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The map label for this gene is ung [H]

Identifier: 89255936

GI number: 89255936

Start: 511277

End: 511939

Strand: Direct

Name: ung [H]

Synonym: FTL_0529

Alternate gene names: 89255936

Gene position: 511277-511939 (Clockwise)

Preceding gene: 89255935

Following gene: 89255940

Centisome position: 26.97

GC content: 33.03

Gene sequence:

>663_bases
ATGACTTGGTCAGATATCTTAGCAGAAGAAAAACAAAAACCTTATTTTAAACAAATACTTGACTTTTTGGCGTGTGAAAG
CGCTAAAGGTAAGGTAATTTTCCCAACGAAGGAAAATATTTTTAATGCTTTTAAGTATACTGAGCTAGATAATCTAAAAG
TAGTCATTTTAGGGCAAGATCCATATCACAACTATAATCAAGCTCATGGTTTAGCGTTCTCAGTGCAAAAATGGGTGGAT
ATTCCACCATCATTGCAAAATATCTATAAAGAGCTTGCCCGCAGTATTCCAAAATTTAAAACTCCAAATCATGGTTATTT
AGTTGATTGGGCAAAGCAAGGAGTGTTTTTATTAAATACTACTTTGACAGTTGAGGCTCATAAAGCAAATTCACATAAGG
ATATAGGTTGGGAGACTTTTACGGATACTGTAATTAACAAAATTTCAGAAAATAAACACAATGTTGTGTTTATGCTTTGG
GGTTCGCATGCACGTAAGAAAAAAGTTCTTATTGATAGTTCAAGGCATTTGATTTTAGAGTCTACACATCCATCGCCTTT
ATCAGCACATAGAGGTTTTCTGGGTTGTAATCATTTTGTTGATTGTAATAAGTATTTGATTGAAAAGAAAGATCAGAAGA
TAGATTGGAATTTACTTTGCTGA

Upstream 100 bases:

>100_bases
TCTTTGAAGGTTTGCAGAAGCAATTACCTGATGTTGAAATTAGATTTAAAACCAGGGTAAATAAACAGGAATTGTCTAAT
ATTTTACAGGAGTACCAAAA

Downstream 100 bases:

>100_bases
ACGATTCCATTATGTGCAGCTTAGAAAAAAAATAATTACTTAACAATATTCCAAGGATCTTGATATTGAGTATGGTTTTC
TACAGGGTTAACTCCTTTAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKWVD
IPPSLQNIYKELARSIPKFKTPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLW
GSHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC

Sequences:

>Translated_220_residues
MTWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKWVD
IPPSLQNIYKELARSIPKFKTPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLW
GSHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC
>Mature_219_residues
TWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKWVDI
PPSLQNIYKELARSIPKFKTPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLWG
SHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=218, Percent_Identity=50.9174311926605, Blast_Score=231, Evalue=3e-61,
Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=50.9174311926605, Blast_Score=231, Evalue=4e-61,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=59.2592592592593, Blast_Score=286, Evalue=8e-79,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=53.2407407407407, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=44.7257383966245, Blast_Score=191, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25426; Mature: 25295

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQD
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEECC
PYHNYNQAHGLAFSVQKWVDIPPSLQNIYKELARSIPKFKTPNHGYLVDWAKQGVFLLNT
CCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEE
TLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLWGSHARKKKVLIDSSRHLILE
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCCEEEEE
STHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC
CCCCCCCHHHCCCCCCCCHHCCCHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
TWSDILAEEKQKPYFKQILDFLACESAKGKVIFPTKENIFNAFKYTELDNLKVVILGQD
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEECC
PYHNYNQAHGLAFSVQKWVDIPPSLQNIYKELARSIPKFKTPNHGYLVDWAKQGVFLLNT
CCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEE
TLTVEAHKANSHKDIGWETFTDTVINKISENKHNVVFMLWGSHARKKKVLIDSSRHLILE
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCCEEEEE
STHPSPLSAHRGFLGCNHFVDCNKYLIEKKDQKIDWNLLC
CCCCCCCHHHCCCCCCCCHHCCCHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA