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The map label for this gene is nuoH

Identifier: 89053676

GI number: 89053676

Start: 1147426

End: 1148466

Strand: Direct

Name: nuoH

Synonym: Jann_1185

Alternate gene names: 89053676

Gene position: 1147426-1148466 (Clockwise)

Preceding gene: 89053675

Following gene: 89053677

Centisome position: 26.57

GC content: 58.89

Gene sequence:

>1041_bases
ATGGTAGAATTTTTCACGCAGACGACGACTGGCGCAATCCTGCTGATCCTGTTGCAGTGTCTGCTTCTGGTTGTGCCGCT
TCTGGTCGCCCTGGCGTTCCTGATGTACGCCGACCGCAAGATCTGGGCCGCCGTGATGATGCGCAAGGGTCCCAACGTGG
TGGGCGCGTTTGGCTTGCTGCAAAGTTTCGCGGATTTCCTGAAGTATATCGTCAAGGAAATCGTGGTGCCTGCGGGGGCG
GACCGAGCGGTTTACTTTCTGGCACCCATCGTCAGCCTTGTCATGGCGTTGATCGCCTGGGCGGTCATTCCGTTCAACGA
TGGTTGGGTGTTGAGCAGCCTCAACGTCGCGGTTCTATACGTCTTCGCCGTGTCCTCGCTGGAGGTCTACGGCGTGATCA
TGGGTGGGTGGGCGTCGAACTCCAAATATCCGTTTCTGGGGTCGTTGCGCTCAGCCGCGCAGATGATTTCGTATGAGGTC
TCCATCGGTCTGATCATCATCGGGGTGATCATCTCCACCGGCTCGATGAATTTCACCGCAATCGTGCACGCGCAGGACGG
GGATCTTGGCCTGCTGAACTGGTACTTCCTGCCGCATTTCCCGATGTTGTTCCTGTTCTTCATCTCGGCGCTTGCCGAAA
CCAACCGCCCGCCGTTTGACCTGCCCGAGGCAGAGGCCGAACTGGTGGCGGGCTATCAGGTGGAATATTCGTCCACCCCG
TTCCTGCTCTTCATGATCGGCGAGCTTGTCGCCGTCGTCCTGATGTGTGCGCTGACCGTGCTGCTGTTCTTCGGCGGCTG
GCTGTCGCCCATCCCCGGCCTGCCCGATGGCGTGTTCTGGATGATCCTGAAAATGCTGGCGGTGTTCTTCATGTTCTCGA
TGGTGAAGGCGATTGTGCCTCGCTACCGCTATGACCAGCTGATGCGCCTGGGTTGGAAAGTCTTCCTGCCGTTCTCATTG
TTCTGGGTCGTGTTCGTGGCCTTTATGGCGCGCTACGAAGTGCTTGGCGGCTTCTGGGCCCGCTTTGCGGTGGGGGGCTG
A

Upstream 100 bases:

>100_bases
ATCTCGCCGGACCTCCCGCGTGGGTTGCAGACCCTGGAAGCGGAATCGGTGGCGGCCGATTGCGCAGAGCAAGGGATACC
GACGGTTTAAGGGACGCCCC

Downstream 100 bases:

>100_bases
TGCTGCGCTCGCTCATCATATTGGCTCTATTGAACGGTGGGGGTCCTGCTAGCGCTGAGGCGCCTGAATGGGGTGTGCCG
CAGCCGTCTCAACTGCAAGT

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVEFFTQTTTGAILLILLQCLLLVVPLLVALAFLMYADRKIWAAVMMRKGPNVVGAFGLLQSFADFLKYIVKEIVVPAGA
DRAVYFLAPIVSLVMALIAWAVIPFNDGWVLSSLNVAVLYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEV
SIGLIIIGVIISTGSMNFTAIVHAQDGDLGLLNWYFLPHFPMLFLFFISALAETNRPPFDLPEAEAELVAGYQVEYSSTP
FLLFMIGELVAVVLMCALTVLLFFGGWLSPIPGLPDGVFWMILKMLAVFFMFSMVKAIVPRYRYDQLMRLGWKVFLPFSL
FWVVFVAFMARYEVLGGFWARFAVGG

Sequences:

>Translated_346_residues
MVEFFTQTTTGAILLILLQCLLLVVPLLVALAFLMYADRKIWAAVMMRKGPNVVGAFGLLQSFADFLKYIVKEIVVPAGA
DRAVYFLAPIVSLVMALIAWAVIPFNDGWVLSSLNVAVLYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEV
SIGLIIIGVIISTGSMNFTAIVHAQDGDLGLLNWYFLPHFPMLFLFFISALAETNRPPFDLPEAEAELVAGYQVEYSSTP
FLLFMIGELVAVVLMCALTVLLFFGGWLSPIPGLPDGVFWMILKMLAVFFMFSMVKAIVPRYRYDQLMRLGWKVFLPFSL
FWVVFVAFMARYEVLGGFWARFAVGG
>Mature_346_residues
MVEFFTQTTTGAILLILLQCLLLVVPLLVALAFLMYADRKIWAAVMMRKGPNVVGAFGLLQSFADFLKYIVKEIVVPAGA
DRAVYFLAPIVSLVMALIAWAVIPFNDGWVLSSLNVAVLYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEV
SIGLIIIGVIISTGSMNFTAIVHAQDGDLGLLNWYFLPHFPMLFLFFISALAETNRPPFDLPEAEAELVAGYQVEYSSTP
FLLFMIGELVAVVLMCALTVLLFFGGWLSPIPGLPDGVFWMILKMLAVFFMFSMVKAIVPRYRYDQLMRLGWKVFLPFSL
FWVVFVAFMARYEVLGGFWARFAVGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=292, Percent_Identity=41.7808219178082, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1788618, Length=308, Percent_Identity=40.5844155844156, Blast_Score=237, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_JANSC (Q28T60)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509127.1
- STRING:   Q28T60
- GeneID:   3933629
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1185
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q28T60
- ProtClustDB:   PRK06076
- BioCyc:   JSP290400:JANN_1185-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38435; Mature: 38435

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdaf10a8)-; HASH(0xf323d6c)-; HASH(0xf2d33d8)-; HASH(0xf323c58)-; HASH(0xf2b9bd8)-; HASH(0xf433138)-; HASH(0xf44b03c)-; HASH(0xf445610)-; HASH(0xf2b9a64)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEFFTQTTTGAILLILLQCLLLVVPLLVALAFLMYADRKIWAAVMMRKGPNVVGAFGLL
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QSFADFLKYIVKEIVVPAGADRAVYFLAPIVSLVMALIAWAVIPFNDGWVLSSLNVAVLY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
VFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVSIGLIIIGVIISTGSMNFTA
HHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IVHAQDGDLGLLNWYFLPHFPMLFLFFISALAETNRPPFDLPEAEAELVAGYQVEYSSTP
EEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCEEEECCCCC
FLLFMIGELVAVVLMCALTVLLFFGGWLSPIPGLPDGVFWMILKMLAVFFMFSMVKAIVP
HHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
RYRYDQLMRLGWKVFLPFSLFWVVFVAFMARYEVLGGFWARFAVGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MVEFFTQTTTGAILLILLQCLLLVVPLLVALAFLMYADRKIWAAVMMRKGPNVVGAFGLL
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QSFADFLKYIVKEIVVPAGADRAVYFLAPIVSLVMALIAWAVIPFNDGWVLSSLNVAVLY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
VFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVSIGLIIIGVIISTGSMNFTA
HHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IVHAQDGDLGLLNWYFLPHFPMLFLFFISALAETNRPPFDLPEAEAELVAGYQVEYSSTP
EEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCEEEECCCCC
FLLFMIGELVAVVLMCALTVLLFFGGWLSPIPGLPDGVFWMILKMLAVFFMFSMVKAIVP
HHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
RYRYDQLMRLGWKVFLPFSLFWVVFVAFMARYEVLGGFWARFAVGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA