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The map label for this gene is mutT [H]

Identifier: 91786733

GI number: 91786733

Start: 854463

End: 854963

Strand: Direct

Name: mutT [H]

Synonym: Bpro_0831

Alternate gene names: 91786733

Gene position: 854463-854963 (Clockwise)

Preceding gene: 91786732

Following gene: 91786736

Centisome position: 16.43

GC content: 64.87

Gene sequence:

>501_bases
ATGACCGCGCAGATTCTCGTGGCCGATGCCGGCCGGCCCCGTGAGGGCGGTGCGGATCGCCAGGTGATCGATGTGGCCGT
AGGGGTTCTGGTGCAGCCCGGCGGCGACTTTCTGCTGACCTCGCGCCCGCCCGGCAAGGTCTACGAAGGCTATTGGGAGT
TTCCCGGCGGCAAGCTGGAGCAGGGCGAGAGTGTCGAGCAGGCGCTGCGCCGCGAACTGCAGGAAGAGATCGGTATCACC
ATCGGCGCCGTGCATCCGTGGAAGGTTGAAATGGTGGACTACCCCCATGCGCTGGTCAGGCTCAACTTCTGCAAGGTGTT
TGAGTGGACGGGTGAACTGCACATGCACGAGGGGCAGTCGTTCGCCTGGCAGTCATTGCCGGTCACCGTGCAGCCGGTGT
TGCCCGGCACGGTTCCGGTGCTAGCTTGGTTTGCCGAAGAGCGGGGCTTTTCGGGCGCGACGCGCTGGTCGCCGGCCCAA
CCCGGTTTGCTCTCTAATTGA

Upstream 100 bases:

>100_bases
CATCGCTGGTATGGGCGCTGGAGCGCGGCTCGCGCAGCGGCCGTGTGGCTTACCAGTTTGCGCGTGACTACGCTGGCCAG
CATCCCGGCGCTTGAGCAGC

Downstream 100 bases:

>100_bases
TAGCTGTAAACCGGGAGCTCATTCGGGTTCTGGCTTGTTTTATGCGCGAAAGCGGTTTCAGCCGCTGAATTCCCACTGTT
TGCTCGCACCCATCACCGCG

Product: NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTAQILVADAGRPREGGADRQVIDVAVGVLVQPGGDFLLTSRPPGKVYEGYWEFPGGKLEQGESVEQALRRELQEEIGIT
IGAVHPWKVEMVDYPHALVRLNFCKVFEWTGELHMHEGQSFAWQSLPVTVQPVLPGTVPVLAWFAEERGFSGATRWSPAQ
PGLLSN

Sequences:

>Translated_166_residues
MTAQILVADAGRPREGGADRQVIDVAVGVLVQPGGDFLLTSRPPGKVYEGYWEFPGGKLEQGESVEQALRRELQEEIGIT
IGAVHPWKVEMVDYPHALVRLNFCKVFEWTGELHMHEGQSFAWQSLPVTVQPVLPGTVPVLAWFAEERGFSGATRWSPAQ
PGLLSN
>Mature_165_residues
TAQILVADAGRPREGGADRQVIDVAVGVLVQPGGDFLLTSRPPGKVYEGYWEFPGGKLEQGESVEQALRRELQEEIGITI
GAVHPWKVEMVDYPHALVRLNFCKVFEWTGELHMHEGQSFAWQSLPVTVQPVLPGTVPVLAWFAEERGFSGATRWSPAQP
GLLSN

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=135, Percent_Identity=36.2962962962963, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1786288, Length=121, Percent_Identity=35.5371900826446, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 18276; Mature: 18145

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQILVADAGRPREGGADRQVIDVAVGVLVQPGGDFLLTSRPPGKVYEGYWEFPGGKLE
CCEEEEEECCCCCCCCCCCHHHEEEEEEEEECCCCCEEEECCCCCCCCCCEEECCCCCCC
QGESVEQALRRELQEEIGITIGAVHPWKVEMVDYPHALVRLNFCKVFEWTGELHMHEGQS
CCCHHHHHHHHHHHHHHCEEEECCCCEEEEEECCCCCCEEEHHHHEEEECCCEEEECCCC
FAWQSLPVTVQPVLPGTVPVLAWFAEERGFSGATRWSPAQPGLLSN
EEEECCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAQILVADAGRPREGGADRQVIDVAVGVLVQPGGDFLLTSRPPGKVYEGYWEFPGGKLE
CEEEEEECCCCCCCCCCCHHHEEEEEEEEECCCCCEEEECCCCCCCCCCEEECCCCCCC
QGESVEQALRRELQEEIGITIGAVHPWKVEMVDYPHALVRLNFCKVFEWTGELHMHEGQS
CCCHHHHHHHHHHHHHHCEEEECCCCEEEEEECCCCCCEEEHHHHEEEECCCEEEECCCC
FAWQSLPVTVQPVLPGTVPVLAWFAEERGFSGATRWSPAQPGLLSN
EEEECCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]