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The map label for this gene is pepQ [H]

Identifier: 89054539

GI number: 89054539

Start: 2052723

End: 2053838

Strand: Direct

Name: pepQ [H]

Synonym: Jann_2048

Alternate gene names: 89054539

Gene position: 2052723-2053838 (Clockwise)

Preceding gene: 89054538

Following gene: 89054540

Centisome position: 47.54

GC content: 65.05

Gene sequence:

>1116_bases
ATGGACATCTACAAAACCCGCCTCGCGCGCTTGCGGACCCGCATGGCCGAGACCGGCACCGACCTTGTGGTCCTTGGCCC
CACCAGCCACATGGCGTGGCTATCGGGCGCGGATCCCCATGGCGATGAACGTCCCGTGATGCTGCTGGTCAGCCAAAGCC
ATGCCGGGTTTCTGATGCCCGCGCTCAATGCCAATTCCGTGCGGCAGGCCACCGATCTACCGTTCGAACCCTGGACCGAT
GAAGCCGGTCCGACCGACGCCCTGGGCCGGTTACTGGAGGTCTGCAACATCTCTGGCCCCGGCAAGACCGTGGCGCTGGA
CGAGGCGATGCGCGCCGATTTCGCGCTGCTTCTGCTGGACGCGATGGAGGCCCCTGTGCGGCGGTTCTCCGGCGATACTC
TGGGCCATTTGCGCGCGATGAAAGACACCGCTGAGGTCGAGGCTTTGCGCACCTGCGCGCATCTCAACGATGCGGCCGCC
TCCGCCGGGTTTGCGTCACTGCGCGCTGGCATGACCGAGCGGGACGTGGCCACGATTATCCGCGACCATTACGTGGCCCA
TGGCGCGAAGCCGGAATTCACTATCGTGGCCTTCGGCGCAAACGGCGCGTTCCCCCATCACCATACCGGCGACACGGTTC
TGCACGACGATATGGCCGTGCTGATTGATACAGGCTGCCGGATCGGCGGCTATCCCAGCGATATGACCCGGTGCGGTTGG
TTCGGCTCCGCACCCTCAGCCGAGTTCCTTCGTGTGGCGGATGTGGTCGAGCGGGCGGTGCAGGCCGCCATCGCGGTCGT
GTGTCCCGGTGTCCTTGCCCGAGAGATAGACGCGGCGGCACGGGGCGTGATTGAGGATGCGGGTTATGGCGACTTCTTCG
TGCACCGCACCGGTCATGGCCTTGGGCTGGATATCCATGAGCCACCATACATCACGGCCACATCCGACACCCTGATGCAG
GCGGGCCATGTCTTCTCCATCGAGCCGGGGATTTACCTGCCGGGACAGTTTGGCCTGCGGCTGGAGGACATCGTCATCGC
GACCGACACCGGCGCGGATGTCCTGTCGGCCCTTCCGCGCACGATCGTGACATCTGTGGATGGCCCGGCCAGCTAA

Upstream 100 bases:

>100_bases
CTTCGTGTTCTACCGGCTTGTCGACAAAAGCTGATCGCACGTGATCTTGTCGCCGGCCCCACAGCGGGCCGGCGATGTTC
GGTTTCCAGAAGGGCCTGCC

Downstream 100 bases:

>100_bases
ATATGGGCGAGTTGGTCAACGCCGGAGCGCGGTATTGTCAATCCACACCTTTGGCCCCCCGCGATAACACACCGGCCCGC
GGGCTGGTTTGACATGGGCG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MDIYKTRLARLRTRMAETGTDLVVLGPTSHMAWLSGADPHGDERPVMLLVSQSHAGFLMPALNANSVRQATDLPFEPWTD
EAGPTDALGRLLEVCNISGPGKTVALDEAMRADFALLLLDAMEAPVRRFSGDTLGHLRAMKDTAEVEALRTCAHLNDAAA
SAGFASLRAGMTERDVATIIRDHYVAHGAKPEFTIVAFGANGAFPHHHTGDTVLHDDMAVLIDTGCRIGGYPSDMTRCGW
FGSAPSAEFLRVADVVERAVQAAIAVVCPGVLAREIDAAARGVIEDAGYGDFFVHRTGHGLGLDIHEPPYITATSDTLMQ
AGHVFSIEPGIYLPGQFGLRLEDIVIATDTGADVLSALPRTIVTSVDGPAS

Sequences:

>Translated_371_residues
MDIYKTRLARLRTRMAETGTDLVVLGPTSHMAWLSGADPHGDERPVMLLVSQSHAGFLMPALNANSVRQATDLPFEPWTD
EAGPTDALGRLLEVCNISGPGKTVALDEAMRADFALLLLDAMEAPVRRFSGDTLGHLRAMKDTAEVEALRTCAHLNDAAA
SAGFASLRAGMTERDVATIIRDHYVAHGAKPEFTIVAFGANGAFPHHHTGDTVLHDDMAVLIDTGCRIGGYPSDMTRCGW
FGSAPSAEFLRVADVVERAVQAAIAVVCPGVLAREIDAAARGVIEDAGYGDFFVHRTGHGLGLDIHEPPYITATSDTLMQ
AGHVFSIEPGIYLPGQFGLRLEDIVIATDTGADVLSALPRTIVTSVDGPAS
>Mature_371_residues
MDIYKTRLARLRTRMAETGTDLVVLGPTSHMAWLSGADPHGDERPVMLLVSQSHAGFLMPALNANSVRQATDLPFEPWTD
EAGPTDALGRLLEVCNISGPGKTVALDEAMRADFALLLLDAMEAPVRRFSGDTLGHLRAMKDTAEVEALRTCAHLNDAAA
SAGFASLRAGMTERDVATIIRDHYVAHGAKPEFTIVAFGANGAFPHHHTGDTVLHDDMAVLIDTGCRIGGYPSDMTRCGW
FGSAPSAEFLRVADVVERAVQAAIAVVCPGVLAREIDAAARGVIEDAGYGDFFVHRTGHGLGLDIHEPPYITATSDTLMQ
AGHVFSIEPGIYLPGQFGLRLEDIVIATDTGADVLSALPRTIVTSVDGPAS

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=227, Percent_Identity=31.2775330396476, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI93141226, Length=226, Percent_Identity=27.8761061946903, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI11559925, Length=283, Percent_Identity=25.0883392226148, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI264681565, Length=224, Percent_Identity=29.9107142857143, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788728, Length=233, Percent_Identity=41.6309012875536, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789275, Length=250, Percent_Identity=26.8, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17509539, Length=229, Percent_Identity=28.3842794759825, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39447; Mature: 39447

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIYKTRLARLRTRMAETGTDLVVLGPTSHMAWLSGADPHGDERPVMLLVSQSHAGFLMP
CCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEE
ALNANSVRQATDLPFEPWTDEAGPTDALGRLLEVCNISGPGKTVALDEAMRADFALLLLD
CCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
AMEAPVRRFSGDTLGHLRAMKDTAEVEALRTCAHLNDAAASAGFASLRAGMTERDVATII
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
RDHYVAHGAKPEFTIVAFGANGAFPHHHTGDTVLHDDMAVLIDTGCRIGGYPSDMTRCGW
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCHHHCCC
FGSAPSAEFLRVADVVERAVQAAIAVVCPGVLAREIDAAARGVIEDAGYGDFFVHRTGHG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
LGLDIHEPPYITATSDTLMQAGHVFSIEPGIYLPGQFGLRLEDIVIATDTGADVLSALPR
CCCCCCCCCEEEECCHHHHHCCCEEEECCCEEECCCCCCEEEEEEEEECCCHHHHHHHHH
TIVTSVDGPAS
HHHCCCCCCCC
>Mature Secondary Structure
MDIYKTRLARLRTRMAETGTDLVVLGPTSHMAWLSGADPHGDERPVMLLVSQSHAGFLMP
CCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEE
ALNANSVRQATDLPFEPWTDEAGPTDALGRLLEVCNISGPGKTVALDEAMRADFALLLLD
CCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
AMEAPVRRFSGDTLGHLRAMKDTAEVEALRTCAHLNDAAASAGFASLRAGMTERDVATII
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
RDHYVAHGAKPEFTIVAFGANGAFPHHHTGDTVLHDDMAVLIDTGCRIGGYPSDMTRCGW
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCHHHCCC
FGSAPSAEFLRVADVVERAVQAAIAVVCPGVLAREIDAAARGVIEDAGYGDFFVHRTGHG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
LGLDIHEPPYITATSDTLMQAGHVFSIEPGIYLPGQFGLRLEDIVIATDTGADVLSALPR
CCCCCCCCCEEEECCHHHHHCCCEEEECCCEEECCCCCCEEEEEEEEECCCHHHHHHHHH
TIVTSVDGPAS
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]