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The map label for this gene is lpxB

Identifier: 89255947

GI number: 89255947

Start: 523006

End: 524148

Strand: Direct

Name: lpxB

Synonym: FTL_0540

Alternate gene names: 89255947

Gene position: 523006-524148 (Clockwise)

Preceding gene: 89255946

Following gene: 89255948

Centisome position: 27.58

GC content: 31.58

Gene sequence:

>1143_bases
ATGAGAATAGGTATTGTAGCTGGAGAGCTTTCGGGCGATCAGTTAGGTGGCACACTAGTTGAGGCTTTAAAGCAAAAATA
CCCTAATGCAATTATTGAAGGTATTGGTGGACCAAAAATGGCAGCCGCTGGTTTTAAAAGCCTTTATCCGATGGATGCAT
TGTCGTTAATCGGCTTCTTAGAAATTATTTCAAAAGGTTTGCGCATATTAAGTATCCGCCGTAAAATCATCAACTATTTT
AAGCAAAATAAACCTGATATATTTATAGGCATAGATGCTCCTGATTTTAATCTTACAGTTGAAAAAGAATTAAGATCTGC
GGGTATCAAAACTATACATTATGTAAGTCCTAAAATATGGGTTTGGCGTGAATACCGTATAAAAAAAATACGTAAAGCAA
CTGATAAAATATTAGCAATTTTACCTTTTGAAACTGAATACTATAAAAATAGACATAAATTTGAAGCTATATATGTTGGT
CATCCATTAGCGAAGAATATTCCAATACATATTGACCGAGCTAAATATAGAGATAAACTTGGATTAAAAGGTAGTTCTTT
ACCAATATTATCAGTTTTACCAGGAAGTCGTACGACAGAAGTTTCAAGATTGTTGCCACTATTTTTGTTAGCATTACAAA
AATTGGTAGATGCTGGATATAAATTTAAAGCGATTATGCCCTTAGCTAAGCCATCATTAAAACCATTATTTGCTAAATAT
AAAGAACAAATTGATAGTTTAGGTATCGAAGTTTTTGAAACGAATTCACATGATGTTTTAAAAGCATCTGATTTAAGTTT
ATTGGCATCAGGAACAGCTACATTGGAGGCTATGTTATGCAAATTACCTATGGTTGTAGGCTATAAACTATCATGGCTAT
CGGCTTTAATTGGTAGGATGCTTATTGGTAATCATAGTTATTGGGCTTTCCCTAATATTTTGCATAAAAATGAAATTATC
AAAGAATTAATACAAGAAGACTGTACAGTAGATAATTTATTTAGCGAGTTAAAAAGGTTGTTTGATGATAAGCGGCGTAA
TGATTATATAGTAGAAGAATTTGAAAAAATTCACAAAGAAATGGTTATTGATACTGAGAGTAAGATCATTCAAGTATTAG
ATACTATGATAGAAAAATCTTAA

Upstream 100 bases:

>100_bases
AAGAAGCTTTTGAGATAATCAAAGCGATGGCAAAAGAAGATAAAGTTATAGAGCCTTTTGTTGATGTGATTGGTACTTCG
CGAAGAGGTATACTAAGATA

Downstream 100 bases:

>100_bases
TTTTTATAATCTTTATATATATAATACATCAGTATAAAAAAGTATAGGTATTAGATAAATGACATTGATATTGGCATTAG
TTTTAGTTTTAGTGGTATTA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRIGIVAGELSGDQLGGTLVEALKQKYPNAIIEGIGGPKMAAAGFKSLYPMDALSLIGFLEIISKGLRILSIRRKIINYF
KQNKPDIFIGIDAPDFNLTVEKELRSAGIKTIHYVSPKIWVWREYRIKKIRKATDKILAILPFETEYYKNRHKFEAIYVG
HPLAKNIPIHIDRAKYRDKLGLKGSSLPILSVLPGSRTTEVSRLLPLFLLALQKLVDAGYKFKAIMPLAKPSLKPLFAKY
KEQIDSLGIEVFETNSHDVLKASDLSLLASGTATLEAMLCKLPMVVGYKLSWLSALIGRMLIGNHSYWAFPNILHKNEII
KELIQEDCTVDNLFSELKRLFDDKRRNDYIVEEFEKIHKEMVIDTESKIIQVLDTMIEKS

Sequences:

>Translated_380_residues
MRIGIVAGELSGDQLGGTLVEALKQKYPNAIIEGIGGPKMAAAGFKSLYPMDALSLIGFLEIISKGLRILSIRRKIINYF
KQNKPDIFIGIDAPDFNLTVEKELRSAGIKTIHYVSPKIWVWREYRIKKIRKATDKILAILPFETEYYKNRHKFEAIYVG
HPLAKNIPIHIDRAKYRDKLGLKGSSLPILSVLPGSRTTEVSRLLPLFLLALQKLVDAGYKFKAIMPLAKPSLKPLFAKY
KEQIDSLGIEVFETNSHDVLKASDLSLLASGTATLEAMLCKLPMVVGYKLSWLSALIGRMLIGNHSYWAFPNILHKNEII
KELIQEDCTVDNLFSELKRLFDDKRRNDYIVEEFEKIHKEMVIDTESKIIQVLDTMIEKS
>Mature_380_residues
MRIGIVAGELSGDQLGGTLVEALKQKYPNAIIEGIGGPKMAAAGFKSLYPMDALSLIGFLEIISKGLRILSIRRKIINYF
KQNKPDIFIGIDAPDFNLTVEKELRSAGIKTIHYVSPKIWVWREYRIKKIRKATDKILAILPFETEYYKNRHKFEAIYVG
HPLAKNIPIHIDRAKYRDKLGLKGSSLPILSVLPGSRTTEVSRLLPLFLLALQKLVDAGYKFKAIMPLAKPSLKPLFAKY
KEQIDSLGIEVFETNSHDVLKASDLSLLASGTATLEAMLCKLPMVVGYKLSWLSALIGRMLIGNHSYWAFPNILHKNEII
KELIQEDCTVDNLFSELKRLFDDKRRNDYIVEEFEKIHKEMVIDTESKIIQVLDTMIEKS

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=37.4331550802139, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_FRAT1 (Q14G55)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667622.1
- ProteinModelPortal:   Q14G55
- STRING:   Q14G55
- GeneID:   4199570
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF1568c
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q14G55
- ProtClustDB:   CLSK935090
- BioCyc:   FTUL393115:FTF1568C-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43088; Mature: 43088

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGIVAGELSGDQLGGTLVEALKQKYPNAIIEGIGGPKMAAAGFKSLYPMDALSLIGFL
CEEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHH
EIISKGLRILSIRRKIINYFKQNKPDIFIGIDAPDFNLTVEKELRSAGIKTIHYVSPKIW
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEHHHHHHCCCCEEEEECCCEE
VWREYRIKKIRKATDKILAILPFETEYYKNRHKFEAIYVGHPLAKNIPIHIDRAKYRDKL
EHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHC
GLKGSSLPILSVLPGSRTTEVSRLLPLFLLALQKLVDAGYKFKAIMPLAKPSLKPLFAKY
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
KEQIDSLGIEVFETNSHDVLKASDLSLLASGTATLEAMLCKLPMVVGYKLSWLSALIGRM
HHHHHHCCCEEEECCCCCEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGNHSYWAFPNILHKNEIIKELIQEDCTVDNLFSELKRLFDDKRRNDYIVEEFEKIHKE
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MVIDTESKIIQVLDTMIEKS
HHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIGIVAGELSGDQLGGTLVEALKQKYPNAIIEGIGGPKMAAAGFKSLYPMDALSLIGFL
CEEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHH
EIISKGLRILSIRRKIINYFKQNKPDIFIGIDAPDFNLTVEKELRSAGIKTIHYVSPKIW
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEHHHHHHCCCCEEEEECCCEE
VWREYRIKKIRKATDKILAILPFETEYYKNRHKFEAIYVGHPLAKNIPIHIDRAKYRDKL
EHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHC
GLKGSSLPILSVLPGSRTTEVSRLLPLFLLALQKLVDAGYKFKAIMPLAKPSLKPLFAKY
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
KEQIDSLGIEVFETNSHDVLKASDLSLLASGTATLEAMLCKLPMVVGYKLSWLSALIGRM
HHHHHHCCCEEEECCCCCEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGNHSYWAFPNILHKNEIIKELIQEDCTVDNLFSELKRLFDDKRRNDYIVEEFEKIHKE
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MVIDTESKIIQVLDTMIEKS
HHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA