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The map label for this gene is nuoD

Identifier: 89053664

GI number: 89053664

Start: 1136567

End: 1137805

Strand: Direct

Name: nuoD

Synonym: Jann_1173

Alternate gene names: 89053664

Gene position: 1136567-1137805 (Clockwise)

Preceding gene: 89053663

Following gene: 89053665

Centisome position: 26.32

GC content: 61.42

Gene sequence:

>1239_bases
ATGATGGACGGCGATATCCGGGTGAATACGTATGACGACGGCTCCACCGATTTCCAGACCGGCGAGCAGAAGATCCGCAA
CTTCAACCTGAACTTCGGGCCGCAGCATCCGGCGGCCCATGGTGTGTTGCGGCTGGTGCTGGAGCTGGACGGAGAGATCT
GCGAGCGCTGTGATCCGCATATCGGGCTGCTGCACCGGGGCACCGAAAAGCTCATGGAGAGCCGGACGTATCTACAGAAC
CTGCCGTATTTCGACCGGCTGGATTATGTGGGCACGATGAACCAGGAGCATGCCTGGTGTCTGGCGATCGAGCGGATGAC
GGGCACGGACGTGCCGCGCCGCGCGCAGCTGATCCGGGTCTTGTATTGCGAGATTGGGCGGATCCTGAACCACCTGCTGA
ACGTCACGACGCAGGCGCTGGATGTGGGCGCGCTGACCCCGCCGCTTTGGGGGTTCGAGGAGCGTGAGAAGCTGATGATC
TTCTACGAGCGGGCCTCTGGCGCGCGTCTGCACGCGGCCTATTTCCGGCCCGGCGGGGTGCACCAAGACCTGCCGCCGGA
GTTGATCGAAGATATCGACACATGGGCCCATGAATTCCCGCAGATGCTGGACGATATCGATGGGCTGTTGAGCGAGAACC
GCATCTTCAAGCAGCGCAACGTCGATATCGGCGTGGTCACGGAAGAAGATATTCAGAACTGGGGCTTTTCCGGCGTGATG
GTGCGCGGATCGGGCTTCGCCTGGGATCTGCGGCGCGCGCAACCCTATGAATGCTATGACGAATTCGAGTTCCAGATCCC
CGTGGGCAAGAATGGCGATTGCTATGACCGCTACCTCTGCCGGATGGCGGAGATGCGCGAATCGACGAAGATCATCCATC
AGGCCTGCGAGAAACTGCGCAATGAGCCCGGTGAGATCATGTCGCGCGGCAAGATGAGCCCGCCGTCGCGGGGGGACATG
AAGACGTCGATGGAAGCGCTGATCCATCACTTCAAGCTCTACACTGAAGGCTTCCACGTGCCCGAGGGTGAGATCTACGC
CTGCGTCGAGGCGCCCAAGGGCGAGTTCGGCGTGTTCCTTGTGGCCGACGGCACCAACAAGCCCTACCGCGCGAAACTGC
GCGCGCCGGGCTTCGCGCATCTGCAGGCGATGGATTACCTGTGCAAAGGGCACCAACTGGCGGATGTGTCGGCGGTGCTG
GGGTCTTTGGACATCGTTTTCGGGGAAGTGGACCGCTAA

Upstream 100 bases:

>100_bases
TCATTGATGCGAAGCCTGCGAACTACACCTTGGCCAACGAGACCAAGGTCATGACACGGGCAGAGGTCTTTGCGATGTTT
GCGACACTGGAGGACGGAGT

Downstream 100 bases:

>100_bases
ACGCCGGGCCAGGCAGCGAGATTTGGGGCAGGGGACCGGTGGGTTGCCTGCCCTTTTTCGTGGGCGGTGGCGTGGTAGGG
TCTGGCCGACCACAATCCAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MMDGDIRVNTYDDGSTDFQTGEQKIRNFNLNFGPQHPAAHGVLRLVLELDGEICERCDPHIGLLHRGTEKLMESRTYLQN
LPYFDRLDYVGTMNQEHAWCLAIERMTGTDVPRRAQLIRVLYCEIGRILNHLLNVTTQALDVGALTPPLWGFEEREKLMI
FYERASGARLHAAYFRPGGVHQDLPPELIEDIDTWAHEFPQMLDDIDGLLSENRIFKQRNVDIGVVTEEDIQNWGFSGVM
VRGSGFAWDLRRAQPYECYDEFEFQIPVGKNGDCYDRYLCRMAEMRESTKIIHQACEKLRNEPGEIMSRGKMSPPSRGDM
KTSMEALIHHFKLYTEGFHVPEGEIYACVEAPKGEFGVFLVADGTNKPYRAKLRAPGFAHLQAMDYLCKGHQLADVSAVL
GSLDIVFGEVDR

Sequences:

>Translated_412_residues
MMDGDIRVNTYDDGSTDFQTGEQKIRNFNLNFGPQHPAAHGVLRLVLELDGEICERCDPHIGLLHRGTEKLMESRTYLQN
LPYFDRLDYVGTMNQEHAWCLAIERMTGTDVPRRAQLIRVLYCEIGRILNHLLNVTTQALDVGALTPPLWGFEEREKLMI
FYERASGARLHAAYFRPGGVHQDLPPELIEDIDTWAHEFPQMLDDIDGLLSENRIFKQRNVDIGVVTEEDIQNWGFSGVM
VRGSGFAWDLRRAQPYECYDEFEFQIPVGKNGDCYDRYLCRMAEMRESTKIIHQACEKLRNEPGEIMSRGKMSPPSRGDM
KTSMEALIHHFKLYTEGFHVPEGEIYACVEAPKGEFGVFLVADGTNKPYRAKLRAPGFAHLQAMDYLCKGHQLADVSAVL
GSLDIVFGEVDR
>Mature_412_residues
MMDGDIRVNTYDDGSTDFQTGEQKIRNFNLNFGPQHPAAHGVLRLVLELDGEICERCDPHIGLLHRGTEKLMESRTYLQN
LPYFDRLDYVGTMNQEHAWCLAIERMTGTDVPRRAQLIRVLYCEIGRILNHLLNVTTQALDVGALTPPLWGFEEREKLMI
FYERASGARLHAAYFRPGGVHQDLPPELIEDIDTWAHEFPQMLDDIDGLLSENRIFKQRNVDIGVVTEEDIQNWGFSGVM
VRGSGFAWDLRRAQPYECYDEFEFQIPVGKNGDCYDRYLCRMAEMRESTKIIHQACEKLRNEPGEIMSRGKMSPPSRGDM
KTSMEALIHHFKLYTEGFHVPEGEIYACVEAPKGEFGVFLVADGTNKPYRAKLRAPGFAHLQAMDYLCKGHQLADVSAVL
GSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=389, Percent_Identity=63.2390745501285, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI260898743, Length=383, Percent_Identity=62.402088772846, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=36.9509043927649, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1789076, Length=405, Percent_Identity=24.9382716049383, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788832, Length=382, Percent_Identity=25.130890052356, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17568379, Length=392, Percent_Identity=59.4387755102041, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=60.2040816326531, Blast_Score=496, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=60.969387755102, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221459469, Length=392, Percent_Identity=54.0816326530612, Blast_Score=453, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_JANSC (Q28T72)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509115.1
- ProteinModelPortal:   Q28T72
- SMR:   Q28T72
- STRING:   Q28T72
- GeneID:   3933617
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1173
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   IFYERAC
- PhylomeDB:   Q28T72
- ProtClustDB:   PRK06075
- BioCyc:   JSP290400:JANN_1173-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 46983; Mature: 46983

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00535 COMPLEX1_49K; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDGDIRVNTYDDGSTDFQTGEQKIRNFNLNFGPQHPAAHGVLRLVLELDGEICERCDPH
CCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCC
IGLLHRGTEKLMESRTYLQNLPYFDRLDYVGTMNQEHAWCLAIERMTGTDVPRRAQLIRV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHH
LYCEIGRILNHLLNVTTQALDVGALTPPLWGFEEREKLMIFYERASGARLHAAYFRPGGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCC
HQDLPPELIEDIDTWAHEFPQMLDDIDGLLSENRIFKQRNVDIGVVTEEDIQNWGFSGVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEHHHHHHCCCCEEE
VRGSGFAWDLRRAQPYECYDEFEFQIPVGKNGDCYDRYLCRMAEMRESTKIIHQACEKLR
EECCCCEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEPGEIMSRGKMSPPSRGDMKTSMEALIHHFKLYTEGFHVPEGEIYACVEAPKGEFGVFL
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEE
VADGTNKPYRAKLRAPGFAHLQAMDYLCKGHQLADVSAVLGSLDIVFGEVDR
EECCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure
MMDGDIRVNTYDDGSTDFQTGEQKIRNFNLNFGPQHPAAHGVLRLVLELDGEICERCDPH
CCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCC
IGLLHRGTEKLMESRTYLQNLPYFDRLDYVGTMNQEHAWCLAIERMTGTDVPRRAQLIRV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHH
LYCEIGRILNHLLNVTTQALDVGALTPPLWGFEEREKLMIFYERASGARLHAAYFRPGGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCC
HQDLPPELIEDIDTWAHEFPQMLDDIDGLLSENRIFKQRNVDIGVVTEEDIQNWGFSGVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEHHHHHHCCCCEEE
VRGSGFAWDLRRAQPYECYDEFEFQIPVGKNGDCYDRYLCRMAEMRESTKIIHQACEKLR
EECCCCEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEPGEIMSRGKMSPPSRGDMKTSMEALIHHFKLYTEGFHVPEGEIYACVEAPKGEFGVFL
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEE
VADGTNKPYRAKLRAPGFAHLQAMDYLCKGHQLADVSAVLGSLDIVFGEVDR
EECCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA