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The map label for this gene is thyX

Identifier: 89053582

GI number: 89053582

Start: 1053758

End: 1054714

Strand: Direct

Name: thyX

Synonym: Jann_1091

Alternate gene names: 89053582

Gene position: 1053758-1054714 (Clockwise)

Preceding gene: 89053578

Following gene: 89053583

Centisome position: 24.4

GC content: 62.07

Gene sequence:

>957_bases
ATGTGGCCTCTAGCCGCTCGCCCCAACCGATTCCGTAGCATTAGGACCTTTGTCATGCCGCTCACCCCTGAACAACTGGA
GGATATCCAGAATTCCCGCGCCAATCCCCAGCCGACGCTGCGTGCGGTCGCCCCGGGGATGGAGCAGCACCTTTATGAGG
CGAAACCGGTCCTCGACCACGGCTTCGTGCGGGTCATCGACTATATGGGCGACGACGCGGCCATCGTGCAGGCGGCGCGG
GTCAGCTACGGGGCGGGGACGAAAAAGGCGCGCGATGACAGCGGCTTGATCCGTTACCTGATGCGCCACTGGCACAGCAC
GCCGTTCGAGATGTGTGAGTTGAAACTGCACGTCAAACTGCCCGTTTTCGTGGCCCGCCAGTGGATCCGCCACCGCACCG
CCAACGTCAACGAATACTCGGCGCGGTATTCGATTCTGGACCGGGAGTTCTACATCCCCCAGCCCGACCAACTGGCCGCG
CAATCGGTGGTCAACAATCAGGGCCGGGGGGAGACTTTGCAGGGCGAGGAGGCTGAGCGCGTTTTGCGGATGCTCAAGGA
CGATGCAGGTCGCGCGTATGATCACTATGAGGAGATGTTATCGCAGGAGGGTCAGCAGGGTCTGGCGCGCGAACTGGCCC
GCATGAACCTGCCCGCGAACGTCTACACCCAATGGTACTGGAAAGTGGACCTGCACAACCTGTTCCACTTCCTCCGCCTG
CGGGCGGATGAGCACGCGCAGTATGAAATCCGCGTCTATGCGGACGCGATCTGCGAGATGGTCAAAGACTGGGTCCCGGC
GGCCTATGGCGCGTTCGAGGACTACCGGATGGGCGGCGTCCAGTTGTCAGGCAAGGGCGTTGAGGTGTTGAGGCGGCGTC
TAGCCGGGGAAGAGGTGACGCAGGAGACGTCTGGGATGAGCAAGGGAGAATGGCGGGAGTTCGAGGCGGTGTTTTAA

Upstream 100 bases:

>100_bases
CAAATCCGGGCGCGCGCGCCGTCATCCGTTCTAGTTTCGCAACGCTTTGCGCGACCATGGTGCCTCAACTTCTTGCGGTC
TGGACATCGCGTGGGGCAAG

Downstream 100 bases:

>100_bases
TGAGTGGAGATGGCAGCCTGGCAAGAAATAACTTTGCACTAGGTTTCTTGTCAGGCTCTCTATTTTCATTGTTTCTCCTG
CTGTTTTTAGATTTCTTTCA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MWPLAARPNRFRSIRTFVMPLTPEQLEDIQNSRANPQPTLRAVAPGMEQHLYEAKPVLDHGFVRVIDYMGDDAAIVQAAR
VSYGAGTKKARDDSGLIRYLMRHWHSTPFEMCELKLHVKLPVFVARQWIRHRTANVNEYSARYSILDREFYIPQPDQLAA
QSVVNNQGRGETLQGEEAERVLRMLKDDAGRAYDHYEEMLSQEGQQGLARELARMNLPANVYTQWYWKVDLHNLFHFLRL
RADEHAQYEIRVYADAICEMVKDWVPAAYGAFEDYRMGGVQLSGKGVEVLRRRLAGEEVTQETSGMSKGEWREFEAVF

Sequences:

>Translated_318_residues
MWPLAARPNRFRSIRTFVMPLTPEQLEDIQNSRANPQPTLRAVAPGMEQHLYEAKPVLDHGFVRVIDYMGDDAAIVQAAR
VSYGAGTKKARDDSGLIRYLMRHWHSTPFEMCELKLHVKLPVFVARQWIRHRTANVNEYSARYSILDREFYIPQPDQLAA
QSVVNNQGRGETLQGEEAERVLRMLKDDAGRAYDHYEEMLSQEGQQGLARELARMNLPANVYTQWYWKVDLHNLFHFLRL
RADEHAQYEIRVYADAICEMVKDWVPAAYGAFEDYRMGGVQLSGKGVEVLRRRLAGEEVTQETSGMSKGEWREFEAVF
>Mature_318_residues
MWPLAARPNRFRSIRTFVMPLTPEQLEDIQNSRANPQPTLRAVAPGMEQHLYEAKPVLDHGFVRVIDYMGDDAAIVQAAR
VSYGAGTKKARDDSGLIRYLMRHWHSTPFEMCELKLHVKLPVFVARQWIRHRTANVNEYSARYSILDREFYIPQPDQLAA
QSVVNNQGRGETLQGEEAERVLRMLKDDAGRAYDHYEEMLSQEGQQGLARELARMNLPANVYTQWYWKVDLHNLFHFLRL
RADEHAQYEIRVYADAICEMVKDWVPAAYGAFEDYRMGGVQLSGKGVEVLRRRLAGEEVTQETSGMSKGEWREFEAVF

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 36795; Mature: 36795

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPLAARPNRFRSIRTFVMPLTPEQLEDIQNSRANPQPTLRAVAPGMEQHLYEAKPVLDH
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHCCHHHH
GFVRVIDYMGDDAAIVQAARVSYGAGTKKARDDSGLIRYLMRHWHSTPFEMCELKLHVKL
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHEEEEECC
PVFVARQWIRHRTANVNEYSARYSILDREFYIPQPDQLAAQSVVNNQGRGETLQGEEAER
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
VLRMLKDDAGRAYDHYEEMLSQEGQQGLARELARMNLPANVYTQWYWKVDLHNLFHFLRL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEEEEHHHHHHHHHH
RADEHAQYEIRVYADAICEMVKDWVPAAYGAFEDYRMGGVQLSGKGVEVLRRRLAGEEVT
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEECCCCHHHHHHHHCCHHHH
QETSGMSKGEWREFEAVF
HHHCCCCCCCCCHHHCCC
>Mature Secondary Structure
MWPLAARPNRFRSIRTFVMPLTPEQLEDIQNSRANPQPTLRAVAPGMEQHLYEAKPVLDH
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHCCHHHH
GFVRVIDYMGDDAAIVQAARVSYGAGTKKARDDSGLIRYLMRHWHSTPFEMCELKLHVKL
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHEEEEECC
PVFVARQWIRHRTANVNEYSARYSILDREFYIPQPDQLAAQSVVNNQGRGETLQGEEAER
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
VLRMLKDDAGRAYDHYEEMLSQEGQQGLARELARMNLPANVYTQWYWKVDLHNLFHFLRL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEEEEHHHHHHHHHH
RADEHAQYEIRVYADAICEMVKDWVPAAYGAFEDYRMGGVQLSGKGVEVLRRRLAGEEVT
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEECCCCHHHHHHHHCCHHHH
QETSGMSKGEWREFEAVF
HHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA