| Definition | Francisella tularensis subsp. holarctica LVS chromosome, complete genome. |
|---|---|
| Accession | NC_007880 |
| Length | 1,895,994 |
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The map label for this gene is uvrA [H]
Identifier: 89256762
GI number: 89256762
Start: 1396896
End: 1399718
Strand: Reverse
Name: uvrA [H]
Synonym: FTL_1473
Alternate gene names: 89256762
Gene position: 1399718-1396896 (Counterclockwise)
Preceding gene: 89256763
Following gene: 89256757
Centisome position: 73.83
GC content: 35.57
Gene sequence:
>2823_bases ATGAAAAAAATTATCGTCAAGGGCGCAAAAACCCATAACCTAAAAAATATTGATGTTGAGATACCACGGGATAAGCTAAC TGTTATCACAGGATTAAGTGGCTCTGGTAAATCTTCATTAGCTTTTGATACTCTATATGCTGAAGGGCAAAGAAGGTATG TTGAGTCATTATCTTCATATGCAAGACAGTTTTTGTCGATGATGGATAAACCAGATATTGAGCATATAGAAGGCCTTTCT CCAGCTATTTCAATAGATCAAAAAACAACATCTCATAATCCAAGATCTACAGTTGGAACTGTAACAGAGATATATGATTA TCTGCGAGTGTTTTTTGCACGAGCTGGTACACCAAAATGTCCGATACATCAAATAGAATTGAAGGCTCAAACTATCAGCC AAATGGTTGATAAAATTTTGGAATTTGATGAAGATTCAAGATTGATGATACTAGCACCAATTATTTCTCAAAAAAAAGGT ACACATCATACTTTATTAGATAAGATATTAGCACAAGGATATGTTCGTGTGCGTATAAATGACGAGTTTTATAACCTTGA TGAAGATTATCCTGAATTGGATCGTTATAAAAAACATAATATTGATGTCGTTATTGATAGATTTAAACCCAAAAAAGAGA ACGAACAACGTATCGCTGAATCAATAGAAACAGCTTTAGACCTTGGTAATGGTATTGTTAAATTAGCAGATATGGCAAAT CAAACTGGCGATGATATCTTATTTTCATCAAAGCATGCTTGTCCTTTGTGTGATTTTGCACTTAAAGAATTATCACCAAG AATTTTTTCTTTTAACAGTCCGTTGGGGGCTTGTAGCAGTTGTGATGGACTTGGTGTTAAAGAATTTTTTGATGAGCAAA AGGTTGTTATAGATCCATCAATTTCACTTAAGCATGGAGCTATAGTTAAGTGGAATAAAACTAATCAATACTATTTTTCT CAATTAGAGTCTTTAGCAACACACTACAAATTTTCTTTAGATGAGCGGTTTGAGAAGCTACCTAAAAGAATTCAAGAAAT AATCTTATATGGTTCTGGTGACGAAGCTATCGTAATGAGTGTTGATTCTATCAGAGGAGGTAGACAAACTCGTATTAAAC CTTTTGAGGGTGTTATACCTCATTTTGAACGCAGATATTATGAGTCTGACTCAGATATGGTTAAAAAAGATCTTTATGAG CTTATGAGTAACCTTGAATGTAAGTCTTGTAATGGTGCGAGAATTAATGAATATGCACGCAATATATTTATTGCTGATAA AAATATAGCTGATGTTTGTGCTTTGCCTATTGATGAGTTATTAAAGTGGTTGGATAGTCTAAAGTTTGTCGGTCAACAAC AAGTTATCGCAGAGAATTTACTCAAAGAGATTAAACTAAGAGTAGAGTTTTTAGCAAATGTTGGGCTAGAGTATTTAAGC TTAGCAAGGCAAGCTGATACTCTCTCTGGTGGTGAGGCTCAGCGTATTCGTTTAGCAAGTCAGATAGGCGCTGGTCTTGT TGGTGTGATGTATATATTAGATGAGCCATCGATAGGTCTTCATCAAAGGGATAATCAACGTTTGCTTGATGCTTTACATA ACCTTAAAAATCTAGGTAATACTGTAATCGTTGTTGAGCATGATGAGGATGCGATTCGTCAAGCAGATTATATAATCGAT ATGGGACCAATGGCAGGTGTACATGGTGGTGAGGTAGTTGCTGCTGGCGGTTATGAAACGATACTCAAGAGTAAAAAGTC TTTAACTGCAGATTATTTAAGTGGTCGTAGAAAAATTGAAGTTCCAAAAACTAGGCTAAAAGCTAGTAAAAATCGTTATC TAGAAATAAGTGGTGCGGTCGGTAATAATCTTCAAGGAGATAATCTTAAAATCCCTCTAGGGGCATTGACATGTGTGACA GGTGTCTCAGGGTCAGGTAAATCAACGCTGATAAATAGAACTTTATATCCTTTGGCTTCTCGTTTACTAAACAGAAGTAT TTTAGTACCAATGCAGTATACCTCACATAAAGGTTTTAATCACCTTGATAAGGTTATAGATATTGATCAATCACCAATAG GTAGAACTCCACGCTCTAATCCAGCAACTTATACGGGAGTGTTTACACCCATACGCGAATTATTTGCTGCAACATCAGAA GCTCGAGCTAGAGGATATATTGCTGGAAGATTTAGCTTTAATGTTCGTGGCGGAAGATGTGAAGCATGTCAAGGTGATGG