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The map label for this gene is nqo1 [H]

Identifier: 89053670

GI number: 89053670

Start: 1142000

End: 1143295

Strand: Direct

Name: nqo1 [H]

Synonym: Jann_1179

Alternate gene names: 89053670

Gene position: 1142000-1143295 (Clockwise)

Preceding gene: 89053669

Following gene: 89053671

Centisome position: 26.45

GC content: 63.12

Gene sequence:

>1296_bases
ATGTTGCAGGACAAAGACCGGATCTTCACCAATATCTACGGCATGCACGACCGGTCCCTGGCCGGTGCCAAGCAGCGTGG
CCATTGGGATGGGACGAAGGATCTGATCGGTCTGGGCCGCGACAAGATCGTGGAGATCATGAAGGCGTCCGGCCTGCGTG
GGCGCGGCGGGGCGGGCTTCCCGACCGGTCTGAAATGGTCGTTCATGCCCAAGGAATCGGACGGCCGCCCGGCTTACCTG
GTGGTGAACGCGGACGAGAGCGAGCCCGGGACCTGCAAGGACCGGGAGATCATGCGCAATGATCCCCACACGCTGATCGA
GGGCTGCCTGATCGCCAGCTTCGCGATGAACGCCAACGCCTGCTACATCTACATCCGTGGCGAATATATCCGCGAGCGGG
AGGCGCTTCAGGCCGCGATTGACGAGGCTTATGAAGACGGGCTTCTGGGCAAGGACGCGGCGAAATCCGGCTGGGATTTT
GATCTTTATCTGGCCCACGGCGCCGGCGCGTATATTTGCGGCGAGGAAACCGCGCTTCTGGAATCGCTGGAAGGCCGCAA
GGGCATGCCCCGCATGAAGCCGCCCTTCCCGGCGGGCGCGGGCCTGTATGGCTGCCCCACCACGGTCAACAATGTCGAAT
CCATCGCCGTCGTGCCCACGATCCTGCGGCGCGGCGCGGAGTGGTTCGCGGGCTTCGGTCGCCCCAACAATGCGGGTACG
AAGCTGTTCGCGATCAGCGGTCATGTGAACCAGCCCTGCGTCGTGGAAGAGGCGATGAGCATTTCCTTCGAGGAGCTGAT
CGAGACCCATTGCGGCGGCATCCGTGGCGGGTGGGACAACCTCAAGGCGGTGATCCCCGGCGGGTCCTCCGTCCCATGCG
TGCGCGGCGAAAACATGCGCGACGCGATCATGGATTTCGACTATCTGCGCAACGATTTGCAGTCGGGCCTTGGCACGGCG
GCGGTCATCGTGATGGATAATTCCACCGACATGATCAAGGCAATCTGGCGGCTCGCGGCCTTCTACAAGCACGAATCCTG
CGGCCAATGCACGCCGTGTCGCGAAGGCACCGGCTGGATGATGCGGGTGATGGAACGGCTGGTGAAGGGTGAGGCGCAGG
TTGAAGAGATTGACATGCTGTTTGACGTCACCAAGCAGGTGGAAGGTCACACGATCTGCGCGCTCGGCGACGCGGCGGCC
TGGCCGATCCAGGGCCTGATCCGCAACTTCCGCGACGAGATCGAAGACCGCATCCGTGTCAAACGCGGTGGCACGGTGGA
GATCGCGGCAGAATAG

Upstream 100 bases:

>100_bases
CGACCTTGCGGCGTTTGCGGCACTGGTATGGGCGCTCGTCGTGACGTATTGGGTGTGGAGAGAGCGCAAGCGCACGCGCG
ACGACCAGGGATAAGACGCC

Downstream 100 bases:

>100_bases
GCGCGGCCCCGCCCTCCGACCAGCGGGCGGCACGTCCTCGCCACAAATGATCCGCGCAGATATGGGGTCTTCAGACCGGC
GCGGGCCATGCTAGCTTGTC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 1; NDH-1, chain 1 [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLQDKDRIFTNIYGMHDRSLAGAKQRGHWDGTKDLIGLGRDKIVEIMKASGLRGRGGAGFPTGLKWSFMPKESDGRPAYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMNANACYIYIRGEYIREREALQAAIDEAYEDGLLGKDAAKSGWDF
DLYLAHGAGAYICGEETALLESLEGRKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRPNNAGT
KLFAISGHVNQPCVVEEAMSISFEELIETHCGGIRGGWDNLKAVIPGGSSVPCVRGENMRDAIMDFDYLRNDLQSGLGTA
AVIVMDNSTDMIKAIWRLAAFYKHESCGQCTPCREGTGWMMRVMERLVKGEAQVEEIDMLFDVTKQVEGHTICALGDAAA
WPIQGLIRNFRDEIEDRIRVKRGGTVEIAAE

Sequences:

>Translated_431_residues
MLQDKDRIFTNIYGMHDRSLAGAKQRGHWDGTKDLIGLGRDKIVEIMKASGLRGRGGAGFPTGLKWSFMPKESDGRPAYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMNANACYIYIRGEYIREREALQAAIDEAYEDGLLGKDAAKSGWDF
DLYLAHGAGAYICGEETALLESLEGRKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRPNNAGT
KLFAISGHVNQPCVVEEAMSISFEELIETHCGGIRGGWDNLKAVIPGGSSVPCVRGENMRDAIMDFDYLRNDLQSGLGTA
AVIVMDNSTDMIKAIWRLAAFYKHESCGQCTPCREGTGWMMRVMERLVKGEAQVEEIDMLFDVTKQVEGHTICALGDAAA
WPIQGLIRNFRDEIEDRIRVKRGGTVEIAAE
>Mature_431_residues
MLQDKDRIFTNIYGMHDRSLAGAKQRGHWDGTKDLIGLGRDKIVEIMKASGLRGRGGAGFPTGLKWSFMPKESDGRPAYL
VVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMNANACYIYIRGEYIREREALQAAIDEAYEDGLLGKDAAKSGWDF
DLYLAHGAGAYICGEETALLESLEGRKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRPNNAGT
KLFAISGHVNQPCVVEEAMSISFEELIETHCGGIRGGWDNLKAVIPGGSSVPCVRGENMRDAIMDFDYLRNDLQSGLGTA
AVIVMDNSTDMIKAIWRLAAFYKHESCGQCTPCREGTGWMMRVMERLVKGEAQVEEIDMLFDVTKQVEGHTICALGDAAA
WPIQGLIRNFRDEIEDRIRVKRGGTVEIAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=418, Percent_Identity=66.2679425837321, Blast_Score=583, Evalue=1e-166,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=66.2679425837321, Blast_Score=583, Evalue=1e-166,
Organism=Escherichia coli, GI1788620, Length=396, Percent_Identity=44.9494949494949, Blast_Score=330, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=417, Percent_Identity=65.2278177458034, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI19920794, Length=419, Percent_Identity=67.3031026252983, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI45550452, Length=430, Percent_Identity=64.8837209302326, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24653819, Length=419, Percent_Identity=46.3007159904535, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24653817, Length=419, Percent_Identity=42.9594272076372, Blast_Score=337, Evalue=9e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47285; Mature: 47285

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNIYGMHDRSLAGAKQRGHWDGTKDLIGLGRDKIVEIMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCHHCCCHHCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESDGRPAYLVVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMNANA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCE
CYIYIRGEYIREREALQAAIDEAYEDGLLGKDAAKSGWDFDLYLAHGAGAYICGEETALL
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGRKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRPNNAGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCC
KLFAISGHVNQPCVVEEAMSISFEELIETHCGGIRGGWDNLKAVIPGGSSVPCVRGENMR
EEEEEECCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCHH
DAIMDFDYLRNDLQSGLGTAAVIVMDNSTDMIKAIWRLAAFYKHESCGQCTPCREGTGWM
HHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
MRVMERLVKGEAQVEEIDMLFDVTKQVEGHTICALGDAAAWPIQGLIRNFRDEIEDRIRV
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEE
KRGGTVEIAAE
CCCCEEEEEEC
>Mature Secondary Structure
MLQDKDRIFTNIYGMHDRSLAGAKQRGHWDGTKDLIGLGRDKIVEIMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCCHHCCCHHCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESDGRPAYLVVNADESEPGTCKDREIMRNDPHTLIEGCLIASFAMNANA
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCE
CYIYIRGEYIREREALQAAIDEAYEDGLLGKDAAKSGWDFDLYLAHGAGAYICGEETALL
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGRKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRPNNAGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCC
KLFAISGHVNQPCVVEEAMSISFEELIETHCGGIRGGWDNLKAVIPGGSSVPCVRGENMR
EEEEEECCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCHH
DAIMDFDYLRNDLQSGLGTAAVIVMDNSTDMIKAIWRLAAFYKHESCGQCTPCREGTGWM
HHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
MRVMERLVKGEAQVEEIDMLFDVTKQVEGHTICALGDAAAWPIQGLIRNFRDEIEDRIRV
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEE
KRGGTVEIAAE
CCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1905152; 1909571; 1605643 [H]