Click here to switch to the map view.

The map label for this gene is purL

Identifier: 89054664

GI number: 89054664

Start: 2177892

End: 2180051

Strand: Reverse

Name: purL

Synonym: Jann_2173

Alternate gene names: 89054664

Gene position: 2180051-2177892 (Counterclockwise)

Preceding gene: 89054665

Following gene: 89054663

Centisome position: 50.49

GC content: 63.15

Gene sequence:

>2160_bases
ATGACCGAGCCGACCATTACAGACGATATCATCAAGGCCCATGGCTTCACCGACGATGAATATGCCGAGGTGAACAAGAT
CCTCGGACGTGCGCCGAATTATACCGAGATGGGCATTTTCTCTGCCATGTGGAACGAGCATTGTTCCTACAAGTCCTCCA
AGAAATGGCTGCGGACCCTGCCCACCGAAGGCCCACAGGTCATTTGCGGCCCCGGGGAAAACGCAGGCATCGTCGATATC
GGTGATGGCCAATGCGTGGTCTTCAAGATGGAAAGCCACAACCACCCCTCTTACATCGAGCCCTACCAGGGGGCTGCCAC
CGGCGTGGGCGGCATTCTGCGCGACGTCTTCACCATGGGCGCGCGGCCGATTGCGGCGATGAATTCGCTCAGCTTCGGAG
AGGTCGCGCACCCCAAAACCCGGCAGCTGGTCCACGGCGTGGTCGAGGGCGTCGGCGGTTACGGCAATTGCTTCGGCGTG
CCGACCATTGGCGGCGAAGTCCGGTTCCACCCCGCCTATAACGGCAATTGTCTGGTCAATGCGTTTGCCGCAGGCCTCGC
GGACACCGACAAGATCTTCTATTCTGCGGCCTCCGGCGTCGGCATGCCCGTCGTCTATCTGGGCGCCAAGACGGGCCGCG
ATGGCGTGGGCGGGGCCACCATGGCCTCCGCTGAATTTGACGACACGATCGAAGAAAAACGCCCCACCGTGCAGGTCGGT
GACCCGTTCACCGAAAAGCGCCTTTTGGAGGCGACGCTGGAACTGATGGCCTCTGGCGCCGTGATTTCCATTCAGGATAT
GGGGGCCGCTGGCCTGACGTGTTCCGCCGTTGAGATGGGCGACAAGGGCGGGCTTGGCATCCGCCTGAACCTTGACGCCG
TGCCGATCCGCGAAGACGCGATGACCGCCTATGAGATGATGCTGTCGGAAAGCCAGGAACGGATGCTGATGGTCCTCAAG
CCCGAGCTGGAAGACACGGCACGGGCGATATTTGAAAAATGGGACCTCGATTTTGCCGTCGTGGGCGAAACAATCCCCGA
AGATCGCTTCGTCATTGTCCACAACGGCGAAACAAAGGCCGATCTGCCCCTGTCCAAGCTGGCGTCCACCGCGCCCGAGT
ACGACCGTCCCTGGGTGCCGACCGACCCGGCCCACGACATGGACGCGGTGCCCGAGGTGGATCCCATCGACGCCCTGCGC
GCGCTTCTCTTCTCGCCCAACTATTGCTCGCGCCAGTGGGTGTACCAGCAGTATGACCATCAGGTGATGGGCGACACCGT
CATGTCCCCCGGCCTCGGCGCAGGCGTGGTGCGGGTTCACGGGACGGACAAGGCGCTGGCCTTCACCTCCGACGTGACGC
CGCGCTACGTGAAGGCAAACCCTGTGGAGGGCGGCAAACAGGCGGTCGCGGAAGCCTACCGAAATCTGACAGCTGTGGGT
GCCAAGCCTCTGGCAACAACGGATAACATGAATTTCGGCAACCCCGAAAAGCCGGAAATCATGGGCCAGTTCGTCGGCGC
GATCAAAGGCATTGGGGAGGCCTGCCTGGCCCTCGACACGCCCATCGTCTCGGGCAATGTGTCGCTTTATAACGAGACGG
ACGGCACCGGCATTCTGCCCACGCCGACCATCGGGGCCGTTGGCCTGCTCTCCAGCATGGACGACCTGATCGCAGGCACC
GCGCGCGACGGCCACGTTTTGCTTCTGGTGGGCGACACCAACGGCCATCTGGGGCAATCCGCCTTGTTGGCGGAGGTCTT
CAACCGCGAAGACGGCGACGCGCCCCATGTCGATCTGGGGGCCGAAAAGCGCAACGGCGATTTCATCCGCGACAACCGCG
ACTGGATCGGGGCCTGTACGGACCTCAGCGATGGCGGCCTCGCGCTGGCGGCATTCGAGGTCGCCCATGCGGCGGGCTGC
GGCATCACGCTTGATGTCGGCGACACCGCCACGCTTTTCGGCGAGGATCAGGCGCGCTATCTGATCTCCACCTCCTTCGA
CGCAGCCGAAGCGCTGATGGTCGCTGCGGGCCGCGCGGGCGTGCCATTGGCCACCGTCGGCAAAGTGGGCGGCGCCAGCC
TGCGCATCGGCACATCTGAGGCACCGCTTGCGGATCTGTCAGCGACCTATACCAACGCCTTCTCCCAAACCTTCGCCTGA

Upstream 100 bases:

>100_bases
CGCCCGCCCATCAGCCCCCCGCGACCACAGGCGCGGCATGCGCGGCCCTTTCCTCTCCGCCAGAGGCCCTCTATAGCTCC
GTCCCAAACGGGGGACTTGC

Downstream 100 bases:

>100_bases
TACGCTTGCGGCGGGGTCCCCCGCGCCCTACATTTTGACGGGACAGCCAAGGAACCGACCAACCATGCCGATGCAAGCCT
CCGAAATCGAAATGCTGCTG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MTEPTITDDIIKAHGFTDDEYAEVNKILGRAPNYTEMGIFSAMWNEHCSYKSSKKWLRTLPTEGPQVICGPGENAGIVDI
GDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEVAHPKTRQLVHGVVEGVGGYGNCFGV
PTIGGEVRFHPAYNGNCLVNAFAAGLADTDKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
DPFTEKRLLEATLELMASGAVISIQDMGAAGLTCSAVEMGDKGGLGIRLNLDAVPIREDAMTAYEMMLSESQERMLMVLK
PELEDTARAIFEKWDLDFAVVGETIPEDRFVIVHNGETKADLPLSKLASTAPEYDRPWVPTDPAHDMDAVPEVDPIDALR
ALLFSPNYCSRQWVYQQYDHQVMGDTVMSPGLGAGVVRVHGTDKALAFTSDVTPRYVKANPVEGGKQAVAEAYRNLTAVG
AKPLATTDNMNFGNPEKPEIMGQFVGAIKGIGEACLALDTPIVSGNVSLYNETDGTGILPTPTIGAVGLLSSMDDLIAGT
ARDGHVLLLVGDTNGHLGQSALLAEVFNREDGDAPHVDLGAEKRNGDFIRDNRDWIGACTDLSDGGLALAAFEVAHAAGC
GITLDVGDTATLFGEDQARYLISTSFDAAEALMVAAGRAGVPLATVGKVGGASLRIGTSEAPLADLSATYTNAFSQTFA

Sequences:

>Translated_719_residues
MTEPTITDDIIKAHGFTDDEYAEVNKILGRAPNYTEMGIFSAMWNEHCSYKSSKKWLRTLPTEGPQVICGPGENAGIVDI
GDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEVAHPKTRQLVHGVVEGVGGYGNCFGV
PTIGGEVRFHPAYNGNCLVNAFAAGLADTDKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
DPFTEKRLLEATLELMASGAVISIQDMGAAGLTCSAVEMGDKGGLGIRLNLDAVPIREDAMTAYEMMLSESQERMLMVLK
PELEDTARAIFEKWDLDFAVVGETIPEDRFVIVHNGETKADLPLSKLASTAPEYDRPWVPTDPAHDMDAVPEVDPIDALR
ALLFSPNYCSRQWVYQQYDHQVMGDTVMSPGLGAGVVRVHGTDKALAFTSDVTPRYVKANPVEGGKQAVAEAYRNLTAVG
AKPLATTDNMNFGNPEKPEIMGQFVGAIKGIGEACLALDTPIVSGNVSLYNETDGTGILPTPTIGAVGLLSSMDDLIAGT
ARDGHVLLLVGDTNGHLGQSALLAEVFNREDGDAPHVDLGAEKRNGDFIRDNRDWIGACTDLSDGGLALAAFEVAHAAGC
GITLDVGDTATLFGEDQARYLISTSFDAAEALMVAAGRAGVPLATVGKVGGASLRIGTSEAPLADLSATYTNAFSQTFA
>Mature_718_residues
TEPTITDDIIKAHGFTDDEYAEVNKILGRAPNYTEMGIFSAMWNEHCSYKSSKKWLRTLPTEGPQVICGPGENAGIVDIG
DGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEVAHPKTRQLVHGVVEGVGGYGNCFGVP
TIGGEVRFHPAYNGNCLVNAFAAGLADTDKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVGD
PFTEKRLLEATLELMASGAVISIQDMGAAGLTCSAVEMGDKGGLGIRLNLDAVPIREDAMTAYEMMLSESQERMLMVLKP
ELEDTARAIFEKWDLDFAVVGETIPEDRFVIVHNGETKADLPLSKLASTAPEYDRPWVPTDPAHDMDAVPEVDPIDALRA
LLFSPNYCSRQWVYQQYDHQVMGDTVMSPGLGAGVVRVHGTDKALAFTSDVTPRYVKANPVEGGKQAVAEAYRNLTAVGA
KPLATTDNMNFGNPEKPEIMGQFVGAIKGIGEACLALDTPIVSGNVSLYNETDGTGILPTPTIGAVGLLSSMDDLIAGTA
RDGHVLLLVGDTNGHLGQSALLAEVFNREDGDAPHVDLGAEKRNGDFIRDNRDWIGACTDLSDGGLALAAFEVAHAAGCG
ITLDVGDTATLFGEDQARYLISTSFDAAEALMVAAGRAGVPLATVGKVGGASLRIGTSEAPLADLSATYTNAFSQTFA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=727, Percent_Identity=23.6588720770289, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI48994899, Length=741, Percent_Identity=24.6963562753036, Blast_Score=119, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17553022, Length=376, Percent_Identity=24.7340425531915, Blast_Score=84, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=803, Percent_Identity=23.6612702366127, Blast_Score=113, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24582111, Length=646, Percent_Identity=23.9938080495356, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24582109, Length=646, Percent_Identity=23.9938080495356, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137292, Length=646, Percent_Identity=23.9938080495356, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_JANSC (Q28QC2)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510115.1
- ProteinModelPortal:   Q28QC2
- SMR:   Q28QC2
- STRING:   Q28QC2
- GeneID:   3934627
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2173
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   Q28QC2
- ProtClustDB:   PRK01213
- BioCyc:   JSP290400:JANN_2173-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 76016; Mature: 75885

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPTITDDIIKAHGFTDDEYAEVNKILGRAPNYTEMGIFSAMWNEHCSYKSSKKWLRTL
CCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
PTEGPQVICGPGENAGIVDIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMG
CCCCCEEEECCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
ARPIAAMNSLSFGEVAHPKTRQLVHGVVEGVGGYGNCFGVPTIGGEVRFHPAYNGNCLVN
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCCCCEEEE
AFAAGLADTDKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
HHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCCHHHHHHCCCEEEEC
DPFTEKRLLEATLELMASGAVISIQDMGAAGLTCSAVEMGDKGGLGIRLNLDAVPIREDA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHH
MTAYEMMLSESQERMLMVLKPELEDTARAIFEKWDLDFAVVGETIPEDRFVIVHNGETKA
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCC
DLPLSKLASTAPEYDRPWVPTDPAHDMDAVPEVDPIDALRALLFSPNYCSRQWVYQQYDH
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCC
QVMGDTVMSPGLGAGVVRVHGTDKALAFTSDVTPRYVKANPVEGGKQAVAEAYRNLTAVG
HHHCCHHCCCCCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHCC
AKPLATTDNMNFGNPEKPEIMGQFVGAIKGIGEACLALDTPIVSGNVSLYNETDGTGILP
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECCCCCCCCC
TPTIGAVGLLSSMDDLIAGTARDGHVLLLVGDTNGHLGQSALLAEVFNREDGDAPHVDLG
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEECC
AEKRNGDFIRDNRDWIGACTDLSDGGLALAAFEVAHAAGCGITLDVGDTATLFGEDQARY
CCCCCCCEEECCCCEEEEECCCCCCCEEEHHHHHHHHCCCCEEEECCCCEEEECCCCCCE
LISTSFDAAEALMVAAGRAGVPLATVGKVGGASLRIGTSEAPLADLSATYTNAFSQTFA
EEECCCCHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEPTITDDIIKAHGFTDDEYAEVNKILGRAPNYTEMGIFSAMWNEHCSYKSSKKWLRTL
CCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
PTEGPQVICGPGENAGIVDIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMG
CCCCCEEEECCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
ARPIAAMNSLSFGEVAHPKTRQLVHGVVEGVGGYGNCFGVPTIGGEVRFHPAYNGNCLVN
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCCCCEEEE
AFAAGLADTDKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVG
HHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCCHHHHHHCCCEEEEC
DPFTEKRLLEATLELMASGAVISIQDMGAAGLTCSAVEMGDKGGLGIRLNLDAVPIREDA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHH
MTAYEMMLSESQERMLMVLKPELEDTARAIFEKWDLDFAVVGETIPEDRFVIVHNGETKA
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCC
DLPLSKLASTAPEYDRPWVPTDPAHDMDAVPEVDPIDALRALLFSPNYCSRQWVYQQYDH
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCC
QVMGDTVMSPGLGAGVVRVHGTDKALAFTSDVTPRYVKANPVEGGKQAVAEAYRNLTAVG
HHHCCHHCCCCCCCCEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHCC
AKPLATTDNMNFGNPEKPEIMGQFVGAIKGIGEACLALDTPIVSGNVSLYNETDGTGILP
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECCCCCCCCC
TPTIGAVGLLSSMDDLIAGTARDGHVLLLVGDTNGHLGQSALLAEVFNREDGDAPHVDLG
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEECC
AEKRNGDFIRDNRDWIGACTDLSDGGLALAAFEVAHAAGCGITLDVGDTATLFGEDQARY
CCCCCCCEEECCCCEEEEECCCCCCCEEEHHHHHHHHCCCCEEEECCCCEEEECCCCCCE
LISTSFDAAEALMVAAGRAGVPLATVGKVGGASLRIGTSEAPLADLSATYTNAFSQTFA
EEECCCCHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA