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The map label for this gene is cysH [H]

Identifier: 89054263

GI number: 89054263

Start: 1760197

End: 1760910

Strand: Reverse

Name: cysH [H]

Synonym: Jann_1772

Alternate gene names: 89054263

Gene position: 1760910-1760197 (Counterclockwise)

Preceding gene: 89054264

Following gene: 89054262

Centisome position: 40.78

GC content: 64.99

Gene sequence:

>714_bases
ATGCCGCTTAAGGAACTTGCTGAGCGCCGCACGCTTCTGCACCGCAAGAGTGACGCGCAGACCGTGCTGGCCCATGCGCT
TGATGATTTGGCCATCGGCCCGGTCGCCATGGTCAGCAGCTTCGGCGCGGAGAGCGTGGTCTTGTTGCATATGGTCAGCC
AGATCGCGCCGGACACGCCGATCCTGTTCATCGACACGGAGATGCTGTTTGACGCGACGCTGACCTATCAGCGTGAGGTG
GCGGAGCAGCTGGGTCTCCGCGATATCCGCGTGGTCAAGCCCGCCCGCGAAGCGCTGCTGGAGCGGGACGTGGACGGCGT
GCTGCACCATTTCGACAAGAATGCCTGCTGCGCGCTGCGGAAGTCGGAGCCGCTGGAGCGCGCGTTGGAGGGCTTTGGCG
GATGGGTCACCGGGCGCAAACGCATCCACGGCGGCCTGCGCAAGTCCTTGCCTTTGTTTGAGAAAAGCGACCGGCGCATC
AAGATCAACCCGCTGGCGTCGTGGACGCAAGGGATGGTCGCGGATTACATCACGCAGCACGATCTGCCGCGCCATCCAAT
GGTCGCGCAGGGCTATCCGTCCATCGGGTGCCAGCCCTGCACCACACCCGCCGGGGCCGATGAAGATCCGCGTGCCGGAC
GGTGGCGGGGATCCGCGAAGACCGAATGCGGCATTCATTTCGAGGACGCGAAGCCGCTTCGGCGCGCGTCCTGA

Upstream 100 bases:

>100_bases
CTTGAGGTGCGTGACAATGCCGACGAGACATTCCTTGAGACCTACCGCCGCCTCGGCGCCGCACCGTTCAAAGCTGCACT
TTATCCCGAGGTGAAAGCCA

Downstream 100 bases:

>100_bases
CAGTTCAAGGAAAGGGACCCGCCATGGCCCAGACGATTGTAACCGATACGGGATTTGCGCCCGACGACTGGAACGGACAC
GCCGCCCCCCTGGCCGATGG

Product: phosphoadenylylsulfate reductase (thioredoxin)

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPLKELAERRTLLHRKSDAQTVLAHALDDLAIGPVAMVSSFGAESVVLLHMVSQIAPDTPILFIDTEMLFDATLTYQREV
AEQLGLRDIRVVKPAREALLERDVDGVLHHFDKNACCALRKSEPLERALEGFGGWVTGRKRIHGGLRKSLPLFEKSDRRI
KINPLASWTQGMVADYITQHDLPRHPMVAQGYPSIGCQPCTTPAGADEDPRAGRWRGSAKTECGIHFEDAKPLRRAS

Sequences:

>Translated_237_residues
MPLKELAERRTLLHRKSDAQTVLAHALDDLAIGPVAMVSSFGAESVVLLHMVSQIAPDTPILFIDTEMLFDATLTYQREV
AEQLGLRDIRVVKPAREALLERDVDGVLHHFDKNACCALRKSEPLERALEGFGGWVTGRKRIHGGLRKSLPLFEKSDRRI
KINPLASWTQGMVADYITQHDLPRHPMVAQGYPSIGCQPCTTPAGADEDPRAGRWRGSAKTECGIHFEDAKPLRRAS
>Mature_236_residues
PLKELAERRTLLHRKSDAQTVLAHALDDLAIGPVAMVSSFGAESVVLLHMVSQIAPDTPILFIDTEMLFDATLTYQREVA
EQLGLRDIRVVKPAREALLERDVDGVLHHFDKNACCALRKSEPLERALEGFGGWVTGRKRIHGGLRKSLPLFEKSDRRIK
INPLASWTQGMVADYITQHDLPRHPMVAQGYPSIGCQPCTTPAGADEDPRAGRWRGSAKTECGIHFEDAKPLRRAS

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=235, Percent_Identity=32.7659574468085, Blast_Score=108, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325425, Length=202, Percent_Identity=35.1485148514851, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 26321; Mature: 26189

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKELAERRTLLHRKSDAQTVLAHALDDLAIGPVAMVSSFGAESVVLLHMVSQIAPDTP
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHCCCCC
ILFIDTEMLFDATLTYQREVAEQLGLRDIRVVKPAREALLERDVDGVLHHFDKNACCALR
EEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
KSEPLERALEGFGGWVTGRKRIHGGLRKSLPLFEKSDRRIKINPLASWTQGMVADYITQH
CCCHHHHHHHHHCCHHCCHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHC
DLPRHPMVAQGYPSIGCQPCTTPAGADEDPRAGRWRGSAKTECGIHFEDAKPLRRAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
PLKELAERRTLLHRKSDAQTVLAHALDDLAIGPVAMVSSFGAESVVLLHMVSQIAPDTP
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHCCCCC
ILFIDTEMLFDATLTYQREVAEQLGLRDIRVVKPAREALLERDVDGVLHHFDKNACCALR
EEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
KSEPLERALEGFGGWVTGRKRIHGGLRKSLPLFEKSDRRIKINPLASWTQGMVADYITQH
CCCHHHHHHHHHCCHHCCHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHC
DLPRHPMVAQGYPSIGCQPCTTPAGADEDPRAGRWRGSAKTECGIHFEDAKPLRRAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]