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The map label for this gene is clpP [H]

Identifier: 89256249

GI number: 89256249

Start: 869765

End: 870370

Strand: Direct

Name: clpP [H]

Synonym: FTL_0892

Alternate gene names: 89256249

Gene position: 869765-870370 (Clockwise)

Preceding gene: 89256248

Following gene: 89256250

Centisome position: 45.87

GC content: 34.32

Gene sequence:

>606_bases
ATGATAACTAATAATCTAGTTCCTACCGTAATTGAAAAAACAGCTGGCGGTGAGAGAGCCTTTGATATTTATTCAAGACT
ACTTAAAGAGCGTATAGTTTTTTTGAATGGTGAGGTAAATGATCACTCAGCTAATCTTGTGATTGCGCAACTATTGTTTC
TAGAGTCAGAAGACCCAGATAAAGATATTTATTTTTATATAAATTCTCCTGGTGGGATGGTTACAGCTGGCATGGGTGTT
TATGATACTATGCAGTTTATCAAACCTGATGTAAGTACTATATGTATTGGTTTGGCTGCGAGTATGGGATCACTTTTGTT
AGCAGGTGGTGCTAAAGGTAAAAGATATAGTCTACCAAGCTCGCAAATTATGATTCATCAGCCTTTAGGTGGCTTTAGAG
GTCAAGCATCTGATATTGAAATTCATGCAAAAAATATTTTACGTATCAAAGATAGACTAAATAAAGTTTTAGCTCATCAT
ACAGGTCAGGATTTAGAAACTATTGTTAAAGATACTGATAGAGATAATTTTATGATGGCTGATGAAGCTAAAGCGTATGG
TCTGATTGATCATGTGATTGAATCTCGTGAAGCAATTATTAAATAA

Upstream 100 bases:

>100_bases
AAAGTAACAGAAAAAACTGAAGATTTCTTTGAGGTTATTAAAGAAAATATGCAAGCTCAACAGGCTGGCTTCTAAGCTGG
CTTTAAAAGAGAGGTTATAA

Downstream 100 bases:

>100_bases
TTAAAGGAAGTCAACTTACTAAAATGGCTAAAATTCTATATTGTTCTTTTTGTGGTAAATCACAACAAGAAGTCAAAAAT
ATTATCTCAGGAAGAGATGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPDKDIYFYINSPGGMVTAGMGV
YDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPSSQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHH
TGQDLETIVKDTDRDNFMMADEAKAYGLIDHVIESREAIIK

Sequences:

>Translated_201_residues
MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPDKDIYFYINSPGGMVTAGMGV
YDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPSSQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHH
TGQDLETIVKDTDRDNFMMADEAKAYGLIDHVIESREAIIK
>Mature_201_residues
MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPDKDIYFYINSPGGMVTAGMGV
YDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPSSQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHH
TGQDLETIVKDTDRDNFMMADEAKAYGLIDHVIESREAIIK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=56.3829787234042, Blast_Score=226, Evalue=1e-59,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=67.0157068062827, Blast_Score=291, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.3763440860215, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=56.3157894736842, Blast_Score=236, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22151; Mature: 22151

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPD
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCC
KDIYFYINSPGGMVTAGMGVYDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPS
CEEEEEEECCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCEECCCC
SQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHHTGQDLETIVKDTDRDNFMMA
CCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEC
DEAKAYGLIDHVIESREAIIK
CCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPD
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCC
KDIYFYINSPGGMVTAGMGVYDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPS
CEEEEEEECCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCEECCCC
SQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHHTGQDLETIVKDTDRDNFMMA
CCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEC
DEAKAYGLIDHVIESREAIIK
CCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA