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The map label for this gene is pepA [H]

Identifier: 89256768

GI number: 89256768

Start: 1404747

End: 1406186

Strand: Reverse

Name: pepA [H]

Synonym: FTL_1479

Alternate gene names: 89256768

Gene position: 1406186-1404747 (Counterclockwise)

Preceding gene: 89256775

Following gene: 89256767

Centisome position: 74.17

GC content: 35.21

Gene sequence:

>1440_bases
ATGAAAATAGTTGTAAATAATCAATCGACATTAGCTGCTGAGCTAATGATAGTTGCTCAAGAAAACTTACAAAAGCTAGT
TGAGCAAACAAAATGCCCAAATTCAAAAGCATTGCTTGATAGAAGAATTTTTAAAGCAAAGTCTGGCGAAGTTTTGCCTT
TATTACATGGTGATAAAATAGTTATCCTTTTAGGTTTGGGTCTAAGGCAAGATTTTATTGCTTCTGAGTATGACAAAATT
ATTGCTAAAGCTGCAGAACAACTTAAAAAATTGGCTATCAAAGAAATTTCTGTAGATATTGATTATGCGTTTGAAAATGA
TAATGTTAAGCAGTTTACTTTAGATACAGTTAGAGCTTTAATATCTGAAACTTATGTTTTTGATCAATTAAAAACTGAGA
AAGAAAATTATTCATTAGAACAAATTGAACTAGTTTACTCGGGTGATCAGGACATAGAAGACTCAGCAAAAATTGGTTCA
GCTATTGCTTGTGGTCAAAACTATGCAAAGGATTTACAAAATCTTCCAGCTAATATATGTACTACTGATTATATGCTAAA
TGAAGCAAGAGAGCTAACATCAAAATATGCAACATTTAGTCTTGATTATCTTGATCAAGATGCTATGGCAGAGTTGGGTA
TGGGATGTGCTTTAGCTGTAGGTCGTGGTTCTTATATGTCTAATTATACTGTGTGTATGGAGTATAAGGGTGGTAATGAA
GGTGATGCTCCTATAGTCTTAGTTGGTAAAGGCTTAGTTTTTGATAATGGAGGCATTTGTATCAAACAAGCAGCTGGTAT
GGATTCGATGAAAATGGATATGGGCGGTGTCGCAGCTGTAATGGGAACTATGAAAGCTATAGCAATGCTAAATCTACCAG
TAAATGTTGTTGGAGTTATGGGGCTTGCTGAAAATGCTGTTGATGCAAGATCTTATAGACCTGGTGATGTGCTTAAGAGT
ATGAAAGGTATCACTGTAGAGGTTAGTAATACAGATGCCGAGGGTAGGCTAGTGTTGTGTGATACGCTTACATATATTGG
TAAATATAAGCCTAAGGCAGTGATTGATTTAGCAACATTAACAGGTGCTATGATTATTTCTTTAGGAGATGCCTATTCTG
GGATGTTTGCTAATAGTGATAAATTAGCTAATAGCCTTGAACAAGCAGCTAATGCTTCTAATGATTTAATTTGGAGATTA
CCTTTACATAAACCATATCTCAAAAAAATAGAAAGTAAAGTTGCCGATATGGATAACTGTGGTCGTGATAGATCTGCCGG
CTCTATAGTCGCAGCATTATTTTTATCAAAATTTACTGAAGACTATGAATGGGCACACCTTGATATTGCTGGCTCTGCAA
TGGGAGATTTTGCAAGCTGTAAAGCCTCAGGCAGACCGGTTCCATTATTAGTTCATTATCTGATATCTCAAGCGAAATAG

Upstream 100 bases:

>100_bases
TCAGTAGATAACGTTACTAGCTTTTAAATTTAATGCGTTAAAATATCTTTTTTGTTATTATATTTGGGAAATCATTATTA
ATAGATCTAATGGAGCTTTA

Downstream 100 bases:

