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The map label for this gene is guaB [H]

Identifier: 89256767

GI number: 89256767

Start: 1403186

End: 1404646

Strand: Reverse

Name: guaB [H]

Synonym: FTL_1478

Alternate gene names: 89256767

Gene position: 1404646-1403186 (Counterclockwise)

Preceding gene: 89256768

Following gene: 89256766

Centisome position: 74.08

GC content: 38.4

Gene sequence:

>1461_bases
ATGTTAAGAATTACTCAGCAGGCAATCACTTTTGATGATGTATTGCTATCACCTAGATATTCAAATGTTCTTCCTCATCA
AGTTGATTTGAAGACAAATATAACTAGAGATATTCAGTTAAATATTCCTTTAGTATCTGCAGCTATGGATACGGTTACTG
AGTCACGCCTAGCTATTGCGATAGCCCAGGAAGGTGGTATTGGTATTATTCATAAGAATATGTCTATTCAAGCCCAAGCC
CAAGAAGTTAAAAAGGTAAAAAGATTTGAAAATGGAATGGTGATTGATCCCATTACCATTAAACAAGAAAGCTCAATTAA
AGAAATCATGCAACTAGCTAAAGAACATAATTTCTCTGGTTTTCCCGTTGTTGATGATAATAATAAAATCATAGGTATTG
TTACAAGGCGTGATTTTAGATTTGCAAAAGATTTAGATGAACCTGTTAGCTCTATTATGACACCTAGAGAAAAACTTGTA
ACAGTGCCTGAAGATGCTTCTCAAGGAGCGATTAAAAAGAAACTTCATGAGCATAAAATTGAGAAGTTGCTTGTAGTTAA
TGAACAAGGCGAGTTGGTCGGTCTTATTACAACAAAAGATATCGAAAGATCACAAAATAAACCAAATGCTTGTAAAGATT
CTCTTGGGCGTTTGAGAGTTGGCGCTGCTGTTGGAACCGCTGTTAATACTAAAGAGCGTGTTGCAGCATTGGCAGCTGAA
GGAGTCGATATTATTGTTGTAGATACTGCTCATGGACATTCACAAGGTGTGTTAGATACAGTTAAGTGGGTTAAAGATAA
CTATCCACATATTCAGGTTATAGGTGGTAATATCGCTACAGCAGAAGCTGCTAAAGATCTAGTTAAAGCTGGTGCTGATG
CTGTCAAGGTTGGTATTGGACCTGGCTCAATCTGTACTACCAGAATTGTTGCTGGTGTTGGTGTACCACAAATTACAGCG
ATAGCTAATGTTGCAGAGGCATTAAAAGGAACTGGAGTGCCTGTGATTGCAGATGGCGGTATTAGATATTCCGGTGATAT
TGCAAAAGCTATAGTTGCTGGAGCATCTGTAGTTATGATTGGAGGGCTTTTTGCAGGTACTGAAGAATCACCAGGGGAGG
TTGAGCTTTTCCAAGGTCGCTCTTATAAATCATATCGTGGTATGGGTTCTCTTGGTGCTATGGAGAAAGGCTCATCTGAT
AGATATTTCCAAAGTGAAACAGAGGCGAAAAAGTTTGTTCCAGAAGGCGTTGAAGGCAGAGTACCATACAAAGGTTTATT
ATCTGCAGTGATTCATCAGCTAATAGGTGGTCTGAAATCTAGTATGGGCTATACTGGCTCAAAAGATATCCAAACAATGC
GAACAGAACCGACATTTGTACAAATTACAGGTGCTGGATTTAATGAATCGCATGTACATAACGTCACGATTACTAAAGAA
CCACCTAATTACCAGTCTTAA

Upstream 100 bases:

>100_bases
TAAATTCTAATACTTATTTCTGGCATATTTTTTCTTATATGGTAAAATAGTTCTGTAATTAAATTCATACTCTTTAGATT
TTAATTACGGAGATCAAAAA

Downstream 100 bases:

>100_bases
AACCTCTTAATTATGATTTTAATAAGTTATAATCTATTAAATTTTACTTAATATTTAATAACTCAATGTCTGAAGCGATA
CTTTTTCTAAATGGTAAAGT

Product: inosine-5-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MLRITQQAITFDDVLLSPRYSNVLPHQVDLKTNITRDIQLNIPLVSAAMDTVTESRLAIAIAQEGGIGIIHKNMSIQAQA
QEVKKVKRFENGMVIDPITIKQESSIKEIMQLAKEHNFSGFPVVDDNNKIIGIVTRRDFRFAKDLDEPVSSIMTPREKLV
TVPEDASQGAIKKKLHEHKIEKLLVVNEQGELVGLITTKDIERSQNKPNACKDSLGRLRVGAAVGTAVNTKERVAALAAE
GVDIIVVDTAHGHSQGVLDTVKWVKDNYPHIQVIGGNIATAEAAKDLVKAGADAVKVGIGPGSICTTRIVAGVGVPQITA
IANVAEALKGTGVPVIADGGIRYSGDIAKAIVAGASVVMIGGLFAGTEESPGEVELFQGRSYKSYRGMGSLGAMEKGSSD
RYFQSETEAKKFVPEGVEGRVPYKGLLSAVIHQLIGGLKSSMGYTGSKDIQTMRTEPTFVQITGAGFNESHVHNVTITKE
PPNYQS

Sequences:

>Translated_486_residues
MLRITQQAITFDDVLLSPRYSNVLPHQVDLKTNITRDIQLNIPLVSAAMDTVTESRLAIAIAQEGGIGIIHKNMSIQAQA
QEVKKVKRFENGMVIDPITIKQESSIKEIMQLAKEHNFSGFPVVDDNNKIIGIVTRRDFRFAKDLDEPVSSIMTPREKLV
TVPEDASQGAIKKKLHEHKIEKLLVVNEQGELVGLITTKDIERSQNKPNACKDSLGRLRVGAAVGTAVNTKERVAALAAE
GVDIIVVDTAHGHSQGVLDTVKWVKDNYPHIQVIGGNIATAEAAKDLVKAGADAVKVGIGPGSICTTRIVAGVGVPQITA
IANVAEALKGTGVPVIADGGIRYSGDIAKAIVAGASVVMIGGLFAGTEESPGEVELFQGRSYKSYRGMGSLGAMEKGSSD
RYFQSETEAKKFVPEGVEGRVPYKGLLSAVIHQLIGGLKSSMGYTGSKDIQTMRTEPTFVQITGAGFNESHVHNVTITKE
PPNYQS
>Mature_486_residues
MLRITQQAITFDDVLLSPRYSNVLPHQVDLKTNITRDIQLNIPLVSAAMDTVTESRLAIAIAQEGGIGIIHKNMSIQAQA
QEVKKVKRFENGMVIDPITIKQESSIKEIMQLAKEHNFSGFPVVDDNNKIIGIVTRRDFRFAKDLDEPVSSIMTPREKLV
TVPEDASQGAIKKKLHEHKIEKLLVVNEQGELVGLITTKDIERSQNKPNACKDSLGRLRVGAAVGTAVNTKERVAALAAE
GVDIIVVDTAHGHSQGVLDTVKWVKDNYPHIQVIGGNIATAEAAKDLVKAGADAVKVGIGPGSICTTRIVAGVGVPQITA
IANVAEALKGTGVPVIADGGIRYSGDIAKAIVAGASVVMIGGLFAGTEESPGEVELFQGRSYKSYRGMGSLGAMEKGSSD
RYFQSETEAKKFVPEGVEGRVPYKGLLSAVIHQLIGGLKSSMGYTGSKDIQTMRTEPTFVQITGAGFNESHVHNVTITKE
PPNYQS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=41.6666666666667, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI217035146, Length=461, Percent_Identity=41.4316702819957, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI34328930, Length=461, Percent_Identity=41.4316702819957, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI34328928, Length=461, Percent_Identity=41.4316702819957, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI156616279, Length=461, Percent_Identity=41.4316702819957, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI217035148, Length=461, Percent_Identity=40.5639913232104, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI217035150, Length=461, Percent_Identity=38.3947939262473, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=36.9918699186992, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=37.5, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=37.246963562753, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=485, Percent_Identity=61.8556701030928, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=34.841628959276, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=472, Percent_Identity=40.0423728813559, Blast_Score=318, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=41.2177985948478, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17560440, Length=257, Percent_Identity=36.5758754863813, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=494, Percent_Identity=39.2712550607287, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.7119341563786, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=39.2241379310345, Blast_Score=325, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.8888888888889, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=41.2280701754386, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=40.3726708074534, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=40.3726708074534, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.0430839002268, Blast_Score=314, Evalue=7e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52092; Mature: 52092

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRITQQAITFDDVLLSPRYSNVLPHQVDLKTNITRDIQLNIPLVSAAMDTVTESRLAIA
CCEECCHHHHHHHHEECCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHCCEEEEE
IAQEGGIGIIHKNMSIQAQAQEVKKVKRFENGMVIDPITIKQESSIKEIMQLAKEHNFSG
EECCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEECCEEECCHHHHHHHHHHHHHCCCCC
FPVVDDNNKIIGIVTRRDFRFAKDLDEPVSSIMTPREKLVTVPEDASQGAIKKKLHEHKI
CCEECCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHHHHHH
EKLLVVNEQGELVGLITTKDIERSQNKPNACKDSLGRLRVGAAVGTAVNTKERVAALAAE
CEEEEECCCCCEEEEEEECCHHHCCCCCCHHHHHHHHEEECHHHCCCCCCHHHHHHHHHC
GVDIIVVDTAHGHSQGVLDTVKWVKDNYPHIQVIGGNIATAEAAKDLVKAGADAVKVGIG
CCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCEEHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVAGVGVPQITAIANVAEALKGTGVPVIADGGIRYSGDIAKAIVAGASVVMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEE
GGLFAGTEESPGEVELFQGRSYKSYRGMGSLGAMEKGSSDRYFQSETEAKKFVPEGVEGR
EEEEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
VPYKGLLSAVIHQLIGGLKSSMGYTGSKDIQTMRTEPTFVQITGAGFNESHVHNVTITKE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEEEECC
PPNYQS
CCCCCC
>Mature Secondary Structure
MLRITQQAITFDDVLLSPRYSNVLPHQVDLKTNITRDIQLNIPLVSAAMDTVTESRLAIA
CCEECCHHHHHHHHEECCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHCCEEEEE
IAQEGGIGIIHKNMSIQAQAQEVKKVKRFENGMVIDPITIKQESSIKEIMQLAKEHNFSG
EECCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEECCEEECCHHHHHHHHHHHHHCCCCC
FPVVDDNNKIIGIVTRRDFRFAKDLDEPVSSIMTPREKLVTVPEDASQGAIKKKLHEHKI
CCEECCCCEEEEEEEECCCHHHHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHHHHHH
EKLLVVNEQGELVGLITTKDIERSQNKPNACKDSLGRLRVGAAVGTAVNTKERVAALAAE
CEEEEECCCCCEEEEEEECCHHHCCCCCCHHHHHHHHEEECHHHCCCCCCHHHHHHHHHC
GVDIIVVDTAHGHSQGVLDTVKWVKDNYPHIQVIGGNIATAEAAKDLVKAGADAVKVGIG
CCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCEEHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVAGVGVPQITAIANVAEALKGTGVPVIADGGIRYSGDIAKAIVAGASVVMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEE
GGLFAGTEESPGEVELFQGRSYKSYRGMGSLGAMEKGSSDRYFQSETEAKKFVPEGVEGR
EEEEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
VPYKGLLSAVIHQLIGGLKSSMGYTGSKDIQTMRTEPTFVQITGAGFNESHVHNVTITKE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEEEECC
PPNYQS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA