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The map label for this gene is ttcA1 [H]

Identifier: 89256381

GI number: 89256381

Start: 999459

End: 1000262

Strand: Reverse

Name: ttcA1 [H]

Synonym: FTL_1043

Alternate gene names: 89256381

Gene position: 1000262-999459 (Counterclockwise)

Preceding gene: 89256382

Following gene: 89256380

Centisome position: 52.76

GC content: 31.22

Gene sequence:

>804_bases
ATGACTAATAATACTGATAAACAAACTTTAAAGAAACTTGAAAGACAGATTTTAAGAAAAACTACTCAAGTAATCAATCA
ATATAATATGATTGAAGATGGCGATAAAATTATGGTATGCCTATCTGGAGGCAAAGATTCTTATTGTTTACTTGAGATGT
TGTTATTACTCCAAAAAAAAGCTCCAATAAGCTTTGAAATCATCGCAGTAAATCTCGATCAGAAACAACCAGGCTTTCCT
GAAGAAGTATTACCTAACTATCTTAAAAATAAAGGGGTAGAATTCCATATCATTGAACGTGATACTTATAGCATAGTAAA
ACGTGTAATTCCTGAAGGGAAAACTACCTGTGGTTTATGCTCCCGTATGCGTCGTGGTATCTTATATGATTTTGCTGAAG
AAAATAATGTAACTAAGGTAGCATTAGGCCATCATCGAGATGACATCATTGAAACATTCTTCTTGAATCTTTTTTATAAT
GGCTCAATCAAAGCTATGCCAACTAAACTACTTAGTGATGATAAACGCAATATCGTAATCCGCCCTCTCGCTTTTGTAAG
CGAAAAAGAAACTTTAGAATACTCTCAATTAAAAGAGTTTCCTATAATTCCTTGTAACCTATGTGGTTCACAAGATAATT
TGCAAAGAGTGTTTATAAAAGATATGCTTAATAGATGGGAACAAAATAATCCTGAAAGAAAAAATGTAATATTCAAAGCT
CTATCAAATATTTCTCCATCACAGATGTTAGATAAAGAGCTTTTTGATTTTATAAATATCTCAAAAGATGATATACAAAG
ATAG

Upstream 100 bases:

>100_bases
GTTATCACTAGAGCAAAAGCCAAATTGGCCTGTTATAATGCTAAAACAGGTAGATTACAAAAAATTCCACCACAATTAAA
ACAATTGATCTTAGAAGAAA

Downstream 100 bases:

>100_bases
TTAAGGAGAAAAAATGAAGTTAAAGAAAATAGTAGCAGTTATATCATGCTCATTATTAGGACTAGCTATGAGTTCATGTT
CAACAAATACAGATTCCGTA

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFP
EEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYN
GSIKAMPTKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
LSNISPSQMLDKELFDFINISKDDIQR

Sequences:

>Translated_267_residues
MTNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFP
EEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYN
GSIKAMPTKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
LSNISPSQMLDKELFDFINISKDDIQR
>Mature_266_residues
TNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPE
EVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLCSRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNG
SIKAMPTKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKAL
SNISPSQMLDKELFDFINISKDDIQR

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=256, Percent_Identity=58.59375, Blast_Score=327, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI193211090, Length=232, Percent_Identity=32.7586206896552, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24651972, Length=213, Percent_Identity=23.943661971831, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 30985; Mature: 30854

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCC
APISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLC
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHH
SRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPTKLLSDDKRNIVI
HHHHHCCEEEHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEE
RPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
EEHHHHCCHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSNISPSQMLDKELFDFINISKDDIQR
HHCCCHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TNNTDKQTLKKLERQILRKTTQVINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCC
APISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIERDTYSIVKRVIPEGKTTCGLC
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHH
SRMRRGILYDFAEENNVTKVALGHHRDDIIETFFLNLFYNGSIKAMPTKLLSDDKRNIVI
HHHHHCCEEEHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEE
RPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKA
EEHHHHCCHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSNISPSQMLDKELFDFINISKDDIQR
HHCCCHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA