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The map label for this gene is hisE

Identifier: 91786713

GI number: 91786713

Start: 836195

End: 836578

Strand: Direct

Name: hisE

Synonym: Bpro_0811

Alternate gene names: 91786713

Gene position: 836195-836578 (Clockwise)

Preceding gene: 91786712

Following gene: 91786714

Centisome position: 16.08

GC content: 64.32

Gene sequence:

>384_bases
ATGTCCTCCAACGACTCCCTCCAGCGCCTGGCGCAGATCATTGAAAGCCGCAAGCCGGCCAACGGCGGCGACCCTGGCAC
CAGCTATGTGGCGCGCCTGTTGCACCGGGGCCCGGACGCCTTCCTGAAAAAAATTGGCGAAGAAGCCACCGAGACCGTGA
TGGCCGCCAAGGATTTGGACCATGGCGGCCCGACCCCGGAGTTGCGGGCCAAGCTGGTCGGCGAGGTGGCTGACCTGTGG
TTTCACAGCCTGATCGCGCTGGCCCATTACGGCCTGCAGCCTGCCGACGTCATCGCTGAACTGGAGCGCCGCGAGGGCAC
CAGCGGCATCGAGGAAAAAGCGCTGCGCAAGGTGCAAAATCGGGATGCGGCTGAAAAGTCCTGA

Upstream 100 bases:

>100_bases
TTTTTCACCTCTACAAAGACGGCCAGTGGGTCGTGACCGAGCCGGTCTTGAAAGATCCCGGCAGCATCTACAAATAGCCT
CAGCCTTACCGGTAACGCGC

Downstream 100 bases:

>100_bases
ATTTTTCCCGGCATTTCCCGCCGCCTTTCCTGCTGACTGGAGCCCCACTTTGGAAACCGATCTGGCCGAATTTGAAATCA
AGAGCAGCGGTGACCGCCTC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MSSNDSLQRLAQIIESRKPANGGDPGTSYVARLLHRGPDAFLKKIGEEATETVMAAKDLDHGGPTPELRAKLVGEVADLW
FHSLIALAHYGLQPADVIAELERREGTSGIEEKALRKVQNRDAAEKS

Sequences:

>Translated_127_residues
MSSNDSLQRLAQIIESRKPANGGDPGTSYVARLLHRGPDAFLKKIGEEATETVMAAKDLDHGGPTPELRAKLVGEVADLW
FHSLIALAHYGLQPADVIAELERREGTSGIEEKALRKVQNRDAAEKS
>Mature_126_residues
SSNDSLQRLAQIIESRKPANGGDPGTSYVARLLHRGPDAFLKKIGEEATETVMAAKDLDHGGPTPELRAKLVGEVADLWF
HSLIALAHYGLQPADVIAELERREGTSGIEEKALRKVQNRDAAEKS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_POLSJ (Q12FC5)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547665.1
- ProteinModelPortal:   Q12FC5
- SMR:   Q12FC5
- STRING:   Q12FC5
- GeneID:   4011369
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_0811
- NMPDR:   fig|296591.1.peg.3123
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   PSP296591:BPRO_0811-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13800; Mature: 13669

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNDSLQRLAQIIESRKPANGGDPGTSYVARLLHRGPDAFLKKIGEEATETVMAAKDLD
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
HGGPTPELRAKLVGEVADLWFHSLIALAHYGLQPADVIAELERREGTSGIEEKALRKVQN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RDAAEKS
CCCCCCC
>Mature Secondary Structure 
SSNDSLQRLAQIIESRKPANGGDPGTSYVARLLHRGPDAFLKKIGEEATETVMAAKDLD
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
HGGPTPELRAKLVGEVADLWFHSLIALAHYGLQPADVIAELERREGTSGIEEKALRKVQN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RDAAEKS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA