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The map label for this gene is glmS [H]

Identifier: 89256224

GI number: 89256224

Start: 844209

End: 845237

Strand: Direct

Name: glmS [H]

Synonym: FTL_0864

Alternate gene names: 89256224

Gene position: 844209-845237 (Clockwise)

Preceding gene: 89256222

Following gene: 89256225

Centisome position: 44.53

GC content: 34.01

Gene sequence:

>1029_bases
ATGAAAACGCTTATGCACCAGGAGGCAAGTAGCAGTTTTGCTAAAGTCGCCAACCAGCTAAAATTAAACAAAGATATTAC
TAAATCAATAGTAAAAATCCTCAAAGAAAAAAATATTAAAAGAATTATTACTATAGCAAGGGGAAGTTCAGACTGTGTCG
CAAATTTTGCAAAATATTTATTTGAAACTCAGCTTGGTTTCAATGTTTCATCACTACCGCCATCTATAACAACGATATAT
GGTAAAAATATTGGTGATAAAGAAACACTGGCGATAGCTATCTCACAATCTGGTGGTAGTCCAGATTTACGCTTAGCTTT
AGAAGGTTGTAAGAAAGCAGGATGTACTACACTAGCAATAGTCAATGTAGAAAAATCTCCTTTAGCTGAAAGTGCGGATT
TGGTTTTACCAGTAAGAGCAGATGCAGAAAATGCTGTTGCAGCGACGAAAAGTGTAATAACTTCTTTAGTTGCGCTGGTA
AGCATTGTGGCTGAATACAATCAAGATCAAGCTTTATTGGATAGTTTAAATACTCTTCCAGAAACACTAGAAAAAAGCTT
AAACTCGGACTGGTCACCGGCAATAAAAGAACTTAAAAAAAGTAAAAACATGTTTGTTATAGGAAGAGGTTTTGGATTTC
CAATTGTTCAAGAGATGGCACTTAAATTTAAGGAAACTTGTGGAATACATGCTGAAGCATTTAGTTCTGCTGAAGTATTA
CATGGTCCATTTGCTCTTATGAATCAAACTTTTACAACATTTACTATTTTACAGCATGATGAAAGTGCTCAAGGTACTCG
TGATATTATTAAGAGAATGACTGATTTAGGAGTTAGAACTATATTTGCCACAACAGATAATCAATCTGATGCAAAAGTTC
ACTTACATGTTGATGTGAAAACTCATCCAATTCTTGAAACTGTAGTCATATTGCAAAAATTCTATCTAATGGTAAATGAA
TTAGCATTGTCATTAGGGTATAGCCCTGATAGCCCTAGTAATTTGAAAAAAGTTACAGAGACTGTTTAA

Upstream 100 bases:

>100_bases
ATTAATATGTCTATTCAAAAATTGATGTGATTTTTTATTGTAAAAACAAAAAAATCGCGCTTATAATGACTTAACCATAA
TTTTATATTCAATAGTAAAA

Downstream 100 bases:

>100_bases
TTTTTTTGAAATATAGATTTACTGATGGCTTTATTTTTAAAGGAGAAAAGAATGAAAGAGGCTAATAAGCTTAAAGTGTT
TATGATTATATTCTTCTCAG

Product: SIS domain-containing protein

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKTLMHQEASSSFAKVANQLKLNKDITKSIVKILKEKNIKRIITIARGSSDCVANFAKYLFETQLGFNVSSLPPSITTIY
GKNIGDKETLAIAISQSGGSPDLRLALEGCKKAGCTTLAIVNVEKSPLAESADLVLPVRADAENAVAATKSVITSLVALV
SIVAEYNQDQALLDSLNTLPETLEKSLNSDWSPAIKELKKSKNMFVIGRGFGFPIVQEMALKFKETCGIHAEAFSSAEVL
HGPFALMNQTFTTFTILQHDESAQGTRDIIKRMTDLGVRTIFATTDNQSDAKVHLHVDVKTHPILETVVILQKFYLMVNE
LALSLGYSPDSPSNLKKVTETV

Sequences:

>Translated_342_residues
MKTLMHQEASSSFAKVANQLKLNKDITKSIVKILKEKNIKRIITIARGSSDCVANFAKYLFETQLGFNVSSLPPSITTIY
GKNIGDKETLAIAISQSGGSPDLRLALEGCKKAGCTTLAIVNVEKSPLAESADLVLPVRADAENAVAATKSVITSLVALV
SIVAEYNQDQALLDSLNTLPETLEKSLNSDWSPAIKELKKSKNMFVIGRGFGFPIVQEMALKFKETCGIHAEAFSSAEVL
HGPFALMNQTFTTFTILQHDESAQGTRDIIKRMTDLGVRTIFATTDNQSDAKVHLHVDVKTHPILETVVILQKFYLMVNE
LALSLGYSPDSPSNLKKVTETV
>Mature_342_residues
MKTLMHQEASSSFAKVANQLKLNKDITKSIVKILKEKNIKRIITIARGSSDCVANFAKYLFETQLGFNVSSLPPSITTIY
GKNIGDKETLAIAISQSGGSPDLRLALEGCKKAGCTTLAIVNVEKSPLAESADLVLPVRADAENAVAATKSVITSLVALV
SIVAEYNQDQALLDSLNTLPETLEKSLNSDWSPAIKELKKSKNMFVIGRGFGFPIVQEMALKFKETCGIHAEAFSSAEVL
HGPFALMNQTFTTFTILQHDESAQGTRDIIKRMTDLGVRTIFATTDNQSDAKVHLHVDVKTHPILETVVILQKFYLMVNE
LALSLGYSPDSPSNLKKVTETV

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=324, Percent_Identity=25.9259259259259, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI205277386, Length=264, Percent_Identity=23.8636363636364, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790167, Length=321, Percent_Identity=28.6604361370716, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17532899, Length=240, Percent_Identity=27.9166666666667, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17532897, Length=240, Percent_Identity=27.9166666666667, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17539970, Length=324, Percent_Identity=26.2345679012346, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322745, Length=376, Percent_Identity=26.063829787234, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357745, Length=320, Percent_Identity=25.9375, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 37243; Mature: 37243

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLMHQEASSSFAKVANQLKLNKDITKSIVKILKEKNIKRIITIARGSSDCVANFAKYL
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHH
FETQLGFNVSSLPPSITTIYGKNIGDKETLAIAISQSGGSPDLRLALEGCKKAGCTTLAI
HHHHCCCCHHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEE
VNVEKSPLAESADLVLPVRADAENAVAATKSVITSLVALVSIVAEYNQDQALLDSLNTLP
EECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ETLEKSLNSDWSPAIKELKKSKNMFVIGRGFGFPIVQEMALKFKETCGIHAEAFSSAEVL
HHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCHHHH
HGPFALMNQTFTTFTILQHDESAQGTRDIIKRMTDLGVRTIFATTDNQSDAKVHLHVDVK
HCCHHHHHCCHHEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECC
THPILETVVILQKFYLMVNELALSLGYSPDSPSNLKKVTETV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKTLMHQEASSSFAKVANQLKLNKDITKSIVKILKEKNIKRIITIARGSSDCVANFAKYL
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHH
FETQLGFNVSSLPPSITTIYGKNIGDKETLAIAISQSGGSPDLRLALEGCKKAGCTTLAI
HHHHCCCCHHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEE
VNVEKSPLAESADLVLPVRADAENAVAATKSVITSLVALVSIVAEYNQDQALLDSLNTLP
EECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ETLEKSLNSDWSPAIKELKKSKNMFVIGRGFGFPIVQEMALKFKETCGIHAEAFSSAEVL
HHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCHHHH
HGPFALMNQTFTTFTILQHDESAQGTRDIIKRMTDLGVRTIFATTDNQSDAKVHLHVDVK
HCCHHHHHCCHHEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECC
THPILETVVILQKFYLMVNELALSLGYSPDSPSNLKKVTETV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]