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The map label for this gene is lon [H]

Identifier: 89256251

GI number: 89256251

Start: 871672

End: 873996

Strand: Direct

Name: lon [H]

Synonym: FTL_0894

Alternate gene names: 89256251

Gene position: 871672-873996 (Clockwise)

Preceding gene: 89256250

Following gene: 89256252

Centisome position: 45.97

GC content: 34.71

Gene sequence:

>2325_bases
ATGTCAGAACCCCTAAATGTCGTTCCTGTTATTCCTTTAAGAGATGTTGTTATTTATCCATCGATGACTCTACCACTTAA
TGTTGGGCGTAAAAAGTCAATAGAGGCAGTTAAACAGGCATCAAATAATTATAATAACTATATTTTATTAGCTACACAAA
AAAATGGTTCGAGTGGCGGTGATGTTGTAGAAAATATATATGATATTGCAACTCTTGCTAAAGTTGTTCAGATAATGAAA
CTTCCTGATGGTAGTCTGAAAATAATAGTCGAGGGTATTGCTAAAAGACTAGTAGCTAAGTATGAAGATATTGATGGTTG
TATCTATGCAAATTTAGATAGTTTACATATTGATGATAACTATGATCCCAGCCAAGTTGATAAAGAACTAAAAGCTATTT
TACTATCAGTTTCTGATTCGCTTAAAAGATTTGTTGATATCAGTGGTAGAGTTTCGAAAGAATCATTAGCTACATTGATA
AATACGGAAGAGCCACATAAATTTATTTATGAAATAGCTACTATACTTAATACAGAAATAGCTAAAAAACAAAAAATCCT
TGAGGCAACGGATATAAAAAATAAAGCCTTGCTACTACTTTCATATCTTTATGAAGAGCTAGAGATACTAGAGCTAGAAG
CTAAGATCAAAGATAGAGTCAAAGCTCAAGTTGATAAGAATCAGCGTGAATACTATCTAAATGAGCAAGTCAAAGCGATA
TATAAAGAGCTTGGTGAAGCTGATGAAGAATCAGAAGTATCTGTTTTGAAAAAAAGGATTGAGCATACTAAGATGTCTAA
AGAGGCAAAAGAGAAATGCTTAAAAGAGCTCAAGAAACTTAAGGCTATGCCGCCTTCTTCATCAGAATCAGCTGTTTCGA
GAAACTATATTGAAACTATACTTTCTCTACCATGGGGTAAGAGGGCAAAAGTTAAAAGAGATATTAATCTTGCTGAGAAA
GTTTTAGAAAAAGATCATTACGGTATCAAAAAAGTTAAAGAAAGGATCCTTGAGCATTTAGCTGTTCAGATTAAAAGAGA
CAGTAATACTAAAGCACCAATTCTGTGCTTAGTAGGACCTCCAGGAGTAGGTAAAACATCTATAGGACAGTCGATTGCTA
GAGCAACAGGGCGTGAGTATGTGCGTATGGCTTTAGGTGGTGTACGTGATGAGTCTGAGATTAGGGGACATCGTCGTACA
TACATAGGTTCTATGCCTGGTCAAATTATCCAAAAGATAATTAAATCAAAGACAGAGAATCCACTTTTCTTATTAGACGA
GATTGATAAAATTTCTTCTGATTTCCGTGGTGATCCATCTGCCGCGCTCTTAGAAGTACTTGATCCAGAGCAAAATAGTA
CATTTAACGATCATTACCTTGAGATAGACTATGATTTATCAAAGGTAATGTTTGTTGCTACAGCAAATTCCTTAGATATA
GATCCAGCATTACGTGATAGATTAGAGATTATCAACTTATCAGGCTATACCGAAATAGAGAAGCAAGCTATCGCAAAACA
GTATTTAATACCTAAAGCATTAGAAAATAATGGTTTGACTAAGGATGAAATTAATTTCACACCAAAAGCTATCCTTGATA
TTATCAGATATTATACAAGAGAGGCTGGTGTAAGAAATCTTCAGCAAAAAATAGATGGTGTTTGCCGTAAAGCAGTTAAA
AATCTCTTAAAGGATTCAAATACTGGCAAAATTTCGATTACACAAAAAAATCTCGAAGATTATCTTGGTGTACATCAGTA
TGATTATGGTGTTAAAAATGCTAAAGCAAAAGTAGGTCAAGTAACAGGTTTAGCTTGGACATCAGTTGGTGGAGAGCTTT
TGACTATAGAAGCTCTAGCAATGCCAGGAAAAGGTAAAGTTAAATATACTGGTAGTCTTGGTGATGTAATGAAAGAATCT
ATAGATGCTGCTTTTAGTGTGGTACGCTCAATGTCAAAAGACTATAAGTTAGAAGATGATTTCTATGAGAAAAAAGATAT
ACATATTCATGTCCCTGAAGGAGCTACACCAAAAGATGGTCCAAGTGCTGGTATTGCGATGACAACGGCTTTAGTTTCTG
TATATACAAACAAACCAGTTAGAAATGATGTGGCAATGACAGGTGAGGTGACACTCCGTGGTGAAGTGCTAGCTATAGGC
GGTTTAAAAGAAAAGCTTTTGGCAGCATTAAGAGGTGGAATTAAGGAGGTTTTGATCCCAAAACAGAATGTTAAAAATTT
AGCCGATGTTGATAAAGAAATCCTGGAAAAACTCGAAATAACCCCTGTAAGTAGCATAAAAGAGGTTTTAGAGAGAGTTT
TTTGA

Upstream 100 bases:

>100_bases
AGTAATTCTAGAGCAGCAAGAACCAATCTTAGCGATAAAAACACAACAGCAAAAACAATTAAAAGATATAATCTAATAAT
TTACAGGAGGATGTAAGTTT

Downstream 100 bases:

>100_bases
TATTTAACTGTTGAAACACTGCATTTTTAGTGTTATAAAGTTAACTGACACTTGTCAATTGTATAAAAATAAAGGAGTTT
AAAAACATGAACAAGAGTGA

Product: DNA-binding, ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MSEPLNVVPVIPLRDVVIYPSMTLPLNVGRKKSIEAVKQASNNYNNYILLATQKNGSSGGDVVENIYDIATLAKVVQIMK
LPDGSLKIIVEGIAKRLVAKYEDIDGCIYANLDSLHIDDNYDPSQVDKELKAILLSVSDSLKRFVDISGRVSKESLATLI
NTEEPHKFIYEIATILNTEIAKKQKILEATDIKNKALLLLSYLYEELEILELEAKIKDRVKAQVDKNQREYYLNEQVKAI
YKELGEADEESEVSVLKKRIEHTKMSKEAKEKCLKELKKLKAMPPSSSESAVSRNYIETILSLPWGKRAKVKRDINLAEK
VLEKDHYGIKKVKERILEHLAVQIKRDSNTKAPILCLVGPPGVGKTSIGQSIARATGREYVRMALGGVRDESEIRGHRRT
YIGSMPGQIIQKIIKSKTENPLFLLDEIDKISSDFRGDPSAALLEVLDPEQNSTFNDHYLEIDYDLSKVMFVATANSLDI
DPALRDRLEIINLSGYTEIEKQAIAKQYLIPKALENNGLTKDEINFTPKAILDIIRYYTREAGVRNLQQKIDGVCRKAVK
NLLKDSNTGKISITQKNLEDYLGVHQYDYGVKNAKAKVGQVTGLAWTSVGGELLTIEALAMPGKGKVKYTGSLGDVMKES
IDAAFSVVRSMSKDYKLEDDFYEKKDIHIHVPEGATPKDGPSAGIAMTTALVSVYTNKPVRNDVAMTGEVTLRGEVLAIG
GLKEKLLAALRGGIKEVLIPKQNVKNLADVDKEILEKLEITPVSSIKEVLERVF

Sequences:

>Translated_774_residues
MSEPLNVVPVIPLRDVVIYPSMTLPLNVGRKKSIEAVKQASNNYNNYILLATQKNGSSGGDVVENIYDIATLAKVVQIMK
LPDGSLKIIVEGIAKRLVAKYEDIDGCIYANLDSLHIDDNYDPSQVDKELKAILLSVSDSLKRFVDISGRVSKESLATLI
NTEEPHKFIYEIATILNTEIAKKQKILEATDIKNKALLLLSYLYEELEILELEAKIKDRVKAQVDKNQREYYLNEQVKAI
YKELGEADEESEVSVLKKRIEHTKMSKEAKEKCLKELKKLKAMPPSSSESAVSRNYIETILSLPWGKRAKVKRDINLAEK
VLEKDHYGIKKVKERILEHLAVQIKRDSNTKAPILCLVGPPGVGKTSIGQSIARATGREYVRMALGGVRDESEIRGHRRT
YIGSMPGQIIQKIIKSKTENPLFLLDEIDKISSDFRGDPSAALLEVLDPEQNSTFNDHYLEIDYDLSKVMFVATANSLDI
DPALRDRLEIINLSGYTEIEKQAIAKQYLIPKALENNGLTKDEINFTPKAILDIIRYYTREAGVRNLQQKIDGVCRKAVK
NLLKDSNTGKISITQKNLEDYLGVHQYDYGVKNAKAKVGQVTGLAWTSVGGELLTIEALAMPGKGKVKYTGSLGDVMKES
IDAAFSVVRSMSKDYKLEDDFYEKKDIHIHVPEGATPKDGPSAGIAMTTALVSVYTNKPVRNDVAMTGEVTLRGEVLAIG
GLKEKLLAALRGGIKEVLIPKQNVKNLADVDKEILEKLEITPVSSIKEVLERVF
>Mature_773_residues
SEPLNVVPVIPLRDVVIYPSMTLPLNVGRKKSIEAVKQASNNYNNYILLATQKNGSSGGDVVENIYDIATLAKVVQIMKL
PDGSLKIIVEGIAKRLVAKYEDIDGCIYANLDSLHIDDNYDPSQVDKELKAILLSVSDSLKRFVDISGRVSKESLATLIN
TEEPHKFIYEIATILNTEIAKKQKILEATDIKNKALLLLSYLYEELEILELEAKIKDRVKAQVDKNQREYYLNEQVKAIY
KELGEADEESEVSVLKKRIEHTKMSKEAKEKCLKELKKLKAMPPSSSESAVSRNYIETILSLPWGKRAKVKRDINLAEKV
LEKDHYGIKKVKERILEHLAVQIKRDSNTKAPILCLVGPPGVGKTSIGQSIARATGREYVRMALGGVRDESEIRGHRRTY
IGSMPGQIIQKIIKSKTENPLFLLDEIDKISSDFRGDPSAALLEVLDPEQNSTFNDHYLEIDYDLSKVMFVATANSLDID
PALRDRLEIINLSGYTEIEKQAIAKQYLIPKALENNGLTKDEINFTPKAILDIIRYYTREAGVRNLQQKIDGVCRKAVKN
LLKDSNTGKISITQKNLEDYLGVHQYDYGVKNAKAKVGQVTGLAWTSVGGELLTIEALAMPGKGKVKYTGSLGDVMKESI
DAAFSVVRSMSKDYKLEDDFYEKKDIHIHVPEGATPKDGPSAGIAMTTALVSVYTNKPVRNDVAMTGEVTLRGEVLAIGG
LKEKLLAALRGGIKEVLIPKQNVKNLADVDKEILEKLEITPVSSIKEVLERVF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=654, Percent_Identity=42.8134556574924, Blast_Score=514, Evalue=1e-145,
Organism=Homo sapiens, GI21396489, Length=833, Percent_Identity=36.6146458583433, Blast_Score=503, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=54.3193717277487, Blast_Score=828, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=704, Percent_Identity=37.9261363636364, Blast_Score=473, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17556486, Length=786, Percent_Identity=35.2417302798982, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=727, Percent_Identity=40.4401650618982, Blast_Score=482, Evalue=1e-137,
Organism=Drosophila melanogaster, GI221513036, Length=666, Percent_Identity=43.5435435435435, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=666, Percent_Identity=43.5435435435435, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86224; Mature: 86093

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLNVVPVIPLRDVVIYPSMTLPLNVGRKKSIEAVKQASNNYNNYILLATQKNGSSGG
CCCCCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
DVVENIYDIATLAKVVQIMKLPDGSLKIIVEGIAKRLVAKYEDIDGCIYANLDSLHIDDN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCC
YDPSQVDKELKAILLSVSDSLKRFVDISGRVSKESLATLINTEEPHKFIYEIATILNTEI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AKKQKILEATDIKNKALLLLSYLYEELEILELEAKIKDRVKAQVDKNQREYYLNEQVKAI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
YKELGEADEESEVSVLKKRIEHTKMSKEAKEKCLKELKKLKAMPPSSSESAVSRNYIETI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LSLPWGKRAKVKRDINLAEKVLEKDHYGIKKVKERILEHLAVQIKRDSNTKAPILCLVGP
HHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
PGVGKTSIGQSIARATGREYVRMALGGVRDESEIRGHRRTYIGSMPGQIIQKIIKSKTEN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHCCCCC
PLFLLDEIDKISSDFRGDPSAALLEVLDPEQNSTFNDHYLEIDYDLSKVMFVATANSLDI
CEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCC
DPALRDRLEIINLSGYTEIEKQAIAKQYLIPKALENNGLTKDEINFTPKAILDIIRYYTR
CHHHHHHHHEEECCCCHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
EAGVRNLQQKIDGVCRKAVKNLLKDSNTGKISITQKNLEDYLGVHQYDYGVKNAKAKVGQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCHHHCCCCCHHHHHHHH
VTGLAWTSVGGELLTIEALAMPGKGKVKYTGSLGDVMKESIDAAFSVVRSMSKDYKLEDD
HCCEEECCCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FYEKKDIHIHVPEGATPKDGPSAGIAMTTALVSVYTNKPVRNDVAMTGEVTLRGEVLAIG
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECEEEEECCEEEEC
GLKEKLLAALRGGIKEVLIPKQNVKNLADVDKEILEKLEITPVSSIKEVLERVF
CHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SEPLNVVPVIPLRDVVIYPSMTLPLNVGRKKSIEAVKQASNNYNNYILLATQKNGSSGG
CCCCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
DVVENIYDIATLAKVVQIMKLPDGSLKIIVEGIAKRLVAKYEDIDGCIYANLDSLHIDDN
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCC
YDPSQVDKELKAILLSVSDSLKRFVDISGRVSKESLATLINTEEPHKFIYEIATILNTEI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AKKQKILEATDIKNKALLLLSYLYEELEILELEAKIKDRVKAQVDKNQREYYLNEQVKAI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
YKELGEADEESEVSVLKKRIEHTKMSKEAKEKCLKELKKLKAMPPSSSESAVSRNYIETI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LSLPWGKRAKVKRDINLAEKVLEKDHYGIKKVKERILEHLAVQIKRDSNTKAPILCLVGP
HHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
PGVGKTSIGQSIARATGREYVRMALGGVRDESEIRGHRRTYIGSMPGQIIQKIIKSKTEN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHCCCCC
PLFLLDEIDKISSDFRGDPSAALLEVLDPEQNSTFNDHYLEIDYDLSKVMFVATANSLDI
CEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCC
DPALRDRLEIINLSGYTEIEKQAIAKQYLIPKALENNGLTKDEINFTPKAILDIIRYYTR
CHHHHHHHHEEECCCCHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
EAGVRNLQQKIDGVCRKAVKNLLKDSNTGKISITQKNLEDYLGVHQYDYGVKNAKAKVGQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCHHHCCCCCHHHHHHHH
VTGLAWTSVGGELLTIEALAMPGKGKVKYTGSLGDVMKESIDAAFSVVRSMSKDYKLEDD
HCCEEECCCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FYEKKDIHIHVPEGATPKDGPSAGIAMTTALVSVYTNKPVRNDVAMTGEVTLRGEVLAIG
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECEEEEECCEEEEC
GLKEKLLAALRGGIKEVLIPKQNVKNLADVDKEILEKLEITPVSSIKEVLERVF
CHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA