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The map label for this gene is hisD2 [H]

Identifier: 89053595

GI number: 89053595

Start: 1064469

End: 1065794

Strand: Direct

Name: hisD2 [H]

Synonym: Jann_1104

Alternate gene names: 89053595

Gene position: 1064469-1065794 (Clockwise)

Preceding gene: 89053594

Following gene: 89053596

Centisome position: 24.65

GC content: 63.65

Gene sequence:

>1326_bases
ATGGCCGAGTATCTGAAACGGGGCAAACCAGCCGATGAACGTGCGGAAGATGACGCCAAGGTGCGCCACACCGTCGAGGG
CATCCTGGGCGATATCGAGGCGCGGGGCGATGCGGCGGTGCGCGATCTGTCGGCTAAATTCGATGGGTATTCGCCTGAAG
CGTTTCGCCTGAGCGCCTCGGAGATCGAGGCCGCGATGCAGAAGGTCTCCACCCGGGAGATGGAAGATATCCGCTTTGCC
CAGACCCAGATCCGCCGGTTTGCCGAGGCGCAGCGCGCGTCGATGACCGACATCGAAGTGGAAACGATGCCGGGCGTGAT
CCTGGGCCACAAGAATATCCCGGTGAATTCCGTGGGCTGCTATGTGCCCGGCGGCAAGTTCCCGATGGTCGCCTCCGCCC
ATATGTCGGTGCTGACGGCGAAAGTGGCAGGCGTGAAACGCGTCGTGGCCTCCGCCCCGCCGATGAACGGTGCGCCGCAC
CCGGCGATCGTGGCCGCGATGCATGAAGGCGGCGCCGATGAAATCCTGTGCCTGGGCGGCGTGCAAGCCGTGGGCGCGAT
GGCGATTGGAACGGAAACGGTGAAGCCCGTCGATATGTTGGTGGGGCCGGGCAATGCCTTTGTGGCGGAAGCGAAGCGAC
AGCTCTTTGGCCGCGTGGGGATTGACCTGTTCGCCGGCCCGACAGAGACCTGCGTGATCGCCGATGAGACCGTCGACGGG
GAGATGTGCGCCACGGACCTGCTGGGGCAGGCGGAGCATGGGTATAACTCCCCCGCCGTGCTGATCACCAATTCGCGCAG
GTTGGCCGATGACACCCTGGCCGAGATCGAGCGGATCCTTGGGATCCTGCCCACCGCCGAGACGGCGCGCGTGTCTTGGG
AGGATTACGGAGAGGTCATCGTCTGCGACAGTTACGACGAGATGCTGGCCGTGTCCGAGGACATCGCGTCGGAGCATATC
CAAGTGATGACCGACCGCGACGACTGGTTTCTGGAGAACATGACCAGCTATGGCGCGCTGTTTCTGGGGCCGCGCACGAA
CGTGGCCAATGGCGACAAGGTGATTGGCACGAACCACACGCTGCCGACGAAGAAGGCGGGCCGGTATACGGGTGGGCTTT
GGGTTGGAAAGTTCCTGAAAACGCATTCGTATCAGAAGGTTGTGACGGATGAGGCGGCGACGCTGGTCGGTGAATACGGC
TCGCGTCTGTGCATGTTGGAGGGCTTCGTGGGCCACGCGGAGCAATGCAACATCCGCGTGCGCCGGTATGGCGGGTTGAA
TGTGCCCTATGGCGAGGGCGCGCCCTACCACGACGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
CAGCGTATCGGCCCATTGTTTTTGCAATCGTATGCAGATTCTTCTTGAAGCGGGTCGAGGCCCTTGTATCCTTGCGCTGA
CCAGTGGCGGAGGGAATGCG

Downstream 100 bases:

>100_bases
GTTTTGGGGGTGGCGGGCCCCGCCCGCCCACCCCTTTTTGTGGGGGCCAGCCCCCACACCCCCGGGATATTTAGAGAACG
GGGAAACAGGGAGAGTGCCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MAEYLKRGKPADERAEDDAKVRHTVEGILGDIEARGDAAVRDLSAKFDGYSPEAFRLSASEIEAAMQKVSTREMEDIRFA
QTQIRRFAEAQRASMTDIEVETMPGVILGHKNIPVNSVGCYVPGGKFPMVASAHMSVLTAKVAGVKRVVASAPPMNGAPH
PAIVAAMHEGGADEILCLGGVQAVGAMAIGTETVKPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETCVIADETVDG
EMCATDLLGQAEHGYNSPAVLITNSRRLADDTLAEIERILGILPTAETARVSWEDYGEVIVCDSYDEMLAVSEDIASEHI
QVMTDRDDWFLENMTSYGALFLGPRTNVANGDKVIGTNHTLPTKKAGRYTGGLWVGKFLKTHSYQKVVTDEAATLVGEYG
SRLCMLEGFVGHAEQCNIRVRRYGGLNVPYGEGAPYHDAAE

Sequences:

>Translated_441_residues
MAEYLKRGKPADERAEDDAKVRHTVEGILGDIEARGDAAVRDLSAKFDGYSPEAFRLSASEIEAAMQKVSTREMEDIRFA
QTQIRRFAEAQRASMTDIEVETMPGVILGHKNIPVNSVGCYVPGGKFPMVASAHMSVLTAKVAGVKRVVASAPPMNGAPH
PAIVAAMHEGGADEILCLGGVQAVGAMAIGTETVKPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETCVIADETVDG
EMCATDLLGQAEHGYNSPAVLITNSRRLADDTLAEIERILGILPTAETARVSWEDYGEVIVCDSYDEMLAVSEDIASEHI
QVMTDRDDWFLENMTSYGALFLGPRTNVANGDKVIGTNHTLPTKKAGRYTGGLWVGKFLKTHSYQKVVTDEAATLVGEYG
SRLCMLEGFVGHAEQCNIRVRRYGGLNVPYGEGAPYHDAAE
>Mature_440_residues
AEYLKRGKPADERAEDDAKVRHTVEGILGDIEARGDAAVRDLSAKFDGYSPEAFRLSASEIEAAMQKVSTREMEDIRFAQ
TQIRRFAEAQRASMTDIEVETMPGVILGHKNIPVNSVGCYVPGGKFPMVASAHMSVLTAKVAGVKRVVASAPPMNGAPHP
AIVAAMHEGGADEILCLGGVQAVGAMAIGTETVKPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETCVIADETVDGE
MCATDLLGQAEHGYNSPAVLITNSRRLADDTLAEIERILGILPTAETARVSWEDYGEVIVCDSYDEMLAVSEDIASEHIQ
VMTDRDDWFLENMTSYGALFLGPRTNVANGDKVIGTNHTLPTKKAGRYTGGLWVGKFLKTHSYQKVVTDEAATLVGEYGS
RLCMLEGFVGHAEQCNIRVRRYGGLNVPYGEGAPYHDAAE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=35.9801488833747, Blast_Score=231, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6319819, Length=416, Percent_Identity=32.6923076923077, Blast_Score=202, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47426; Mature: 47295

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYLKRGKPADERAEDDAKVRHTVEGILGDIEARGDAAVRDLSAKFDGYSPEAFRLSAS
CCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEECHH
EIEAAMQKVSTREMEDIRFAQTQIRRFAEAQRASMTDIEVETMPGVILGHKNIPVNSVGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCEE
YVPGGKFPMVASAHMSVLTAKVAGVKRVVASAPPMNGAPHPAIVAAMHEGGADEILCLGG
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEECC
VQAVGAMAIGTETVKPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETCVIADETVDG
HHHHHHHEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCC
EMCATDLLGQAEHGYNSPAVLITNSRRLADDTLAEIERILGILPTAETARVSWEDYGEVI
HHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHCEECHHCCCCEE
VCDSYDEMLAVSEDIASEHIQVMTDRDDWFLENMTSYGALFLGPRTNVANGDKVIGTNHT
EECCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCEEEECCCCCCCCCCEEEECCCC
LPTKKAGRYTGGLWVGKFLKTHSYQKVVTDEAATLVGEYGSRLCMLEGFVGHAEQCNIRV
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEE
RRYGGLNVPYGEGAPYHDAAE
EEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEYLKRGKPADERAEDDAKVRHTVEGILGDIEARGDAAVRDLSAKFDGYSPEAFRLSAS
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEECHH
EIEAAMQKVSTREMEDIRFAQTQIRRFAEAQRASMTDIEVETMPGVILGHKNIPVNSVGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCEE
YVPGGKFPMVASAHMSVLTAKVAGVKRVVASAPPMNGAPHPAIVAAMHEGGADEILCLGG
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEECC
VQAVGAMAIGTETVKPVDMLVGPGNAFVAEAKRQLFGRVGIDLFAGPTETCVIADETVDG
HHHHHHHEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCC
EMCATDLLGQAEHGYNSPAVLITNSRRLADDTLAEIERILGILPTAETARVSWEDYGEVI
HHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHCEECHHCCCCEE
VCDSYDEMLAVSEDIASEHIQVMTDRDDWFLENMTSYGALFLGPRTNVANGDKVIGTNHT
EECCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCEEEECCCCCCCCCCEEEECCCC
LPTKKAGRYTGGLWVGKFLKTHSYQKVVTDEAATLVGEYGSRLCMLEGFVGHAEQCNIRV
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEE
RRYGGLNVPYGEGAPYHDAAE
EEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]