>100_bases
TAAATTCTAATACTTATTTCTGGCATATTTTTTCTTATATGGTAAAATAGTTCTGTAATTAAATTCATACTCTTTAGATT
TTAATTACGGAGATCAAAAA

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKIVVNNQSTLAAELMIVAQENLQKLVEQTKCPNSKALLDRRIFKAKSGEVLPLLHGDKIVILLGLGLRQDFIASEYDKI
IAKAAEQLKKLAIKEISVDIDYAFENDNVKQFTLDTVRALISETYVFDQLKTEKENYSLEQIELVYSGDQDIEDSAKIGS
AIACGQNYAKDLQNLPANICTTDYMLNEARELTSKYATFSLDYLDQDAMAELGMGCALAVGRGSYMSNYTVCMEYKGGNE
GDAPIVLVGKGLVFDNGGICIKQAAGMDSMKMDMGGVAAVMGTMKAIAMLNLPVNVVGVMGLAENAVDARSYRPGDVLKS
MKGITVEVSNTDAEGRLVLCDTLTYIGKYKPKAVIDLATLTGAMIISLGDAYSGMFANSDKLANSLEQAANASNDLIWRL
PLHKPYLKKIESKVADMDNCGRDRSAGSIVAALFLSKFTEDYEWAHLDIAGSAMGDFASCKASGRPVPLLVHYLISQAK

Sequences:

>Translated_479_residues
MKIVVNNQSTLAAELMIVAQENLQKLVEQTKCPNSKALLDRRIFKAKSGEVLPLLHGDKIVILLGLGLRQDFIASEYDKI
IAKAAEQLKKLAIKEISVDIDYAFENDNVKQFTLDTVRALISETYVFDQLKTEKENYSLEQIELVYSGDQDIEDSAKIGS
AIACGQNYAKDLQNLPANICTTDYMLNEARELTSKYATFSLDYLDQDAMAELGMGCALAVGRGSYMSNYTVCMEYKGGNE
GDAPIVLVGKGLVFDNGGICIKQAAGMDSMKMDMGGVAAVMGTMKAIAMLNLPVNVVGVMGLAENAVDARSYRPGDVLKS
MKGITVEVSNTDAEGRLVLCDTLTYIGKYKPKAVIDLATLTGAMIISLGDAYSGMFANSDKLANSLEQAANASNDLIWRL
PLHKPYLKKIESKVADMDNCGRDRSAGSIVAALFLSKFTEDYEWAHLDIAGSAMGDFASCKASGRPVPLLVHYLISQAK
>Mature_479_residues
MKIVVNNQSTLAAELMIVAQENLQKLVEQTKCPNSKALLDRRIFKAKSGEVLPLLHGDKIVILLGLGLRQDFIASEYDKI
IAKAAEQLKKLAIKEISVDIDYAFENDNVKQFTLDTVRALISETYVFDQLKTEKENYSLEQIELVYSGDQDIEDSAKIGS
AIACGQNYAKDLQNLPANICTTDYMLNEARELTSKYATFSLDYLDQDAMAELGMGCALAVGRGSYMSNYTVCMEYKGGNE
GDAPIVLVGKGLVFDNGGICIKQAAGMDSMKMDMGGVAAVMGTMKAIAMLNLPVNVVGVMGLAENAVDARSYRPGDVLKS
MKGITVEVSNTDAEGRLVLCDTLTYIGKYKPKAVIDLATLTGAMIISLGDAYSGMFANSDKLANSLEQAANASNDLIWRL
PLHKPYLKKIESKVADMDNCGRDRSAGSIVAALFLSKFTEDYEWAHLDIAGSAMGDFASCKASGRPVPLLVHYLISQAK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=358, Percent_Identity=37.9888268156425, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI47155554, Length=314, Percent_Identity=32.8025477707006, Blast_Score=132, Evalue=9e-31,
Organism=Escherichia coli, GI1790710, Length=458, Percent_Identity=43.2314410480349, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87082123, Length=310, Percent_Identity=36.4516129032258, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=296, Percent_Identity=34.4594594594595, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=143, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24661038, Length=358, Percent_Identity=33.5195530726257, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21355725, Length=358, Percent_Identity=33.7988826815642, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161077148, Length=363, Percent_Identity=28.9256198347107, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI20130057, Length=363, Percent_Identity=28.9256198347107, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI20129969, Length=414, Percent_Identity=28.0193236714976, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24662227, Length=405, Percent_Identity=26.9135802469136, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21355645, Length=402, Percent_Identity=26.6169154228856, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24662223, Length=402, Percent_Identity=26.6169154228856, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI21357381, Length=286, Percent_Identity=34.965034965035, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379063, Length=286, Percent_Identity=34.965034965035, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379062, Length=286, Percent_Identity=34.965034965035, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19922386, Length=332, Percent_Identity=28.3132530120482, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI20129963, Length=367, Percent_Identity=28.0653950953678, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646701, Length=252, Percent_Identity=29.3650793650794, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=252, Percent_Identity=29.3650793650794, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=252, Percent_Identity=29.3650793650794, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51990; Mature: 51990

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVNNQSTLAAELMIVAQENLQKLVEQTKCPNSKALLDRRIFKAKSGEVLPLLHGDKI
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCEE
VILLGLGLRQDFIASEYDKIIAKAAEQLKKLAIKEISVDIDYAFENDNVKQFTLDTVRAL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEHHHHHHHH
ISETYVFDQLKTEKENYSLEQIELVYSGDQDIEDSAKIGSAIACGQNYAKDLQNLPANIC
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHCCHHHCCHHHHHHHHHCCCHHH
TTDYMLNEARELTSKYATFSLDYLDQDAMAELGMGCALAVGRGSYMSNYTVCMEYKGGNE
HHHHHHHHHHHHHHHHHEEEEHHCCHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCC
GDAPIVLVGKGLVFDNGGICIKQAAGMDSMKMDMGGVAAVMGTMKAIAMLNLPVNVVGVM
CCCCEEEEECCEEEECCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
GLAENAVDARSYRPGDVLKSMKGITVEVSNTDAEGRLVLCDTLTYIGKYKPKAVIDLATL
HHHHCCHHCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEHHHHHHCCCCCCEEEHHHH
TGAMIISLGDAYSGMFANSDKLANSLEQAANASNDLIWRLPLHKPYLKKIESKVADMDNC
HHHHEEEECCHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCHHHC
GRDRSAGSIVAALFLSKFTEDYEWAHLDIAGSAMGDFASCKASGRPVPLLVHYLISQAK
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKIVVNNQSTLAAELMIVAQENLQKLVEQTKCPNSKALLDRRIFKAKSGEVLPLLHGDKI
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCEE
VILLGLGLRQDFIASEYDKIIAKAAEQLKKLAIKEISVDIDYAFENDNVKQFTLDTVRAL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEHHHHHHHH
ISETYVFDQLKTEKENYSLEQIELVYSGDQDIEDSAKIGSAIACGQNYAKDLQNLPANIC
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHCCHHHCCHHHHHHHHHCCCHHH
TTDYMLNEARELTSKYATFSLDYLDQDAMAELGMGCALAVGRGSYMSNYTVCMEYKGGNE
HHHHHHHHHHHHHHHHHEEEEHHCCHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCC
GDAPIVLVGKGLVFDNGGICIKQAAGMDSMKMDMGGVAAVMGTMKAIAMLNLPVNVVGVM
CCCCEEEEECCEEEECCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
GLAENAVDARSYRPGDVLKSMKGITVEVSNTDAEGRLVLCDTLTYIGKYKPKAVIDLATL
HHHHCCHHCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEHHHHHHCCCCCCEEEHHHH
TGAMIISLGDAYSGMFANSDKLANSLEQAANASNDLIWRLPLHKPYLKKIESKVADMDNC
HHHHEEEECCHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCHHHC
GRDRSAGSIVAALFLSKFTEDYEWAHLDIAGSAMGDFASCKASGRPVPLLVHYLISQAK
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA