Click here to switch to the map view.

The map label for this gene is mvaB [H]

Identifier: 89053640

GI number: 89053640

Start: 1110991

End: 1111845

Strand: Direct

Name: mvaB [H]

Synonym: Jann_1149

Alternate gene names: 89053640

Gene position: 1110991-1111845 (Clockwise)

Preceding gene: 89053639

Following gene: 89053641

Centisome position: 25.73

GC content: 68.19

Gene sequence:

>855_bases
ATGACTGAATGGGTGGACATCTTCGAGGTTGGTCCCCGCGATGGCCTGCAGAACGAGGCGCGGCTGATCCCGACGGACGA
CAAGATCGCGCTGATTAACCTGCTCTCGCGCGCCGGATTCCGGCGGATCGAGGTGGCGTCCTTCGTCTCACCCAAATGGG
TGCCGCAGATGGCGGATGGGGCCGACGTTCTGGCCGGGATCACGCGGGCGCCGGGTGTCAGCTACGCGGCCCTGACGCCG
AATATGCGCGGCTATGACGGCGCTCTCGGGGCCAAGGCCGATGAGATCGCGATTTTCGCCAGCGCCTCGGAAGGGTTCTC
CAAGGCCAACCTCAACGCCACGATTGCCGAGAGCCTTGTTCGGTTCGCCGATGTGGCGCAGGCCGCCAGGGCGGCGGGTG
TGCCGATGCGGGGCTATGTCTCCTGCGTCACGCAATGCCCGTTTGACGGAGAAACCCCGCCTGAGAATGTCGCCCGTGTG
GCCGCCGCCCTGCGCGACATGGGGGCCTATGAAATATCGCTCGGCGACACCCTAGGGCGGGCCTACCCCGCGCAGGTCGA
TGCGATGCTGGCGGCGGTGTTGCCGGAGGTGCCGGCGGGCAGGCTTGCGGGACATTTCCACGACACATCCGGGCGCGCGC
TGGACAATGTGGACGCGGCGCTGGCGCGGGGATTGCGCGTGTTCGACGGTGCCGTGGGCGGCCTTGGGGGCTGCCCCTAT
GCGCCCGGCGCCAAGGGCAATGTGGCGACGGAGGCGTTGGACGCGCATCTGCGCCGACGCGGGTTCGAGACGGGTCTGGA
TGCCGATGTGCTGGCCCGGGCCGGGGCTTTGGCGCGCGGTTTGCGGAAGGAATGA

Upstream 100 bases:

>100_bases
TATTGGGCGCGGTTGACGGCGCGGCCCGGGTTTCAGGCGGCGGCTGCGCTGGAAGGCCCGCAGACATTCTATGCGAAGGA
CTTCTACGAGGTGCCGGTCG

Downstream 100 bases:

>100_bases
CGATGGACACTTTGGATGTAACGGTGGACGCGCGCGGGGTGGCCACTCTGACGCTGAACCGGGTGGACGTGCACAACGCC
ATGAACGCCGCGATGATCGC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVASFVSPKWVPQMADGADVLAGITRAPGVSYAALTP
NMRGYDGALGAKADEIAIFASASEGFSKANLNATIAESLVRFADVAQAARAAGVPMRGYVSCVTQCPFDGETPPENVARV
AAALRDMGAYEISLGDTLGRAYPAQVDAMLAAVLPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLGGCPY
APGAKGNVATEALDAHLRRRGFETGLDADVLARAGALARGLRKE

Sequences:

>Translated_284_residues
MTEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVASFVSPKWVPQMADGADVLAGITRAPGVSYAALTP
NMRGYDGALGAKADEIAIFASASEGFSKANLNATIAESLVRFADVAQAARAAGVPMRGYVSCVTQCPFDGETPPENVARV
AAALRDMGAYEISLGDTLGRAYPAQVDAMLAAVLPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLGGCPY
APGAKGNVATEALDAHLRRRGFETGLDADVLARAGALARGLRKE
>Mature_283_residues
TEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVASFVSPKWVPQMADGADVLAGITRAPGVSYAALTPN
MRGYDGALGAKADEIAIFASASEGFSKANLNATIAESLVRFADVAQAARAAGVPMRGYVSCVTQCPFDGETPPENVARVA
AALRDMGAYEISLGDTLGRAYPAQVDAMLAAVLPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLGGCPYA
PGAKGNVATEALDAHLRRRGFETGLDADVLARAGALARGLRKE

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=275, Percent_Identity=52, Blast_Score=297, Evalue=8e-81,
Organism=Homo sapiens, GI109150427, Length=275, Percent_Identity=52, Blast_Score=297, Evalue=9e-81,
Organism=Homo sapiens, GI62198232, Length=271, Percent_Identity=51.6605166051661, Blast_Score=287, Evalue=6e-78,
Organism=Homo sapiens, GI260654708, Length=273, Percent_Identity=36.2637362637363, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17510563, Length=264, Percent_Identity=48.4848484848485, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24582381, Length=271, Percent_Identity=52.7675276752767, Blast_Score=282, Evalue=1e-76,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 29620; Mature: 29489

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVASFVSPKWVPQMADG
CCCCEEHEECCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCC
ADVLAGITRAPGVSYAALTPNMRGYDGALGAKADEIAIFASASEGFSKANLNATIAESLV
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
RFADVAQAARAAGVPMRGYVSCVTQCPFDGETPPENVARVAAALRDMGAYEISLGDTLGR
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHCC
AYPAQVDAMLAAVLPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLGGCPY
CCHHHHHHHHHHHHCCCCCCHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
APGAKGNVATEALDAHLRRRGFETGLDADVLARAGALARGLRKE
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVASFVSPKWVPQMADG
CCCEEHEECCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCC
ADVLAGITRAPGVSYAALTPNMRGYDGALGAKADEIAIFASASEGFSKANLNATIAESLV
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
RFADVAQAARAAGVPMRGYVSCVTQCPFDGETPPENVARVAAALRDMGAYEISLGDTLGR
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHCC
AYPAQVDAMLAAVLPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLGGCPY
CCHHHHHHHHHHHHCCCCCCHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
APGAKGNVATEALDAHLRRRGFETGLDADVLARAGALARGLRKE
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]