Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 89054513

GI number: 89054513

Start: 2025402

End: 2026187

Strand: Direct

Name: ubiE [H]

Synonym: Jann_2022

Alternate gene names: 89054513

Gene position: 2025402-2026187 (Clockwise)

Preceding gene: 89054512

Following gene: 89054515

Centisome position: 46.91

GC content: 53.31

Gene sequence:

>786_bases
ATGGGTATGGAATACGACGACGCCGCAGCGGAGCGATTGGAGGCGGTGTACCTTGGTCCGGACGTAGTTTCTCAAAGAGA
TAACACCCTTCAAAGGATTTCGGTTCAAGAGGGCGAGCGGGTCTTGGATATTGGAAGCGGCCCCGGCTTTCTCGCGGCTC
AAATAGCGGATCAATCAGGACCCGATGGTGAAGTTGTAGGCATCGATATTTCGGAGCAGATGGTAGACCGCGCAACGCAG
CGAAGCGAGCATAGCTGGCTAAGTTATCGTTGCGCAGATGCGACCGAACTCCCGTTTGAAGACAGTTACTTCGATGTGGT
CGTTAGCACCCAAGTTGCTGAATACGTGCCTGATATAGCGAAGTTTTGCAGCGAGGTTTTTCGTGTTCTCAAACCCGGCG
GACGTGCGCTGATCCTTGCGACAGACTGGGAAGGTGTCTGTTGGCACAGTGAATATCCGGGTCGAATGGACAAGGTGCTC
AAGGCTTTTGCACCACATTGCGCCGACAGCAAACTTCCGCGAACGCTTGGCGCGCGCCTTCGAAACGCGGGTTTGATCGT
CAATGAGGTGAGCTATTTCTCCATCATTAATACTGACAGGTACGATGGTTGCTATGGCGAAATGGTGGTGCCCTTCATTG
TGGCCTACGTGAACGGGCAAAAAACGGTTCCGGACGATGAGCTGCAGGCTTGGGCAGAGGAGCAAGCGTCACTCAATGCA
AGAGGAGACCACTTCTTCTCGACTGGTCGGTTTAGTTTCTCTGTCAGGAAACCTTCCGAAACCTGA

Upstream 100 bases:

>100_bases
TGAATTGCCTTCGTGTCGGTAACGCGCGGCGATGCCGCCCCATTTCCCGACCAGCAGACGCAATGCTAGCGTGACTTCCA
ACAATTGGAGGAATCACTCT

Downstream 100 bases:

>100_bases
AGCGGCCATTGGCGCAGTCGCAGCGAATTAGCGCTTAGTCCCGCGGAGCAGTCAATGGCGCTGTCAAATTGTTGCACACC
TTTGCCAACCTCCGCATCGG

Product: hypothetical protein

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MGMEYDDAAAERLEAVYLGPDVVSQRDNTLQRISVQEGERVLDIGSGPGFLAAQIADQSGPDGEVVGIDISEQMVDRATQ
RSEHSWLSYRCADATELPFEDSYFDVVVSTQVAEYVPDIAKFCSEVFRVLKPGGRALILATDWEGVCWHSEYPGRMDKVL
KAFAPHCADSKLPRTLGARLRNAGLIVNEVSYFSIINTDRYDGCYGEMVVPFIVAYVNGQKTVPDDELQAWAEEQASLNA
RGDHFFSTGRFSFSVRKPSET

Sequences:

>Translated_261_residues
MGMEYDDAAAERLEAVYLGPDVVSQRDNTLQRISVQEGERVLDIGSGPGFLAAQIADQSGPDGEVVGIDISEQMVDRATQ
RSEHSWLSYRCADATELPFEDSYFDVVVSTQVAEYVPDIAKFCSEVFRVLKPGGRALILATDWEGVCWHSEYPGRMDKVL
KAFAPHCADSKLPRTLGARLRNAGLIVNEVSYFSIINTDRYDGCYGEMVVPFIVAYVNGQKTVPDDELQAWAEEQASLNA
RGDHFFSTGRFSFSVRKPSET
>Mature_260_residues
GMEYDDAAAERLEAVYLGPDVVSQRDNTLQRISVQEGERVLDIGSGPGFLAAQIADQSGPDGEVVGIDISEQMVDRATQR
SEHSWLSYRCADATELPFEDSYFDVVVSTQVAEYVPDIAKFCSEVFRVLKPGGRALILATDWEGVCWHSEYPGRMDKVLK
AFAPHCADSKLPRTLGARLRNAGLIVNEVSYFSIINTDRYDGCYGEMVVPFIVAYVNGQKTVPDDELQAWAEEQASLNAR
GDHFFSTGRFSFSVRKPSET

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Escherichia coli, GI48994983, Length=109, Percent_Identity=35.7798165137615, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561380, Length=104, Percent_Identity=40.3846153846154, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25143945, Length=131, Percent_Identity=29.7709923664122, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 28939; Mature: 28807

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMEYDDAAAERLEAVYLGPDVVSQRDNTLQRISVQEGERVLDIGSGPGFLAAQIADQSG
CCCCCCHHHHHHHHEEEECCHHHHCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCC
PDGEVVGIDISEQMVDRATQRSEHSWLSYRCADATELPFEDSYFDVVVSTQVAEYVPDIA
CCCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHH
KFCSEVFRVLKPGGRALILATDWEGVCWHSEYPGRMDKVLKAFAPHCADSKLPRTLGARL
HHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
RNAGLIVNEVSYFSIINTDRYDGCYGEMVVPFIVAYVNGQKTVPDDELQAWAEEQASLNA
HHCCEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
RGDHFFSTGRFSFSVRKPSET
CCCCEEECCEEEEEECCCCCC
>Mature Secondary Structure 
GMEYDDAAAERLEAVYLGPDVVSQRDNTLQRISVQEGERVLDIGSGPGFLAAQIADQSG
CCCCCHHHHHHHHEEEECCHHHHCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCC
PDGEVVGIDISEQMVDRATQRSEHSWLSYRCADATELPFEDSYFDVVVSTQVAEYVPDIA
CCCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHH
KFCSEVFRVLKPGGRALILATDWEGVCWHSEYPGRMDKVLKAFAPHCADSKLPRTLGARL
HHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
RNAGLIVNEVSYFSIINTDRYDGCYGEMVVPFIVAYVNGQKTVPDDELQAWAEEQASLNA
HHCCEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
RGDHFFSTGRFSFSVRKPSET
CCCCEEECCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]