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The map label for this gene is lpxA [H]

Identifier: 89255946

GI number: 89255946

Start: 522227

End: 523006

Strand: Direct

Name: lpxA [H]

Synonym: FTL_0539

Alternate gene names: 89255946

Gene position: 522227-523006 (Clockwise)

Preceding gene: 89255945

Following gene: 89255947

Centisome position: 27.54

GC content: 35.51

Gene sequence:

>780_bases
GTGATACATAGTTTGGCAGTAGTACATGAGAGCGCCAAAATAGCCGATAGTGCTATAATAGGGCCATTCTGTGTTATTGG
GAAGAATGTTGTTATTGGTGAAAATACTGAGTTAAAAAGCCATGTAACAATTGGTGATAATGCAGTTATAGGCAAAAATA
ATCGCATTTTCCAATATGCTTCAATTGGTGATGATCCAATTGATTATACATATAAAAAAGGTGACTTTTCTCAAGTTGTA
ATTGGGGATAATAATATTATCAGAGAGTGTGCTACTATTCATGGTGGAACTGCAAAAGAAATTGGGGTAACATCTGTTGG
TAATAACAACATTATTATGTGTTATGTACATATTGGGCATGATTGCAAAATGGGCAGTTACATAAACTTAGTAAATGGTG
TTGGTCTAGCTGGACATGTGCATATTGATGATTATGCAATATTAAGTTCTAATGTTGGTGTTCATCAATTTTGTAGAGTT
GGTAAACATGCTTTTATTGCTCATGCAGCACTAGTTGGTAAGGATGTACCCCCGTATTTAATGGTTACTGCTGTGAATGC
TGGCTCAACTCCTTGTGGTATAAATACAGAAGGTTTAAAGCGTCGTGGATTTACGCCTGAAGAGATGAAAAAAATCAAAG
AAGTCTACAAGGTGTTGTATCGCAAAGGTTTGATGATGAAAGAAGCTTTTGAGATAATCAAAGCGATGGCAAAAGAAGAT
AAAGTTATAGAGCCTTTTGTTGATGTGATTGGTACTTCGCGAAGAGGTATACTAAGATAA

Upstream 100 bases:

>100_bases
AACAAAAAAATATTATCTGTACAGCAGAGTCAGTCGCAAAGGTTGATGGACAAATTGTTTGTTCAGCTGAATTAATGGCA
GCATATAAGGACTACTAATC

Downstream 100 bases:

>100_bases
TGAGAATAGGTATTGTAGCTGGAGAGCTTTCGGGCGATCAGTTAGGTGGCACACTAGTTGAGGCTTTAAAGCAAAAATAC
CCTAATGCAATTATTGAAGG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MIHSLAVVHESAKIADSAIIGPFCVIGKNVVIGENTELKSHVTIGDNAVIGKNNRIFQYASIGDDPIDYTYKKGDFSQVV
IGDNNIIRECATIHGGTAKEIGVTSVGNNNIIMCYVHIGHDCKMGSYINLVNGVGLAGHVHIDDYAILSSNVGVHQFCRV
GKHAFIAHAALVGKDVPPYLMVTAVNAGSTPCGINTEGLKRRGFTPEEMKKIKEVYKVLYRKGLMMKEAFEIIKAMAKED
KVIEPFVDVIGTSRRGILR

Sequences:

>Translated_259_residues
MIHSLAVVHESAKIADSAIIGPFCVIGKNVVIGENTELKSHVTIGDNAVIGKNNRIFQYASIGDDPIDYTYKKGDFSQVV
IGDNNIIRECATIHGGTAKEIGVTSVGNNNIIMCYVHIGHDCKMGSYINLVNGVGLAGHVHIDDYAILSSNVGVHQFCRV
GKHAFIAHAALVGKDVPPYLMVTAVNAGSTPCGINTEGLKRRGFTPEEMKKIKEVYKVLYRKGLMMKEAFEIIKAMAKED
KVIEPFVDVIGTSRRGILR
>Mature_259_residues
MIHSLAVVHESAKIADSAIIGPFCVIGKNVVIGENTELKSHVTIGDNAVIGKNNRIFQYASIGDDPIDYTYKKGDFSQVV
IGDNNIIRECATIHGGTAKEIGVTSVGNNNIIMCYVHIGHDCKMGSYINLVNGVGLAGHVHIDDYAILSSNVGVHQFCRV
GKHAFIAHAALVGKDVPPYLMVTAVNAGSTPCGINTEGLKRRGFTPEEMKKIKEVYKVLYRKGLMMKEAFEIIKAMAKED
KVIEPFVDVIGTSRRGILR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=259, Percent_Identity=43.6293436293436, Blast_Score=220, Evalue=9e-59,
Organism=Escherichia coli, GI1786376, Length=149, Percent_Identity=31.5436241610738, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28125; Mature: 28125

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHSLAVVHESAKIADSAIIGPFCVIGKNVVIGENTELKSHVTIGDNAVIGKNNRIFQYA
CCCCEEEHHHHHHHHHHHHCCCHHHHCCEEEECCCCCCCEEEEECCCEEECCCCCEEEEE
SIGDDPIDYTYKKGDFSQVVIGDNNIIRECATIHGGTAKEIGVTSVGNNNIIMCYVHIGH
CCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEECC
DCKMGSYINLVNGVGLAGHVHIDDYAILSSNVGVHQFCRVGKHAFIAHAALVGKDVPPYL
CCCCCCCHHHHCCCCEEEEEEECCEEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCCEE
MVTAVNAGSTPCGINTEGLKRRGFTPEEMKKIKEVYKVLYRKGLMMKEAFEIIKAMAKED
EEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
KVIEPFVDVIGTSRRGILR
CHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIHSLAVVHESAKIADSAIIGPFCVIGKNVVIGENTELKSHVTIGDNAVIGKNNRIFQYA
CCCCEEEHHHHHHHHHHHHCCCHHHHCCEEEECCCCCCCEEEEECCCEEECCCCCEEEEE
SIGDDPIDYTYKKGDFSQVVIGDNNIIRECATIHGGTAKEIGVTSVGNNNIIMCYVHIGH
CCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEECC
DCKMGSYINLVNGVGLAGHVHIDDYAILSSNVGVHQFCRVGKHAFIAHAALVGKDVPPYL
CCCCCCCHHHHCCCCEEEEEEECCEEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCCEE
MVTAVNAGSTPCGINTEGLKRRGFTPEEMKKIKEVYKVLYRKGLMMKEAFEIIKAMAKED
EEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
KVIEPFVDVIGTSRRGILR
CHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA