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The map label for this gene is ygeZ [H]

Identifier: 91212251

GI number: 91212251

Start: 3188862

End: 3190259

Strand: Direct

Name: ygeZ [H]

Synonym: UTI89_C3258

Alternate gene names: 91212251

Gene position: 3188862-3190259 (Clockwise)

Preceding gene: 91212250

Following gene: 91212252

Centisome position: 62.95

GC content: 52.65

Gene sequence:

>1398_bases
TTGGAGTTTGCTATGCGCGTATTGATAAAAAACGGCATTGTTGTTAATGCAGATGGACAGGCGAAGCAGGATTTGCTGAT
TGAAAGCGGGATTGTTCGCCAGTTGGGTACCGATATTTCGCCGCAACTCCCTTGCGAAGAAATTGATGCCTCTGGCTGTT
ACGTTTTCCCTGGCGGCGTGGATGTCCATACGCATTTCAATATTGATGTCGGCATCGCGCGCAGTTGTGATGATTTTTTT
ACCGGTACCCGCGCTGCTGCGTGTGGCGGTACAACAACCATTATTGACCATATGGGATTTGGCCCAAATGGCTGCCGGTT
ACGCCATCAACTGGAAGTTTATCGCGGTTATGCCGCCCACAAAGCAGTCATCGACTACAGCTTTCACGGTGTCATTCAAC
ATATTAATCACGCTATCCTCGACGAAATTCCGATGATGGTTGAGGAAGGACTGAGCAGTTTTAAACTCTATTTAACCTAT
CAATATAAACTCAACGATGATGAAGTGTTGCAGGCATTACGCCGCTTGCATGAGTCCGGCGCGCTGACCACCGTACACCC
GGAAAATGACGCAGCTATCGCCAGCAAGCGGGCGGAGTTTATCGCCGCAGGGTTAACCGCGCCGCGTTATCATGCCTTGA
GTCGACCTCTGGAATGCGAAGCGGAAGCCATCGCCCGCATGATTAACCTGGCACAAATTGCCGGTAACGCCCCGCTCTAT
ATCGTGCACCTGTCTAACGGCTTAGGTCTGGATTATCTGCGTCTTGCCCGTGCGAATCACCAGCCAGTCTGGGTTGAAAC
CTGCCCACAATATCTCCTGTTGGACGAACGCAGTTACGATACAGAAGATGGCATGAAGTTCATTCTTAGCCCACCGCTGC
GTAACGTACGCGAGCAGGACAAACTGTGGTGTGGCATCAGCGATGGTGCGATTGACGTGGTGGCAACCGATCACTGCACC
TTCTCGATGGCTCAACGCCTGCAAATTTCTAAAGGCGATTTCAGCCGCTGCCCAAATGGCTTACCCGGTGTGGAGAACCG
CATGCAACTGCTGTTCTCCAGTGGCGTGATGACGGGACGTATCTCACTGGAGCGTTTTGTTGAGTTAACCAGTGCAATGC
CCGCCAGGCTGTTTGGCCTGTGGCCGCAAAAAGGGATATTAGCGCCCGGTTCCGATGGTGACGTGGTGATTATCGACCCA
CGTCAGAGCCAACAAATTCAGCATCGCCATCTCCACGACAACGCCGACTACTCGCCCTGGGAGGGGTTTACCTGTCAGGG
CGCGATTGTCAGAACATTATCCCGTGGTGAAACGATTTTCTGCGACGGCACCTTTACAGGCAAAGCCGGGCGAGGTCGTT
TCCTGCGACGCAAACCGTTTGTCCCTCCCGTGCTCTAA

Upstream 100 bases:

>100_bases
CTGGTAACCTGTGCCGCTATGTACGCTGCAATCCCATTAAGCTGGCTGGCAACCGAATAATTACTCTTCACTTATCCCCC
TCCGGTTCGCCGGAGGGTTT

Downstream 100 bases:

>100_bases
CCACTGCCAGGGATCTATACACAATCAAGAATGATGAGTGAGGAAAAATGAGTAAGAAAATTGTTCTCGCCCTGGGCGGG
AATGCGCTGGGCGATGACCT

Product: phenylhydantoinase

Products: NA

Alternate protein names: Hydantoin-utilizing enzyme hyuA [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MEFAMRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHTHFNIDVGIARSCDDFF
TGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTY
QYKLNDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLY
IVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCT
FSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISLERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDP
RQSQQIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL

Sequences:

>Translated_465_residues
MEFAMRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHTHFNIDVGIARSCDDFF
TGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTY
QYKLNDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLY
IVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCT
FSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISLERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDP
RQSQQIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
>Mature_465_residues
MEFAMRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGVDVHTHFNIDVGIARSCDDFF
TGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTY
QYKLNDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLY
IVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQDKLWCGISDGAIDVVATDHCT
FSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRISLERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDP
RQSQQIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=471, Percent_Identity=36.7303609341826, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4503379, Length=462, Percent_Identity=34.8484848484849, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4503377, Length=462, Percent_Identity=35.2813852813853, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=35.2813852813853, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI62422571, Length=462, Percent_Identity=35.2813852813853, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI19923821, Length=464, Percent_Identity=34.051724137931, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI190194363, Length=462, Percent_Identity=33.982683982684, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI18105007, Length=405, Percent_Identity=24.1975308641975, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=98.0477223427332, Blast_Score=941, Evalue=0.0,
Organism=Escherichia coli, GI1786722, Length=448, Percent_Identity=30.1339285714286, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71989490, Length=467, Percent_Identity=35.5460385438972, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17539558, Length=463, Percent_Identity=35.2051835853132, Blast_Score=261, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI86575075, Length=473, Percent_Identity=28.3298097251586, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI193204318, Length=459, Percent_Identity=24.1830065359477, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=423, Percent_Identity=28.1323877068558, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI221377917, Length=481, Percent_Identity=35.7588357588358, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI17137462, Length=468, Percent_Identity=35.6837606837607, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24644287, Length=310, Percent_Identity=36.7741935483871, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24644289, Length=235, Percent_Identity=39.1489361702128, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24642586, Length=408, Percent_Identity=25.4901960784314, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18859883, Length=461, Percent_Identity=24.295010845987, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 51450; Mature: 51450

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFAMRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGV
CCHHHEEHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEECCCE
DVHTHFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAH
EEEEEEEEEEECCCCCHHHHCCCCHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHCHHHH
KAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESG
HEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCC
ALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLY
CEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEE
IVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQD
EEECCCCCCHHHHHHHHCCCCEEEHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHC
KLWCGISDGAIDVVATDHCTFSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGR
CEEEEECCCEEEEEEECCHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHCCCEEEE
ISLERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPW
HHHHHHHHHHHCCHHHHHCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCC
EGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
CCCEECHHHHHHHCCCCEEEECCEECCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MEFAMRVLIKNGIVVNADGQAKQDLLIESGIVRQLGTDISPQLPCEEIDASGCYVFPGGV
CCHHHEEHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEECCCE
DVHTHFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAH
EEEEEEEEEEECCCCCHHHHCCCCHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHCHHHH
KAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESG
HEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCC
ALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLY
CEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEE
IVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNVREQD
EEECCCCCCHHHHHHHHCCCCEEEHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHC
KLWCGISDGAIDVVATDHCTFSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGR
CEEEEECCCEEEEEEECCHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHCCCEEEE
ISLERFVELTSAMPARLFGLWPQKGILAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPW
HHHHHHHHHHHCCHHHHHCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCC
EGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
CCCEECHHHHHHHCCCCEEEECCEECCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA