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The map label for this gene is pah [H]

Identifier: 89054458

GI number: 89054458

Start: 1960047

End: 1961012

Strand: Direct

Name: pah [H]

Synonym: Jann_1967

Alternate gene names: 89054458

Gene position: 1960047-1961012 (Clockwise)

Preceding gene: 89054457

Following gene: 89054459

Centisome position: 45.39

GC content: 65.22

Gene sequence:

>966_bases
ATGTCCGATCCGTTCTTTCAGCCGCCTTCGGGCACCGATTTGCCGCGCTATGCGGGCGTGCCATCGTTCATGCGGTTGCC
GTATCTGGCCGCCGATGACCCCAAGCGGGCCGAAGTCGATATCGGCATCTTCGGGTTGCCGTGGGACGGGGCCACGTCGA
ACCGGCCCGGCGCGCGCCATGGGCCCAGGGCGCTGCGCGATGCCTCCACCATGATCCGGGAGATGAACCGCTCCACCGGG
CAATTGCCGTTTCAGGCCGCGAATATCGCCGATCTGGGCGATGTGGCGATGAGCCCCGTGGATCAGGATGAGGCCTTGCG
GGATGCGCAGGCCTTCGTGGCCGCCCTGTTGGGTCAGGACATCCGCCCCTTCATGGTGGGCGGCGATCACCTGTGTACGC
TGACCGTGTTGCGGGAATTGCGCGCCACGCGGGGAGAGGCCTTTGGGTTGGTGCTGCTGGACAGCCACACTGATCTCTAT
CCACCCTACTTTGGCGGCAAGACCCTGACCCACGGCAACCCGTTCCGGCAGGCGATTGAGGAGGGATGCCTGGACCCCAC
ACGCTGTGTGATGGCGGGGATGCGGGGCACGTCCTACAACACCTCGGACTTCGACTATGGTCACGAGAAGGGCGTGCGGA
TCATGCCGATTGAGGAATGTATGGAGCGGGGGTGGAGCTCGGTCATGCAGGTCTGTCGCGAGGTCGTGGGCGACGCGCCG
ACCTATGTGTCGTTTGACATCGACTTCATCGACCCGGCTTTCGCGCCGGGAACGGGCACGCCCGAGGTGGGGGGCCCGAC
ATCGTTCGAGGCGATTTCCTGCGTGCGGGCGTTGCGGGGGCTGGACGTGATCGGTGCGGATCTGGTGGAGGTCTCGCCGC
CGTTCGACAATAACGGGATCACGTCCTGGCTTGGCGCGTCGGTCATGTTCGAGCTGATCTGCGCGATGCAGCCGGAGGGT
GCGTGA

Upstream 100 bases:

>100_bases
GATTTGAGTTGTATTTGCCAAGATGAAGGAGAGCGTGTCGCGGGGTGACAGGCGTGGCGGGCGGGTCTAGCGTAGCGGGA
GATTTTGTGAAGGAAGCCCC

Downstream 100 bases:

>100_bases
GTTATCCAGCGAACAGAACGCCGGATCATCTGTTGGAAAGTGACCGCGCGGCGGGTTTTGAGATCAGCGCCGATTTTGAG
CGGTTCGATCAGCGCAATGA

Product: agmatinase

Products: NA

Alternate protein names: Proclavaminic acid amidino hydrolase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSDPFFQPPSGTDLPRYAGVPSFMRLPYLAADDPKRAEVDIGIFGLPWDGATSNRPGARHGPRALRDASTMIREMNRSTG
QLPFQAANIADLGDVAMSPVDQDEALRDAQAFVAALLGQDIRPFMVGGDHLCTLTVLRELRATRGEAFGLVLLDSHTDLY
PPYFGGKTLTHGNPFRQAIEEGCLDPTRCVMAGMRGTSYNTSDFDYGHEKGVRIMPIEECMERGWSSVMQVCREVVGDAP
TYVSFDIDFIDPAFAPGTGTPEVGGPTSFEAISCVRALRGLDVIGADLVEVSPPFDNNGITSWLGASVMFELICAMQPEG
A

Sequences:

>Translated_321_residues
MSDPFFQPPSGTDLPRYAGVPSFMRLPYLAADDPKRAEVDIGIFGLPWDGATSNRPGARHGPRALRDASTMIREMNRSTG
QLPFQAANIADLGDVAMSPVDQDEALRDAQAFVAALLGQDIRPFMVGGDHLCTLTVLRELRATRGEAFGLVLLDSHTDLY
PPYFGGKTLTHGNPFRQAIEEGCLDPTRCVMAGMRGTSYNTSDFDYGHEKGVRIMPIEECMERGWSSVMQVCREVVGDAP
TYVSFDIDFIDPAFAPGTGTPEVGGPTSFEAISCVRALRGLDVIGADLVEVSPPFDNNGITSWLGASVMFELICAMQPEG
A
>Mature_320_residues
SDPFFQPPSGTDLPRYAGVPSFMRLPYLAADDPKRAEVDIGIFGLPWDGATSNRPGARHGPRALRDASTMIREMNRSTGQ
LPFQAANIADLGDVAMSPVDQDEALRDAQAFVAALLGQDIRPFMVGGDHLCTLTVLRELRATRGEAFGLVLLDSHTDLYP
PYFGGKTLTHGNPFRQAIEEGCLDPTRCVMAGMRGTSYNTSDFDYGHEKGVRIMPIEECMERGWSSVMQVCREVVGDAPT
YVSFDIDFIDPAFAPGTGTPEVGGPTSFEAISCVRALRGLDVIGADLVEVSPPFDNNGITSWLGASVMFELICAMQPEGA

Specific function: Catalyzes The Formation Of Putrescine From Agmatine. [C]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family [H]

Homologues:

Organism=Homo sapiens, GI37537722, Length=313, Percent_Identity=41.5335463258786, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4502215, Length=317, Percent_Identity=23.3438485804416, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI10947139, Length=305, Percent_Identity=24.5901639344262, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789306, Length=280, Percent_Identity=38.5714285714286, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71996843, Length=214, Percent_Identity=28.0373831775701, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005925
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.22 [H]

Molecular weight: Translated: 34717; Mature: 34585

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00148 ARGINASE_2 ; PS01053 ARGINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPFFQPPSGTDLPRYAGVPSFMRLPYLAADDPKRAEVDIGIFGLPWDGATSNRPGARH
CCCCCCCCCCCCCCCHHCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCC
GPRALRDASTMIREMNRSTGQLPFQAANIADLGDVAMSPVDQDEALRDAQAFVAALLGQD
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
IRPFMVGGDHLCTLTVLRELRATRGEAFGLVLLDSHTDLYPPYFGGKTLTHGNPFRQAIE
CCCEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHH
EGCLDPTRCVMAGMRGTSYNTSDFDYGHEKGVRIMPIEECMERGWSSVMQVCREVVGDAP
HHCCCHHHHHHHCCCCCCCCCCCCCCCHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
TYVSFDIDFIDPAFAPGTGTPEVGGPTSFEAISCVRALRGLDVIGADLVEVSPPFDNNGI
CEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCHHEECCCCCCCCCH
TSWLGASVMFELICAMQPEGA
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDPFFQPPSGTDLPRYAGVPSFMRLPYLAADDPKRAEVDIGIFGLPWDGATSNRPGARH
CCCCCCCCCCCCCCHHCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCC
GPRALRDASTMIREMNRSTGQLPFQAANIADLGDVAMSPVDQDEALRDAQAFVAALLGQD
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
IRPFMVGGDHLCTLTVLRELRATRGEAFGLVLLDSHTDLYPPYFGGKTLTHGNPFRQAIE
CCCEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHH
EGCLDPTRCVMAGMRGTSYNTSDFDYGHEKGVRIMPIEECMERGWSSVMQVCREVVGDAP
HHCCCHHHHHHHCCCCCCCCCCCCCCCHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
TYVSFDIDFIDPAFAPGTGTPEVGGPTSFEAISCVRALRGLDVIGADLVEVSPPFDNNGI
CEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCHHEECCCCCCCCCH
TSWLGASVMFELICAMQPEGA
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8088547 [H]