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The map label for this gene is hemF [H]

Identifier: 89256361

GI number: 89256361

Start: 980597

End: 981523

Strand: Reverse

Name: hemF [H]

Synonym: FTL_1022

Alternate gene names: 89256361

Gene position: 981523-980597 (Counterclockwise)

Preceding gene: 89256380

Following gene: 89256360

Centisome position: 51.77

GC content: 33.98

Gene sequence:

>927_bases
ATGCAAGAAAAAATTTCAAAATTTGAAGATTTTCTAACACAACTTCAACAAAATATTACCACAGCTCTAGAGCAGCATGA
AACAAATGCTGCAAAATTTATTTCTGACAAATGGCAAAAACCAGATACTCCCGATCAAAAACTTAAAGGCTATGGTAACT
CTATGATTATAGAAGGTGGCGAAATATTTGAAAAAGGTGTAGTAGCTTTTTCTAGAGTCCACGGTAGTGAGCTACCACCA
TCTGCTACAGCAAAAAGACAAGAATTAGCTGGTAAATCTTTTATAGCTACAGGGCTTTCATTAGTTATCCACCCCCGCAA
TCCTTTTGTGCCAACATCTCATGCTAATTTTAGAATTTTTATTGCTGGTGCTGATACTGATAATCCAATATGGTGGTTTG
GTGGAGGTTTTGATCTAACACCATACTATCCTTTTGAGGAGGATGCGATTCACTGGCATCAAACAGCAAAAAATATTTGT
GACAAGCATGATAAAACCTATTATCCAAAATTCAAAAAATGGTGTGATGAGTATTTTTATCTCAAACATCGTGATGAGTA
TCGTGGGGTTGGTGGTTTATTTTTTGATGATTTAAATGATAAATCTTTTGATGAATGCTTTAATTTTGTAACTGACTGTG
CAAATTCTTATTTAGATGCTTATATTCCAATAGTAGCACAAAGAAAAAATATTGAATATTCACAAAAGCATAAAGATTTT
CAACTTTATCGTCGTGGTAGATATGTTGAATTTAACTTAGTGTTTGATAGAGGTACGATATTTGGCTTACAAAGTGGTGG
ACGAACTGAGTCAATACTCTCATCAATGCCACCAATGGCAACTTGGAAATATAATTGGCAACCTGAACCAGGTTCTGAAG
AAGAAAAAGTTTACCAATATATAAAACCTCGCGATTGGATTAAATAA

Upstream 100 bases:

>100_bases
TTTTACAAGCAATTTTATTTCCCTACTGCTAAAATATCATTTATTAATTTCAGCTTCTATTTGTTTAAAATAGAATTTAA
AATCGAAGGTTTAGTATCAC

Downstream 100 bases:

>100_bases
TAGGTATTACAACAAAAATCAATTATGAGAAAAATATTCACTATCGGCATTTTAACCCTCATAGCTATAACACCAATCTT
TGCCAAAGATTCATATAATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPP
SATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNIC
DKHDKTYYPKFKKWCDEYFYLKHRDEYRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPEPGSEEEKVYQYIKPRDWIK

Sequences:

>Translated_308_residues
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPP
SATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNIC
DKHDKTYYPKFKKWCDEYFYLKHRDEYRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPEPGSEEEKVYQYIKPRDWIK
>Mature_308_residues
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPP
SATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNIC
DKHDKTYYPKFKKWCDEYFYLKHRDEYRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPEPGSEEEKVYQYIKPRDWIK

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=314, Percent_Identity=43.312101910828, Blast_Score=261, Evalue=8e-70,
Organism=Escherichia coli, GI1788777, Length=307, Percent_Identity=55.3745928338762, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320249, Length=321, Percent_Identity=44.2367601246106, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI17864388, Length=310, Percent_Identity=47.0967741935484, Blast_Score=295, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35877; Mature: 35877

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECH
EIFEKGVVAFSRVHGSELPPSATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCEEEE
IAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNICDKHDKTYYPKFKKWCDEYFY
EEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LKHRDEYRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
HHCCHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPEPGSEEEKVYQY
HHHHCCCEEEEEEEEECCEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
IKPRDWIK
HCCCCCCC
>Mature Secondary Structure
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECH
EIFEKGVVAFSRVHGSELPPSATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCEEEE
IAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNICDKHDKTYYPKFKKWCDEYFY
EEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LKHRDEYRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
HHCCHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPEPGSEEEKVYQY
HHHHCCCEEEEEEEEECCEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
IKPRDWIK
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA