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The map label for this gene is acdA [H]

Identifier: 89053633

GI number: 89053633

Start: 1103262

End: 1104422

Strand: Direct

Name: acdA [H]

Synonym: Jann_1142

Alternate gene names: 89053633

Gene position: 1103262-1104422 (Clockwise)

Preceding gene: 89053632

Following gene: 89053634

Centisome position: 25.55

GC content: 61.76

Gene sequence:

>1161_bases
ATGTTCCTTGGGGCGATGAATTTCGATTTGGGCGAAGATGTCACCGCCCTGCGCGACATGGTGCATTCCTGGGCGCAGGA
GCGGGTGAAGCCGCTGGCCGCCAAGACCGATGCCGACAACGCCTTTCCCAATGAATTATGGGCCGAGATGGGGGAGTTGG
GACTGCTGGGCATCACCGTCGACGAAGAGCATGGCGGCGCGGGGATGGGGTATCTGGCGCACACCGTCGCGGTGGAAGAG
ATCAGCCGCGTCTCGGCCTCCATCGGGTTGTCCTACGGGGCGCATTCCAACCTCTGCGTCAATCAGATCAAGCTGAATGG
CACACCCGAGCAGAAAGCGAAATACCTGCCCCGGCTGGTGAGCGGAGACCATGTGGGCGCGCTGGCGATGTCGGAGGCAG
GCGCGGGATCGGACGTCGTGTCGATGTCCCTGCGCGCCGAGAAACGCAATGACCGCTACTTGCTGAACGGCACGAAATAC
TGGATCACCAACGGCCCGGACGCGGACACGCTGGTGGTCTATGCCAAGACGGACCCGGATGCGGGCTCGCGCGGGATCAC
GGCCTTTCTTATAGAAAAAGAGATGCATGGCTTCAGCACCTCTCCGCATTTCGACAAGATGGGGATGCGCGGGTCCAACA
CGGCGGAGTTGGTCTTCGAGGATGTCGAGGTCCCGTTCGAGAATGTGCTGGGCGAGGAAGGACGGGGTGTTGCCGTCCTG
ATGAGCGGGCTGGATTATGAGCGGGTGGTGCTGTCAGGGGTGAATATCGGGATCATGGCGGGCTGTCTGGACGAGGTCAT
GCCCTACCTGAAAGAGCGCAAACAATTTGGCCAGCCGATTGGGGACTTCCAGCTGATGCAGGGCAAGATCGCGGATATGT
ATACCAGCATGAATTCCGCGCGCGCCTACGCCTATGAGGTCGCCAAGGCCTGCGATCGGGGGCAGGTGACGCGGCAGGAT
GCGGCGGCCTGTGTCTTGTATGCGTCCGAAGAGGGGATGAAGGTGGCCCACCAGGCCGTGCAGGCGATGGGTGGGGCCGG
GTTCATGAACGACAGCGTGGTGTCGCGCATGTTCCGCGATGCCAAGCTGATGGAAATCGGGGCCGGCACCTCTGAAATCC
GGCGGATGCTGGTCGGGCGCGAATTGATGGGGATGATGTGA

Upstream 100 bases:

>100_bases
GATGGGTGCGGACCAGGGCGCGCAGAGATAGGATTGGCTTTGACTCGGTGCACCTCTTGGGATTAAATGAACAAGTGTTC
AATTAAAGGGAGTGGCGCAG

Downstream 100 bases:

>100_bases
GGTTTGGCTGAGGTCGGATTGCGTTCTCCTGGCAAGATGAACGGGGGGCTGTGTGTCAGTGTCCGTTGGCGGTGGGCGGC
GCTGAGATGATGCGCCAGAT

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MFLGAMNFDLGEDVTALRDMVHSWAQERVKPLAAKTDADNAFPNELWAEMGELGLLGITVDEEHGGAGMGYLAHTVAVEE
ISRVSASIGLSYGAHSNLCVNQIKLNGTPEQKAKYLPRLVSGDHVGALAMSEAGAGSDVVSMSLRAEKRNDRYLLNGTKY
WITNGPDADTLVVYAKTDPDAGSRGITAFLIEKEMHGFSTSPHFDKMGMRGSNTAELVFEDVEVPFENVLGEEGRGVAVL
MSGLDYERVVLSGVNIGIMAGCLDEVMPYLKERKQFGQPIGDFQLMQGKIADMYTSMNSARAYAYEVAKACDRGQVTRQD
AAACVLYASEEGMKVAHQAVQAMGGAGFMNDSVVSRMFRDAKLMEIGAGTSEIRRMLVGRELMGMM

Sequences:

>Translated_386_residues
MFLGAMNFDLGEDVTALRDMVHSWAQERVKPLAAKTDADNAFPNELWAEMGELGLLGITVDEEHGGAGMGYLAHTVAVEE
ISRVSASIGLSYGAHSNLCVNQIKLNGTPEQKAKYLPRLVSGDHVGALAMSEAGAGSDVVSMSLRAEKRNDRYLLNGTKY
WITNGPDADTLVVYAKTDPDAGSRGITAFLIEKEMHGFSTSPHFDKMGMRGSNTAELVFEDVEVPFENVLGEEGRGVAVL
MSGLDYERVVLSGVNIGIMAGCLDEVMPYLKERKQFGQPIGDFQLMQGKIADMYTSMNSARAYAYEVAKACDRGQVTRQD
AAACVLYASEEGMKVAHQAVQAMGGAGFMNDSVVSRMFRDAKLMEIGAGTSEIRRMLVGRELMGMM
>Mature_386_residues
MFLGAMNFDLGEDVTALRDMVHSWAQERVKPLAAKTDADNAFPNELWAEMGELGLLGITVDEEHGGAGMGYLAHTVAVEE
ISRVSASIGLSYGAHSNLCVNQIKLNGTPEQKAKYLPRLVSGDHVGALAMSEAGAGSDVVSMSLRAEKRNDRYLLNGTKY
WITNGPDADTLVVYAKTDPDAGSRGITAFLIEKEMHGFSTSPHFDKMGMRGSNTAELVFEDVEVPFENVLGEEGRGVAVL
MSGLDYERVVLSGVNIGIMAGCLDEVMPYLKERKQFGQPIGDFQLMQGKIADMYTSMNSARAYAYEVAKACDRGQVTRQD
AAACVLYASEEGMKVAHQAVQAMGGAGFMNDSVVSRMFRDAKLMEIGAGTSEIRRMLVGRELMGMM

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=57.0666666666667, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=56.4864864864865, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=38.1962864721485, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=35.2459016393443, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI76496475, Length=411, Percent_Identity=35.2798053527981, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4557235, Length=411, Percent_Identity=35.2798053527981, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=35.9773371104816, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=33.6021505376344, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=33.245382585752, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=33.245382585752, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=29.8941798941799, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4503943, Length=382, Percent_Identity=31.6753926701571, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI7669494, Length=353, Percent_Identity=32.5779036827195, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI48976061, Length=282, Percent_Identity=26.9503546099291, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI211971008, Length=282, Percent_Identity=26.9503546099291, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=21.9858156028369, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=28.2722513089005, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=28.5714285714286, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=24.9097472924188, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081702, Length=350, Percent_Identity=24, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=55.9681697612732, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=35.0404312668464, Blast_Score=247, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=32.3450134770889, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=34.5549738219895, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=34.1207349081365, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=39.9280575539568, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=32.8083989501312, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=32.7635327635328, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=36.1313868613139, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=30.4232804232804, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.5281385281385, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=351, Percent_Identity=31.6239316239316, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=30.1630434782609, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=295, Percent_Identity=33.2203389830508, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=28.042328042328, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=29.1845493562232, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI86563383, Length=329, Percent_Identity=25.531914893617, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=329, Percent_Identity=25.531914893617, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17531913, Length=170, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=53.8057742782152, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=37.9679144385027, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=35.3099730458221, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=35.5614973262032, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI281363737, Length=359, Percent_Identity=35.933147632312, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=34.8284960422164, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=28.4210526315789, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24652780, Length=321, Percent_Identity=23.3644859813084, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41800; Mature: 41800

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLGAMNFDLGEDVTALRDMVHSWAQERVKPLAAKTDADNAFPNELWAEMGELGLLGITV
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEE
DEEHGGAGMGYLAHTVAVEEISRVSASIGLSYGAHSNLCVNQIKLNGTPEQKAKYLPRLV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
SGDHVGALAMSEAGAGSDVVSMSLRAEKRNDRYLLNGTKYWITNGPDADTLVVYAKTDPD
CCCCCCEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEEECCCC
AGSRGITAFLIEKEMHGFSTSPHFDKMGMRGSNTAELVFEDVEVPFENVLGEEGRGVAVL
CCCCCCEEEEEEHHHCCCCCCCCHHHCCCCCCCHHHEEEECCCCCHHHHCCCCCCCEEEE
MSGLDYERVVLSGVNIGIMAGCLDEVMPYLKERKQFGQPIGDFQLMQGKIADMYTSMNSA
ECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYAYEVAKACDRGQVTRQDAAACVLYASEEGMKVAHQAVQAMGGAGFMNDSVVSRMFRD
HHHHHHHHHHHCCCCCCHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHC
AKLMEIGAGTSEIRRMLVGRELMGMM
CHHEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLGAMNFDLGEDVTALRDMVHSWAQERVKPLAAKTDADNAFPNELWAEMGELGLLGITV
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEE
DEEHGGAGMGYLAHTVAVEEISRVSASIGLSYGAHSNLCVNQIKLNGTPEQKAKYLPRLV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
SGDHVGALAMSEAGAGSDVVSMSLRAEKRNDRYLLNGTKYWITNGPDADTLVVYAKTDPD
CCCCCCEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEEECCCC
AGSRGITAFLIEKEMHGFSTSPHFDKMGMRGSNTAELVFEDVEVPFENVLGEEGRGVAVL
CCCCCCEEEEEEHHHCCCCCCCCHHHCCCCCCCHHHEEEECCCCCHHHHCCCCCCCEEEE
MSGLDYERVVLSGVNIGIMAGCLDEVMPYLKERKQFGQPIGDFQLMQGKIADMYTSMNSA
ECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYAYEVAKACDRGQVTRQDAAACVLYASEEGMKVAHQAVQAMGGAGFMNDSVVSRMFRD
HHHHHHHHHHHCCCCCCHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHC
AKLMEIGAGTSEIRRMLVGRELMGMM
CHHEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]