CGTTATAAAGGTAGAGATGCATTTTCTCGCAGATGTTTATGTTGCTTGTGATGTTTGTCAAGGCAAGCGTTATAATCGCG AAACTTTAGCGGTGCAATACAAAGGTAAAAATATTTACGAAGTATTGGAGATGACTGTCGAAGAGGCACTTGAATTTTAT GATGCAGTACCAAGTATTAAGACTAAGCTGGAAGCTTTGATGAACGTTGGACTGTCGTATATTAAGCTAGGACAAAGTGC TACTACTCTTTCTGGTGGTGAAGCACAAAGAGTTAAATTAGCAAAAGAGCTATCAAAACGTTCAACTAGTAAAACCTTAT ATATATTGGATGAGCCGACCACTGGTTTACATTTTTATGATATTCATCAACTTCTAAAAGTAATCATGGATCTGCGTGAT AAAGGTAATACTGTTGTAATTATTGAACATAATTTAGATGTGATAAAAATGGCAGATTGGCTTGTTGATTTAGGTCCAGA AGGTGGTAGTAAAGGAGGGCAGATAATTTTTGAGGGAACTCCAGAGGATATAATTAACTGTAAAAAATCATACACTGGTA AGTATCTTAAAGATTTACTCTAG
Upstream 100 bases:
>100_bases TTACTTTAGATACGCCTAAAGGTAAAGTTACATACGAAATTGTAGCTGTAGAATATAAATAACCTAAAAATCTAATCTAT ATTTCTTTACAAGAATTTTT
Downstream 100 bases:
>100_bases CTAAACTAAGATATTGGTACGCTGTTTAAATTATTAGGTCTATAAAATACTACATAAACTAAAATCATTAAAAGCCCGAT AGAGTATATAAATTGAACTG
Product: DNA excision repair enzyme, subunit A
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 940; Mature: 940
Protein sequence:
>940_residues MKKIIVKGAKTHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSSYARQFLSMMDKPDIEHIEGLS PAISIDQKTTSHNPRSTVGTVTEIYDYLRVFFARAGTPKCPIHQIELKAQTISQMVDKILEFDEDSRLMILAPIISQKKG THHTLLDKILAQGYVRVRINDEFYNLDEDYPELDRYKKHNIDVVIDRFKPKKENEQRIAESIETALDLGNGIVKLADMAN QTGDDILFSSKHACPLCDFALKELSPRIFSFNSPLGACSSCDGLGVKEFFDEQKVVIDPSISLKHGAIVKWNKTNQYYFS QLESLATHYKFSLDERFEKLPKRIQEIILYGSGDEAIVMSVDSIRGGRQTRIKPFEGVIPHFERRYYESDSDMVKKDLYE LMSNLECKSCNGARINEYARNIFIADKNIADVCALPIDELLKWLDSLKFVGQQQVIAENLLKEIKLRVEFLANVGLEYLS LARQADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNQRLLDALHNLKNLGNTVIVVEHDEDAIRQADYIID MGPMAGVHGGEVVAAGGYETILKSKKSLTADYLSGRRKIEVPKTRLKASKNRYLEISGAVGNNLQGDNLKIPLGALTCVT GVSGSGKSTLINRTLYPLASRLLNRSILVPMQYTSHKGFNHLDKVIDIDQSPIGRTPRSNPATYTGVFTPIRELFAATSE ARARGYIAGRFSFNVRGGRCEACQGDGVIKVEMHFLADVYVACDVCQGKRYNRETLAVQYKGKNIYEVLEMTVEEALEFY DAVPSIKTKLEALMNVGLSYIKLGQSATTLSGGEAQRVKLAKELSKRSTSKTLYILDEPTTGLHFYDIHQLLKVIMDLRD KGNTVVIIEHNLDVIKMADWLVDLGPEGGSKGGQIIFEGTPEDIINCKKSYTGKYLKDLL
Sequences:
>Translated_940_residues MKKIIVKGAKTHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSSYARQFLSMMDKPDIEHIEGLS PAISIDQKTTSHNPRSTVGTVTEIYDYLRVFFARAGTPKCPIHQIELKAQTISQMVDKILEFDEDSRLMILAPIISQKKG THHTLLDKILAQGYVRVRINDEFYNLDEDYPELDRYKKHNIDVVIDRFKPKKENEQRIAESIETALDLGNGIVKLADMAN QTGDDILFSSKHACPLCDFALKELSPRIFSFNSPLGACSSCDGLGVKEFFDEQKVVIDPSISLKHGAIVKWNKTNQYYFS QLESLATHYKFSLDERFEKLPKRIQEIILYGSGDEAIVMSVDSIRGGRQTRIKPFEGVIPHFERRYYESDSDMVKKDLYE LMSNLECKSCNGARINEYARNIFIADKNIADVCALPIDELLKWLDSLKFVGQQQVIAENLLKEIKLRVEFLANVGLEYLS LARQADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNQRLLDALHNLKNLGNTVIVVEHDEDAIRQADYIID MGPMAGVHGGEVVAAGGYETILKSKKSLTADYLSGRRKIEVPKTRLKASKNRYLEISGAVGNNLQGDNLKIPLGALTCVT GVSGSGKSTLINRTLYPLASRLLNRSILVPMQYTSHKGFNHLDKVIDIDQSPIGRTPRSNPATYTGVFTPIRELFAATSE ARARGYIAGRFSFNVRGGRCEACQGDGVIKVEMHFLADVYVACDVCQGKRYNRETLAVQYKGKNIYEVLEMTVEEALEFY DAVPSIKTKLEALMNVGLSYIKLGQSATTLSGGEAQRVKLAKELSKRSTSKTLYILDEPTTGLHFYDIHQLLKVIMDLRD KGNTVVIIEHNLDVIKMADWLVDLGPEGGSKGGQIIFEGTPEDIINCKKSYTGKYLKDLL >Mature_940_residues MKKIIVKGAKTHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSSYARQFLSMMDKPDIEHIEGLS PAISIDQKTTSHNPRSTVGTVTEIYDYLRVFFARAGTPKCPIHQIELKAQTISQMVDKILEFDEDSRLMILAPIISQKKG THHTLLDKILAQGYVRVRINDEFYNLDEDYPELDRYKKHNIDVVIDRFKPKKENEQRIAESIETALDLGNGIVKLADMAN QTGDDILFSSKHACPLCDFALKELSPRIFSFNSPLGACSSCDGLGVKEFFDEQKVVIDPSISLKHGAIVKWNKTNQYYFS QLESLATHYKFSLDERFEKLPKRIQEIILYGSGDEAIVMSVDSIRGGRQTRIKPFEGVIPHFERRYYESDSDMVKKDLYE LMSNLECKSCNGARINEYARNIFIADKNIADVCALPIDELLKWLDSLKFVGQQQVIAENLLKEIKLRVEFLANVGLEYLS LARQADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNQRLLDALHNLKNLGNTVIVVEHDEDAIRQADYIID MGPMAGVHGGEVVAAGGYETILKSKKSLTADYLSGRRKIEVPKTRLKASKNRYLEISGAVGNNLQGDNLKIPLGALTCVT GVSGSGKSTLINRTLYPLASRLLNRSILVPMQYTSHKGFNHLDKVIDIDQSPIGRTPRSNPATYTGVFTPIRELFAATSE ARARGYIAGRFSFNVRGGRCEACQGDGVIKVEMHFLADVYVACDVCQGKRYNRETLAVQYKGKNIYEVLEMTVEEALEFY DAVPSIKTKLEALMNVGLSYIKLGQSATTLSGGEAQRVKLAKELSKRSTSKTLYILDEPTTGLHFYDIHQLLKVIMDLRD KGNTVVIIEHNLDVIKMADWLVDLGPEGGSKGGQIIFEGTPEDIINCKKSYTGKYLKDLL
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=941, Percent_Identity=62.3804463336876, Blast_Score=1224, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 105046; Mature: 105046
Theoretical pI: Translated: 7.43; Mature: 7.43
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKIIVKGAKTHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSSY CCCEEEECCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHH ARQFLSMMDKPDIEHIEGLSPAISIDQKTTSHNPRSTVGTVTEIYDYLRVFFARAGTPKC HHHHHHHHCCCCHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC PIHQIELKAQTISQMVDKILEFDEDSRLMILAPIISQKKGTHHTLLDKILAQGYVRVRIN CCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECHHCCCCCHHHHHHHHHHCCEEEEEEC DEFYNLDEDYPELDRYKKHNIDVVIDRFKPKKENEQRIAESIETALDLGNGIVKLADMAN CCEECCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHC QTGDDILFSSKHACPLCDFALKELSPRIFSFNSPLGACSSCDGLGVKEFFDEQKVVIDPS CCCCCEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCC ISLKHGAIVKWNKTNQYYFSQLESLATHYKFSLDERFEKLPKRIQEIILYGSGDEAIVMS CEECCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCEEEEE VDSIRGGRQTRIKPFEGVIPHFERRYYESDSDMVKKDLYELMSNLECKSCNGARINEYAR EHHCCCCCCCCCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC NIFIADKNIADVCALPIDELLKWLDSLKFVGQQQVIAENLLKEIKLRVEFLANVGLEYLS EEEEECCCCHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH LARQADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNQRLLDALHNLKNLGN HHHHHCCCCCCCHHHHHHHHHHCCHHEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCC TVIVVEHDEDAIRQADYIIDMGPMAGVHGGEVVAAGGYETILKSKKSLTADYLSGRRKIE EEEEEECCHHHHHHHCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEC VPKTRLKASKNRYLEISGAVGNNLQGDNLKIPLGALTCVTGVSGSGKSTLINRTLYPLAS CCHHHHHHCCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHH RLLNRSILVPMQYTSHKGFNHLDKVIDIDQSPIGRTPRSNPATYTGVFTPIRELFAATSE HHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH ARARGYIAGRFSFNVRGGRCEACQGDGVIKVEMHFLADVYVACDVCQGKRYNRETLAVQY HHHCCEEEEEEEEEECCCEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEE KGKNIYEVLEMTVEEALEFYDAVPSIKTKLEALMNVGLSYIKLGQSATTLSGGEAQRVKL CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHH AKELSKRSTSKTLYILDEPTTGLHFYDIHQLLKVIMDLRDKGNTVVIIEHNLDVIKMADW HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH LVDLGPEGGSKGGQIIFEGTPEDIINCKKSYTGKYLKDLL HHCCCCCCCCCCCEEEECCCCHHHHHHHHHHCHHHHHHCC >Mature Secondary Structure MKKIIVKGAKTHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSSY CCCEEEECCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHH ARQFLSMMDKPDIEHIEGLSPAISIDQKTTSHNPRSTVGTVTEIYDYLRVFFARAGTPKC HHHHHHHHCCCCHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC PIHQIELKAQTISQMVDKILEFDEDSRLMILAPIISQKKGTHHTLLDKILAQGYVRVRIN CCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECHHCCCCCHHHHHHHHHHCCEEEEEEC DEFYNLDEDYPELDRYKKHNIDVVIDRFKPKKENEQRIAESIETALDLGNGIVKLADMAN CCEECCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHC QTGDDILFSSKHACPLCDFALKELSPRIFSFNSPLGACSSCDGLGVKEFFDEQKVVIDPS CCCCCEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCC ISLKHGAIVKWNKTNQYYFSQLESLATHYKFSLDERFEKLPKRIQEIILYGSGDEAIVMS CEECCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCEEEEE VDSIRGGRQTRIKPFEGVIPHFERRYYESDSDMVKKDLYELMSNLECKSCNGARINEYAR EHHCCCCCCCCCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC NIFIADKNIADVCALPIDELLKWLDSLKFVGQQQVIAENLLKEIKLRVEFLANVGLEYLS EEEEECCCCHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH LARQADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNQRLLDALHNLKNLGN HHHHHCCCCCCCHHHHHHHHHHCCHHEEHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCC TVIVVEHDEDAIRQADYIIDMGPMAGVHGGEVVAAGGYETILKSKKSLTADYLSGRRKIE EEEEEECCHHHHHHHCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEC VPKTRLKASKNRYLEISGAVGNNLQGDNLKIPLGALTCVTGVSGSGKSTLINRTLYPLAS CCHHHHHHCCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHH RLLNRSILVPMQYTSHKGFNHLDKVIDIDQSPIGRTPRSNPATYTGVFTPIRELFAATSE HHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH ARARGYIAGRFSFNVRGGRCEACQGDGVIKVEMHFLADVYVACDVCQGKRYNRETLAVQY HHHCCEEEEEEEEEECCCEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEE KGKNIYEVLEMTVEEALEFYDAVPSIKTKLEALMNVGLSYIKLGQSATTLSGGEAQRVKL CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHH AKELSKRSTSKTLYILDEPTTGLHFYDIHQLLKVIMDLRDKGNTVVIIEHNLDVIKMADW HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH LVDLGPEGGSKGGQIIFEGTPEDIINCKKSYTGKYLKDLL HHCCCCCCCCCCCEEEECCCCHHHHHHHHHHCHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10984043 [H]