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The map label for this gene is kefB [H]

Identifier: 89256294

GI number: 89256294

Start: 912557

End: 913732

Strand: Direct

Name: kefB [H]

Synonym: FTL_0943

Alternate gene names: 89256294

Gene position: 912557-913732 (Clockwise)

Preceding gene: 89256293

Following gene: 89256296

Centisome position: 48.13

GC content: 32.4

Gene sequence:

>1176_bases
ATGCACAACGAGTCTTTGATTTCCATTTTCGTTTTTGTAATGCTGGGCATTCTAGTAGTTACAATAGTCCTAAAAAAACT
AAAACAACCATATGTTGTAGCATATTTATTGACAGGAATATTATTAGGACCGTATGGATTAAGATTGATTCAAGATCAAG
AGAATCTTGCAAGGTTAGGTGAAATAGGGGTTATCCTATTATTATTTTTTGCAGGGATGGAAGTCTCACCACGTAAATTT
GCTGAAAACTGGCAAGTTCCGACTATTGGTACAATGCTGCAAATGCTAATAACAAGTCTAATAGTTTCTATAATTGGAGT
AGCATTAGGATGGAGTATTGCAAAGATATTACTTTTTGGAGCGGTTATTAGCTTAAGTAGTACAGCTGTTGTGCTTAAAT
TATTAAATGATAGTGGCAGTATGAAGACTCGTCTAGGGCAAAATGTTTTAGGAATTCTTTTAATCCAAGATTTAGCAGTA
GTGCCTATGCTTATTCTTGTAAGATTAATCGGAGGCGAGGAGCTATCAATAAGTCAAATAGTAACTCAAATTTTAGGTGG
TATTCTTGTAATATCTATAGCAGCCATTATGGCGGTTAAAAAGAATATCAAAATATCTTTTATTTCTGTGTTGGGAAAGG
ACGAGGAAATGAGAGTTTTTGCAGCTCTAGTAATTTGTTTTGGGATGGCAGCACTTACAGAATCATTAGAATTATCATCT
GCTCTGGGTGCATTTGTAGGGGGGATAATCGTTTCTACACTTGAAGAAACAGAGTGGGTTGGACATAGTCTCTCAACTGT
TAAGACTATTTTTATGGCATTATTTTTTATATCTGTAGGAATGTTGATAGATTTAAAATTATTTTGGAATCATATATTTT
TATTTATGGCATTATTGCTATTGATATATTCACTGAATACAACTATCAATGCTTTAATATTTAAAGCACTTAGACAGAGA
ACAGAAGAAGCATTGATAGGTGGAGCGATGTTATCACAAATAGGAGAGTTTAGCTTTGTATTGATTTCTATGGGTTTTGC
ATCAGGAATTTTAAGTTTAACAATATATCATTATTGTATTACGTTGATATCTTTATCGTTATTGTTTAGTCCATTATGGA
TTAGTGGTGTTAATCTCTATATTAAAAAGTATATTAAGAAAAAGCCTCAGAATTAA

Upstream 100 bases:

>100_bases
TAATTTATACAATAAATAATTTAGAGAGAATTAATAATCTTAGTATAATTTGTTTAATATATGCAGTATTATTACTGTAG
TTATTTTATGATGTAAAGAT

Downstream 100 bases:

>100_bases
TTATGTTAATAAGTTCTCGTGTATAGGCTTGTTCAATCTCTTTTCTATGCTCAACATAACAGTAGAAATTAGCTTGGATG
TTTATAACATTTTCTTTATC

Product: Sodium/hydrogen exchanger family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHNESLISIFVFVMLGILVVTIVLKKLKQPYVVAYLLTGILLGPYGLRLIQDQENLARLGEIGVILLLFFAGMEVSPRKF
AENWQVPTIGTMLQMLITSLIVSIIGVALGWSIAKILLFGAVISLSSTAVVLKLLNDSGSMKTRLGQNVLGILLIQDLAV
VPMLILVRLIGGEELSISQIVTQILGGILVISIAAIMAVKKNIKISFISVLGKDEEMRVFAALVICFGMAALTESLELSS
ALGAFVGGIIVSTLEETEWVGHSLSTVKTIFMALFFISVGMLIDLKLFWNHIFLFMALLLLIYSLNTTINALIFKALRQR
TEEALIGGAMLSQIGEFSFVLISMGFASGILSLTIYHYCITLISLSLLFSPLWISGVNLYIKKYIKKKPQN

