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The map label for this gene is hflK [H]

Identifier: 88657696

GI number: 88657696

Start: 1078544

End: 1079617

Strand: Direct

Name: hflK [H]

Synonym: ECH_1050

Alternate gene names: 88657696

Gene position: 1078544-1079617 (Clockwise)

Preceding gene: 88657748

Following gene: 88658164

Centisome position: 91.69

GC content: 33.52

Gene sequence:

>1074_bases
ATGTTTGATGATTATGATCCTTGGAATAGTAATAACAAAGAAGACCACAAATCTAAAGGATATAAAAATTCCAATGATAT
TAATAAAGTTATTCACTATTTCAACAATACATTTGGTTCATTTTTAAAAAACAAGAAAGGCATTCGACCTAATAATCATG
GAAAAACACAATTTATTATCGCATTTTTAGTCATGATGCTTCTATACATGGGGTCTGGGTTTTACATAGTCGAACCTGAA
GAAGAAGCTGTACAACTACTATTTGGTAAATATCATGACACTGTAGGTCCCGGGTTGCGTTATTATCTCCCATCCCCTAT
TGGACAGGTAATTAAGTTAAAAGTTAAAACAGTTAACAGGGAAGAAATAGGTTCTAGGTTTTATTCAGATAGCACTTCAG
GCCATGGCGAAGGTGTTATGTTAACTGGAGATGAAAACATCGTTAACATAAACTTTGATGTTCATTGGCGCATCAACAAT
GCATACAACTACTTGTTTAAAGTCAGAGATAACCAAGTAGGAGATACAGTAAAAAATGCAGCTGAAAGTGCAATGCGTGA
AGTTATTGGAAAAAGCTCTATATCTTTTGCAATTGAGGGGAAAGGAAGAGCCATAATATCACAAGAAACTAAGACATTAC
TACAGCATATTCTAGATCAATATAATATGGGAGTTGAAATTTTATCAATTCAGCTAAAAAAAGTTGATCCTCCAGAAAAA
GTGATCAATTCTTTTAGAGATGTACAGAGTGCAAGAGCTGATAAAGAAAAGTTGATTAACGAGGCATATGCATACCGTAA
TCAAGTACTGCCAAAAGCTAAAGGTGAGGCTATAAAAATTAAACTAGATGCAGAAGCATACGAAAGTGAAGTAGTTAACG
CAGCTGAAGGTAATACAAAAAGGTTCATTGCTCTCTATAAAGAATACGTATATCAACCTGATGCAATGAGAAATCGTTTA
TATTTAGAAACAATGGAAGAAATATTAAATAAAAATGATAAGGTAGTTGTCAGCGATGATCTGAAAGGTATGCTTTCTTA
CTTCCCGTTAGCAGATCCTAGAAATAGTAGGTAA

Upstream 100 bases:

>100_bases
TGGTATTTTAATGTTAACAACAGTTATGTTTTGTTATATATTAGATACGGTACAGTGCTGAAAATGAGTAATGCATTTAG
TTAAATAGGTGGAATAGCTT

Downstream 100 bases:

>100_bases
GTTTATGAGTAAATCATTTAAGTTCATATTAGGGTTTTTAACTATCGCAACAGTTATCGTATCATTAAACTCCATGTTTA
TTGTCGATGAAGCACATCAA

Product: hflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MFDDYDPWNSNNKEDHKSKGYKNSNDINKVIHYFNNTFGSFLKNKKGIRPNNHGKTQFIIAFLVMMLLYMGSGFYIVEPE
EEAVQLLFGKYHDTVGPGLRYYLPSPIGQVIKLKVKTVNREEIGSRFYSDSTSGHGEGVMLTGDENIVNINFDVHWRINN
AYNYLFKVRDNQVGDTVKNAAESAMREVIGKSSISFAIEGKGRAIISQETKTLLQHILDQYNMGVEILSIQLKKVDPPEK
VINSFRDVQSARADKEKLINEAYAYRNQVLPKAKGEAIKIKLDAEAYESEVVNAAEGNTKRFIALYKEYVYQPDAMRNRL
YLETMEEILNKNDKVVVSDDLKGMLSYFPLADPRNSR

Sequences:

>Translated_357_residues
MFDDYDPWNSNNKEDHKSKGYKNSNDINKVIHYFNNTFGSFLKNKKGIRPNNHGKTQFIIAFLVMMLLYMGSGFYIVEPE
EEAVQLLFGKYHDTVGPGLRYYLPSPIGQVIKLKVKTVNREEIGSRFYSDSTSGHGEGVMLTGDENIVNINFDVHWRINN
AYNYLFKVRDNQVGDTVKNAAESAMREVIGKSSISFAIEGKGRAIISQETKTLLQHILDQYNMGVEILSIQLKKVDPPEK
VINSFRDVQSARADKEKLINEAYAYRNQVLPKAKGEAIKIKLDAEAYESEVVNAAEGNTKRFIALYKEYVYQPDAMRNRL
YLETMEEILNKNDKVVVSDDLKGMLSYFPLADPRNSR
>Mature_357_residues
MFDDYDPWNSNNKEDHKSKGYKNSNDINKVIHYFNNTFGSFLKNKKGIRPNNHGKTQFIIAFLVMMLLYMGSGFYIVEPE
EEAVQLLFGKYHDTVGPGLRYYLPSPIGQVIKLKVKTVNREEIGSRFYSDSTSGHGEGVMLTGDENIVNINFDVHWRINN
AYNYLFKVRDNQVGDTVKNAAESAMREVIGKSSISFAIEGKGRAIISQETKTLLQHILDQYNMGVEILSIQLKKVDPPEK
VINSFRDVQSARADKEKLINEAYAYRNQVLPKAKGEAIKIKLDAEAYESEVVNAAEGNTKRFIALYKEYVYQPDAMRNRL
YLETMEEILNKNDKVVVSDDLKGMLSYFPLADPRNSR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=279, Percent_Identity=36.9175627240143, Blast_Score=171, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 40801; Mature: 40801

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDDYDPWNSNNKEDHKSKGYKNSNDINKVIHYFNNTFGSFLKNKKGIRPNNHGKTQFII
CCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
AFLVMMLLYMGSGFYIVEPEEEAVQLLFGKYHDTVGPGLRYYLPSPIGQVIKLKVKTVNR
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEEECCH
EEIGSRFYSDSTSGHGEGVMLTGDENIVNINFDVHWRINNAYNYLFKVRDNQVGDTVKNA
HHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEEEEECCCEEEEEEECCCCCCHHHHHH
AESAMREVIGKSSISFAIEGKGRAIISQETKTLLQHILDQYNMGVEILSIQLKKVDPPEK
HHHHHHHHHCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHH
VINSFRDVQSARADKEKLINEAYAYRNQVLPKAKGEAIKIKLDAEAYESEVVNAAEGNTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCHH
RFIALYKEYVYQPDAMRNRLYLETMEEILNKNDKVVVSDDLKGMLSYFPLADPRNSR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFDDYDPWNSNNKEDHKSKGYKNSNDINKVIHYFNNTFGSFLKNKKGIRPNNHGKTQFII
CCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
AFLVMMLLYMGSGFYIVEPEEEAVQLLFGKYHDTVGPGLRYYLPSPIGQVIKLKVKTVNR
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEEECCH
EEIGSRFYSDSTSGHGEGVMLTGDENIVNINFDVHWRINNAYNYLFKVRDNQVGDTVKNA
HHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEEEEECCCEEEEEEECCCCCCHHHHHH
AESAMREVIGKSSISFAIEGKGRAIISQETKTLLQHILDQYNMGVEILSIQLKKVDPPEK
HHHHHHHHHCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHH
VINSFRDVQSARADKEKLINEAYAYRNQVLPKAKGEAIKIKLDAEAYESEVVNAAEGNTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCHH
RFIALYKEYVYQPDAMRNRLYLETMEEILNKNDKVVVSDDLKGMLSYFPLADPRNSR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]