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The map label for this gene is echA12 [H]

Identifier: 89053817

GI number: 89053817

Start: 1290709

End: 1291515

Strand: Direct

Name: echA12 [H]

Synonym: Jann_1326

Alternate gene names: 89053817

Gene position: 1290709-1291515 (Clockwise)

Preceding gene: 89053816

Following gene: 89053818

Centisome position: 29.89

GC content: 61.09

Gene sequence:

>807_bases
ATGAGCATGCGCACGGATGTGACGCACTTTATGTGCGAGATTGAAAACGGCATCGCGACGGTTGCGCTGGACCGACCCGA
CCGCAAGAACCCGCTGACATTCGATAGCTACGCCGAGTTGCGCGATTGGTTCCGGGATCTGCAATACGCTGATGATGTGA
GTGCCGTGGTGTTTGCGTCAAACGGTGGCAACTTCAGCTCGGGCGGGGACGTGCACGATATCATTGGGCCCCTGACCAGC
ATGTCGATGAAGGAGCTTCTGGCCTTCACGCGCATGACCGGCGATCTGGTCAAGGCGATGGTCAACTGCGGAAAGCCGGT
GATTGCGGCCATCGACGGCATTTGCGTTGGCGCAGGCGCGATCATCGCCATGGCCTCGGACCTGCGGATCGCGACGCCGG
ACGCCAAGGTGGCGTTCCTGTTCACCCGCGTGGGCCTTGCGGGCTGCGATATGGGGGCTTGCGCGATCCTTCCACGGATC
ATCGGACAGGGCCGCGCGGCAGAGTTGCTCTATACTGGCCGGTCGATGTCTGCCGACGAAGGTCATGCCTGGGGCTTCCA
CAACAAGCTGGCCTCCGCAGACAATCTGGCATCTGAGGCGCAGGCACTGGCCACCCGCATCGCGGCGGGGCCGACGTTTG
GCAACATGATGACGAAGACGATGCTGGCGCAGGAATGGTCAATGTCGATTGAACAGGCGATTGAGGCCGAGGCGCAGGCC
CAGGCGATCTGCATGCAAACGGCGGATTTTGAGCGGGCCTACAAGGCCTTTGTCGCCAAGGAAAAACCAGTGTTCGAGGG
CAATTGA

Upstream 100 bases:

>100_bases
CGTGGATCAGCGATATGCTCGGCGATTTCACCGCTGAGGAGGCGCGCGATATTCGATTGCGGCTGGAGCAACTTGAAGAC
AGTGCCAACGGAGACGAGAC

Downstream 100 bases:

>100_bases
TGGCAGACAAATCGTTCCTCAGCTGGCCGTTTTTTGAAGAGCGGCACCGTGATCTGGCAGGCGCGCTTGATGCTTGGGCG
ACGGCGGAGCTGGCCGGTAT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSMRTDVTHFMCEIENGIATVALDRPDRKNPLTFDSYAELRDWFRDLQYADDVSAVVFASNGGNFSSGGDVHDIIGPLTS
MSMKELLAFTRMTGDLVKAMVNCGKPVIAAIDGICVGAGAIIAMASDLRIATPDAKVAFLFTRVGLAGCDMGACAILPRI
IGQGRAAELLYTGRSMSADEGHAWGFHNKLASADNLASEAQALATRIAAGPTFGNMMTKTMLAQEWSMSIEQAIEAEAQA
QAICMQTADFERAYKAFVAKEKPVFEGN

Sequences:

>Translated_268_residues
MSMRTDVTHFMCEIENGIATVALDRPDRKNPLTFDSYAELRDWFRDLQYADDVSAVVFASNGGNFSSGGDVHDIIGPLTS
MSMKELLAFTRMTGDLVKAMVNCGKPVIAAIDGICVGAGAIIAMASDLRIATPDAKVAFLFTRVGLAGCDMGACAILPRI
IGQGRAAELLYTGRSMSADEGHAWGFHNKLASADNLASEAQALATRIAAGPTFGNMMTKTMLAQEWSMSIEQAIEAEAQA
QAICMQTADFERAYKAFVAKEKPVFEGN
>Mature_267_residues
SMRTDVTHFMCEIENGIATVALDRPDRKNPLTFDSYAELRDWFRDLQYADDVSAVVFASNGGNFSSGGDVHDIIGPLTSM
SMKELLAFTRMTGDLVKAMVNCGKPVIAAIDGICVGAGAIIAMASDLRIATPDAKVAFLFTRVGLAGCDMGACAILPRII
GQGRAAELLYTGRSMSADEGHAWGFHNKLASADNLASEAQALATRIAAGPTFGNMMTKTMLAQEWSMSIEQAIEAEAQAQ
AICMQTADFERAYKAFVAKEKPVFEGN

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=254, Percent_Identity=27.5590551181102, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI20127408, Length=186, Percent_Identity=27.4193548387097, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI68989263, Length=201, Percent_Identity=30.3482587064677, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI31542718, Length=254, Percent_Identity=25.9842519685039, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI194097323, Length=254, Percent_Identity=25.1968503937008, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI116235487, Length=138, Percent_Identity=31.8840579710145, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787660, Length=263, Percent_Identity=30.0380228136882, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790281, Length=196, Percent_Identity=25.5102040816327, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI221142681, Length=172, Percent_Identity=27.3255813953488, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788682, Length=212, Percent_Identity=28.7735849056604, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=22.5190839694656, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788597, Length=188, Percent_Identity=26.5957446808511, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=191, Percent_Identity=29.3193717277487, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=198, Percent_Identity=28.7878787878788, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=252, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=25.78125, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=262, Percent_Identity=23.2824427480916, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=25.9842519685039, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=247, Percent_Identity=25.1012145748988, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19920382, Length=259, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=27.5193798449612, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357171, Length=207, Percent_Identity=30.4347826086957, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24654903, Length=257, Percent_Identity=24.5136186770428, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129971, Length=252, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24653477, Length=252, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24650670, Length=202, Percent_Identity=27.2277227722772, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922422, Length=249, Percent_Identity=22.0883534136546, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28710; Mature: 28579

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMRTDVTHFMCEIENGIATVALDRPDRKNPLTFDSYAELRDWFRDLQYADDVSAVVFAS
CCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEC
NGGNFSSGGDVHDIIGPLTSMSMKELLAFTRMTGDLVKAMVNCGKPVIAAIDGICVGAGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCHH
IIAMASDLRIATPDAKVAFLFTRVGLAGCDMGACAILPRIIGQGRAAELLYTGRSMSADE
HHHHHCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GHAWGFHNKLASADNLASEAQALATRIAAGPTFGNMMTKTMLAQEWSMSIEQAIEAEAQA
CCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAICMQTADFERAYKAFVAKEKPVFEGN
HHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SMRTDVTHFMCEIENGIATVALDRPDRKNPLTFDSYAELRDWFRDLQYADDVSAVVFAS
CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEC
NGGNFSSGGDVHDIIGPLTSMSMKELLAFTRMTGDLVKAMVNCGKPVIAAIDGICVGAGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCHH
IIAMASDLRIATPDAKVAFLFTRVGLAGCDMGACAILPRIIGQGRAAELLYTGRSMSADE
HHHHHCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GHAWGFHNKLASADNLASEAQALATRIAAGPTFGNMMTKTMLAQEWSMSIEQAIEAEAQA
CCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAICMQTADFERAYKAFVAKEKPVFEGN
HHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]