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The map label for this gene is trpC [H]

Identifier: 89054368

GI number: 89054368

Start: 1865989

End: 1866789

Strand: Reverse

Name: trpC [H]

Synonym: Jann_1877

Alternate gene names: 89054368

Gene position: 1866789-1865989 (Counterclockwise)

Preceding gene: 89054369

Following gene: 89054367

Centisome position: 43.23

GC content: 65.67

Gene sequence:

>801_bases
ATGTCCATGAGCACCATTCTAGACAAGATCAAAGCCTACAAGCTGGAGGAAGTGGCCGCCGCAAAGGCCGCCCGCCCCCG
GTCCGAGGTGGAAGAGGCCGCGAAAGCCGCGCCACGTGTGCGCGGGTTCGCCGATGCGCTATGGGCCGCGCAGACCCATG
GCTATGGGTTGATTGCCGAGATCAAGAAGGCGAGCCCCTCCAAAGGCTTGATCCGCGACGATTTCGATCCGCCGGCCCTT
GCCCGCGCCTATGAGGCCGGTGGGGCCACTTGTCTGTCTGTCCTAACGGACACGCCATCATTCCAGGGCGCGCCCGAGTT
CCTCGTGGCCGCCCGCGCCGCAACGTCCCTGCCCTGCCTGCGCAAGGATTTCCTCTATGACCCCTACCAGGTGGCCGAGG
CGCGGGCCTGGGGGGCCGATTGCATTCTGATCATCATGGCCAGCGTGTCCGATACCCAGGCGGCTGAATTGGAAGACGCG
GCGCGCCACTGGAACATGGACGCATTGATCGAGGTTCACGACGGTGCGGAGCTGGACCGCGCCATGGACCTGAAGTCGCC
CCTTCTGGGGATCAACAACCGCAACCTGAACACGTTCGAGACGTCGCTGGACACGACCCGCACCCTCGCCGCCCGCGTGC
CTGAGGGTCGCATGGTGATCTCCGAGTCCGGGCTGTTCACGCCTGCGGATCTGGCGGATATGGCCCGCGTCGGGGCGCGG
ACGTTCCTGATCGGTGAAAGCCTGATGCGGCAGCCGGACGTGACGGCGGCGACCCAGGCCTTGCTGGCAGATCCCGTCTG
A

Upstream 100 bases:

>100_bases
TTCGGGCTGACCCTCGCCCTTATCGGCGGCGTTGCCATGCGTATCGCCCGCAAACAAACTGCGCGTCCCTCGACAGGCCC
GCAGGCGTGACCTAAGAACC

Downstream 100 bases:

>100_bases
TGGCGCGGCTCACGCATTTCGACGGCGACGGTCAGGCCCATATGGTCGATGTCTCGGGCAAGGCTGTGACGGACCGCATA
GCCGTCGCGGACTGCTACAT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSMSTILDKIKAYKLEEVAAAKAARPRSEVEEAAKAAPRVRGFADALWAAQTHGYGLIAEIKKASPSKGLIRDDFDPPAL
ARAYEAGGATCLSVLTDTPSFQGAPEFLVAARAATSLPCLRKDFLYDPYQVAEARAWGADCILIIMASVSDTQAAELEDA
ARHWNMDALIEVHDGAELDRAMDLKSPLLGINNRNLNTFETSLDTTRTLAARVPEGRMVISESGLFTPADLADMARVGAR
TFLIGESLMRQPDVTAATQALLADPV

Sequences:

>Translated_266_residues
MSMSTILDKIKAYKLEEVAAAKAARPRSEVEEAAKAAPRVRGFADALWAAQTHGYGLIAEIKKASPSKGLIRDDFDPPAL
ARAYEAGGATCLSVLTDTPSFQGAPEFLVAARAATSLPCLRKDFLYDPYQVAEARAWGADCILIIMASVSDTQAAELEDA
ARHWNMDALIEVHDGAELDRAMDLKSPLLGINNRNLNTFETSLDTTRTLAARVPEGRMVISESGLFTPADLADMARVGAR
TFLIGESLMRQPDVTAATQALLADPV
>Mature_265_residues
SMSTILDKIKAYKLEEVAAAKAARPRSEVEEAAKAAPRVRGFADALWAAQTHGYGLIAEIKKASPSKGLIRDDFDPPALA
RAYEAGGATCLSVLTDTPSFQGAPEFLVAARAATSLPCLRKDFLYDPYQVAEARAWGADCILIIMASVSDTQAAELEDAA
RHWNMDALIEVHDGAELDRAMDLKSPLLGINNRNLNTFETSLDTTRTLAARVPEGRMVISESGLFTPADLADMARVGART
FLIGESLMRQPDVTAATQALLADPV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=260, Percent_Identity=40.3846153846154, Blast_Score=165, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322638, Length=233, Percent_Identity=35.1931330472103, Blast_Score=139, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28579; Mature: 28448

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSTILDKIKAYKLEEVAAAKAARPRSEVEEAAKAAPRVRGFADALWAAQTHGYGLIAE
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
IKKASPSKGLIRDDFDPPALARAYEAGGATCLSVLTDTPSFQGAPEFLVAARAATSLPCL
HHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHH
RKDFLYDPYQVAEARAWGADCILIIMASVSDTQAAELEDAARHWNMDALIEVHDGAELDR
HHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHEEEECCCCHHHH
AMDLKSPLLGINNRNLNTFETSLDTTRTLAARVPEGRMVISESGLFTPADLADMARVGAR
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHH
TFLIGESLMRQPDVTAATQALLADPV
HHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SMSTILDKIKAYKLEEVAAAKAARPRSEVEEAAKAAPRVRGFADALWAAQTHGYGLIAE
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
IKKASPSKGLIRDDFDPPALARAYEAGGATCLSVLTDTPSFQGAPEFLVAARAATSLPCL
HHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHH
RKDFLYDPYQVAEARAWGADCILIIMASVSDTQAAELEDAARHWNMDALIEVHDGAELDR
HHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHEEEECCCCHHHH
AMDLKSPLLGINNRNLNTFETSLDTTRTLAARVPEGRMVISESGLFTPADLADMARVGAR
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHH
TFLIGESLMRQPDVTAATQALLADPV
HHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA