGTTGGGCGAACTGGCCGAAGAAGGCCTGGTGGTGCTGGACGACGCTGG
CATCCAGGTCACGGCCAAGGGCTGGTTTTTTGTGCGGGCCGTGGCCATGGTGTTTGACCGCTACCTGCAGGCCGACCGCA
ACCGCGCGAAGTTCTCGCGCATTATCTGA

Upstream 100 bases:

>100_bases
TGGTGCCCTTCTGATCTGGATCAAATTGTCTCCAGTCCACGCATGGAACGACTGATTTAGATCAAGCCGGTGGGCTGCGG
GACGCGGCACACTTTGCTCC

Downstream 100 bases:

>100_bases
AGCGCGCCAACTGTCATGTCGACCACGTTGGCTGTCACGGCGCTGCTGATGGGGCTGGCCGGTGGCCCGCATTGTGTGGC
CATGTGCGGCGCGGCCTGCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTTVSPDLLRRFDVPGPRYTSYPTADRFVEAFTAADYGQALAQRRSGPAALGQPQPLSLYLHIPFCESLCYYCACNKIIT
KHHERAATYLRYLSREVDLHTARLGLEQPVTQLHLGGGTPTFLSDAELGELMAMLRRSFALVPGGEYSIEIDPRTVDGAR
LATLAELGFNRISFGVQDFDPDVQKAVHRIQPAEQVFALMEQARAIGFDSVNIDLIYGLPRQTPESFARTLAQVQQLRPD
RIALYAYAHLPERFKPQRRIVSAELPGAAAKLAMLSQSLSAFEAAGYVYIGMDHFALPGDALAVAKRQGRLHRNFQGYST
QPDCDLIGLGVSAIGRIGATYSQNAKTMEEYCDHLDQGRLPVARGLALSRDDLARRAVIVALMCQGQVLFESIEQAWLLD
FQTYFAAELEQLGELAEEGLVVLDDAGIQVTAKGWFFVRAVAMVFDRYLQADRNRAKFSRII

Sequences:

>Translated_462_residues
MTTVSPDLLRRFDVPGPRYTSYPTADRFVEAFTAADYGQALAQRRSGPAALGQPQPLSLYLHIPFCESLCYYCACNKIIT
KHHERAATYLRYLSREVDLHTARLGLEQPVTQLHLGGGTPTFLSDAELGELMAMLRRSFALVPGGEYSIEIDPRTVDGAR
LATLAELGFNRISFGVQDFDPDVQKAVHRIQPAEQVFALMEQARAIGFDSVNIDLIYGLPRQTPESFARTLAQVQQLRPD
RIALYAYAHLPERFKPQRRIVSAELPGAAAKLAMLSQSLSAFEAAGYVYIGMDHFALPGDALAVAKRQGRLHRNFQGYST
QPDCDLIGLGVSAIGRIGATYSQNAKTMEEYCDHLDQGRLPVARGLALSRDDLARRAVIVALMCQGQVLFESIEQAWLLD
FQTYFAAELEQLGELAEEGLVVLDDAGIQVTAKGWFFVRAVAMVFDRYLQADRNRAKFSRII
>Mature_461_residues
TTVSPDLLRRFDVPGPRYTSYPTADRFVEAFTAADYGQALAQRRSGPAALGQPQPLSLYLHIPFCESLCYYCACNKIITK
HHERAATYLRYLSREVDLHTARLGLEQPVTQLHLGGGTPTFLSDAELGELMAMLRRSFALVPGGEYSIEIDPRTVDGARL
ATLAELGFNRISFGVQDFDPDVQKAVHRIQPAEQVFALMEQARAIGFDSVNIDLIYGLPRQTPESFARTLAQVQQLRPDR
IALYAYAHLPERFKPQRRIVSAELPGAAAKLAMLSQSLSAFEAAGYVYIGMDHFALPGDALAVAKRQGRLHRNFQGYSTQ
PDCDLIGLGVSAIGRIGATYSQNAKTMEEYCDHLDQGRLPVARGLALSRDDLARRAVIVALMCQGQVLFESIEQAWLLDF
QTYFAAELEQLGELAEEGLVVLDDAGIQVTAKGWFFVRAVAMVFDRYLQADRNRAKFSRII

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=411, Percent_Identity=26.5206812652068, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082341, Length=455, Percent_Identity=49.2307692307692, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1789325, Length=282, Percent_Identity=30.1418439716312, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51315; Mature: 51184

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVSPDLLRRFDVPGPRYTSYPTADRFVEAFTAADYGQALAQRRSGPAALGQPQPLSLY
CCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
LHIPFCESLCYYCACNKIITKHHERAATYLRYLSREVDLHTARLGLEQPVTQLHLGGGTP
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCHHHEEECCCCC
TFLSDAELGELMAMLRRSFALVPGGEYSIEIDPRTVDGARLATLAELGFNRISFGVQDFD
CCCCCHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCHHHHHHHHHCCHHHCCCCCCCC
PDVQKAVHRIQPAEQVFALMEQARAIGFDSVNIDLIYGLPRQTPESFARTLAQVQQLRPD
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
RIALYAYAHLPERFKPQRRIVSAELPGAAAKLAMLSQSLSAFEAAGYVYIGMDHFALPGD
CEEEEEEHHCCHHCCHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCH
ALAVAKRQGRLHRNFQGYSTQPDCDLIGLGVSAIGRIGATYSQNAKTMEEYCDHLDQGRL
HHHHHHHHCHHHCCCCCCCCCCCCCEEECCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
PVARGLALSRDDLARRAVIVALMCQGQVLFESIEQAWLLDFQTYFAAELEQLGELAEEGL
CHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VVLDDAGIQVTAKGWFFVRAVAMVFDRYLQADRNRAKFSRII
EEEECCCEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure 
TTVSPDLLRRFDVPGPRYTSYPTADRFVEAFTAADYGQALAQRRSGPAALGQPQPLSLY
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
LHIPFCESLCYYCACNKIITKHHERAATYLRYLSREVDLHTARLGLEQPVTQLHLGGGTP
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCHHHEEECCCCC
TFLSDAELGELMAMLRRSFALVPGGEYSIEIDPRTVDGARLATLAELGFNRISFGVQDFD
CCCCCHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCHHHHHHHHHCCHHHCCCCCCCC
PDVQKAVHRIQPAEQVFALMEQARAIGFDSVNIDLIYGLPRQTPESFARTLAQVQQLRPD
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
RIALYAYAHLPERFKPQRRIVSAELPGAAAKLAMLSQSLSAFEAAGYVYIGMDHFALPGD
CEEEEEEHHCCHHCCHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCH
ALAVAKRQGRLHRNFQGYSTQPDCDLIGLGVSAIGRIGATYSQNAKTMEEYCDHLDQGRL
HHHHHHHHCHHHCCCCCCCCCCCCCEEECCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
PVARGLALSRDDLARRAVIVALMCQGQVLFESIEQAWLLDFQTYFAAELEQLGELAEEGL
CHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VVLDDAGIQVTAKGWFFVRAVAMVFDRYLQADRNRAKFSRII
EEEECCCEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]