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The map label for this gene is dxr [H]

Identifier: 89255941

GI number: 89255941

Start: 516506

End: 517663

Strand: Direct

Name: dxr [H]

Synonym: FTL_0534

Alternate gene names: 89255941

Gene position: 516506-517663 (Clockwise)

Preceding gene: 89255940

Following gene: 89255942

Centisome position: 27.24

GC content: 33.16

Gene sequence:

>1158_bases
ATGTTTAAAAAAACTAAGATTACTATATTAGGAGCTACAGGATCTATAGGTGATAGCACTTTAGCTGTTATTAGAGAGAC
TAATGATTTTGAAGTTTTTGCATTAACTGCATTTAGTAATGTTGAAAAGCTGGCAGAGCTATGTCAAGAGTTTAAGCCTA
AATTTGCTGTAGTTCCAGACTTGTCAAAAAAACAAAAGTTACAATCATTAGTTACTGATGTTGAGGTTTTGGTTGGTGAA
AGTGGGCTTGAAAAAGTATCTAGCTTAGCTGAAATTGATATTGTCATGTCTGCTATAGTTGGTATAGCAGGGTTAAAACC
AACCTTTGCAGCAGCTAAAGCTGGTAAGAAAATTTTGCTTGCTAATAAAGAATCTTTGGTAACAGCAGGACACTTGCTGA
TAGATGAGGTTGTAAAGAATAATGCTCAACTTATTCCTGTGGATAGTGAACATAATGCTATATTTCAGTGTATTGATAAT
CATGATAAGAAGTGTTTGCCAGAGATTGATAAGATAATTTTAACAGCATCTGGAGGTCCTTTTAGAGACAAACAACTACA
TGAGTTAACGGATGTAACACCCGAGCAAGCATGCAATCATCCTAATTGGCAAATGGGCAGAAAAATATCGGTTGATTCAT
CAACTATGGTAAATAAAGCGTTAGAAGTTATCGAAGCGTATTGGCTTTTTTCTGTTTCAGCTGATAAAATAGGCGTTCTG
ATTCATCCACAGAGTGTAACTCATTCTATTGTCAGATATGTTGATGGTAGCTATATAGCGCAGTTAGGTGTGCCTGATAT
GAAAACACCTATAGCCAACGCAATGTACTATCCAAAGAGAGGATCAGTTAACGTTGAGAGCTTAGATTTTACAAAATATC
AGCTAACCTTCAGAGAAGCTTGTTTTGAAAGATTTGAAGCTTTGAAAATAGTTTTTAATAATTTACAAAATAAAAATTAT
GCTGCTAACATAGTTTTTAATGCTGCTAATGAGGAGCTTGTGGCTGCATTTTTAAACAAAAAAATTAAATATTTAGAGAT
AATAGAAGTAAACAAAAAAGTAACAAAAGAGTTAAATTTTGAGAATCCAAAAAATATAGAAGAAGTTTTTGAAATAGATA
GAAAAACTCGTGAATATGTGGATTCTGTTTTGGGGTAA

Upstream 100 bases:

>100_bases
TAAAAGTAGTTAAGCAAGATGATGTTGAGGATAATCAAGATATAGAAAATAATGAAGATATAGAATCTTCTGATGTTACT
GTGCAGAGTGAATAATTGGC

Downstream 100 bases:

>100_bases
ATTGAGTGTTTTTTTTAAGAAAGAAGTTTGTGTTAGCCTCTCTTCTTGTGGGTATTGCATTTAATGGTTGGGCTGATAAT
GATAGCTTTATATTAGATAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MFKKTKITILGATGSIGDSTLAVIRETNDFEVFALTAFSNVEKLAELCQEFKPKFAVVPDLSKKQKLQSLVTDVEVLVGE
SGLEKVSSLAEIDIVMSAIVGIAGLKPTFAAAKAGKKILLANKESLVTAGHLLIDEVVKNNAQLIPVDSEHNAIFQCIDN
HDKKCLPEIDKIILTASGGPFRDKQLHELTDVTPEQACNHPNWQMGRKISVDSSTMVNKALEVIEAYWLFSVSADKIGVL
IHPQSVTHSIVRYVDGSYIAQLGVPDMKTPIANAMYYPKRGSVNVESLDFTKYQLTFREACFERFEALKIVFNNLQNKNY
AANIVFNAANEELVAAFLNKKIKYLEIIEVNKKVTKELNFENPKNIEEVFEIDRKTREYVDSVLG

Sequences:

>Translated_385_residues
MFKKTKITILGATGSIGDSTLAVIRETNDFEVFALTAFSNVEKLAELCQEFKPKFAVVPDLSKKQKLQSLVTDVEVLVGE
SGLEKVSSLAEIDIVMSAIVGIAGLKPTFAAAKAGKKILLANKESLVTAGHLLIDEVVKNNAQLIPVDSEHNAIFQCIDN
HDKKCLPEIDKIILTASGGPFRDKQLHELTDVTPEQACNHPNWQMGRKISVDSSTMVNKALEVIEAYWLFSVSADKIGVL
IHPQSVTHSIVRYVDGSYIAQLGVPDMKTPIANAMYYPKRGSVNVESLDFTKYQLTFREACFERFEALKIVFNNLQNKNY
AANIVFNAANEELVAAFLNKKIKYLEIIEVNKKVTKELNFENPKNIEEVFEIDRKTREYVDSVLG
>Mature_385_residues
MFKKTKITILGATGSIGDSTLAVIRETNDFEVFALTAFSNVEKLAELCQEFKPKFAVVPDLSKKQKLQSLVTDVEVLVGE
SGLEKVSSLAEIDIVMSAIVGIAGLKPTFAAAKAGKKILLANKESLVTAGHLLIDEVVKNNAQLIPVDSEHNAIFQCIDN
HDKKCLPEIDKIILTASGGPFRDKQLHELTDVTPEQACNHPNWQMGRKISVDSSTMVNKALEVIEAYWLFSVSADKIGVL
IHPQSVTHSIVRYVDGSYIAQLGVPDMKTPIANAMYYPKRGSVNVESLDFTKYQLTFREACFERFEALKIVFNNLQNKNY
AANIVFNAANEELVAAFLNKKIKYLEIIEVNKKVTKELNFENPKNIEEVFEIDRKTREYVDSVLG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=386, Percent_Identity=48.7046632124352, Blast_Score=351, Evalue=4e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42830; Mature: 42830

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKTKITILGATGSIGDSTLAVIRETNDFEVFALTAFSNVEKLAELCQEFKPKFAVVPD
CCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHCCCEEECCC
LSKKQKLQSLVTDVEVLVGESGLEKVSSLAEIDIVMSAIVGIAGLKPTFAAAKAGKKILL
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEE
ANKESLVTAGHLLIDEVVKNNAQLIPVDSEHNAIFQCIDNHDKKCLPEIDKIILTASGGP
ECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCHHHCHHCEEEEEECCCC
FRDKQLHELTDVTPEQACNHPNWQMGRKISVDSSTMVNKALEVIEAYWLFSVSADKIGVL
CCCHHHHHHHCCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHEEECCCCEEEE
IHPQSVTHSIVRYVDGSYIAQLGVPDMKTPIANAMYYPKRGSVNVESLDFTKYQLTFREA
ECCHHHHHHHHHHHCCCCEEECCCCCCCCCHHHCEECCCCCCCCEEEECCHHHHHHHHHH
CFERFEALKIVFNNLQNKNYAANIVFNAANEELVAAFLNKKIKYLEIIEVNKKVTKELNF
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEEEEEHHHHHHHHCCC
ENPKNIEEVFEIDRKTREYVDSVLG
CCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKKTKITILGATGSIGDSTLAVIRETNDFEVFALTAFSNVEKLAELCQEFKPKFAVVPD
CCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHCCCEEECCC
LSKKQKLQSLVTDVEVLVGESGLEKVSSLAEIDIVMSAIVGIAGLKPTFAAAKAGKKILL
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEE
ANKESLVTAGHLLIDEVVKNNAQLIPVDSEHNAIFQCIDNHDKKCLPEIDKIILTASGGP
ECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCHHHCHHCEEEEEECCCC
FRDKQLHELTDVTPEQACNHPNWQMGRKISVDSSTMVNKALEVIEAYWLFSVSADKIGVL
CCCHHHHHHHCCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHEEECCCCEEEE
IHPQSVTHSIVRYVDGSYIAQLGVPDMKTPIANAMYYPKRGSVNVESLDFTKYQLTFREA
ECCHHHHHHHHHHHCCCCEEECCCCCCCCCHHHCEECCCCCCCCEEEECCHHHHHHHHHH
CFERFEALKIVFNNLQNKNYAANIVFNAANEELVAAFLNKKIKYLEIIEVNKKVTKELNF
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEEEEEHHHHHHHHCCC
ENPKNIEEVFEIDRKTREYVDSVLG
CCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA