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The map label for this gene is fabH

Identifier: 89054275

GI number: 89054275

Start: 1772085

End: 1773065

Strand: Reverse

Name: fabH

Synonym: Jann_1784

Alternate gene names: 89054275

Gene position: 1773065-1772085 (Counterclockwise)

Preceding gene: 89054276

Following gene: 89054274

Centisome position: 41.06

GC content: 62.39

Gene sequence:

>981_bases
ATGATCATCCGAGCGGTTCCCGTCGGCATCGGCCATTATTTGCCCGAACGCGTTGTCCCCAACGCTGAGTTTGAGGCGAT
GGAGGGGTTGGAGACCTCCGACGAATGGATCAGGGCGAGGTCCGGGATCGAACGCCGTCATTTCGCCGCCGAGGGGGAGA
CGACCAGCCAGATGGCCGTCACCGCCGCCCGGAAGGCGCTGGATCATGCGGCGCTGAACCCGGACGATATCGACGCTGTC
ATCGTCGCCACATCCACGCCTGACCTGACGTTTCCGTCCGTCGCCACAATGGTGCAGGCGGGCCTTGGGATGACGGGGGG
ATTCGCATTCGATGTGCAGGCGGTCTGCGCCGGATTCGTCTATGCGCTGGCAAACGCCAACGCTTTGATCGTGTCCGGTC
AGGCGAACCGCGTGCTGGTGATCGGGGCAGAGACCTTCAGCCGAATCATGGACTGGACCGACCGCACGACCTGCGTCTTG
TTCGGGGACGGCGCGGGCGCGTTGATCCTGGAAGGACGCGACAGCGCAGGCACCCCGCAAGATCGCGGCATCCTGTCCAC
GGATCTCCATTCCGACGGCACCCACCGCGAGTTGCTCTATGTCGACGGCGGCGTATCCAGCACCGGAACGACGGGTGTGC
TGAAAATGCAGGGCAAGGAAGTCTTTCGCCATGCAATTGAAAAACTTACCAAAACGGCTGATACAGGCCTCGCGAAGGCA
GGTGTCACCGTCGGCGATGTTGATTGGGTCGTGCCCCATCAGGCCAACATTCGCATCATCTCTGGCACCGTGAAGAAGTT
CGGCCTGCCGATGGATAAGGTCATCGTCACCGTTCAGGATCATGGTAATACCTCTGCCGCGTCGATCCCGCTGGCGATGT
CGGTGGGGGTGGGCGACGGGCGCATTCAACCCGGTCATTTGCTGGTCACGGAAGCCATTGGCGGGGGCCTCGCCTGGGGC
GCTGTGGTGATGCGCTGGTAA

Upstream 100 bases:

>100_bases
CACAGCTGTCGGCCACCGGGTTCCACAAACGTCTGGCCGCGCGCATCGCCCAGGCCGAAGCCGCCGCCAGCGTCGCGATA
CAGAAAGAGGGATCGTCCGA

Downstream 100 bases:

>100_bases
GCGTTAACGCGCCACAGAAACGACGCCGCGCAACACACTGTATTGACTAAAGAAACCGCATAATTCATCCTGTCCTCCAA
ATCAGGGGGACTGGATATAT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIIRAVPVGIGHYLPERVVPNAEFEAMEGLETSDEWIRARSGIERRHFAAEGETTSQMAVTAARKALDHAALNPDDIDAV
IVATSTPDLTFPSVATMVQAGLGMTGGFAFDVQAVCAGFVYALANANALIVSGQANRVLVIGAETFSRIMDWTDRTTCVL
FGDGAGALILEGRDSAGTPQDRGILSTDLHSDGTHRELLYVDGGVSSTGTTGVLKMQGKEVFRHAIEKLTKTADTGLAKA
GVTVGDVDWVVPHQANIRIISGTVKKFGLPMDKVIVTVQDHGNTSAASIPLAMSVGVGDGRIQPGHLLVTEAIGGGLAWG
AVVMRW

Sequences:

>Translated_326_residues
MIIRAVPVGIGHYLPERVVPNAEFEAMEGLETSDEWIRARSGIERRHFAAEGETTSQMAVTAARKALDHAALNPDDIDAV
IVATSTPDLTFPSVATMVQAGLGMTGGFAFDVQAVCAGFVYALANANALIVSGQANRVLVIGAETFSRIMDWTDRTTCVL
FGDGAGALILEGRDSAGTPQDRGILSTDLHSDGTHRELLYVDGGVSSTGTTGVLKMQGKEVFRHAIEKLTKTADTGLAKA
GVTVGDVDWVVPHQANIRIISGTVKKFGLPMDKVIVTVQDHGNTSAASIPLAMSVGVGDGRIQPGHLLVTEAIGGGLAWG
AVVMRW
>Mature_326_residues
MIIRAVPVGIGHYLPERVVPNAEFEAMEGLETSDEWIRARSGIERRHFAAEGETTSQMAVTAARKALDHAALNPDDIDAV
IVATSTPDLTFPSVATMVQAGLGMTGGFAFDVQAVCAGFVYALANANALIVSGQANRVLVIGAETFSRIMDWTDRTTCVL
FGDGAGALILEGRDSAGTPQDRGILSTDLHSDGTHRELLYVDGGVSSTGTTGVLKMQGKEVFRHAIEKLTKTADTGLAKA
GVTVGDVDWVVPHQANIRIISGTVKKFGLPMDKVIVTVQDHGNTSAASIPLAMSVGVGDGRIQPGHLLVTEAIGGGLAWG
AVVMRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=320, Percent_Identity=45.625, Blast_Score=281, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_JANSC (Q28RG1)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509726.1
- ProteinModelPortal:   Q28RG1
- SMR:   Q28RG1
- STRING:   Q28RG1
- GeneID:   3934233
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1784
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   DAGISAN
- PhylomeDB:   Q28RG1
- ProtClustDB:   CLSK933877
- BioCyc:   JSP290400:JANN_1784-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34258; Mature: 34258

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 253-253 ACT_SITE 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRAVPVGIGHYLPERVVPNAEFEAMEGLETSDEWIRARSGIERRHFAAEGETTSQMAV
CEEEEEECCHHHHCHHHCCCCCCHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCCHHHHHH
TAARKALDHAALNPDDIDAVIVATSTPDLTFPSVATMVQAGLGMTGGFAFDVQAVCAGFV
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
YALANANALIVSGQANRVLVIGAETFSRIMDWTDRTTCVLFGDGAGALILEGRDSAGTPQ
HHHHCCCEEEEECCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCC
DRGILSTDLHSDGTHRELLYVDGGVSSTGTTGVLKMQGKEVFRHAIEKLTKTADTGLAKA
CCCCEEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHC
GVTVGDVDWVVPHQANIRIISGTVKKFGLPMDKVIVTVQDHGNTSAASIPLAMSVGVGDG
CCEECCEEEECCCCCCEEEEECCHHHHCCCHHHEEEEEECCCCCCCEECEEEEEECCCCC
RIQPGHLLVTEAIGGGLAWGAVVMRW
CCCCCCEEEEECCCCCCEEHEEEECC
>Mature Secondary Structure
MIIRAVPVGIGHYLPERVVPNAEFEAMEGLETSDEWIRARSGIERRHFAAEGETTSQMAV
CEEEEEECCHHHHCHHHCCCCCCHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCCHHHHHH
TAARKALDHAALNPDDIDAVIVATSTPDLTFPSVATMVQAGLGMTGGFAFDVQAVCAGFV
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
YALANANALIVSGQANRVLVIGAETFSRIMDWTDRTTCVLFGDGAGALILEGRDSAGTPQ
HHHHCCCEEEEECCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCC
DRGILSTDLHSDGTHRELLYVDGGVSSTGTTGVLKMQGKEVFRHAIEKLTKTADTGLAKA
CCCCEEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHC
GVTVGDVDWVVPHQANIRIISGTVKKFGLPMDKVIVTVQDHGNTSAASIPLAMSVGVGDG
CCEECCEEEECCCCCCEEEEECCHHHHCCCHHHEEEEEECCCCCCCEECEEEEEECCCCC
RIQPGHLLVTEAIGGGLAWGAVVMRW
CCCCCCEEEEECCCCCCEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA