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The map label for this gene is adk [H]

Identifier: 89256165

GI number: 89256165

Start: 780918

End: 781574

Strand: Reverse

Name: adk [H]

Synonym: FTL_0795

Alternate gene names: 89256165

Gene position: 781574-780918 (Counterclockwise)

Preceding gene: 89256173

Following gene: 89256158

Centisome position: 41.22

GC content: 33.64

Gene sequence:

>657_bases
ATGCGTATAATACTTTTAGGAGCACCTGGAGCCGGTAAAGGAACTCAAGCAAAGATAATTGAACAAAAATATAATATCGC
TCATATTTCTACTGGAGATATGATAAGAGAAACTATAAAATCAGGTTCGGTACTTGGTCAAGAATTAAAAAAAGTTCTTG
ATGCTGGAGAGTTAGTTTCAGATGAGTTTATTATCAAAATTGTCAAAGATAGAATTTCAAAAAATGATTGTAACAATGGC
TTTTTATTAGATGGTGTCCCTAGAACTATTCCACAAGCACAAGAATTAGACAAGTTAGGTGTAAATATTGACTATATAGT
TGAGGTAGATGTGGCTGATAACCTTCTTATAGAGAGAATTACAGGTAGGAGAATACATCCAGCATCTGGTAGAACTTATC
ACACTAAATTTAACCCACCTAAAGTAGCCGACAAAGATGATGTAACCGGTGAACCACTAATAACTCGTACAGATGACAAT
GAAGACACAGTTAAACAAAGACTATCTGTATACCATGCTCAAACCGCCAAGTTAATCGATTTTTACAGAAATTTCTCATC
AACGAACACTAAAATACCAAAATATATTAAGATAAACGGCGATCAAGCTGTTGAGAAAGTGTCTCAGGATATTTTTGATC
AGCTTAATAAAAGATAA

Upstream 100 bases:

>100_bases
AAAATTAGGTACTCTATTTCTAGATATATAAGCTTGTTTATTTTATAATTAAATCCACATTAAGTAAACTGTAGTTTTAA
AACGTTAAGGTTAATTAACA

Downstream 100 bases:

>100_bases
TTCTTAAAAAAACAATCCTCTTTATGAGTAATTACTACTTAGCTTAAATATTAAAGAGTTGGTAAGGATTTGGAAATAAA
TATTTTAGAAGTAATTATCA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSVLGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNG
FLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDN
EDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR

Sequences:

>Translated_218_residues
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSVLGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNG
FLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDN
EDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
>Mature_218_residues
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSVLGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNG
FLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDN
EDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=187, Percent_Identity=52.9411764705882, Blast_Score=218, Evalue=3e-57,
Organism=Homo sapiens, GI4502013, Length=187, Percent_Identity=52.9411764705882, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=39.9014778325123, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI310110345, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI53832003, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI8051579, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI53832001, Length=203, Percent_Identity=37.4384236453202, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI22749187, Length=222, Percent_Identity=28.8288288288288, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=29.3023255813954, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI28144897, Length=215, Percent_Identity=26.046511627907, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI28144899, Length=215, Percent_Identity=26.046511627907, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=58.0188679245283, Blast_Score=261, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=51.063829787234, Blast_Score=213, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=34.5945945945946, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=29.9539170506912, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=24.4131455399061, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=222, Percent_Identity=48.1981981981982, Blast_Score=225, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=40.5405405405405, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=28.2407407407407, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=55.1912568306011, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=40.1098901098901, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=40.1098901098901, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=29.3838862559242, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=29.3838862559242, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24390; Mature: 24390

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSVLGQELKKVLDAGELVS
CEEEEEECCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DEFIIKIVKDRISKNDCNNGFLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERI
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHCCCEEEEEEECCCCHHHHHHH
TGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDNEDTVKQRLSVYHAQTAKLID
CCCEECCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
FYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
HHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSVLGQELKKVLDAGELVS
CEEEEEECCCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DEFIIKIVKDRISKNDCNNGFLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERI
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHCCCEEEEEEECCCCHHHHHHH
TGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDNEDTVKQRLSVYHAQTAKLID
CCCEECCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
FYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
HHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA