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The map label for this gene is umuC [H]

Identifier: 89885827

GI number: 89885827

Start: 105088

End: 106386

Strand: Reverse

Name: umuC [H]

Synonym: Rfer_4341

Alternate gene names: 89885827

Gene position: 106386-105088 (Counterclockwise)

Preceding gene: 89885828

Following gene: 89885825

Centisome position: 41.32

GC content: 60.12

Gene sequence:

>1299_bases
GTGTACGCCCTCGTTGATTGCAATAATTTTTATGCCAGCTGTGAACGCGTGTTTCGCCCCAGTTTGCGGGGCATACCTGT
GGTCGTGCTCAGCAACAACGATGGCGCGTGCGTAGCGCGCAGCGATGAGGCTAAAAACCTTGGAATCAAGATGGGCGAGC
CTTGGTTCAAGGTCCGTCACCTGGCGGAGTCCCATGGATTGGTCGCGTTGTCCGCCAACTTTGCACTCTACGGCGACATC
AGCGATCGCGTGATGAGTCTGGCGGCCGGGCTCGGAGTCAAAACTGAAATCTATTCCATCGACGAATGCTTCGTCACCGT
GGATGGGATTCCCGGCGACCTGGTCGCGCGAGCCCACAAAATTCGCGCACGGATACTCCAGTGGGTCGGAATTCCCTGTG
GGATAGGCATCGGACCGACCAAAACGCTTGCGAAGCTGGCCAATCATGTCGCCAAGAGTGCCGAAAGGAAGCCAGGCAGC
TACCCCGTGCACCTGGCCCAGGTGTGCGACCTTTCTGGACTGACGCCGCCAGAGTTGGAATCCGTGATGGCGGCCACCGA
GATCAACGAAGTATGGGGCATTGGCCGGCAACTTACCAAGCAGCTAAACGAGTCCGGTATCACCACCGTTCTTGAATTGG
TCCGCCTGGATCCGGCCATGGTCAGAGCCCGGTGGTCGGTCATCCTGGAGCGCACGGTGAGGGAGCTCCAGGGCACCTCA
TGTATCGCATTCGATGACGCACCGTCGCCCAAGCAGGAGATCGCCTGTACGCGCTCGTTTGGGCATCCGGTTACGGAGTT
GCGTGAGCTCAATGAGGCCGTTACCGAGTTCGCCAGTCGTGGCGCCGTCAAGCTGCGAAAACAAGGCAGTCAGGCCGGCC
AAGTCATGGTGTTTATCCGCACCAGCCCATTTCGCAAGGATACGCAGTACAGCCGGTGCATCACGGTGCCGTTGCGGCGG
CCCAGCGCAGATACCGCGGCGATTGTTGGCGCCGCTCTGTCTGGTCTGCGAGCGATCTACAAGCCCGGGTTCAAATATGC
CAAGGCCGGTGTCATGCTGCTCGACCTGCAGTCGGACACAGTGCAACAAACCGAGCTCGATTTCGAGGAGGACGCCGGCC
CAGATCGTGGCCGTCTCATGGCTTCCTTGGATGAGCTCAACCACCGGTACGGCCGGGGCACGGTGTTGATGGCCAGTGCC
GGGCTGGCCGGAGATAGGCGGGTTTGGTCCATGAAACAGGAGCGCAGAACGCCGGGGTACACGACTTGCTGGGCAGAGAT
CCCCGTTGCACGAGCTTGA

Upstream 100 bases:

>100_bases
CAATCCGACGTTCGCGGAGATCGTGCCGAAGGACGGCCAGACCATTGAAATCTGGGGTGTTGTTACCGCCACCATCAAGC
AATTATTGAGCTGATTTTTC

Downstream 100 bases:

>100_bases
CATCCTCTGCGCCCTGAAGGCATGTGACACACTATTTCTTGCAAAACAGTGTCACTTTTACTTCGCCGGATGGTGCCAGA
CCAAATGTCGGGTCGCCGTC

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MYALVDCNNFYASCERVFRPSLRGIPVVVLSNNDGACVARSDEAKNLGIKMGEPWFKVRHLAESHGLVALSANFALYGDI
SDRVMSLAAGLGVKTEIYSIDECFVTVDGIPGDLVARAHKIRARILQWVGIPCGIGIGPTKTLAKLANHVAKSAERKPGS
YPVHLAQVCDLSGLTPPELESVMAATEINEVWGIGRQLTKQLNESGITTVLELVRLDPAMVRARWSVILERTVRELQGTS
CIAFDDAPSPKQEIACTRSFGHPVTELRELNEAVTEFASRGAVKLRKQGSQAGQVMVFIRTSPFRKDTQYSRCITVPLRR
PSADTAAIVGAALSGLRAIYKPGFKYAKAGVMLLDLQSDTVQQTELDFEEDAGPDRGRLMASLDELNHRYGRGTVLMASA
GLAGDRRVWSMKQERRTPGYTTCWAEIPVARA

Sequences:

>Translated_432_residues
MYALVDCNNFYASCERVFRPSLRGIPVVVLSNNDGACVARSDEAKNLGIKMGEPWFKVRHLAESHGLVALSANFALYGDI
SDRVMSLAAGLGVKTEIYSIDECFVTVDGIPGDLVARAHKIRARILQWVGIPCGIGIGPTKTLAKLANHVAKSAERKPGS
YPVHLAQVCDLSGLTPPELESVMAATEINEVWGIGRQLTKQLNESGITTVLELVRLDPAMVRARWSVILERTVRELQGTS
CIAFDDAPSPKQEIACTRSFGHPVTELRELNEAVTEFASRGAVKLRKQGSQAGQVMVFIRTSPFRKDTQYSRCITVPLRR
PSADTAAIVGAALSGLRAIYKPGFKYAKAGVMLLDLQSDTVQQTELDFEEDAGPDRGRLMASLDELNHRYGRGTVLMASA
GLAGDRRVWSMKQERRTPGYTTCWAEIPVARA
>Mature_432_residues
MYALVDCNNFYASCERVFRPSLRGIPVVVLSNNDGACVARSDEAKNLGIKMGEPWFKVRHLAESHGLVALSANFALYGDI
SDRVMSLAAGLGVKTEIYSIDECFVTVDGIPGDLVARAHKIRARILQWVGIPCGIGIGPTKTLAKLANHVAKSAERKPGS
YPVHLAQVCDLSGLTPPELESVMAATEINEVWGIGRQLTKQLNESGITTVLELVRLDPAMVRARWSVILERTVRELQGTS
CIAFDDAPSPKQEIACTRSFGHPVTELRELNEAVTEFASRGAVKLRKQGSQAGQVMVFIRTSPFRKDTQYSRCITVPLRR
PSADTAAIVGAALSGLRAIYKPGFKYAKAGVMLLDLQSDTVQQTELDFEEDAGPDRGRLMASLDELNHRYGRGTVLMASA
GLAGDRRVWSMKQERRTPGYTTCWAEIPVARA

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=426, Percent_Identity=44.6009389671362, Blast_Score=343, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47189; Mature: 47189

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALVDCNNFYASCERVFRPSLRGIPVVVLSNNDGACVARSDEAKNLGIKMGEPWFKVRH
CEEEEECCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHH
LAESHGLVALSANFALYGDISDRVMSLAAGLGVKTEIYSIDECFVTVDGIPGDLVARAHK
HHHHCCEEEEECCEEEEECHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCHHHHHHHHH
IRARILQWVGIPCGIGIGPTKTLAKLANHVAKSAERKPGSYPVHLAQVCDLSGLTPPELE
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHH
SVMAATEINEVWGIGRQLTKQLNESGITTVLELVRLDPAMVRARWSVILERTVRELQGTS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCE
CIAFDDAPSPKQEIACTRSFGHPVTELRELNEAVTEFASRGAVKLRKQGSQAGQVMVFIR
EEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEE
TSPFRKDTQYSRCITVPLRRPSADTAAIVGAALSGLRAIYKPGFKYAKAGVMLLDLQSDT
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCC
VQQTELDFEEDAGPDRGRLMASLDELNHRYGRGTVLMASAGLAGDRRVWSMKQERRTPGY
HHHHCCCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
TTCWAEIPVARA
EEEEECCCCCCC
>Mature Secondary Structure
MYALVDCNNFYASCERVFRPSLRGIPVVVLSNNDGACVARSDEAKNLGIKMGEPWFKVRH
CEEEEECCHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHH
LAESHGLVALSANFALYGDISDRVMSLAAGLGVKTEIYSIDECFVTVDGIPGDLVARAHK
HHHHCCEEEEECCEEEEECHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCHHHHHHHHH
IRARILQWVGIPCGIGIGPTKTLAKLANHVAKSAERKPGSYPVHLAQVCDLSGLTPPELE
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHH
SVMAATEINEVWGIGRQLTKQLNESGITTVLELVRLDPAMVRARWSVILERTVRELQGTS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCE
CIAFDDAPSPKQEIACTRSFGHPVTELRELNEAVTEFASRGAVKLRKQGSQAGQVMVFIR
EEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEE
TSPFRKDTQYSRCITVPLRRPSADTAAIVGAALSGLRAIYKPGFKYAKAGVMLLDLQSDT
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCC
VQQTELDFEEDAGPDRGRLMASLDELNHRYGRGTVLMASAGLAGDRRVWSMKQERRTPGY
HHHHCCCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
TTCWAEIPVARA
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]