Sequences:

>Translated_391_residues
MHNESLISIFVFVMLGILVVTIVLKKLKQPYVVAYLLTGILLGPYGLRLIQDQENLARLGEIGVILLLFFAGMEVSPRKF
AENWQVPTIGTMLQMLITSLIVSIIGVALGWSIAKILLFGAVISLSSTAVVLKLLNDSGSMKTRLGQNVLGILLIQDLAV
VPMLILVRLIGGEELSISQIVTQILGGILVISIAAIMAVKKNIKISFISVLGKDEEMRVFAALVICFGMAALTESLELSS
ALGAFVGGIIVSTLEETEWVGHSLSTVKTIFMALFFISVGMLIDLKLFWNHIFLFMALLLLIYSLNTTINALIFKALRQR
TEEALIGGAMLSQIGEFSFVLISMGFASGILSLTIYHYCITLISLSLLFSPLWISGVNLYIKKYIKKKPQN
>Mature_391_residues
MHNESLISIFVFVMLGILVVTIVLKKLKQPYVVAYLLTGILLGPYGLRLIQDQENLARLGEIGVILLLFFAGMEVSPRKF
AENWQVPTIGTMLQMLITSLIVSIIGVALGWSIAKILLFGAVISLSSTAVVLKLLNDSGSMKTRLGQNVLGILLIQDLAV
VPMLILVRLIGGEELSISQIVTQILGGILVISIAAIMAVKKNIKISFISVLGKDEEMRVFAALVICFGMAALTESLELSS
ALGAFVGGIIVSTLEETEWVGHSLSTVKTIFMALFFISVGMLIDLKLFWNHIFLFMALLLLIYSLNTTINALIFKALRQR
TEEALIGGAMLSQIGEFSFVLISMGFASGILSLTIYHYCITLISLSLLFSPLWISGVNLYIKKYIKKKPQN

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=381, Percent_Identity=26.246719160105, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786232, Length=384, Percent_Identity=26.8229166666667, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789749, Length=362, Percent_Identity=27.9005524861878, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786685, Length=391, Percent_Identity=27.1099744245524, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 42761; Mature: 42761

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNESLISIFVFVMLGILVVTIVLKKLKQPYVVAYLLTGILLGPYGLRLIQDQENLARLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EIGVILLLFFAGMEVSPRKFAENWQVPTIGTMLQMLITSLIVSIIGVALGWSIAKILLFG
HHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVISLSSTAVVLKLLNDSGSMKTRLGQNVLGILLIQDLAVVPMLILVRLIGGEELSISQI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VTQILGGILVISIAAIMAVKKNIKISFISVLGKDEEMRVFAALVICFGMAALTESLELSS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAFVGGIIVSTLEETEWVGHSLSTVKTIFMALFFISVGMLIDLKLFWNHIFLFMALLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIYSLNTTINALIFKALRQRTEEALIGGAMLSQIGEFSFVLISMGFASGILSLTIYHYCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLISLSLLFSPLWISGVNLYIKKYIKKKPQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHNESLISIFVFVMLGILVVTIVLKKLKQPYVVAYLLTGILLGPYGLRLIQDQENLARLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EIGVILLLFFAGMEVSPRKFAENWQVPTIGTMLQMLITSLIVSIIGVALGWSIAKILLFG
HHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVISLSSTAVVLKLLNDSGSMKTRLGQNVLGILLIQDLAVVPMLILVRLIGGEELSISQI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VTQILGGILVISIAAIMAVKKNIKISFISVLGKDEEMRVFAALVICFGMAALTESLELSS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAFVGGIIVSTLEETEWVGHSLSTVKTIFMALFFISVGMLIDLKLFWNHIFLFMALLL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIYSLNTTINALIFKALRQRTEEALIGGAMLSQIGEFSFVLISMGFASGILSLTIYHYCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLISLSLLFSPLWISGVNLYIKKYIKKKPQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA