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The map label for this gene is folKP [H]

Identifier: 89256577

GI number: 89256577

Start: 1207611

End: 1208876

Strand: Direct

Name: folKP [H]

Synonym: FTL_1265

Alternate gene names: 89256577

Gene position: 1207611-1208876 (Clockwise)

Preceding gene: 89256576

Following gene: 89256578

Centisome position: 63.69

GC content: 29.7

Gene sequence:

>1266_bases
GTGCAATATATTATAGGAATTGGAACAAATAGTGGTTTTACTATCGAAAATATTCATCTTGCAATAACTGCACTAGAATC
GCAACAAAATATAAGAATCATCAGAAAAGCAAGCTTATACAGTAGTAAAGCTGTCCTTAAAGAAGACGCTCCTAAAGAAT
GGGATATTAGATTTTTAAATACAGCTGTAAAAATTAGCTCTTCACTAAAGCCTGATGAACTTTTAGTACTCTTAAAAGAC
ATAGAATTAAAAATAGGTAGAGACCTAAATGCTCCTGCATGGTCACCTCGAGTAATTGATTTAGATATTCTTGCTGCTGA
AGATCTAATTTTAGAAACAGACAAACTTACTATTCCTCATAAAGAACTAATTAATCGTAGTTTTGCGTTGGCTCCTTTAT
TAGAATTATCAAAGGGTTGGCATCACCCTAAATATGTTGAATGGGATCTTAATATAAGATTAAAAGAATTAGGTGAGATA
GTAAAACTTAAACAAACTCTTGCAAATACAATACGTATGGGTATAGTTAATCTGTCAAATCAATCTTTTTCAGATGGTAA
TTTTGACGATAATCAACGTAAATTAAACCTTGATGAGCTAATACAAAGTGGTGCTGAAATTATTGATATCGGAGCTGAAT
CGACTAAGCCTGATGCCAAGCCTATATCGATTGAAGAAGAATTTAACAAATTAAATGAATTCCTAGAATACTTTAAATCA
CAACTGGCAAATTTGATTTATAAACCATTAGTCAGTATTGACACACGCAAACTAGAGGTAATGCAAAAAATTCTCGCTAA
GCATCATGATATTATCTGGATGATAAATGATGTTGAATGTAATAATATTGAGCAAAAAGCACAGCTTATAGCTAAATATA
ATAAAAAGTATGTTATAATTCATAATTTGGGTATTACAGATAGAAATCAATATTTAGATAAAGAAAATGCTATAGATAAT
GTTTGTGATTATATTGAGCAAAAAAAACAAATTCTTCTAAAACATGGTATAGCACAACAAAATATTTATTTTGATATTGG
CTTTGGTTTTGGTAAAAAATCAGATACCGCTAGATACTTATTAGAGAATATCATCGAGATAAAAAGAAGATTAGAATTAA
AAGCATTAGTTGGTCACTCACGTAAGCCATCAGTTTTAGGATTAACAAAAGATAGTAATTTAGCAACTTTAGATCGAGCT
ACAAGAGAGCTTTCAAGAAAATTAGAGAAACTAGATATTGATATTATAAGAGTACACAAGATTTAA

Upstream 100 bases:

>100_bases
CAAAAAAACTATAGTGATATAACTATCAAATACTTGAAAATTAAAAAAAAGCCCCCAATTTCTCAAATAGAGTCAGCTTG
TTTTATAATTAGGAACTAGT

Downstream 100 bases:

>100_bases
TAAGGAAATATTATGCCATACAATCCATCATTAGAAGCATTATTAGACACTCCTGAAATAAGAAGAATTAAAAAGCTTGA
TTTAACACAGCAGCGTGAAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase

Products: NA

Alternate protein names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; Dihydropteroate synthase; DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD
IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI
VKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLNEFLEYFKS
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNLGITDRNQYLDKENAIDN
VCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIKRRLELKALVGHSRKPSVLGLTKDSNLATLDRA
TRELSRKLEKLDIDIIRVHKI

Sequences:

>Translated_421_residues
MQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD
IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI
VKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLNEFLEYFKS
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNLGITDRNQYLDKENAIDN
VCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIKRRLELKALVGHSRKPSVLGLTKDSNLATLDRA
TRELSRKLEKLDIDIIRVHKI
>Mature_421_residues
MQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD
IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI
VKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLNEFLEYFKS
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNLGITDRNQYLDKENAIDN
VCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIKRRLELKALVGHSRKPSVLGLTKDSNLATLDRA
TRELSRKLEKLDIDIIRVHKI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=134, Percent_Identity=35.8208955223881, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=29.4573643410853, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324073, Length=517, Percent_Identity=23.9845261121857, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000550
- InterPro:   IPR000489 [H]

Pfam domain/function: PF01288 HPPK; PF00809 Pterin_bind [H]

EC number: =2.7.6.3; =2.5.1.15 [H]

Molecular weight: Translated: 48248; Mature: 48248

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLN
CCEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEHH
TAVKISSSLKPDELLVLLKDIELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPH
HHHHHCCCCCHHHHEEEEEHHHHEECCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCH
KELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEIVKLKQTLANTIRMGIVNLSN
HHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHEEEECC
QSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLNEFLEYFKS
CCCCCCCCCCCCCEECHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVII
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEE
HNLGITDRNQYLDKENAIDNVCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYL
EECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
LENIIEIKRRLELKALVGHSRKPSVLGLTKDSNLATLDRATRELSRKLEKLDIDIIRVHK
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
I
C
>Mature Secondary Structure
MQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAVLKEDAPKEWDIRFLN
CCEEEEECCCCCEEEEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEHH
TAVKISSSLKPDELLVLLKDIELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPH
HHHHHCCCCCHHHHEEEEEHHHHEECCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCH
KELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEIVKLKQTLANTIRMGIVNLSN
HHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHEEEECC
QSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAKPISIEEEFNKLNEFLEYFKS
CCCCCCCCCCCCCEECHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVII
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEE
HNLGITDRNQYLDKENAIDNVCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKKSDTARYL
EECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
LENIIEIKRRLELKALVGHSRKPSVLGLTKDSNLATLDRATRELSRKLEKLDIDIIRVHK
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]